quinolinic acid has been researched along with Absence Seizure in 61 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 7.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "Inosine (INO) has an anticonvulsant effect against seizures induced by antagonists of GABAergic system." | 7.77 | Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors. ( Almeida, RF; Faraco, RB; Fernandes, VF; Ganzella, M; Souza, DO, 2011) |
| " In this study, we investigated whether atorvastatin would have protective effects against hippocampal cell death promoted by quinolinic acid (QA)-induced seizures in mice." | 7.75 | Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake. ( Boeck, CR; Carqueja, CL; Dal'agnolo, D; de Araújo Herculano, B; Martins, WC; Piermartiri, TC; Stroeh, E; Tasca, CI; Vandresen-Filho, S, 2009) |
| " In order to test this hypothesis, evaluation of glutathione (GSH) scavenger system was carried out in mice showing the neuroprotective effect of NMDA preconditioning against quinolinic acid (QA)-induced seizures." | 7.74 | Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus. ( Boeck, CR; Dafre, AL; de Araújo Herculano, B; Franco, JL; Tasca, CI; Vandresen-Filho, S, 2007) |
| " Guanine-based purines (GBPs) guanosine 5'-monophosphate (GMP and guanosine) have been shown to exert anticonvulsant effects against QA-induced seizures." | 7.74 | Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines. ( Schmidt, AP; Souza, DO; Tasca, CI; Tavares, RG, 2008) |
| "Acute and chronic administration of the nucleoside guanosine have been shown to prevent quinolinic acid (QA) and alpha-dendrotoxin-induced seizures, as well as to impair memory and anxiety in rats and mice." | 7.73 | Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice. ( Avila, TT; Schmidt, AP; Souza, DO, 2005) |
| " Quinolinic acid (QA)-induced seizures are used to average NMDA receptors-evoked neurotoxicity in animal models." | 7.72 | NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice. ( Boeck, CR; Ganzella, M; Lottermann, A; Vendite, D, 2004) |
| "Administration of reserpine, trifluperidol, chlorpromazine, haloperidol, spiroperidol, and thioproperazine to adult mice shortened the latency and increased the number of animals with clonic seizures induced by 1-kynurenine sulfate or its metabolite quinolinic acid." | 7.68 | Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice. ( Lapin, IP; Ryzov, IV, 1990) |
| "Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0." | 7.68 | A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus. ( Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G, 1991) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 7.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| "We investigated in rats whether alterations in noradrenergic function caused by 6-hydroxydopamine or alpha- and beta-adrenoceptor agonists and antagonists would modify the susceptibility of the brain to electroencephalographic seizures induced by intrahippocampal infusion of quinolinic acid." | 7.67 | Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1987) |
| " The anticonvulsant effect of MK-801 was evaluated against limbic seizures (measured by EEG) induced by intrahippocampal injection of 120 nmol of quinolinic acid, an agonist of the N-methyl-D-aspartate-type receptors, in freely moving rats." | 7.67 | Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. ( Caccia, S; Conti, I; Samanin, R; Serafini, R; Stasi, MA; Tridico, RV; Vezzani, A, 1989) |
| "Infection-triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions." | 5.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "p." | 5.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 5.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 5.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 5.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content." | 5.27 | A noradrenergic component of quinolinic acid-induced seizures. ( Schwarcz, R; Vezzani, A, 1985) |
| " Specially, chemical preconditioning models using N-methyl-d-aspartate (NMDA) pre-treatment, which has demonstrated to lead to neuroprotection against seizures and damage to neuronal tissue induced by quinolinic acid (QA)." | 4.87 | Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid. ( Muller, Gdo A; Severino, PC; Tasca, CI; Vandresen-Filho, S, 2011) |
| " We have previously demonstrated that N-methyl-D-aspartate (NMDA) preconditioning in mice showed 50 % of protection against seizures and full protection against damage to neuronal tissue induced by quinolinic acid (QA)." | 3.81 | N-methyl-D-aspartate preconditioning prevents quinolinic acid-induced deregulation of glutamate and calcium homeostasis in mice hippocampus. ( Bertoldo, DB; Constantino, LC; Dal-Cim, T; Martins, WC; Molz, S; Severino, PC; Silva, FR; Tasca, CI; Vandresen-Filho, S, 2015) |
| "Aloysia gratissima aqueous extract (AE) was investigated as a putative protective agent against quinolinic acid (QA)-induced seizures in mice and hippocampal cell damage." | 3.80 | Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity. ( Bertoldo, DB; Dal-Cim, T; Maraschin, M; Martins, WC; Tasca, CI; Vandresen-Filho, S; Zeni, AL, 2014) |
| "Preconditioning by N-methyl-d-aspartate (NMDA) may be promoted in vivo by the administration of a sub-convulsing dose of NMDA, with a neuroprotective effect against seizures and neuronal death induced by the infusion of quinolinic acid (QA) in mice." | 3.77 | NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. ( Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2011) |
| "Inosine (INO) has an anticonvulsant effect against seizures induced by antagonists of GABAergic system." | 3.77 | Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors. ( Almeida, RF; Faraco, RB; Fernandes, VF; Ganzella, M; Souza, DO, 2011) |
| " In this study, we investigated whether atorvastatin would have protective effects against hippocampal cell death promoted by quinolinic acid (QA)-induced seizures in mice." | 3.75 | Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake. ( Boeck, CR; Carqueja, CL; Dal'agnolo, D; de Araújo Herculano, B; Martins, WC; Piermartiri, TC; Stroeh, E; Tasca, CI; Vandresen-Filho, S, 2009) |
| " In order to test this hypothesis, evaluation of glutathione (GSH) scavenger system was carried out in mice showing the neuroprotective effect of NMDA preconditioning against quinolinic acid (QA)-induced seizures." | 3.74 | Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus. ( Boeck, CR; Dafre, AL; de Araújo Herculano, B; Franco, JL; Tasca, CI; Vandresen-Filho, S, 2007) |
| " Guanine-based purines (GBPs) guanosine 5'-monophosphate (GMP and guanosine) have been shown to exert anticonvulsant effects against QA-induced seizures." | 3.74 | Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines. ( Schmidt, AP; Souza, DO; Tasca, CI; Tavares, RG, 2008) |
| " Quinolinic acid (QA) is a glutamatergic agent that induces seizures and is involved in the etiology of epilepsy." | 3.73 | In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine. ( Abud, J; Schmidt, AP; Souza, DO; Tasca, CI; Tavares, RG, 2005) |
