quinolinic acid has been researched along with Acquired Immunodeficiency Syndrome in 12 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "HIV, soluble HLA class I (sHLA-I), quinolinic acid (QUIN), and the monokines IL-1β, IL-6, and TNF-α were measured by ELISA and PCR in brain tissue of 60 AIDS autopsies without evidence of CNS opportunistic infections." | 3.69 | Macrophage Activation Factors in the Brains of AIDS Patients. ( Achim, CL; Baldwin, M; Heyes, MP; Hilty, C; Masliah, E; Sarnacki, P; Wiley, CA, 1996) |
| "Quinolinic acid (QUIN) is a neurotoxic tryptophan metabolite produced by macrophages in response to stimulation with cytokines or infection with HIV-1." | 1.30 | Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages. ( Armati, PJ; Brew, BJ; Kerr, SJ; Pemberton, LA; Smythe, G; Tattam, B, 1997) |
| "CSF quinolinic acid levels were also elevated in all infected macaques, but particularly those with retrovirus-induced encephalitis." | 1.30 | Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques. ( Achim, CL; Heyes, MP; Lackner, A; Markey, SP; Saito, K; Wiley, CA, 1998) |
| "Quinolinic acid (QUIN) is a neurotoxin implicated in the neurologic deficits associated with human immunodeficiency virus type 1 (HIV-1) infection." | 1.29 | Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type 1 disease: relationships to clinical status and therapeutic response. ( Brouwers, P; Heyes, MP; Markey, SP; Moss, HA; Pizzo, PA; Poplack, DG; Wolters, PL, 1993) |
| "Quinolinic acid (QUIN) is an neurotoxic N-methyl-D-aspartate receptor agonist and an L-tryptophan metabolite of the kynurenine pathway." | 1.28 | Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients. ( Bhalla, RB; Brew, BJ; Der, M; Heyes, MP; Lee, K; Markey, SP; Price, RW; Quearry, BJ; Saito, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bipath, P | 1 |
| Levay, PF | 1 |
| Viljoen, M | 1 |
| Nair, MP | 1 |
| Samikkannu, T | 1 |
| Achim, CL | 2 |
| Masliah, E | 1 |
| Heyes, MP | 7 |
| Sarnacki, P | 1 |
| Hilty, C | 1 |
| Baldwin, M | 1 |
| Wiley, CA | 2 |
| Brouwers, P | 1 |
| Moss, HA | 1 |
| Wolters, PL | 1 |
| Poplack, DG | 1 |
| Markey, SP | 5 |
| Pizzo, PA | 1 |
| Giulian, D | 1 |
| Yu, J | 1 |
| Li, X | 1 |
| Tom, D | 1 |
| Li, J | 1 |
| Wendt, E | 1 |
| Lin, SN | 1 |
| Schwarcz, R | 1 |
| Noonan, C | 1 |
| Kerr, SJ | 1 |
| Armati, PJ | 1 |
| Pemberton, LA | 1 |
| Smythe, G | 1 |
| Tattam, B | 1 |
| Brew, BJ | 2 |
| Saito, K | 2 |
| Lackner, A | 1 |
| Fuchs, D | 1 |
| Weiss, G | 1 |
| Werner-Felmayer, G | 1 |
| Reibnegger, G | 1 |
| Wachter, H | 1 |
| Quearry, BJ | 1 |
| Price, RW | 2 |
| Lee, K | 1 |
| Bhalla, RB | 2 |
| Der, M | 1 |
| Brew, B | 1 |
| Martin, A | 1 |
| Salazar, A | 1 |
| Rubinow, D | 1 |
| Lane, C | 1 |
2 reviews available for quinolinic acid and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Arachidonic Acid; Central Nervous System | 2012 |
Quinolinic acid and inflammation.
Topics: Acquired Immunodeficiency Syndrome; Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; HIV | 1993 |
10 other studies available for quinolinic acid and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highl | 2015 |
| Macrophage Activation Factors in the Brains of AIDS Patients.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Br | 1996 |
Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type 1 disease: relationships to clinical status and therapeutic response.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Analysis of Variance; Child; Child, Presc | 1993 |
Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cells, Cultured; HIV-1; Humans; Neurotoxins; Phagocytes; | 1996 |
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Aggregation; Cells, Cultured; Coloring Agents; Fetus | 1997 |
Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Central Nervous System; Cerebral Cortex; HIV-1; | 1998 |
Immune activation and neuronal injury in AIDS.
Topics: Acquired Immunodeficiency Syndrome; HIV-1; Humans; Interferon-gamma; Nervous System Diseases; Neuron | 1992 |
Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; beta 2-Microglobulin; Biopterins; Blood-B | 1992 |
Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Extracellular Space; Humans; Quinolinic A | 1991 |
Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Pyridines; Quinolinic Acid; Quinoli | 1989 |