quinolinic acid has been researched along with AIDS, Simian in 14 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased concentrations of the excitotoxin quinolinic acid (QUIN) have been implicated in the neurologic deficits and brain atrophy that may accompany infection with the human immunodeficiency virus type-1." | 3.68 | Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid. ( Frank, JA; Gravell, M; Heyes, MP; Jordan, EK; Lee, K; Markey, SP; Saito, K; Snoy, PJ, 1992) |
| "These are astrocytosis, up-regulation of mRNA encoding the neuropeptide somatostatin (SRIF) and an increased expression of MHC Class II antigen." | 2.39 | Neuronal substrates for SIV encephalopathy. ( da Cunha, A; Eiden, LE; Rausch, DM, 1994) |
| "Zidovudine treatment was well tolerated by rhesus infants with minimal, transient side effects." | 1.29 | Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus. ( Eiden, LE; Heyes, MP; Murray, EA; Rausch, DM, 1995) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (92.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drewes, JL | 1 |
| Meulendyke, KA | 1 |
| Liao, Z | 1 |
| Witwer, KW | 1 |
| Gama, L | 1 |
| Ubaida-Mohien, C | 1 |
| Li, M | 1 |
| Notarangelo, FM | 1 |
| Tarwater, PM | 1 |
| Schwarcz, R | 1 |
| Graham, DR | 1 |
| Zink, MC | 1 |
| Smith, MO | 2 |
| Heyes, MP | 8 |
| Lackner, AA | 2 |
| Rausch, DM | 4 |
| Murray, EA | 2 |
| Eiden, LE | 4 |
| Black, R | 1 |
| Sager, P | 1 |
| Heyes, M | 1 |
| da Cunha, A | 1 |
| Lendvay, J | 1 |
| Sharer, LR | 1 |
| Ward, JM | 1 |
| Rehm, S | 1 |
| Nohr, D | 1 |
| Weihe, E | 1 |
| Lane, JH | 1 |
| Sasseville, VG | 1 |
| Vogel, P | 1 |
| Pauley, DR | 1 |
| Namboodiri, AM | 1 |
| Venkateshan, CN | 1 |
| Narayanan, R | 1 |
| Blinder, K | 1 |
| Moffett, JR | 1 |
| Gajdusek, DC | 1 |
| Gravell, M | 4 |
| Gibbs, CJ | 1 |
| Coe, CL | 1 |
| Reyes, TM | 1 |
| Pauza, CD | 1 |
| Reinhard, JF | 1 |
| Saito, K | 2 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Jordan, EK | 1 |
| Lee, K | 1 |
| Frank, JA | 1 |
| Snoy, PJ | 1 |
| Markey, SP | 3 |
| April, M | 2 |
| Blackmore, D | 2 |
| London, WT | 2 |
| Yergey, JA | 2 |
| Eckhaus, M | 1 |
| Vickers, JH | 1 |
1 review available for quinolinic acid and AIDS, Simian
| Article | Year |
|---|---|
Neuronal substrates for SIV encephalopathy.
Topics: Animals; Astrocytes; Cognition Disorders; Disease Progression; Encephalitis, Viral; Gene Expression | 1994 |
13 other studies available for quinolinic acid and AIDS, Simian
| Article | Year |
|---|---|
Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Topics: Animals; Anti-Retroviral Agents; Brain; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass S | 2015 |
Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus.
Topics: Animals; Antibodies, Viral; Central Nervous System; Immunoglobulin G; Macaca mulatta; Male; Meningit | 1995 |
Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus.
Topics: Animals; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Central Nervous Syst | 1995 |
Summary of workshop contributions. Third Workshop on NeuroAIDS.
Topics: Adult; AIDS Dementia Complex; Animals; Blood-Brain Barrier; Child; Cytokines; Cytopathogenic Effect, | 1994 |
Effects of chronic zidovudine administration on CNS function and virus burden after perinatal SIV infection in rhesus monkeys.
Topics: Animals; Animals, Newborn; Antigens, Viral; Cognition; Macaca mulatta; Motor Activity; Nervous Syste | 1994 |
Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys.
Topics: Animals; Brain; Cerebral Cortex; Cognition; Cognition Disorders; Glial Fibrillary Acidic Protein; Ma | 1994 |
Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation.
Topics: Animals; Brain; Capillaries; Central Nervous System Diseases; Cerebrovascular Circulation; DNA, Vira | 1996 |
Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys.
Topics: Animals; Antibody Specificity; Cell Size; Cells, Cultured; Immunohistochemistry; Kynurenine; Macaca | 1996 |
Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS.
Topics: Animals; Biomarkers; Blood-Brain Barrier; CD4-CD8 Ratio; Lymphocyte Subsets; Macaca mulatta; Male; Q | 1997 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
Topics: Animals; Atrophy; Brain; Cisterna Magna; Convulsants; Injections; Kynurenic Acid; Macaca mulatta; Qu | 1992 |
Quinolinic acid concentrations are increased in cerebrospinal fluid of Rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.
Topics: Animals; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Retrovi | 1991 |
Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.
Topics: Animals; Brain; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Reference Values; | 1990 |