quinazolines has been researched along with Osteosarcoma in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Anders Kolb, E; Earley, E; Erickson, S; Gatto, G; Gill, J; Gorlick, R; Harrison, D; Hingorani, P; Houghton, P; Kurmasheva, R; Roth, M; Smith, M; Teicher, B; Zhang, W | 1 |
| Hu, J; Zhou, Y | 1 |
| Foster, RA; Ludwig, L; Mutsaers, AJ; Schott, CR; Wood, GA | 1 |
| Fanelli, M; Hattinger, CM; Landuzzi, L; Magagnoli, G; Michelacci, F; Picci, P; Sero, V; Serra, M; Tavanti, E; Vella, S; Versteeg, R | 1 |
| Gao, S; Liu, ZL; Long, XH; Luo, QF; Peng, AF; Wen, HC; Zhang, GM; Zhang, L; Zhou, RP; Zhou, Y | 1 |
| Fanelli, M; Gudeman, B; Hattinger, CM; Michelacci, F; Picci, P; Sero, V; Serra, M; Tavanti, E; Valsasina, B; Vella, S; Versteeg, R | 1 |
| Chen, JM; Chen, S; Du, W; Huang, W; Liu, J; Liu, RY; Pan, C; Shen, J; Wu, J; Zhou, L; Zhou, Y; Zhu, X | 1 |
| Chen, L; Deng, ZL; He, BC; Ke, ZY; Liu, Y; Meng, ZJ; Pi, CJ; Shu, KJ; Wu, N; Yin, LJ; Zhang, RX; Zou, X | 1 |
| Berger, W; Kubista, B; Lötsch, D; Mayr, L; Micksche, M; Pirker, C; Sevelda, F; van Schoonhoven, S; Windhager, R | 1 |
| Fukuoka, N; Horie, R; Mori, M; Nakamura, O; Nishimura, H; Yamagami, Y; Yamamoto, T | 1 |
| Adamson, PC; Blaney, SM; Dancey, JE; Gilbertson, RJ; Hamilton, M; Ingle, AM; Jakacki, RI; Krailo, MD; Tersak, J; Voss, SD | 1 |
| Billups, CA; Carol, H; Gorlick, R; Houghton, PJ; Keir, ST; Kolb, EA; Lock, R; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA | 1 |
| Botchkina, G; Formentini, A; Ju, J; Kornmann, M; Song, B; Titmus, MA; Wang, Y | 1 |
| Kim, SY; Niswander, LM | 1 |
| Chen, HJ; Chiu, YJ; Chung, JG; Hour, MJ; Huang, WW; Jin, YA; Kuo, SC; Lu, CC; Yang, JS | 1 |
| Chen, KT; Chiu, YJ; Chuang, YH; Chung, JG; Hour, MJ; Kuo, SC; Lu, CC; Tsai, SC; Yang, JS | 1 |
| Kim, HS; Lee, SY; Shin, SJ | 1 |
| Cheshire, PJ; Daw, N; Germain, GS; Gilbertson, R; Harwood, FC; Houghton, PJ; Jenkins, JJ; Leggas, M; Panetta, JC; Peterson, J; Schuetz, JD; Stewart, CF | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Fudenberg, HH; Hynes, JB; Tsang, KY | 1 |
| Braña, MF; Castellano, JM; Keilhauer, G; Machuca, A; Martín, Y; Redondo, C; Schlick, E; Walker, N | 1 |
| Amyx, H; Boytos, CM; Duch, DS; Ferone, R; Smith, GK; Wilson, HR | 1 |
| Ben-Bassat, H; Gal, I; Klein, BY; Shlomai, Z; Tepper, SH | 1 |
| Bertino, JR; Fan, J; Hochhauser, D; Li, WW | 1 |
| Cox, WG; Singer, VL | 1 |
| Cox, WG; Doty, SB; Singer, VL; Stiner, D; Telford, WG | 1 |
1 review(s) available for quinazolines and Osteosarcoma
| Article | Year |
|---|---|
Stratifying osteosarcoma: minimizing and maximizing therapy.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Dacarbazine; Humans; Integrins; Osteosarcoma; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Survivors; Temozolomide; Treatment Outcome; Vascular Endothelial Growth Factor A | 2010 |
1 trial(s) available for quinazolines and Osteosarcoma
| Article | Year |
|---|---|
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bone Neoplasms; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Diarrhea; Drug Eruptions; ErbB Receptors; Erlotinib Hydrochloride; Humans; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Osteosarcoma; Quinazolines; Rhabdomyosarcoma; Temozolomide | 2008 |
25 other study(ies) available for quinazolines and Osteosarcoma
| Article | Year |
|---|---|
Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium in vivo models of osteosarcoma.
Topics: Child; Humans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines | 2023 |
Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Osteosarcoma; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction | 2018 |
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells.
