quinazolines has been researched along with Trypanosomiasis, African in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bishop, OT; Boyom, FF; Dize, D; Duffy, J; Fokou, PVT; Keumoe, R; Kouipou Toghueo, RM; Laleu, B; Njanpa, CN; Tata, RB; Tchatat, MB; Tchuenguia, VC; Yamthe, LT | 1 |
| Bachovchin, KA; Brady, KG; Erath, J; Gallerstein, MF; Leed, SE; Mensa-Wilmot, K; Pollastri, MP; Rodriguez, A; Sciotti, RJ; Tanghe, S; Woodring, JL | 1 |
| Bachovchin, KA; Bag, S; Buskes, MJ; Ferrins, L; Jalani, HB; Klug, DM; Mehta, N; Mensa-Wilmot, K; Momper, JD; Pollastri, MP; Rodriguez, A; Schneider, KM; Sciotti, RJ; Sharma, A; Singh, B; Tanghe, S | 1 |
| Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C | 1 |
| Behera, R; Mensa-Wilmot, K; Thomas, SM | 1 |
| Behera, R; Guyett, PJ; Mensa-Wilmot, K; Ogata, Y; Pollastri, M | 1 |
| Barrett, MP; Clark, RL; Clements, CJ; Huggan, JK; Mackay, SP; Owusu-Dapaah, G; Rathnam, RP; Spencer, J | 1 |
7 other study(ies) available for quinazolines and Trypanosomiasis, African
| Article | Year |
|---|---|
Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of
Topics: Animals; Humans; Iron; Ligands; Quinazolines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African | 2022 |
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
Topics: Aniline Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Topics: Animals; Blood Proteins; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Half-Life; Hepatocytes; Humans; Lapatinib; Mice; Microsomes, Liver; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thermodynamics; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Water | 2019 |
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs.
Topics: Animals; Axitinib; Benzamides; Erlotinib Hydrochloride; Female; HeLa Cells; Humans; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lapatinib; Mice; Morpholines; Piperazines; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Trypanosomiasis, African | 2014 |
Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies.
Topics: Chromatography, Affinity; Endocytosis; ErbB Receptors; Humans; Lapatinib; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Peptides; Phosphorylation; Proteomics; Protozoan Proteins; Quinazolines; Signal Transduction; Tandem Mass Spectrometry; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
Topics: Animals; Benzodiazepines; Humans; Microbial Sensitivity Tests; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |