quinazolines has been researched along with Polyploid in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 17 (73.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alimoghaddam, K; Ghaffari, SH; Ghanizadeh-Vesali, S; Ghavamzadeh, A; Mesbahi, Y; Zekri, A | 1 |
| He, W; Huang, S; Ji, D; Lan, H; Li, L; Li, Z; Liu, X; Wang, Y; Wu, Z; Xu, J; Yang, F; Zhang, W; Zhou, W | 1 |
| Cheung, HK; Coxon, A; Crispino, JD; Hanestad, K; Juan, G; Marinaccio, C; Ninniri, MSS; Payton, M; Wayne, WC | 1 |
| Bertran-Alamillo, J; Burbridge, M; Cantero, F; Cardona, AF; Castellví, J; Cattan, V; Codony-Servat, C; Codony-Servat, J; García-Román, S; Giménez-Capitán, A; Karachaliou, N; Molina-Vila, MA; Rodríguez, S; Roman, R; Rosell, R; Schoumacher, M; Teixidó, C; Viteri, S | 1 |
| Chen, JJ; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Long, ZJ; Wang, LX; Wang, SW; Xu, DF; Yan, M; Zheng, FM | 1 |
| Eastmond, DA; Gollapudi, P; Hasegawa, LS | 1 |
| Alimoghaddam, K; Estiar, MA; Ghaffari, SH; Ghavamzadeh, A; Modarressi, MH; Yaghmaie, M; Zekri, A | 1 |
| Gelston, E; Liu, A; Liu, Q; Wang, B; Wang, H; Wu, X; Xu, J; Xu, L; Zeng, Y; Zhou, W; Zou, Z | 1 |
| Bunn, PA; Chan, DC; Gao, D; Helfrich, BA; Kim, J; Tan, AC; Zhang, Z | 1 |
| Ashton, S; Barry, ST; Caddy, J; Curtis, NJ; Derbyshire, N; Floc'h, N; Harris, E; Hattersley, M; Jacobs, VN; Maratea, K; Odedra, R; Pease, EJ; Pilling, JE; Taylor, P; Trueman, D; Wen, S | 1 |
| Bekier, ME; Chadee, DN; Diakonova, M; Katusin, JD; Kaur, H; Kosik, A; Taylor, WR; Zhou, X | 1 |
| Ambrosini, G; Cheema, H; Coward, J; Ho, AL; Keen, N; Nair, JS; Schwartz, GK; Tse, AN | 1 |
| Castedo, M; Jemaá, M; Kepp, O; Kroemer, G; Métivier, D; Rello-Varona, S; Senovilla, L; Vitale, I | 1 |
| de Stanchina, E; Nair, JS; Schwartz, GK | 1 |
| Sabisz, M; Skladanowski, A; Wesierska-Gadek, J | 1 |
| Chen, J; Gully, CP; Lee, MH; Velazquez-Torres, G; Wang, E; Yeung, JA; Yeung, SC; Zhang, F | 1 |
| de Weger, RA; Moelans, CB; van Diest, PJ | 1 |
| Eberhardt, WE; Groneberg, M; Kübler, D; Pöttgen, C; Sak, A; Stuschke, M | 1 |
| Avanzi, MP; Chen, A; He, W; Mitchell, WB | 1 |
| Chen, Y; Foucar, CE; Ma, HT; Man, WY; Marxer, M; Poon, RY | 1 |
| Adam-Klages, S; Arnold, N; Caliebe, A; Eckmann-Scholz, C; Fredrik, R; Hilpert, F; Ma, Y; Schem, C; Sebens, S; Weimer, J | 1 |
| Beckmann, R; Burke, T; Collins, E; Dempsey, J; Diaz, B; Toth, J; Yang, H; Ye, X | 1 |
| Burnett, A; Mills, K; Pepper, C; Walsby, E; Walsh, V | 1 |
23 other study(ies) available for quinazolines and Polyploid
| Article | Year |
|---|---|
Reactive oxygen species generation and increase in mitochondrial copy number: new insight into the potential mechanism of cytotoxicity induced by aurora kinase inhibitor, AZD1152-HQPA.
Topics: Aurora Kinase B; Cell Line, Tumor; Cell Survival; Humans; Male; Mitochondria; Neoplastic Stem Cells; Organophosphates; Polyploidy; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species | 2017 |
CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance.
Topics: Adult; Aniline Compounds; Antineoplastic Agents, Phytogenic; bcl-X Protein; Benzamides; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin G1; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Paclitaxel; Polyploidy; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA Interference; Sulfonamides; Triple Negative Breast Neoplasms | 2017 |
Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes.
Topics: Animals; Apoptosis; Aurora Kinases; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase; Humans; Leukemia, Myeloid, Acute; Megakaryocytes; Mice; Mitosis; Organophosphates; Phthalazines; Polyploidy; Protein Isoforms; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2018 |
AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Aurora Kinase B; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Progression; Drug Resistance, Neoplasm; ErbB Receptors; Female; G1 Phase Cell Cycle Checkpoints; Histones; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Organophosphates; Phosphorylation; Polyploidy; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Survival Analysis; Treatment Outcome; Xenograft Model Antitumor Assays | 2019 |
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Aurora Kinases; Benzamides; Cell Line, Tumor; Deoxyglucose; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; HL-60 Cells; Humans; Indoles; Lactic Acid; Leukemia, Myeloid, Acute; Piperazines; Polyploidy; Purines; Quinazolines; Sequestosome-1 Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; U937 Cells | 2013 |
A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors.
Topics: Aurora Kinase B; Benzamides; Cell Line; Chromosomes, Human; Flavonoids; Flavonols; Humans; Micronuclei, Chromosome-Defective; Piperazines; Polyploidy; Protein Kinase Inhibitors; Quinazolines | 2014 |
Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.
Topics: Aurora Kinase B; Brain Neoplasms; Caspase 3; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Cell Shape; Cell Survival; DNA Damage; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Micronucleus, Germline; Mutation; Organophosphates; Polyploidy; Protein Kinase Inhibitors; Quinazolines; Transcription, Genetic; Tumor Stem Cell Assay | 2016 |
Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells.
Topics: Aniline Compounds; Apoptosis; bcl-X Protein; Benzamides; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin B1; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Indoles; Leukemia, Myeloid, Acute; Mitosis; Oxindoles; Phosphorylation; Polyploidy; Quinazolines; RNA, Small Interfering; Sulfonamides; U937 Cells; Vinblastine | 2015 |
Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Aurora Kinase B; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Amplification; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, myc; Histones; Humans; Lung Neoplasms; Mice; Organophosphates; Phosphorylation; Polyploidy; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Bone Marrow; Cell Line, Tumor; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Mice; Nanoparticles; Organophosphates; Polyploidy; Protein Kinase Inhibitors; Quinazolines; Rats; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Investigating the role of Aurora kinases in RAS signaling.
Topics: Animals; Aurora Kinase B; Aurora Kinases; Benzamides; Cell Cycle; Cell Line, Tumor; Fibroblasts; Histones; Humans; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; NIH 3T3 Cells; Phosphorylation; Polyploidy; Protein Serine-Threonine Kinases; Quinazolines; raf Kinases; ras Proteins; Rats; Signal Transduction | 2009 |
Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.
Topics: Amino Acid Sequence; Aurora Kinase B; Aurora Kinases; HCT116 Cells; Histones; Humans; Mitosis; Molecular Sequence Data; Organophosphates; Phosphorylation; Phosphoserine; Polyploidy; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2009 |
Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Kinesins; Mitosis; Neoplasms; Polyploidy; Quinazolines; RNA, Small Interfering; Thiones | 2009 |
The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Aurora Kinases; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Humans; Irinotecan; Mice; Organophosphates; Polyploidy; Protein Serine-Threonine Kinases; Quinazolines; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays | 2009 |
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
Topics: Acridines; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cyclin B1; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Gene Expression Regulation; HeLa Cells; Humans; Mitosis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polyploidy; Proteasome Endopeptidase Complex; Quinazolines; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53 | 2010 |
Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer.
Topics: Aneuploidy; Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Aurora Kinases; Breast Neoplasms; Cell Proliferation; Female; G2 Phase; Humans; Mice; Mitosis; Neoplasm Metastasis; Organophosphates; Polyploidy; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Quinazolines; Tumor Stem Cell Assay; Ubiquitination; Xenograft Model Antitumor Assays | 2010 |
Chromosome 17 polysomy without HER2 amplification does not predict response to lapatinib in metastatic breast cancer--letter.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chromosomes, Human, Pair 17; Female; Gene Amplification; Humans; Lapatinib; Neoplasm Metastasis; Polyploidy; Prognosis; Quinazolines; Receptor, ErbB-2 | 2010 |
Inhibiting the aurora B kinase potently suppresses repopulation during fractionated irradiation of human lung cancer cell lines.
Topics: Apoptosis; Aurora Kinase B; Aurora Kinases; Carcinoma, Non-Small-Cell Lung; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt Radioisotopes; Combined Modality Therapy; Dose Fractionation, Radiation; Enzyme Inhibitors; G2 Phase; Humans; Lung Neoplasms; Neoplasm Proteins; Polyploidy; Protein Serine-Threonine Kinases; Quinazolines; Tumor Stem Cell Assay | 2012 |
Optimizing megakaryocyte polyploidization by targeting multiple pathways of cytokinesis.
Topics: Actin Cytoskeleton; Amides; Benzamides; Blood Platelets; Cells, Cultured; Cytokinesis; Enzyme Inhibitors; Fetal Blood; Humans; Indoles; Megakaryocytes; Microtubules; Niacinamide; Ploidies; Polyploidy; Pyridines; Quinazolines; Signal Transduction; src-Family Kinases; Sulfonamides; Vitamin B Complex | 2012 |
Tetraploidization increases sensitivity to Aurora B kinase inhibition.
Topics: 3T3 Cells; Animals; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Cell Line, Tumor; Cytochalasin B; Cytokinesis; Diploidy; HeLa Cells; Humans; Mice; Polyploidy; Protein Serine-Threonine Kinases; Quinazolines; RNA Interference; RNA, Small Interfering | 2012 |
Aurora kinase inhibitor AZD1152 has an additional effect of platinum on a sequential application at the human ovarian cancer cell line SKOV3.
Topics: Antineoplastic Agents; Apoptosis; Aurora Kinase B; Carboplatin; Carcinoma; Caspase 3; Caspase 7; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Synergism; Female; Humans; Organophosphates; Ovarian Neoplasms; Polyploidy; Quinazolines | 2013 |
Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase.
Topics: Aurora Kinase B; Aurora Kinases; Benzamides; Cell Cycle Proteins; Cell Line, Tumor; Humans; Indoles; Mitosis; Polyploidy; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Quinazolines; RNA Interference; Sulfonamides | 2005 |
Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts.
Topics: Antineoplastic Agents; Apoptosis; Aurora Kinases; Benzamides; Blast Crisis; Cell Proliferation; Enzyme Inhibitors; Histones; Humans; Leukemia, Myeloid, Acute; Organophosphates; Phosphorylation; Ploidies; Polyploidy; Protein Serine-Threonine Kinases; Quinazolines; Tumor Cells, Cultured | 2008 |