| "Acute and chronic administration of the nucleoside guanosine have been shown to prevent quinolinic acid (QA) and alpha-dendrotoxin-induced seizures, as well as to impair memory and anxiety in rats and mice." | 3.73 | Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice. ( Avila, TT; Schmidt, AP; Souza, DO, 2005) |
| "We assessed inbred, outbred and hybrid mouse strains for susceptibility to seizures and neurodegeneration induced by systemic administration of kainic acid (KA)." | 3.73 | Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. ( McLin, JP; Steward, O, 2006) |
| " Quinolinic acid (QA)-induced seizures are used to average NMDA receptors-evoked neurotoxicity in animal models." | 3.72 | NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice. ( Boeck, CR; Ganzella, M; Lottermann, A; Vendite, D, 2004) |
| "Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0." | 3.68 | A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus. ( Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G, 1991) |
| "Administration of reserpine, trifluperidol, chlorpromazine, haloperidol, spiroperidol, and thioproperazine to adult mice shortened the latency and increased the number of animals with clonic seizures induced by 1-kynurenine sulfate or its metabolite quinolinic acid." | 3.68 | Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice. ( Lapin, IP; Ryzov, IV, 1990) |
| " The anticonvulsant effect of MK-801 was evaluated against limbic seizures (measured by EEG) induced by intrahippocampal injection of 120 nmol of quinolinic acid, an agonist of the N-methyl-D-aspartate-type receptors, in freely moving rats." | 3.67 | Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. ( Caccia, S; Conti, I; Samanin, R; Serafini, R; Stasi, MA; Tridico, RV; Vezzani, A, 1989) |
| "An effect of the beta-stereoisomer of kainic acid on seizures produced by intracerebroventricular injections of excitatory amino acids was tested in mice." | 3.67 | Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist? ( Collins, JF; Meldrum, BS; Turski, L, 1985) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 3.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| "We investigated in rats whether alterations in noradrenergic function caused by 6-hydroxydopamine or alpha- and beta-adrenoceptor agonists and antagonists would modify the susceptibility of the brain to electroencephalographic seizures induced by intrahippocampal infusion of quinolinic acid." | 3.67 | Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1987) |
| "Infection-triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions." | 1.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions." | 1.62 | Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy. ( Bertram, EH; Buckmaster, PS; Ghobadi, SN; Habte, FG; Hou, Q; Huang, A; Keunen, O; Lee, KS; Li, N; Narang, S; Qiu, L; Wang, J; Wintermark, M; Zhang, Y, 2021) |
| "Quinolinic acid (QA) is a NMDA receptor agonist implicated in pathological conditions, such as neurodegenerative diseases and epilepsy." | 1.42 | Cerebral cortex, hippocampus, striatum and cerebellum show differential susceptibility to quinolinic acid-induced oxidative stress. ( Bertoldo, DB; De Bem, AF; Mancini, G; Martins, WC; Tasca, CI; Vandresen-Filho, S, 2015) |
| "QA is used in experimental models of seizures studying the effects of overstimulation of the glutamatergic system." | 1.36 | Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model. ( Antoniolli, E; Antunes, C; da Silva Filho, M; Kalinine, E; Portela, LV; Souza, DO; Torres, FV; Tort, AB, 2010) |
| "These changes preceded the onset of EEG seizures, which had a mean onset of 108 h after inoculation." | 1.35 | Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. ( Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J, 2008) |
| "However, in Huntington's disease there is a very early downregulation of CB(1) receptors in striatal neurons that, together with the undesirable psychoactive effects triggered by CB(1) receptor activation, foster the search for alternative pharmacological treatments." | 1.35 | Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. ( Aguado, T; Azcoitia, I; Benito, C; Carrasco, C; Fernández-Ruiz, J; Galve-Roperh, I; Guzmán, M; Julien, B; Palazuelos, J; Pazos, MR; Resel, E; Romero, J; Sagredo, O, 2009) |
| "p." | 1.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 1.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| "Rats treated with magnesium sulfate (subcutaneously injected, up to 600 mg/kg) were found to be protected from kainate neurotoxicity depending on the dose and time of application." | 1.28 | Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus. ( Abicht, K; Fischer, S; Hass, P; Keilhoff, G; Wolf, G, 1991) |
| "Tonic-clonic seizures were induced by 225-450 mg/kg Quin." | 1.28 | Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. ( Castiglioni, M; Samanin, R; Stasi, MA; Vezzani, A; Weckermann, B; Wu, HQ, 1989) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 1.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| "Tiletamine-induced convulsions were antagonized by the broad spectrum excitatory amino acid antagonist, gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS), and were potentiated by the competitive NMDA antagonist, 2-amino-7-phosphonohepatanoate (AP7)." | 1.27 | Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine. ( Klockgether, T; Lehmann, J; Schwarz, M; Sontag, KH; Turski, L, 1988) |
| " Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content." | 1.27 | A noradrenergic component of quinolinic acid-induced seizures. ( Schwarcz, R; Vezzani, A, 1985) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 1.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "c." | 1.26 | [Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole]. ( Lapin, IP; Ryzhov, IV, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (27.87) | 18.7374 |
| 1990's | 16 (26.23) | 18.2507 |
| 2000's | 13 (21.31) | 29.6817 |
| 2010's | 12 (19.67) | 24.3611 |
| 2020's | 3 (4.92) | 2.80 |
| Authors | Studies |
|---|---|
| Barbieri Caus, L | 1 |
| Pasquetti, MV | 1 |
| Seminotti, B | 1 |
| Woontner, M | 1 |
| Wajner, M | 1 |
| Calcagnotto, ME | 1 |
| Dale, RC | 1 |
| Thomas, T | 1 |
| Patel, S | 1 |
| Han, VX | 1 |
| Kothur, K | 1 |
| Troedson, C | 1 |
| Gupta, S | 1 |
| Gill, D | 1 |
| Malone, S | 1 |
| Waak, M | 1 |
| Calvert, S | 1 |
| Subramanian, G | 1 |
| Andrews, PI | 1 |
| Kandula, T | 1 |
| Menezes, MP | 1 |
| Ardern-Holmes, S | 1 |
| Mohammad, S | 1 |
| Bandodkar, S | 1 |
| Yan, J | 1 |
| Zhang, Y | 1 |
| Buckmaster, PS | 1 |
| Qiu, L | 1 |
| Wang, J | 1 |
| Keunen, O | 1 |
| Ghobadi, SN | 1 |
| Huang, A | 1 |
| Hou, Q | 1 |
| Li, N | 1 |
| Narang, S | 1 |
| Habte, FG | 1 |
| Bertram, EH | 2 |
| Lee, KS | 1 |
| Wintermark, M | 1 |
| Petkau, TL | 1 |
| Zhu, S | 1 |
| Lu, G | 1 |
| Fernando, S | 1 |
| Cynader, M | 1 |
| Leavitt, BR | 1 |
| Zeni, AL | 1 |
| Vandresen-Filho, S | 9 |
| Dal-Cim, T | 2 |
| Martins, WC | 5 |
| Bertoldo, DB | 3 |
| Maraschin, M | 1 |
| Tasca, CI | 11 |
| Severino, PC | 2 |
| Constantino, LC | 1 |
| Molz, S | 1 |
| Silva, FR | 1 |
| Vataev, SI | 1 |
