Page last updated: 2024-08-21

quinazolines and Leukemia L 1210

quinazolines has been researched along with Leukemia L 1210 in 121 studies

Research

Studies (121)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (45.45)	18.7374
1990's	52 (42.98)	18.2507
2000's	12 (9.92)	29.6817
2010's	2 (1.65)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cipak, L; Jantova, S; Repicky, A	1
Chandra, KL; Desper, J; Naganaboina, VK; Perchellet, EM; Perchellet, JP; Rayat, S; Waters, AM	1
Cipak, L	1
Cipák, L; Horváth, V; Jantová, S; Rauko, P; Slamenová, D	1
Cascioferro, S; Daidone, G; Maggio, B; Plescia, F; Raffa, D; Schillaci, D	2
Cabezas-Herrera, J; Durrant, MC; García-Cánovas, F; Navarro-Perán, E; Rodríguez-López, JN; Thorneley, RN	1
Bavetsias, V; Forster, MD; Gibbs, DD; Green, M; Henderson, E; Jackman, AL; Mitchell, F; Raynaud, F; Theti, DS; Valenti, M; Wood, N	1
Elslager, EF; Johnson, JL; Werbel, LM	1
Bertino, J; Cashmore, A; Eibl, B; Kamen, BA	1
Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ	1
Calvert, AH; Harrap, KR; Jackman, AL; Taylor, GA	2
Atassi, G; Brassinne, C; Coune, A; Frühling, J; Hildebrand, J; Laduron, C; Penasse, W; Ruysschaert, JM	1
Baron, M; Cros, S; Giorgi-Renault, S; Mailliet, P; Paoletti, C; Renault, J; Voisin, E	1
Calvert, AH; Harrap, KR; Hart, LI; Jackman, AL	1
Bertino, JR; Fernandes, DJ; Hynes, JB	1
Brown, SJ; Calvert, AH; Harrap, KR; Jackman, AL; Jones, M; Jones, TR	1
Calvert, AH; Dady, PJ; Grzelakowska-Sztabert, B; Harrap, KR; Jones, TR; Paine, RM; Taylor, GA	1
Boyle, FT; Brown, M; Brunton, L; Jackman, AL; Kimbell, R	1
Bavetsias, V; Bisset, GM; Boyle, FT; Brown, M; Brunton, L; Hughes, LR; Jackman, AL; Kimbell, R; Marsham, P	1
Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R	1
Bleasdale, C; Bowman, K; Calvert, AH; Curtin, NJ; Durkacz, BW; Griffin, RJ; Newell, DR; Pemberton, LC; Porteous, JK; Rhodes, D	1
Boyle, FT; Brown, M; Brunton, L; Harrap, KR; Jackman, AL; Kimbell, R; Wardleworth, JM	1
Barker, AJ; Boyle, FT; Calvert, AH; Hughes, LR; Jackman, AL; Kimbell, R; Marsham, PR; O'Connor, BM; Pegg, SJ; Wardleworth, JM	1
Chong, LK; Tattersall, MH	1
Harrap, KR	1
Braña, MF; Castellano, JM; Keilhauer, G; Machuca, A; Martín, Y; Redondo, C; Schlick, E; Walker, N	1
Chen, XH; Dai, ZR; Liu, JQ; Meng, XY; Yu, AZ; Zhang, XP	1
Fetzer, OS; Freisheim, JH; Hynes, JB; Shane, B	1
Freisheim, JH; Hagan, RL; Hynes, JB; Shane, B	1
Bavetsias, V; Bisset, GM; Calvert, AH; Gibson, W; Harrap, KR; Jackman, AL; Jodrell, DI; Kimbell, R; Smith, MN; Stephens, TC	1
Boyle, FT; Brown, M; Hughes, LR; Jackman, AL; Kimbell, R; Matusiak, ZS; Slater, AM; Smith, MN; Stephens, TC	1
Bavetsias, V; Bisset, GM; Boyle, FT; Jackman, AL; Pawelczak, K; Thornton, TJ	1
Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R	1
Boyle, FT; Jackman, AL; Jansen, G; Schornagel, JH; Westerhof, GR	1
Banks, S; Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Heath, LS; Humphreys, J; Knick, V; Pendergast, W; Singer, S	1
Bavetsias, V; Bisset, GM; Boyle, FT; Gibson, W; Jackman, AL; Kimbell, R	1
Boyle, FT; Hennequin, LF; Jackman, AL; Kimbell, R; Marsham, PR; Wardleworth, JM	1
Bartlett, CA; Boritzki, TJ; Hillard, JA; Howland, EF; Johnston, AL; Kosa, M; Margosiak, SA; Morse, CA; Shetty, BV; Webber, S	1
Appelt, K; Bacquet, RJ; Bartlett, CA; Booth, CL; Herrmann, SM; Howland, EF; Janson, CA; Jones, TR; Kathardekar, V; Lewis, KK; Marzoni, GP; Matthews, DA; Moomaw, EW; Morse, CA; Palmer, CL; Smith, WW; Varney, MD; Villafranca, JE; Ward, RW; Webber, S; Webber, SE; Welsh, KM; White, J	1
Aherne, GW; Boyle, FT; Brunton, L; Jackman, AL; Jansen, G; Kimbell, R; Smith, MN; Stephens, TC; Wardleworth, JM	1
Bowman, KJ; Curtin, NJ; Golding, BT; Griffin, RJ; White, A	1
Bowman, K; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Newell, DR; Pemberton, LC; Srinivasan, S	1
Brunton, LA; Jackman, AL; Kimbell, R; Ormerod, MG; Skelton, LA; Titley, J	1
Bowman, KJ; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Huang, B; Loughlin, PJ; Newell, DR; Turner, RN	1
Boyle, FT; Brown, M; Hennequin, LF; Jackman, AL; Kimbell, R; Marsham, PR; Wardleworth, JM	1
Jiang, L; Lee, PC; Rathod, PK; White, J	1
Bavetsias, V; Boyle, FT; Jackman, AL; Kimbell, R; Marriott, JH; Matusiak, ZS; Melin, C	1
Aherne, GW; Brunton, L; Clarke, SJ; Farrugia, DC; Jackman, AL	1
Besson, T; Guillaumet, G; Lamazzi, C; Léonce, S; Pfeiffer, B; Rees, CW; Renard, P	1
Ackland, SP; Sakoff, JA	1
Bowman, KJ; Calvert, AH; Curtin, NJ; Newell, DR	1
Bertino, JR; Chen, BK; Horváth, C	1
Bertino, JR; Hynes, JB; Moroson, BA; Scanlon, KJ	1
Allen, BA; Hillcoat, BL; Ledig, KW; McCormack, JJ	1
Bertino, JR; Cashmore, AR; Elslager, EF; Moroson, BA; Sawicki, WL	1
De Martino, G; Massa, S	1
Buck, JM; D'Souza, L; Freisheim, JH; Hynes, JB	1
Colvin, PL; Eason, DE; Garrett, CM; Hynes, JB	1
Hynes, JB; Oatis, JE	1
Garrett, CM; Hynes, JB	1
Donsback, RC; Sirotnak, FM	1
Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O	1
Barker, AJ; Bishop, JA; Burrows, KD; Hughes, LR; Jackman, AL; O'Connor, BM; Roberts, N; Warner, P	1
Jackman, AL; Kimbell, R; Ward, WH	1
Bishop, JA; Calvert, AH; Jackman, AL; Marsham, PR; O'Connor, BM; Thornton, TJ	1
Galivan, J; Malik, ND; Piper, JR; Rhee, MS; Sirotnak, FM	1
