Page last updated: 2024-10-20

quinolinic acid and Aging

quinolinic acid has been researched along with Aging in 29 studies

Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking."8.12Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022)
"Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)."7.79Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013)
" A comparative study of electrophysiological and behavioural features in aged rats and in young rats following chronic administration of a naturally occurring brain metabolite, quinolinic acid (QUIN), recently demonstrated to increase in the cerebral cortex of rats as a function of age, is reported."5.27Experimental models of aging and quinolinic acid. ( Aldinio, C; Aporti, F; Calderini, G; Mazzari, S; Toffano, G; Zanotti, A, 1985)
"The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking."4.12Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022)
" Low xanthurenic acid occurred in both AD and with aging."3.85Kynurenine Pathway Metabolites in Alzheimer's Disease. ( Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A, 2017)
"Quinolinic acid (QUIN) is a neuroactive metabolite of the kinurenine pathway, considered to be involved in aging and some neurodegenerative disorders, including Huntington׳s disease."3.80Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats. ( Ferreira, F; Gonçalves Fernandes, C; Pessoa-Pureur, R; Pierozan, P, 2014)
"Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)."3.79Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013)
"The kynurenine pathway of tryptophan catabolism plays an important role in several biological systems affected by aging."3.77Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. ( Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H, 2011)
"In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h."1.35Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009)
"The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years."1.35[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]. ( Bagdy, G; Domokos, A; Garab, D; Kálmán, J; Kálmán, S; Pákáski, M; Puskás, L; Szucs, S; Zelena, D; Zvara, A, 2009)
"Huntington's disease is an inherited neurodegenerative condition characterized by movement disorders, and mood and cognitive disturbance."1.33Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease. ( Barker, RA; Morton, AJ; Phillips, W, 2006)
"Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system."1.32Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004)
"Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss."1.31Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. ( Brundin, P; Castilho, RF; DiFiglia, M; Hansson, O; Petersén, A; Przedborski, S; Puschban, Z; Rice, M; Romero, N; Sapp, E; Sulzer, D, 2001)
"Phthalic acid was a potent competitive inhibitor of brain QPRTase."1.27Quinolinic acid phosphoribosyltransferase in rat brain. ( Foster, AC; Schwarcz, R; Zinkand, WC, 1985)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's5 (17.24)18.2507
2000's10 (34.48)29.6817
2010's8 (27.59)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Solvang, SH1
Hodge, A1
Watne, LO1
Cabral-Marques, O1
Nordrehaug, JE1
Giles, GG1
Dugué, PA1
Nygård, O1
Ueland, PM2
McCann, A1
Idland, AV1
Midttun, Ø2
Ulvik, A2
Halaas, NB1
Tell, GS1
Giil, LM2
Refsum, H1
Advani, R1
Smith, AD1
Mazarei, G1
Budac, DP1
Lu, G1
Adomat, H1
Tomlinson Guns, ES1
Möller, T1
Leavitt, BR1
Strong, MK1
Southwell, AL1
Yonan, JM1
Hayden, MR1
Macgregor, GR1
Thompson, LM1
Steward, O1
Pierozan, P1
Gonçalves Fernandes, C1
Ferreira, F1
Pessoa-Pureur, R1
de Bie, J1
Guest, J1
Guillemin, GJ2
Grant, R2
Coggan, SE1
Smythe, GA1
Bilgin, A1
Grant, RS1
Kálmán, S1
Pákáski, M1
Szucs, S1
Garab, D1
Domokos, A1
Zvara, A1
Puskás, L1
Bagdy, G1
Zelena, D1
Kálmán, J1
Kim, SH1
Thomas, CA1
André, VM1
Cummings, DM1
Cepeda, C1
Levine, MS1
Ehrlich, ME1
Braidy, N1
Mansour, H1
Chan-Ling, T1
Tan, L2
Yu, JT1
Sun, Z1
Chen, Q2
Reiner, A2
de Oliveira, DL1
Horn, JF1
Rodrigues, JM1
Frizzo, ME1
Moriguchi, E1
Souza, DO1
Wofchuk, S1
Pezzi, S1
Checa, N3
Alberch, J3
Phillips, W1
Morton, AJ1
Barker, RA1
Moroni, F2
Lombardi, G2
Moneti, G1
Aldinio, C2
Nakano, K1
Takahashi, S1
Mizobuchi, M1
Kuroda, T1
Masuda, K1
Kitoh, J1
Ceresoli, G1
Guidetti, P1
Schwarcz, R2
Figueredo-Cardenas, G1
Canals, JM2
Cannazza, G1
Chiarugi, A1
Parenti, C1
Zanoli, P1
Baraldi, M1
Gratacòs, E1
Petersén, A1
Hansson, O1
Puschban, Z1
Sapp, E1
Romero, N1
Castilho, RF1
Sulzer, D1
Rice, M1
DiFiglia, M1
Przedborski, S1
Brundin, P1
Taylor, R1
Finn, SF1
Hyman, BT1
Storey, E1
Miller, JM1
Beal, MF1
Shaw, C1
Prusky, G1
van Huizen, F1
Cynader, M1
Foster, AC1
Zinkand, WC1
Aporti, F1
Calderini, G1
Mazzari, S1
Zanotti, A1
Toffano, G1
Carlà, V1

