quinolinic acid has been researched along with Aging in 29 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking." | 8.12 | Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022) |
| "Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)." | 7.79 | Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013) |
| " A comparative study of electrophysiological and behavioural features in aged rats and in young rats following chronic administration of a naturally occurring brain metabolite, quinolinic acid (QUIN), recently demonstrated to increase in the cerebral cortex of rats as a function of age, is reported." | 5.27 | Experimental models of aging and quinolinic acid. ( Aldinio, C; Aporti, F; Calderini, G; Mazzari, S; Toffano, G; Zanotti, A, 1985) |
| "The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking." | 4.12 | Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022) |
| " Low xanthurenic acid occurred in both AD and with aging." | 3.85 | Kynurenine Pathway Metabolites in Alzheimer's Disease. ( Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A, 2017) |
| "Quinolinic acid (QUIN) is a neuroactive metabolite of the kinurenine pathway, considered to be involved in aging and some neurodegenerative disorders, including Huntington׳s disease." | 3.80 | Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats. ( Ferreira, F; Gonçalves Fernandes, C; Pessoa-Pureur, R; Pierozan, P, 2014) |
| "Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)." | 3.79 | Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013) |
| "The kynurenine pathway of tryptophan catabolism plays an important role in several biological systems affected by aging." | 3.77 | Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. ( Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H, 2011) |
| "In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h." | 1.35 | Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009) |
| "The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years." | 1.35 | [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]. ( Bagdy, G; Domokos, A; Garab, D; Kálmán, J; Kálmán, S; Pákáski, M; Puskás, L; Szucs, S; Zelena, D; Zvara, A, 2009) |
| "Huntington's disease is an inherited neurodegenerative condition characterized by movement disorders, and mood and cognitive disturbance." | 1.33 | Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease. ( Barker, RA; Morton, AJ; Phillips, W, 2006) |
| "Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system." | 1.32 | Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004) |
| "Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss." | 1.31 | Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. ( Brundin, P; Castilho, RF; DiFiglia, M; Hansson, O; Petersén, A; Przedborski, S; Puschban, Z; Rice, M; Romero, N; Sapp, E; Sulzer, D, 2001) |
| "Phthalic acid was a potent competitive inhibitor of brain QPRTase." | 1.27 | Quinolinic acid phosphoribosyltransferase in rat brain. ( Foster, AC; Schwarcz, R; Zinkand, WC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Solvang, SH | 1 |
| Hodge, A | 1 |
| Watne, LO | 1 |
| Cabral-Marques, O | 1 |
| Nordrehaug, JE | 1 |
| Giles, GG | 1 |
| Dugué, PA | 1 |
| Nygård, O | 1 |
| Ueland, PM | 2 |
| McCann, A | 1 |
| Idland, AV | 1 |
| Midttun, Ø | 2 |
| Ulvik, A | 2 |
| Halaas, NB | 1 |
| Tell, GS | 1 |
| Giil, LM | 2 |
| Refsum, H | 1 |
| Advani, R | 1 |
| Smith, AD | 1 |
| Mazarei, G | 1 |
| Budac, DP | 1 |
| Lu, G | 1 |
| Adomat, H | 1 |
| Tomlinson Guns, ES | 1 |
| Möller, T | 1 |
| Leavitt, BR | 1 |
| Strong, MK | 1 |
| Southwell, AL | 1 |
| Yonan, JM | 1 |
| Hayden, MR | 1 |
| Macgregor, GR | 1 |
| Thompson, LM | 1 |
| Steward, O | 1 |
| Pierozan, P | 1 |
| Gonçalves Fernandes, C | 1 |
| Ferreira, F | 1 |
| Pessoa-Pureur, R | 1 |
| de Bie, J | 1 |
| Guest, J | 1 |
| Guillemin, GJ | 2 |
| Grant, R | 2 |
| Coggan, SE | 1 |
| Smythe, GA | 1 |
| Bilgin, A | 1 |
| Grant, RS | 1 |
| Kálmán, S | 1 |
| Pákáski, M | 1 |
| Szucs, S | 1 |
| Garab, D | 1 |
| Domokos, A | 1 |
| Zvara, A | 1 |
| Puskás, L | 1 |
| Bagdy, G | 1 |
| Zelena, D | 1 |
| Kálmán, J | 1 |
| Kim, SH | 1 |
| Thomas, CA | 1 |
| André, VM | 1 |
| Cummings, DM | 1 |
| Cepeda, C | 1 |
| Levine, MS | 1 |
| Ehrlich, ME | 1 |
| Braidy, N | 1 |
| Mansour, H | 1 |
| Chan-Ling, T | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Sun, Z | 1 |
| Chen, Q | 2 |
| Reiner, A | 2 |
| de Oliveira, DL | 1 |
| Horn, JF | 1 |
| Rodrigues, JM | 1 |
| Frizzo, ME | 1 |
| Moriguchi, E | 1 |
| Souza, DO | 1 |
| Wofchuk, S | 1 |
| Pezzi, S | 1 |
| Checa, N | 3 |
| Alberch, J | 3 |
| Phillips, W | 1 |
| Morton, AJ | 1 |
| Barker, RA | 1 |
| Moroni, F | 2 |
| Lombardi, G | 2 |
| Moneti, G | 1 |
| Aldinio, C | 2 |
| Nakano, K | 1 |
| Takahashi, S | 1 |
| Mizobuchi, M | 1 |
| Kuroda, T | 1 |
| Masuda, K | 1 |
| Kitoh, J | 1 |