| Mal'gina, NA | 1 |
| Oganesian, GA | 1 |
| Mancini, G | 1 |
| De Bem, AF | 1 |
| Piermartiri, TC | 2 |
| de Araújo Herculano, B | 3 |
| Dal'agnolo, D | 1 |
| Stroeh, E | 1 |
| Carqueja, CL | 1 |
| Boeck, CR | 5 |
| Palazuelos, J | 1 |
| Aguado, T | 1 |
| Pazos, MR | 1 |
| Julien, B | 1 |
| Carrasco, C | 1 |
| Resel, E | 1 |
| Sagredo, O | 1 |
| Benito, C | 1 |
| Romero, J | 1 |
| Azcoitia, I | 1 |
| Fernández-Ruiz, J | 1 |
| Guzmán, M | 1 |
| Galve-Roperh, I | 1 |
| Torres, FV | 1 |
| da Silva Filho, M | 1 |
| Antunes, C | 1 |
| Kalinine, E | 1 |
| Antoniolli, E | 1 |
| Portela, LV | 1 |
| Souza, DO | 8 |
| Tort, AB | 1 |
| Anderson, G | 1 |
| Rodriguez, M | 1 |
| Muller, Gdo A | 1 |
| Ganzella, M | 3 |
| Faraco, RB | 1 |
| Almeida, RF | 1 |
| Fernandes, VF | 1 |
| Russi, MA | 1 |
| Rieger, DK | 1 |
| Costa, AP | 1 |
| Lopes, MW | 1 |
| Cunha, RM | 1 |
| Teixeira, EH | 1 |
| Nascimento, KS | 1 |
| Cavada, BS | 1 |
| Leal, RB | 1 |
| Hoeller, AA | 1 |
| Herculano, BA | 1 |
| Duzzioni, M | 1 |
| Duarte, FS | 1 |
| Boeck, CC | 1 |
| de Lima, TC | 1 |
| Marino-Neto, J | 1 |
| Lottermann, A | 1 |
| Vendite, D | 2 |
| Schweigert, ID | 1 |
| de Oliveira, DL | 1 |
| Scheibel, F | 1 |
| da Costa, F | 1 |
| Wofchuk, ST | 1 |
| Perry, ML | 1 |
| Schmidt, AP | 4 |
| Avila, TT | 1 |
| Nicolaidis, R | 1 |
| Bruno, AN | 1 |
| Sarkis, JJ | 1 |
| Tavares, RG | 2 |
| Abud, J | 1 |
| Jardim, FM | 1 |
| McLin, JP | 1 |
| Steward, O | 1 |
| Franco, JL | 1 |
| Dafre, AL | 1 |
| Lehrmann, E | 1 |
| Guidetti, P | 1 |
| Löve, A | 1 |
| Williamson, J | 1 |
| Schwarcz, R | 6 |
| Foster, AC | 1 |
| Vezzani, A | 10 |
| French, ED | 3 |
| Ryzhov, IV | 4 |
| Lapin, IP | 10 |
| Gruber, B | 1 |
| Greber, S | 1 |
| Rupp, E | 1 |
| Sperk, G | 1 |
| Guzeva, VI | 1 |
| Mikhailov, IB | 1 |
| Melnikova, NV | 1 |
| Mirzaev, SM | 1 |
| Ryzov, IV | 3 |
| Oxenkrug, GF | 1 |
| Gasparini, F | 1 |
| Bruno, V | 1 |
| Battaglia, G | 1 |
| Lukic, S | 1 |
| Leonhardt, T | 1 |
| Inderbitzin, W | 1 |
| Laurie, D | 1 |
| Sommer, B | 1 |
| Varney, MA | 1 |
| Hess, SD | 1 |
| Johnson, EC | 1 |
| Kuhn, R | 1 |
| Urwyler, S | 1 |
| Sauer, D | 1 |
| Portet, C | 1 |
| Schmutz, M | 1 |
| Nicoletti, F | 1 |
| Flor, PJ | 1 |
| Elisabetsky, E | 1 |
| Brum, LF | 1 |
| Lara, DR | 1 |
| de Faria Maraschin, J | 1 |
| da Silveira Perla, A | 1 |
| Onofre Souza, D | 1 |
| Serafini, R | 2 |
| Stasi, MA | 4 |
| Viganò, G | 1 |
| Rizzi, M | 1 |
| Samanin, R | 6 |
| Nash, DR | 1 |
| Kaplan, SM | 1 |
| Norman, AB | 2 |
| Sanberg, PR | 2 |
| Fischer, W | 1 |
| Wolf, G | 2 |
| Fischer, S | 2 |
| Hass, P | 2 |
| Abicht, K | 1 |
| Keilhoff, G | 2 |
| Kozlovsky, VL | 1 |
| Kenunen, OG | 1 |
| Young, RS | 1 |
| Petroff, OA | 1 |
| Novotny, EJ | 1 |
| Wong, M | 1 |
| Kozlovskiĭ, VL | 1 |
| Prakh'e, IV | 1 |
| Geĭnisman, NV | 1 |
| Milaśius, AM | 1 |
| Grinevićius, KK | 1 |
| Giordano, M | 1 |
| Ford, LM | 1 |
| Brauckmann, JL | 1 |
| Caccia, S | 1 |
| Conti, I | 1 |
| Tridico, RV | 1 |
| Wu, HQ | 4 |
| Castiglioni, M | 1 |
| Weckermann, B | 1 |
| Klockgether, T | 1 |
| Turski, L | 2 |
| Schwarz, M | 1 |
| Sontag, KH | 1 |
| Lehmann, J | 1 |
| Meldrum, BS | 1 |
| Collins, JF | 1 |
| Slepokurov, MV | 1 |
| Mandel'shtam, IuE | 1 |
| Aleksandrov, VG | 1 |
| Ben-Ari, Y | 1 |
| Prakhie, IB | 1 |
| Kiseleva, IP | 1 |
| Tullii, M | 2 |
| Whetsell, WO | 1 |
| Piotrovskiĭ, LB | 1 |
| Aleksandrova, IIa | 1 |
| Angelico, P | 1 |
| Ungerstedt, U | 1 |
3 reviews available for quinolinic acid and Absence Seizure
| Article | Year |
|---|---|
Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin.
