Compounds > quinazolines
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quinazolines and Uveal Neoplasms

quinazolines has been researched along with Uveal Neoplasms in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amaro, A; Angelini, G; Esposito, AI; Lanza, F; Mirisola, V; Mosci, C; Musso, A; Nasciuti, F; Perri, P; Pfeffer, U; Poggi, A; Puzone, R; Salvi, S; Tosetti, F; Truini, M1
Bastian, BC; Chen, X; Emery, C; Jager, MJ; Porter, D; Tan, L; Wu, Q1
Ambrosini, G; de Stanchina, E; Musi, E; Schwartz, GK1
Adamus, G; Amundson, D; Boon, CJ; Haanen, JB; Jager, MJ; Kapiteijn, EH; Keunen, JE; Luyten, GP; Marinkovic, M; van Dijk, EH; van Herpen, CM1
Carita, G; Cassoux, N; Dahmani, A; De Koning, L; Decaudin, D; Emery, C; Frisch-Dit-Leitz, E; Halilovic, E; Jeay, S; Laurent, C; Némati, F; Piperno-Neumann, S; Raymondie, C; Roman-Roman, S; Schoumacher, M; Wylie, A1
Fletcher, JA; Hodi, FS; Li, J; Wu, X; Zhu, M1
Cree, IA; Di Nicolantonio, F; Glaysher, S; Johnson, P; Knight, LA; Mercer, S; Sharma, S; Whitehouse, P1

Trials

1 trial(s) available for quinazolines and Uveal Neoplasms

ArticleYear
Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma.
    Ophthalmology, 2015, Volume: 122, Issue:9

    Topics: Adult; Aged; Autoantibodies; Benzimidazoles; Central Serous Chorioretinopathy; Cross-Sectional Studies; Drug Combinations; Electrooculography; Electroretinography; Eye Proteins; Female; Fluorescein Angiography; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Prospective Studies; Protein Kinase C; Pyrroles; Quinazolines; Skin Neoplasms; Subretinal Fluid; Tomography, Optical Coherence; Uveal Neoplasms; Visual Acuity

2015

Other Studies

6 other study(ies) available for quinazolines and Uveal Neoplasms

ArticleYear
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:15

    Topics: Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; Cell Line, Tumor; Cell Proliferation; Cetuximab; ErbB Receptors; Gefitinib; Humans; Melanoma; Quinazolines; Signal Transduction; Transcriptome; Uveal Neoplasms

2013
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
    Oncogene, 2014, Sep-25, Volume: 33, Issue:39

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinases; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation, Missense; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Signal Transduction; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays

2014
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays

2014
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
    Oncotarget, 2016, Jun-07, Volume: 7, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Enzyme Inhibitors; Everolimus; Humans; Isoquinolines; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mice; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-mdm2; Pyrroles; Quinazolines; Tumor Suppressor Protein p53; Uveal Neoplasms; Xenograft Model Antitumor Assays

2016
Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Gene Expression; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Isoenzymes; MAP Kinase Signaling System; Melanoma; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Quinazolines; Uveal Neoplasms

2012
The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours.
    BMC cancer, 2004, Nov-23, Volume: 4

    Topics: Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Busulfan; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gefitinib; Gemcitabine; Humans; Melanoma; Neoplasms; Neoplasms, Unknown Primary; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Quinazolines; Sarcoma; Skin Neoplasms; Stomach Neoplasms; Uveal Neoplasms

2004