| Ceresoli, G | 1 |
| Guidetti, P | 1 |
| Schwarcz, R | 2 |
| Figueredo-Cardenas, G | 1 |
| Canals, JM | 2 |
| Cannazza, G | 1 |
| Chiarugi, A | 1 |
| Parenti, C | 1 |
| Zanoli, P | 1 |
| Baraldi, M | 1 |
| Gratacòs, E | 1 |
| Petersén, A | 1 |
| Hansson, O | 1 |
| Puschban, Z | 1 |
| Sapp, E | 1 |
| Romero, N | 1 |
| Castilho, RF | 1 |
| Sulzer, D | 1 |
| Rice, M | 1 |
| DiFiglia, M | 1 |
| Przedborski, S | 1 |
| Brundin, P | 1 |
| Taylor, R | 1 |
| Finn, SF | 1 |
| Hyman, BT | 1 |
| Storey, E | 1 |
| Miller, JM | 1 |
| Beal, MF | 1 |
| Shaw, C | 1 |
| Prusky, G | 1 |
| van Huizen, F | 1 |
| Cynader, M | 1 |
| Foster, AC | 1 |
| Zinkand, WC | 1 |
| Aporti, F | 1 |
| Calderini, G | 1 |
| Mazzari, S | 1 |
| Zanotti, A | 1 |
| Toffano, G | 1 |
| Carlà, V | 1 |
1 review available for quinolinic acid and Aging
| Article | Year |
|---|---|
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
28 other studies available for quinolinic acid and Aging
| Article | Year |
|---|---|
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; C | 2017 |
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamin | 2013 |
Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Huntingti | 2012 |
Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats.
Topics: Aging; Animals; Astrocytes; Cerebral Cortex; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; | 2014 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas | 2009 |
[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain].
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Mitogen-Activated Protein | 2009 |
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Electron Transport Chain Complex Proteins; | 2011 |
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectro | 2011 |
Enkephalinergic striatal projection neurons become less affected by quinolinic acid than substance P-containing striatal projection neurons as rats age.
Topics: Aging; Animals; Cell Survival; Corpus Striatum; Efferent Pathways; Enkephalins; In Situ Hybridizatio | 2003 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2004 |
The vulnerability of striatal projection neurons and interneurons to excitotoxicity is differentially regulated by dopamine during development.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Gene Expression Regu | 2005 |
Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease.
Topics: Aging; Animals; Disease Models, Animal; Doublecortin Domain Proteins; Huntington Disease; Immunohist | 2006 |
The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process.
Topics: Aging; Animals; Brain; Cerebral Cortex; Female; Guinea Pigs; Male; Mass Spectrometry; Neurotoxins; P | 1984 |
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methi | 1993 |
Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.
Topics: Aging; Animals; Brain; Corpus Striatum; Functional Laterality; Glutamate Decarboxylase; Ibotenic Aci | 1997 |
Age-dependent differences in survival of striatal somatostatin-NPY-NADPH-diaphorase-containing interneurons versus striatal projection neurons after intrastriatal injection of quinolinic acid in rats.
Topics: Aging; Animals; Cell Survival; Corpus Striatum; Injections; Interneurons; Male; NADPH Dehydrogenase; | 1997 |
Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Corpus Striatum; Injections; Ma | 2000 |
Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.
Topics: Aging; Animals; Animals, Newborn; Brain; Embryo, Mammalian; Female; Kynurenic Acid; Male; ortho-Amin | 2001 |
TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia.
Topics: Aging; Animals; Animals, Newborn; Basal Ganglia; Cerebral Cortex; Corpus Striatum; Injections; Male; | 2001 |
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
Topics: Aging; Animals; Ascorbic Acid; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Respons | 2001 |
A lot of "excitement' about neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate | 1991 |
Effects of aging on quinolinic acid lesions in rat striatum.
Topics: Aging; Animals; Biomarkers; Cerebral Cortex; Corpus Striatum; Disease Susceptibility; Hippocampus; M | 1991 |
Differential effects of quinolinic acid lesions on muscarinic acetylcholine receptors in cat visual cortex during postnatal development.
Topics: Aging; Animals; Cats; Pirenzepine; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Muscarin | 1989 |
Quinolinic acid phosphoribosyltransferase in rat brain.
Topics: Aging; Animals; Brain; Kinetics; Liver; Nicotinamide Mononucleotide; Pentosyltransferases; Phosphori | 1985 |
Experimental models of aging and quinolinic acid.
Topics: Aging; Animals; Avoidance Learning; Brain; Electroencephalography; Models, Biological; Pyridines; Qu | 1985 |
The physiopathological role of quinolinic acid in the mammalian central nervous system.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic En | 1988 |