Gibson, W; Jackman, AL; Jodrell, DI; Stephens, TC	1
Chen, XH; Dai, ZR; Liu, JQ; Xu, XG; Yu, AZ; Zhang, XP	1
Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF	2
Goldman, ID; Seither, RL; Trent, DF	2
Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA	1
Chen, XH; Meng, XY; Yu, AZ; Zhang, XP	1
Atassi, G; Baron, M; Bissery, MC; Cros, S; Gebel-Servolles, P; Giorgi-Renault, S; Lavelle, F; Paoletti, C; Renault, J	1
Calvert, AH; Flinn, A; Jackman, AL; Jones, TR; O'Connor, BM; Thornton, TJ; Warner, P	1
Bishop, JA; Calvert, AH; Hayter, AJ; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM; Oldfield, J; Wardleworth, JM	1
Bishop, JA; Calvert, AH; Daw, MR; Hayter, AJ; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM; Snowden, JL	1
Dexter, DL; Dusak, BA; Hamel, E; Hesson, DP; Jiang, JB; Kang, GJ	1
Matherly, LH; Muench, SP	1
Keyomarsi, K; Moran, RG	1
Fry, DW	1
Bishop, JA; Burrows, KD; Calvert, AH; Hughes, LR; Jackman, AL; Jones, TR; Marsham, PR; O'Connor, BM; Oldfield, J; Smith, RC	1
Bishop, JA; Calvert, AH; Hughes, LR; Jackman, AL; Jones, TR; Marsham, PR; O'Connor, BM; Thornton, TJ	1
Bishop, JA; Bisset, GM; Calvert, AH; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM; Oldfield, J; Thornton, TJ	1
Berman, EM; Fry, DW; McNamara, DJ; Werbel, LM	1
Barlowe, CK; Goldman, ID; Matherly, LH	1
Calvert, AH; Jackman, AL; Jones, TR; Newell, DR; Sikora, E; Simmonds, AJ	1
Calvert, AH; Jackman, AL; Newell, DR; Sikora, E	1
Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Piper, JR; Sirotnak, FM; Thorndike, J	1
Bertino, JR; Chou, TC; Romanini, A; Sherwood, RF; Sobrero, AF	1
Balmanno, K; Calvert, AH; Hughes, LR; Jackman, AL; Taylor, GA	1
Chen, GD; Dai, ZR; Li, BS; Li, GY; Xin, ZM; Zhang, XP; Zhou, WC	1
Li, BS; Li, GD; Xin, ZM; Zhang, XP; Zhou, WC	1
Calvert, AH; Flinn, A; Jackman, AL; Jones, TR; Newell, DR; Thornton, TJ	1
Cole, A; Freisheim, JH; Hagan, RL; Hynes, JB; Kohler, W; Patil, SA	1
Goldman, ID; Matherly, LH; Schuetz, JD; Westin, EH	1
Bishop, JA; Calvert, AH; Chambers, P; Hayter, AJ; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM	1
Betteridge, RF; Calvert, AH; Jackman, AL; Jones, TR; Neidle, S	1
Griswold, DP; Hook, KE; Leopold, WR; Nelson, JM; Roberts, BJ	1
Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL	1
Gaumont, Y; Hsiao, MC; Kalman, TI; Kisliuk, RL; Nair, IG; Nair, MG; Nanavati, NT	1
Atassi, G; Dumont, P; Kabbe, HJ; Yoder, O	1
Crossley, PH; Imam, AM; Jackman, AL; Little, PF	1
Betteridge, RF; Calvert, AH; Davies, LC; Harrap, KR; Jackman, AL; Jones, TR; Smithers, MJ; Taylor, MA	1
Gale, GR; Hynes, JB; Smith, AB	1
Cheng, YC; Dutschman, GE; Fisher, MH; Nair, MG; Nanavathi, NT; Starnes, MC	1
Freisheim, JH; Hynes, JB; Kumar, A; Susten, SS	1
Betteridge, RF; Calvert, AH; Eakin, MA; Harland, SJ; Hayter, AJ; Jackman, AL; Jones, TR; Newell, DR; Smithers, MJ; Stocker, A	1
McCormack, JJ; Richter, WE	1
Donsbach, RC; Sirotnak, FM	2
Atwell, GJ; Cain, BF	1
Modest, EJ; Rosowsky, A	1
Hutchison, DJ	2
Buskirk, HH; Li, LH; Moxley, TE; Neil, GL	1
Bertino, JR; Capizzi, RL; Cashmore, AR; Johns, DG; Nahas, A	1
Abboud, G; Bertino, JR; Fölsch, E; Gralla, E	1

Reviews

4 review(s) available for quinazolines and Leukemia L 1210

Article	Year
The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Animals; Antineoplastic Agents; Biological Transport; Clinical Trials, Phase II as Topic; Drug Resistance; Humans; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1994
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture. Cancer research, 1995, Jul-01, Volume: 55, Issue:13 Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance; Female; Humans; Leukemia L1210; Mice; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase	1995
Synthesis and biological activity of tricyclic antifolate compounds with fixed geometry. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Humans; Leukemia L1210; Liver; Malaria; Mammary Neoplasms, Experimental; Mice; Mouth Neoplasms; Pyrimethamine; Quinazolines; Structure-Activity Relationship	1971
New approaches to chemotherapy. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Administration, Oral; Aminopterin; Animals; Enterococcus faecalis; Folic Acid Antagonists; Injections, Intraperitoneal; Lethal Dose 50; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines	1971

Other Studies

117 other study(ies) available for quinazolines and Leukemia L 1210

Article	Year
3-(5-Nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c]quinazoline induces ROS-mitochondrial mediated death signaling and activation of p38 MAPK in murine L1210 leukemia cells. Neoplasma, 2009, Volume: 56, Issue:6 Topics: Animals; Apoptosis; Caspase 3; Cytochromes c; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Leukemia L1210; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Quinazolines; Reactive Oxygen Species; Signal Transduction; Triazoles	2009
Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro. Anticancer research, 2011, Volume: 31, Issue:6 Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; DNA, Neoplasm; Female; Humans; Ki-67 Antigen; Leukemia L1210; Mice; Quinazolines	2011
Novel nonclassical antifolate, 2-[N-(2´-Hydroxyethyl)amino]methyl-3H-quinazolin-4-one, with a potent antineoplastic activity toward leukemia cells. Neoplasma, 2012, Volume: 59, Issue:6 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Cisplatin; Dacarbazine; Female; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mitogen-Activated Protein Kinases; Quinazolines; Temozolomide; U937 Cells	2012
Induction of cytotoxicity and ssDNA breaks by 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline in tumor cells cultured in vitro. Toxicology in vitro : an international journal published in association with BIBRA, 2003, Volume: 17, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Cycle; Cell Survival; Comet Assay; DNA, Single-Stranded; Humans; Leukemia L1210; Mice; Quinazolines; Tetrazoles; Tumor Cells, Cultured	2003
Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones. Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Division; Dogs; HL-60 Cells; Humans; Indicators and Reagents; K562 Cells; Leukemia; Leukemia L1210; Magnetic Resonance Spectroscopy; Quinazolines; Structure-Activity Relationship	2004
Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones. Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:6 Topics: Animals; Antineoplastic Agents; Colchicine; Czech Republic; Drug Evaluation, Preclinical; HL-60 Cells; Humans; K562 Cells; Leukemia L1210; Molecular Structure; Oxazoles; Quinazolines	2004
The antifolate activity of tea catechins. Cancer research, 2005, Mar-15, Volume: 65, Issue:6 Topics: Animals; Catechin; Cattle; Chickens; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Liver; Mice; Models, Molecular; Quinazolines; Tea; Tetrahydrofolate Dehydrogenase	2005
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer research, 2005, Dec-15, Volume: 65, Issue:24 Topics: Animals; Apoptosis; Biological Transport; Carrier Proteins; Cell Proliferation; Choriocarcinoma; Enzyme Inhibitors; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Idoxuridine; Iodine Radioisotopes; Leukemia L1210; Lung Neoplasms; Membrane Transport Proteins; Mice; Mice, Nude; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; Thymidylate Synthase; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured	2005
Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. Journal of medicinal chemistry, 1983, Volume: 26, Issue:12 Topics: Animals; Antimalarials; Antineoplastic Agents; Bacteria; Drug Resistance; Folic Acid Antagonists; Haplorhini; Leukemia L1210; Leukemia P388; Mice; Plasmodium falciparum; Quinazolines; Trimetrexate	1983
Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro. Biochemical pharmacology, 1984, May-15, Volume: 33, Issue:10 Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Trimetrexate	1984
Biochemical pharmacology of the lipophilic antifolate, trimetrexate. Advances in enzyme regulation, 1984, Volume: 22 Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate	1984
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717. Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20 Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; Male; Methyltransferases; Mice; Mice, Inbred DBA; Quinazolines; Thymidine; Thymidylate Synthase	1984
Antitumor activity of a water-insoluble compound entrapped in liposomes on L1210 leukemia in mice. Journal of the National Cancer Institute, 1983, Volume: 70, Issue:6 Topics: Animals; Chromatography, Gel; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Liposomes; Male; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Quinazolines	1983
Heterocyclic Quinones. 4. A new highly cytotoxic drug: 6,7-bis(1-aziridinyl)-5,8-quinazolinedione. Journal of medicinal chemistry, 1983, Volume: 26, Issue:12 Topics: Animals; Antineoplastic Agents; Leukemia L1210; Leukemia P388; Mice; Mutagenicity Tests; Quinazolines; Sarcoma 180	1983
Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics. Advances in experimental medicine and biology, 1984, Volume: 165 Pt B Topics: Animals; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methyltransferases; Mice; Quinazolines; Thymidylate Synthase	1984
Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717. Advances in experimental medicine and biology, 1984, Volume: 165 Pt B Topics: Animals; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methyltransferases; Mice; Mice, Inbred Strains; Nucleosides; Purines; Pyrimidines; Quinazolines; Thymidylate Synthase	1984
Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase. Cancer research, 1983, Volume: 43, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase	1983
A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice. European journal of cancer, 1981, Volume: 17, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase	1981
Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. European journal of cancer, 1980, Volume: 16, Issue:5 Topics: Animals; Cell Survival; Female; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Thymidylate Synthase	1980
Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity. Anti-cancer drug design, 1995, Volume: 10, Issue:7 Topics: Animals; Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Peptide Synthases; Polyglutamic Acid; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase	1995
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation. Anti-cancer drug design, 1995, Volume: 10, Issue:7 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glutamates; Leukemia L1210; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1995
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. British journal of cancer, 1995, Volume: 71, Issue:5 Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured	1995
Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP). Anti-cancer drug design, 1995, Volume: 10, Issue:6 Topics: Animals; Benzoxazoles; Binding Sites; Enzyme Inhibitors; Humans; Leukemia L1210; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines	1995
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series. Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6 Topics: Animals; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1995
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase. Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6 Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxanthine; Hypoxanthines; Leukemia L1210; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1995
Benzimidazo[1,2-c]quinazolines: a new class of antitumor compounds. Anti-cancer drug design, 1994, Volume: 9, Issue:6 Topics: Animals; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Division; Colonic Neoplasms; Crystallography, X-Ray; DNA; Humans; Intercalating Agents; Leukemia L1210; Molecular Conformation; Molecular Structure; Osteosarcoma; Quinazolines; Tumor Cells, Cultured	1994
[Synthesis and biological activities of 2,4-diamino-5-fluoro-6-substituted benzylamino quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1994, Volume: 29, Issue:4 Topics: Animals; Antimalarials; Antineoplastic Agents; Leukemia L1210; Malaria; Mice; Plasmodium berghei; Quinazolines; Tumor Cells, Cultured	1994
Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Cell Survival; Fluorine; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured	1993
Synthesis and biological evaluation of analogues of 5,8-dideazaisofolic acid (IAHQ) modified at positions 2, 4 and 9. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Cell Survival; Folic Acid Antagonists; Kinetics; Leukemia L1210; Liver; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured	1993
Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase	1993
Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1993
Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583). Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Molecular Structure; Peptides; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1993
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides	1993
The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Quinazolines; Receptors, Cell Surface; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1993
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer research, 1993, Feb-15, Volume: 53, Issue:4 Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Colonic Neoplasms; Female; Humans; Indoles; Isoindoles; Leucovorin; Leukemia L1210; Leukemia, T-Cell; Methotrexate; Quinazolines; Structure-Activity Relationship; Subrenal Capsule Assay; Tetrahydrofolates; Thymidylate Synthase	1993
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Division; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1996
Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent. Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3 Topics: Animals; Folic Acid Antagonists; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; X-Ray Diffraction	1996
AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:6 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Enzyme Inhibitors; Folic Acid Antagonists; Growth Inhibitors; Humans; Leukemia L1210; Leukemia L5178; Mice; Quinazolines; Rats; Solubility; Thymidylate Synthase	1996
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase. Journal of medicinal chemistry, 1996, Feb-16, Volume: 39, Issue:4 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Binding Sites; Cell Line; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Conformation; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1996
Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:6 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Female; Humans; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay	1997
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. British journal of cancer, 1998, Volume: 78, Issue:10 Topics: Amides; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzimidazoles; Bleomycin; Cell Death; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Tumor Cells, Cultured	1998
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). Journal of medicinal chemistry, 1998, Dec-17, Volume: 41, Issue:26 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured	1998
A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus. British journal of cancer, 1999, Volume: 79, Issue:11-12 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; Chemical Precipitation; Colony-Forming Units Assay; Cytoprotection; DNA, Neoplasm; Folic Acid; Humans; Leukemia L1210; Lipid Metabolism; Mice; Quinazolines; Solubility; Tumor Cells, Cultured	1999
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding. British journal of cancer, 1999, Volume: 80, Issue:11 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Survival; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Orosomucoid; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured	1999
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. Journal of medicinal chemistry, 1999, Sep-23, Volume: 42, Issue:19 Topics: Animals; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Leukemia L1210; Mice; Models, Chemical; Quinazolines; Thymidylate Synthase	1999
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:4 Topics: Animals; Cell Division; Enzyme Inhibitors; Erythrocytes; Folic Acid Antagonists; Indoles; Isoindoles; Kinetics; Leukemia L1210; Mice; Plasmodium falciparum; Quinazolines; Thymidine; Thymidylate Synthase	2000
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,). Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10 Topics: Animals; Antineoplastic Agents; Cell Division; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Leukemia L1210; Methotrexate; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tritium; Tumor Cells, Cultured	2000
Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cell Division; Cell Line; Drug Interactions; Humans; Intestinal Mucosa; Intestine, Small; Leucovorin; Leukemia L1210; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Neutropenia; Polyglutamic Acid; Quinazolines; Thiophenes; Thrombocytopenia	2000
Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines. Bioorganic & medicinal chemistry letters, 2000, Oct-02, Volume: 10, Issue:19 Topics: Animals; Cell Division; HT29 Cells; Humans; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Quinolines	2000
Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells. Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Caspases; Cell Membrane Permeability; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia L1210; Mitochondria; Neoplasm Proteins; Quinazolines; S Phase; Thymidylate Synthase; Time Factors	2000
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. British journal of cancer, 2001, Jan-05, Volume: 84, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Nucleic Acid Synthesis Inhibitors; Proteins; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2001
Multivariate analysis and quantitative structure-activity relationships. Inhibition of dihydrofolate reductase and thymidylate synthetase by quinazolines. Journal of medicinal chemistry, 1979, Volume: 22, Issue:5 Topics: Analysis of Variance; Animals; Factor Analysis, Statistical; Folic Acid Antagonists; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Methyltransferases; Mice; Models, Biological; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1979
Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources. Molecular pharmacology, 1979, Volume: 16, Issue:1 Topics: Animals; Cell Division; Folic Acid; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Methyltransferases; Mice; Neoplasms, Experimental; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1979
Inhibition of dihydrofolate reductases by derivatives of 2,4-diaminopyrroloquinazoline. Biochemical pharmacology, 1979, Nov-01, Volume: 28, Issue:21 Topics: Animals; Crithidia; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Lacticaseibacillus casei; Leukemia L1210; Liver; Quinazolines; Rats	1979
2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo. Biochemical pharmacology, 1979, Jun-15, Volume: 28, Issue:12 Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia L1210; Mice; Neoplasms, Experimental; Quinazolines	1979
[Research on substances with antiblastic activity. LXII. Synthesis and antineoplastic activity of pyrrolo-[2,1-b] quinazoline derivatives and of 4H-pyrrolo[2,1-b] [1,3] benzodiazepine derivatives]. Il Farmaco; edizione scientifica, 1978, Volume: 33, Issue:4 Topics: Animals; Antineoplastic Agents; Benzodiazepines; Drug Evaluation, Preclinical; Leukemia L1210; Mice; Pyrroles; Quinazolines	1978
Quinazolines as inhibitors of dihydrofolate reductase. 3. Analogs of pteroic and isopteroic acids. Journal of medicinal chemistry, 1975, Volume: 18, Issue:12 Topics: Animals; Enterococcus faecalis; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Malaria; Mice; Plasmodium berghei; Pterins; Quinazolines; Rats	1975
Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids. Journal of medicinal chemistry, 1977, Volume: 20, Issue:4 Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Mice; Quinazolines; Rats; Streptococcus; Structure-Activity Relationship	1977
Sycnthesis of quinazoline analogues of folic acid modified at postion 10. Journal of medicinal chemistry, 1977, Volume: 20, Issue:11 Topics: Animals; Antineoplastic Agents; Folic Acid; Leukemia L1210; Mice; Quinazolines	1977
Synthesis of quinazoline analogs of isofolic acid. Journal of medicinal chemistry, 1975, Volume: 18, Issue:6 Topics: Animals; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Mice; Quinazolines; Rats; Structure-Activity Relationship	1975
Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors. Cancer research, 1975, Volume: 35, Issue:7 Topics: Aminopterin; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Chick Embryo; DNA, Neoplasm; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Quinazolines; Sarcoma 180; Tetrahydrofolate Dehydrogenase; Time Factors	1975
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. Cancer research, 1992, Apr-15, Volume: 52, Issue:8 Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1992
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. Journal of medicinal chemistry, 1992, Jul-24, Volume: 35, Issue:15 Topics: Animals; Cell Survival; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1992
Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. Biochemical pharmacology, 1992, May-08, Volume: 43, Issue:9 Topics: Animals; Binding Sites; Cell Division; Kinetics; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1992
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12 Topics: Animals; Antineoplastic Agents; Benzene; Cell Division; Fluorine; Folic Acid Antagonists; Leukemia L1210; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1992
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin. Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2 Topics: Aminopterin; Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured	1992
ICI D1694, an inhibitor of thymidylate synthase for clinical study. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Animals; Breast Neoplasms; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Mice; Neoplasms, Experimental; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1991
[Synthesis and biological activities of 2,4-diamino-5-chloro-6-substituted quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1991, Volume: 26, Issue:11 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Antineoplastic Agents; Leukemia L1210; Melanoma, Experimental; Mice; Microbial Sensitivity Tests; Plasmodium berghei; Quinazolines; Streptococcus pneumoniae; Tumor Cells, Cultured	1991
Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition. The Journal of biological chemistry, 1991, Mar-05, Volume: 266, Issue:7 Topics: Animals; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Quinazolines; Quinazolinones; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured	1991
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells. The Journal of biological chemistry, 1991, Mar-25, Volume: 266, Issue:9 Topics: Animals; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thermodynamics; Trimetrexate; Tumor Cells, Cultured	1991
Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate. Biochemical pharmacology, 1991, Aug-08, Volume: 42, Issue:5 Topics: Animals; Cell Compartmentation; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mitochondria; Quinazolines; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured	1991
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer research, 1991, Oct-15, Volume: 51, Issue:20 Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase	1991
[Synthesis and antibacterial as well as antineoplastic activities of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1991, Volume: 26, Issue:5 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Leukemia L1210; Quinazolines; Staphylococcus; Tumor Cells, Cultured	1991
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Female; Humans; Leukemia L1210; Leukemia, Experimental; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Structure; Neoplasms, Experimental; Quinazolines; Sarcoma, Experimental; Structure-Activity Relationship	1991
Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. Journal of medicinal chemistry, 1991, Volume: 34, Issue:3 Topics: Animals; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1991
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. Journal of medicinal chemistry, 1991, Volume: 34, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1991
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. Journal of medicinal chemistry, 1991, Volume: 34, Issue:7 Topics: Animals; Bridged-Ring Compounds; Cell Line; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1991
Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. Journal of medicinal chemistry, 1990, Volume: 33, Issue:6 Topics: Animals; Antineoplastic Agents; Humans; Leukemia L1210; Mice; Microtubules; Quinazolines; Structure-Activity Relationship; Styrenes; Tubulin; Tumor Cells, Cultured	1990
Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured	1990
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate. The Journal of biological chemistry, 1990, Nov-05, Volume: 265, Issue:31 Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Models, Structural; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1990
Cytotoxic synergism between trimetrexate and etoposide. Evidence that trimetrexate potentiates etoposide-induced protein-associated DNA strand breaks in L1210 leukemia cells through alterations in intracellular ATP concentrations. Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9 Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA Damage; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured	1990
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. Journal of medicinal chemistry, 1990, Volume: 33, Issue:11 Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Chemistry, Physical; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Liver; Mice; Molecular Structure; Quinazolines; Rats; Structure-Activity Relationship; Thymidylate Synthase	1990
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. Journal of medicinal chemistry, 1990, Volume: 33, Issue:11 Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1990
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. Journal of medicinal chemistry, 1990, Volume: 33, Issue:11 Topics: Animals; Antineoplastic Agents; Arginine; Cell Division; Folic Acid Antagonists; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1990
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1990
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells. Cancer research, 1986, Volume: 46, Issue:2 Topics: Animals; Cell Survival; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimetrexate	1986
Development of an assay for the estimation of N10-propargyl-5,8-dideazafolic acid polyglutamates in tumor cells. Analytical biochemistry, 1988, Aug-01, Volume: 172, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Folic Acid; Leukemia L1210; Mice; Neoplasms; Peptides; Polyglutamic Acid; Quinazolines; Thymidylate Synthase	1988
Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro. Biochemical pharmacology, 1988, Nov-01, Volume: 37, Issue:21 Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Folic Acid; Leukemia L1210; Mice; Peptides; Polyglutamic Acid; Quinazolines; Thymidylate Synthase; Time Factors	1988
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts. Cancer research, 1989, Jan-01, Volume: 49, Issue:1 Topics: Acyltransferases; Animals; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Leukemia L1210; Lymphoma; Mice; Molecular Conformation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Trimetrexate	1989
Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2. Cancer research, 1989, Nov-01, Volume: 49, Issue:21 Topics: Animals; Cell Line; Cell Survival; Clone Cells; Cysteine Endopeptidases; Drug Resistance; Drug Synergism; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Quinazolines; Trimetrexate; Tumor Stem Cell Assay	1989
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells. The Journal of biological chemistry, 1989, Oct-15, Volume: 264, Issue:29 Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate	1989
Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Animals; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mice, Inbred DBA; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured	1989
[Synthesis and antimalarial as well as antitumor activities of 2,4-diamino-6-(N-methyl-substituted benzylamino) quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:2 Topics: Animals; Antimalarials; Antineoplastic Agents; Leukemia L1210; Malaria; Mice; Plasmodium berghei; Quinazolines	1989
[Synthesis and antimalarial as well as antitumor activities of 1-methyl-2,4-diamino-6-(N-methyl-substituted benzylamion) quinazolinium iodides]. Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:12 Topics: Animals; Antimalarials; Antineoplastic Agents; Benzylamines; Chemical Phenomena; Chemistry; Diamines; Leukemia L1210; Mice; Plasmodium berghei; Quinazolines; Tumor Cells, Cultured	1989
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency. Journal of medicinal chemistry, 1989, Volume: 32, Issue:4 Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Hydrogen Bonding; Leukemia L1210; Liver; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thymidylate Synthase	1989
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts. Journal of medicinal chemistry, 1989, Volume: 32, Issue:4 Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1989
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. The Journal of biological chemistry, 1988, Jul-15, Volume: 263, Issue:20 Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Gene Amplification; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phenotype; Quinazolines; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate	1988
Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position. Journal of medicinal chemistry, 1989, Volume: 32, Issue:3 Topics: Animals; Chemical Phenomena; Chemistry; Chlorine; Folic Acid Antagonists; Leukemia L1210; Mice; Nitrogen; Oxygen; Quinazolines; Structure-Activity Relationship; Sulfur; Thymidylate Synthase; Tumor Cells, Cultured	1989
Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent. Anti-cancer drug design, 1989, Volume: 3, Issue:4 Topics: Animals; Chemical Phenomena; Chemistry; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Folic Acid Antagonists; Leukemia L1210; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1989
Cell cycle effects of trimetrexate (CI-898). Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Cells, Cultured; Cricetinae; Demecolcine; Drug Evaluation, Preclinical; Female; Flow Cytometry; Injections, Intraperitoneal; Interphase; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ovary; Quinazolines; Trimetrexate	1986
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies. Cancer research, 1986, Volume: 46, Issue:6 Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium	1986
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF). Journal of medicinal chemistry, 1986, Volume: 29, Issue:9 Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Quinazolines; Streptococcus; Structure-Activity Relationship; Thymidylate Synthase	1986
A new antitumour agent, batracylin, selected by a preclinical solid tumour model. Drugs under experimental and clinical research, 1988, Volume: 14, Issue:9 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Leukemia L1210; Leukemia P388; Melanoma, Experimental; Mice; Quinazolines	1988
Analysis of thymidylate synthase gene amplification and of mRNA levels in the cell cycle. The Journal of biological chemistry, 1987, May-25, Volume: 262, Issue:15 Topics: Animals; Cell Cycle; Cell Line; DNA; Folic Acid; Folic Acid Antagonists; Gene Amplification; Leukemia L1210; Mice; Nucleic Acid Hybridization; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	1987
Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid. Journal of medicinal chemistry, 1986, Volume: 29, Issue:6 Topics: Animals; Folic Acid Antagonists; Leukemia L1210; Mice; Models, Molecular; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1986
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil. Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil	1986
Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase. Cancer research, 1985, Volume: 45, Issue:2 Topics: Animals; Cell Division; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Lacticaseibacillus casei; Leukemia L1210; Mathematics; Methotrexate; Methyltransferases; Pteroylpolyglutamic Acids; Quinazolines; Thymidylate Synthase	1985
Inhibition of dihydrofolate reductase, methotrexate transport, and growth of methotrexate-sensitive and -resistant L1210 leukemia cells in vitro by 5-substituted 2,4-diaminoquinazolines. Biochemical pharmacology, 1985, Jun-15, Volume: 34, Issue:12 Topics: Animals; Biological Transport; Cells, Cultured; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship	1985
Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent. Journal of medicinal chemistry, 1985, Volume: 28, Issue:10 Topics: Alkylation; Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase	1985
Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds. Journal of medicinal chemistry, 1974, Volume: 17, Issue:9 Topics: Animals; Chagas Disease; Diamines; Enterococcus faecalis; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Malaria; Mice; Plasmodium berghei; Quinazolines; Rats; Trypanosoma cruzi	1974
Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell. Cancer research, 1972, Volume: 32, Issue:10 Topics: Aminopterin; Animals; Antineoplastic Agents; Ascitic Fluid; Aspartic Acid; Benzoates; Binding, Competitive; Biological Transport, Active; Cell Line; Cells, Cultured; Diffusion; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Streptococcus pneumoniae; Temperature; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium	1972
Potential antitumor agents. 13. Bisquaternary salts. Journal of medicinal chemistry, 1973, Volume: 16, Issue:6 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Hydrogen-Ion Concentration; Leukemia L1210; Methods; Mice; Quinazolines; Quinolines; Structure-Activity Relationship	1973
Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells. Cancer research, 1974, Volume: 34, Issue:2 Topics: Aminopterin; Animals; Biological Transport, Active; Cells, Cultured; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Pyrimidines; Quinazolines	1974
Antitumor effects of the antispermatogenic agent, 2,3-dihydro-2-(1-naphthyl)-4(1H)-quinazolinone (NSC-145669). Cancer chemotherapy reports, 1972, Volume: 56, Issue:2 Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzene Derivatives; Carbon Isotopes; Cells, Cultured; DNA, Neoplasm; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Ketones; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred Strains; Naphthalenes; Neoplasm Proteins; Neoplasm Transplantation; Organ Size; Quinazolines; Quinolines; RNA, Neoplasm; Time Factors	1972
Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells. Biochemical pharmacology, 1970, Volume: 19, Issue:4 Topics: Adult; Aged; Animals; Biological Transport; Cell Line; Chemical Precipitation; Chromatography; Chromatography, Gel; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid Antagonists; Humans; Hydroxyapatites; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Mice; Quaternary Ammonium Compounds; Quinazolines; Spectrophotometry; Sulfates; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays	1970
Studies with a 2,4-diamino-5-chloro-quinazoline antifolate: in vitro and invivo correlates in normal and lymphosarcoma dogs. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Animals; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; DNA, Neoplasm; Dogs; Folic Acid Antagonists; Hydrogen-Ion Concentration; Injections, Intravenous; Leukemia L1210; Lymphoma, Non-Hodgkin; Methotrexate; Quinazolines; Thymine Nucleotides; Time Factors; Tritium	1971
Quinazoline antifolates: biologic activities. Cancer chemotherapy reports, 1968, Volume: 52, Issue:7 Topics: Animals; Cell Line; Culture Techniques; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Streptococcus	1968