Topics: Anticonvulsants; Comorbidity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interl | 2011 |
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutam | 2011 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Diseas | 1986 |
58 other studies available for quinolinic acid and Absence Seizure
| Article | Year |
|---|---|
Increased susceptibility to quinolinic acid-induced seizures and long-term changes in brain oscillations in an animal model of glutaric acidemia type I.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Disease Models, Ani | 2022 |
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neu | 2023 |
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Temporal Lobe; Intraoperative Neurop | 2021 |
Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Topics: Animals; Fluoresceins; Granulins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; | 2013 |
Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity.
Topics: Animals; Biological Transport; Cell Death; Cell Survival; Coumaric Acids; Excitatory Amino Acid Agon | 2014 |
N-methyl-D-aspartate preconditioning prevents quinolinic acid-induced deregulation of glutamate and calcium homeostasis in mice hippocampus.
Topics: Animals; Calcium; D-Aspartic Acid; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Homeo | 2015 |
[Inferior colliculus stimulation effects in KrushinskiI-Molodkina strain rats].
Topics: Acoustic Stimulation; Animals; Electric Stimulation; Epilepsy, Reflex; Inferior Colliculi; Male; Mot | 2014 |
Cerebral cortex, hippocampus, striatum and cerebellum show differential susceptibility to quinolinic acid-induced oxidative stress.
Topics: Analysis of Variance; Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Glutathione Pero | 2015 |
Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake.
Topics: Analysis of Variance; Animals; Atorvastatin; Cell Death; Complex Mixtures; Disease Models, Animal; D | 2009 |
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Corpus Striatum; Humans; Huntingtin Protein; Huntington | 2009 |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid An | 2010 |
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent | 2011 |
Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors.
Topics: Animals; Anticonvulsants; Injections, Intraventricular; Inosine; Male; Mice; Quinolinic Acid; Recept | 2011 |
ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice.
Topics: Animals; Blotting, Western; Canavalia; Hippocampus; In Vitro Techniques; Male; Mice; Plant Lectins; | 2012 |
NMDA preconditioning attenuates cortical and hippocampal seizures induced by intracerebroventricular quinolinic acid infusion.
Topics: Animals; Brain Waves; Cerebral Cortex; Hippocampus; Infusions, Intraventricular; Male; Mice; N-Methy | 2013 |
NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice.
Topics: Animals; Apoptosis; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Ago | 2004 |
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Respons | 2005 |
Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice.
Topics: Animals; Dose-Response Relationship, Drug; Guanine Nucleotides; Injections, Intraventricular; Male; | 2005 |
Increase of adenine nucleotide hydrolysis in rat hippocampal slices after seizures induced by quinolinic acid.
Topics: Adenine Nucleotides; Animals; Convulsants; Hippocampus; Hydrolysis; In Vitro Techniques; Injections, | 2005 |
In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine.
Topics: Animals; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraperitoneal; Injections, Int | 2005 |
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice.
Topics: AIDS Dementia Complex; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Encephalitis; | 2006 |
Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.
Topics: Animals; Cell Count; Dentate Gyrus; Drug Resistance; Excitatory Amino Acid Agonists; Fluoresceins; F | 2006 |
Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines.
Topics: Animals; Brain; Glutamic Acid; Guanine; Male; Quinolinic Acid; Rats; Rats, Wistar; Seizures; Synapti | 2008 |
Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Excitator | 2007 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Di | 2008 |
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Kynurenic Acid; Male; Nerve Dege | 1984 |
[Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole].
Topics: Animals; Anticonvulsants; Kynurenine; Mice; Pentylenetetrazole; Quinolinic Acid; Quinolinic Acids; S | 1981 |
Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection.
Topics: Animals; Gene Expression; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Kinetics; M | 1994 |
The kynurenines and the seizures.
Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Micro | 1996 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid | 1998 |
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Topics: Animals; Anticonvulsants; Brain; Cell Line; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; E | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine | 1999 |
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interaction | 2000 |
A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.
Topics: Animals; Atropine; Convulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Octreotide; | 1991 |
An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
Topics: Animals; Animals, Newborn; Body Weight; Brain Diseases; Brain Tissue Transplantation; Corpus Striatu | 1991 |
[Pharmacologic modulation of central noradrenergic mechanisms and the effect of selected substances on chemically-induced seizures: the maximal quinolinic acid seizure test (mouse)].
Topics: Animals; Anticonvulsants; Convulsants; Male; Mice; Norepinephrine; Quinolinic Acid; Quinolinic Acids | 1991 |
Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus.
Topics: Animals; Convulsants; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Kainic Acid; Magne | 1991 |
Behavioral abnormalities in rats after single treatment with quinolinic acid during early ontogenesis.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Brain; Catalepsy; Conditioning, Ope | 1991 |
Neonatal excitotoxic brain injury. Physiologic, metabolic, and pathologic findings.
Topics: Animals; Brain; Female; Magnetic Resonance Spectroscopy; Male; Neurotoxins; Pyridines; Quinolinic Ac | 1990 |
[The neurodegenerative and convulsant action of quinolinic acid].
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; M | 1990 |
Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice.
Topics: Animals; Anticonvulsants; Catecholamines; Convulsants; Dopamine; Kynurenine; Male; Mice; Mice, Inbre | 1990 |
Effect of quinolinic acid on wakefulness and sleep in the rabbit.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Male; Quinolinic Acid; Qui | 1990 |
Subcutaneously applied magnesium protects reliably against quinolinate-induced N-methyl-D-aspartate (NMDA)-mediated neurodegeneration and convulsions in rats: are there therapeutical implications.
Topics: Animals; Cerebral Ventricles; Hippocampus; Magnesium Sulfate; Male; Nerve Degeneration; Neurotoxins; | 1990 |
MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum.
Topics: Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Feeding Behavior; Motor Activity; Pyridines; Quino | 1990 |
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.
Topics: Animals; Anticonvulsants; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; | 1989 |
Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood-Brain Barrier; Cerebral Co | 1989 |
Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cyclohexanes; Dose-Response Relationship, Drug; Injections, | 1988 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocyste | 1985 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug | 1986 |
Seizures and brain damage: are excitatory amino acids involved?
Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Ne | 1986 |
A noradrenergic component of quinolinic acid-induced seizures.
Topics: Animals; Brain; Male; Norepinephrine; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbr | 1985 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; | 1986 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
Anti-excitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro.
Topics: Action Potentials; Animals; Dialysis; Hippocampus; Kynurenic Acid; Organ Culture Techniques; Pyridin | 1986 |
[Selective anticonvulsive action of N-substituted imidazole-4,5-dicarboxylic acids against quinolinic acid].
Topics: Animals; Anticonvulsants; Dicarboxylic Acids; Imidazoles; Male; Mice; Pyridines; Quinolinic Acid; Qu | 1988 |
Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Calcium; Dialysis; Dose-Response Relationship, Dr | 1988 |
Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Hippocampus; Hydroxydopamines; Male; Methoxami | 1987 |
In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1985 |