Reviews

1 review available for quinolinic acid and Aging

ArticleYear
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
    Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2

    Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting

2012

Other Studies

28 other studies available for quinolinic acid and Aging

ArticleYear
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan

2022
Kynurenine Pathway Metabolites in Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; C

2017
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
    Journal of neurochemistry, 2013, Volume: 127, Issue:6

    Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamin

2013
Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.
    Journal of Huntington's disease, 2012, Volume: 1, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Huntingti

2012
Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats.
    Brain research, 2014, Aug-19, Volume: 1577

    Topics: Aging; Animals; Astrocytes; Cerebral Cortex; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases;

2014
Central kynurenine pathway shift with age in women.
    Journal of neurochemistry, 2016, Volume: 136, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni

2016
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
    Journal of neurochemistry, 2009, Volume: 108, Issue:5

    Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas

2009
[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain].
    Ideggyogyaszati szemle, 2009, Sep-30, Volume: 62, Issue:9-10

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Mitogen-Activated Protein

2009
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.
    ASN neuro, 2011, Jun-07, Volume: 3, Issue:3

    Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Electron Transport Chain Complex Proteins;

2011
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
    The FEBS journal, 2011, Volume: 278, Issue:22

    Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectro

2011
Enkephalinergic striatal projection neurons become less affected by quinolinic acid than substance P-containing striatal projection neurons as rats age.
    Experimental neurology, 2003, Volume: 184, Issue:2

    Topics: Aging; Animals; Cell Survival; Corpus Striatum; Efferent Pathways; Enkephalins; In Situ Hybridizatio

2003
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim

2004
The vulnerability of striatal projection neurons and interneurons to excitotoxicity is differentially regulated by dopamine during development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2005, Volume: 23, Issue:4

    Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Gene Expression Regu

2005
Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease.
    Neuroreport, 2006, Oct-23, Volume: 17, Issue:15

    Topics: Aging; Animals; Disease Models, Animal; Doublecortin Domain Proteins; Huntington Disease; Immunohist

2006
The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process.
    Neuroscience letters, 1984, Jun-01, Volume: 47, Issue:1

    Topics: Aging; Animals; Brain; Cerebral Cortex; Female; Guinea Pigs; Male; Mass Spectrometry; Neurotoxins; P

1984
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methi

1993
Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.
    Brain research. Developmental brain research, 1997, May-20, Volume: 100, Issue:1

    Topics: Aging; Animals; Brain; Corpus Striatum; Functional Laterality; Glutamate Decarboxylase; Ibotenic Aci

1997
Age-dependent differences in survival of striatal somatostatin-NPY-NADPH-diaphorase-containing interneurons versus striatal projection neurons after intrastriatal injection of quinolinic acid in rats.
    Experimental neurology, 1997, Volume: 146, Issue:2

    Topics: Aging; Animals; Cell Survival; Corpus Striatum; Injections; Interneurons; Male; NADPH Dehydrogenase;

1997
Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections.
    Experimental neurology, 2000, Volume: 165, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Corpus Striatum; Injections; Ma

2000
Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.
    Neurochemical research, 2001, Volume: 26, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Brain; Embryo, Mammalian; Female; Kynurenic Acid; Male; ortho-Amin

2001
TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia.
    Experimental neurology, 2001, Volume: 172, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Basal Ganglia; Cerebral Cortex; Corpus Striatum; Injections; Male;

2001
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
    The European journal of neuroscience, 2001, Volume: 14, Issue:9

    Topics: Aging; Animals; Ascorbic Acid; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Respons

2001
A lot of "excitement' about neurodegeneration.
    Science (New York, N.Y.), 1991, Jun-07, Volume: 252, Issue:5011

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate

1991
Effects of aging on quinolinic acid lesions in rat striatum.
    Brain research, 1991, Oct-25, Volume: 562, Issue:2

    Topics: Aging; Animals; Biomarkers; Cerebral Cortex; Corpus Striatum; Disease Susceptibility; Hippocampus; M

1991
Differential effects of quinolinic acid lesions on muscarinic acetylcholine receptors in cat visual cortex during postnatal development.
    Brain research bulletin, 1989, Volume: 22, Issue:4

    Topics: Aging; Animals; Cats; Pirenzepine; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Muscarin

1989
Quinolinic acid phosphoribosyltransferase in rat brain.
    Journal of neurochemistry, 1985, Volume: 44, Issue:2

    Topics: Aging; Animals; Brain; Kinetics; Liver; Nicotinamide Mononucleotide; Pentosyltransferases; Phosphori

1985
Experimental models of aging and quinolinic acid.
    Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:11

    Topics: Aging; Animals; Avoidance Learning; Brain; Electroencephalography; Models, Biological; Pyridines; Qu

1985
The physiopathological role of quinolinic acid in the mammalian central nervous system.
    Annali dell'Istituto superiore di sanita, 1988, Volume: 24, Issue:3

    Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic En

1988