Topics: Animals; Autophagy; Benzylamines; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dogs; Doxorubicin; Drug Interactions; Inhibitory Concentration 50; Osteosarcoma; Quinazolines | 2018 |
Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma.
Topics: Adult; Antineoplastic Agents; Aurora Kinases; Benzamides; Bone Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Osteosarcoma; Piperazines; Protein Kinase Inhibitors; Quinazolines; Tumor Cells, Cultured; Young Adult | 2013 |
Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitro.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fatty Acid Synthase, Type I; Humans; Lapatinib; Neoplasm Invasiveness; Osteosarcoma; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction | 2014 |
Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Bone Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Interactions; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Osteosarcoma; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyrazoles; Quinazolines; RNA, Messenger; RNA, Small Interfering | 2014 |
ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Celecoxib; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; ErbB Receptors; Female; G1 Phase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma; Phosphorylation; Piperidines; Quinazolines; Xenograft Model Antitumor Assays | 2015 |
Evodiamine inhibits the proliferation of human osteosarcoma cells by blocking PI3K/Akt signaling.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2015 |
EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2015 |
Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells.
Topics: Apoptosis; Autophagy; Benzylamines; Cell Line, Tumor; Cell Proliferation; Humans; Osteosarcoma; Phosphorylation; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program.
Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Female; Glioblastoma; Humans; Injections, Intraperitoneal; Kinesins; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Mice, SCID; Osteosarcoma; Quinazolines; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma, Ewing; Single-Blind Method; Spindle Apparatus; Tumor Stem Cell Assay; Wilms Tumor; Xenograft Model Antitumor Assays | 2009 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases | 2010 |
Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caspases; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; DNA-Binding Proteins; DNA, Neoplasm; Humans; Osteosarcoma; Oxidative Stress; Protein Serine-Threonine Kinases; Quinazolines; Reactive Oxygen Species; Signal Transduction; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation | 2011 |
The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Humans; MAP Kinase Kinase 4; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Models, Molecular; Molecular Targeted Therapy; Neoplasm Metastasis; Oncogene Protein v-akt; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Real-Time Polymerase Chain Reaction; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction | 2011 |
ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
Topics: Antioxidants; Apoptosis; Benzothiazoles; Butadienes; Cell Line, Tumor; Cyclic N-Oxides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteosarcoma; Phosphorylation; Piperazines; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Bone Neoplasms; Camptothecin; Cell Line, Tumor; Drug Synergism; ErbB Receptors; Female; Gefitinib; Humans; Irinotecan; Mice; Mice, Inbred ICR; Mice, SCID; Neoplasm Proteins; Osteosarcoma; Quinazolines; Xenograft Model Antitumor Assays | 2004 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytotoxicity, Immunologic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Lymphocyte Activation; Methotrexate; Neoplasms; Osteosarcoma; Pregnancy; Quinazolines; Sarcoma, Experimental | 1982 |
Benzimidazo[1,2-c]quinazolines: a new class of antitumor compounds.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Division; Colonic Neoplasms; Crystallography, X-Ray; DNA; Humans; Intercalating Agents; Leukemia L1210; Molecular Conformation; Molecular Structure; Osteosarcoma; Quinazolines; Tumor Cells, Cultured | 1994 |
Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.
Topics: Animals; Body Weight; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Humans; Indoles; Intestinal Diseases; Isoindoles; Leucovorin; Mice; Neoplasms, Experimental; Osteosarcoma; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells.
Topics: Alkaline Phosphatase; Animals; Benzylidene Compounds; Bone Marrow; Bone Neoplasms; Calcification, Physiologic; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Osteosarcoma; Protein-Tyrosine Kinases; Quinazolines; Rats; Stem Cells; Stromal Cells; Tumor Cells, Cultured; Tyrphostins | 1997 |
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; Doxorubicin; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methotrexate; Osteosarcoma; Phosphorylation; Quinazolines; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Tetracycline; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1997 |
A high-resolution, fluorescence-based method for localization of endogenous alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Female; Fluorescent Dyes; Immunohistochemistry; Intestines; Kidney; Kinetics; Microscopy, Fluorescence; Organophosphorus Compounds; Osteosarcoma; Ovary; Quinazolines; Quinazolinones; Rats; Sensitivity and Specificity; Tumor Cells, Cultured; Zebrafish | 1999 |
Detection of endogenous alkaline phosphatase activity in intact cells by flow cytometry using the fluorogenic ELF-97 phosphatase substrate.
Topics: Alkaline Phosphatase; Animals; Bone Neoplasms; Chick Embryo; Coloring Agents; Flow Cytometry; Fluorescent Dyes; Microscopy, Fluorescence; Organic Chemicals; Organophosphorus Compounds; Osteosarcoma; Quinazolines; Quinazolinones; Rats; Reaction Time; Substrate Specificity; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |