quinazolines has been researched along with Leucocythaemia in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (12.73) | 18.7374 |
| 1990's | 15 (27.27) | 18.2507 |
| 2000's | 18 (32.73) | 29.6817 |
| 2010's | 13 (23.64) | 24.3611 |
| 2020's | 2 (3.64) | 2.80 |
| Authors | Studies |
|---|---|
| Arimondo, PB; Barbachowska, M; Bon, C; Djokovic, N; Halby, L; Jallet, C; Nikolic, K; Ruzic, D; Si, Y; Soresinetti, L; Tafit, A | 1 |
| Chen, R; Jing, W; Li, W; Luo, J; Peng, S; Su, X; Wang, Z; Ye, X; Zhou, M | 1 |
| Akashi, K; Al-Raqad, M; Arai, F; Bauer, DE; Buonamici, S; Canver, MC; Cole, MA; Ishikawa, Y; Macias-Trevino, C; Maeda, M; Maeda, T; Masuda, T; Nakano, M; Orkin, SH; Pinello, L; Reversade, B; Schoonenberg, VAC; Seiler, M; Semba, Y; Shboul, M; Yamauchi, T; Yao, Q | 1 |
| Aoki, I; Bakalova, R; Getsov, P; Ivanova, D; Lazarova, D; Zhelev, Z | 1 |
| Günther, S; Lucas, X | 1 |
| Fu, LW; He, JH; Huang, ZC; To, KK; Wang, F; Wang, XK; Xu, JH; Ye, S; Zhang, H | 1 |
| Dong, F; Liu, X; Luan, C; Luan, S; Shao, H; Sun, C; Zhang, G | 1 |
| Aoki, I; Bakalova, R; Ivanova, D; Lazarova, D; Saga, T; Zhelev, Z | 1 |
| Ledford, H | 1 |
| Bullinger, L; Chen, J; Fröhling, S; Gilliland, DG; Golub, TR; Gu, TL; Lee, BH; Monti, S; Tam, WF; Wang, A | 1 |
| Kiyoi, H | 4 |
| DeRyckere, D; Gore, L; Macy, ME | 1 |
| Fiedler, W; Wellbrock, J | 1 |
| Alli, C; Alzani, R; Avanzi, N; Ballinari, D; Beria, I; Cappella, P; Caruso, M; Casolaro, A; Ciavolella, A; Cucchi, U; De Ponti, A; Felder, E; Fiorentini, F; Galvani, A; Gianellini, LM; Giorgini, ML; Isacchi, A; Lansen, J; Moll, J; Pesenti, E; Rizzi, S; Rocchetti, M; Sola, F; Valsasina, B | 1 |
| Bligh, SW; Hartley, JA; Hartley, JM; Pan, X; Wang, Z; White, KN | 1 |
| Cipak, L | 1 |
| Wiart, C | 1 |
| Cascioferro, S; Daidone, G; Maggio, B; Plescia, F; Raffa, D; Schillaci, D | 1 |
| Barbui, T | 1 |
| Berg, SL; Bernstein, M; Blaney, SM; Horton, TM; Kamen, B; Kuhn, J; Langevin, AM; Weitman, S | 1 |
| Lee, LH; Wong, GC | 1 |
| Ikezoe, T; Koeffler, HP; Komatsu, N; Kuwayama, Y; Nishioka, C; Taguchi, H; Takeshita, A; Tasaka, T; Togitani, K; Yang, J; Yang, Y | 1 |
| Bandobashi, K; Ikezoe, T; Koeffler, HP; Komatsu, N; Kuwayama, Y; Nishioka, C; Taguchi, H; Taniguchi, A; Tasaka, T; Togitani, K; Yang, J; Yokoyama, A | 1 |
| Bertino, JR; Cashmore, AR; Chang, PK; Mini, E; Moroson, BA; Schornagel, JH; Sciarini, LJ | 1 |
| Bertino, JR; Cardenas, RM; Fernandes, DJ; Hynes, JB | 1 |
| Barrows, LR; Chen, AY; LaVoie, EJ; Liu, LF; McQueen, CA; Meegalla, SK; Stevens, GJ; Yu, C | 1 |
| Ando, K; Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Gibson, W; Jackman, AL; Kimbell, R; Kobayashi, H; Miyachi, H; Takemura, Y | 2 |
| Appelt, K; Bacquet, RJ; Bartlett, CA; Booth, CL; Herrmann, SM; Howland, EF; Janson, CA; Jones, TR; Kathardekar, V; Lewis, KK; Marzoni, GP; Matthews, DA; Moomaw, EW; Morse, CA; Palmer, CL; Smith, WW; Varney, MD; Villafranca, JE; Ward, RW; Webber, S; Webber, SE; Welsh, KM; White, J | 1 |
| Cheson, BD; Phillips, PH; Sorensen, JM | 1 |
| Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Barbui, T; Brière, J; Dupuy, E; Finazzi, G; Kiladjian, JJ | 1 |
| Faure, MP; Jolivet, J; Matherly, LH; Taub, JW; Wong, SC | 1 |
| Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Ghosh, S; Liu, XP; Mahajan, S; Mao, C; Narla, RK; Sudbeck, EA; Uckun, FM | 1 |
| Aherne, GW; Barnes, MJ; Calvete, JA; Estlin, EJ; Hardcastle, A; Lunec, J; McGuire, JJ; Newell, DR; Pearson, AD; Taylor, GA | 1 |
| Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC | 1 |
| Canestrari, JG; McGuire, JJ; Nagel, GS | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Hehlmann, R; Lengfelder, E | 1 |
| Ghosh, S; Liu, XP; Myers, DE; Sudbeck, EA; Uckun, FM; Zheng, Y | 1 |
| Briere, J; Guilmin, F | 1 |
| Cipák, L; Jantová, S; Kubíková, J; Maliar, T; Mikulásová, M; Rauko, P; Spirková, K; Stankovský, S; Urbancíková, M | 1 |
| Ikeda, Y | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Jackman, AL; Jansen, G; Newell, DR; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
| Jansen, G; Rijksen, G; Schornagel, JH; van der Veer, LJ; Westerhof, GR | 1 |
| Arkin, H; Holland, JF; Kamen, BA; Ohnuma, T; Vallabhajosula, S | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Bertino, JR; McGuire, JJ; Narayanan, R; Rodenhuis, S | 1 |
| Bertino, JR; McGuire, JJ; Rodenhuis, S; Sawicki, WL | 1 |
9 review(s) available for quinazolines and Leucocythaemia
| Article | Year |
|---|---|
[FLT3 kinase inhibitors for the treatment of acute leukemia].
Topics: Acute Disease; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Indazoles; Leukemia; Mutation; Piperazines; Quinazolines; Signal Transduction; Staurosporine | 2010 |
Clinical experience with antiangiogenic therapy in leukemia.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Clinical Trials as Topic; Humans; Indoles; Lenalidomide; Leukemia; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib; Thalidomide; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2011 |
The leukemia controversy in myeloproliferative disorders: is it a natural progression of disease, a secondary sequela of therapy, or a combination of both?
Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Antiviral Agents; Disease Progression; Female; Humans; Hydroxyurea; Interferon-alpha; Leukemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Polycythemia Vera; Quinazolines; Risk Factors; Thrombocythemia, Essential; Thrombosis | 2004 |
[Possibility of targeting FLT3 kinase for the treatment of leukemia].
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib | 2005 |
[Novel molecularly target therapies for leukemia].
Topics: Antineoplastic Agents; Carbazoles; Farnesyltranstransferase; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia; Piperazines; Quinazolines; Staurosporine | 2007 |
Treatment strategies in essential thrombocythemia. A critical appraisal of various experiences in different centers.
Topics: Adult; Aged; Alkylating Agents; Anemia, Megaloblastic; Arrhythmias, Cardiac; Bone Marrow Diseases; Busulfan; Female; Hemorrhage; Humans; Hydroxyurea; Immunologic Factors; Incidence; Interferon-alpha; Ischemic Attack, Transient; Leukemia; Male; Middle Aged; Pipobroman; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Quinazolines; Risk Factors; Thrombocythemia, Essential; Thrombosis | 1996 |
[Polycythemia vera: current status of therapy].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bloodletting; Clinical Trials as Topic; Fibrinolytic Agents; Humans; Hydroxyurea; Interferon-alpha; Leukemia; Middle Aged; Phlebotomy; Pipobroman; Platelet Aggregation Inhibitors; Polycythemia Vera; Prognosis; Prospective Studies; Quinazolines; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Thromboembolism | 2000 |
Tyrosine kinase inhibitors against EGF receptor-positive malignancies.
Topics: Adenocarcinoma; Amides; Aniline Compounds; Animals; Antineoplastic Agents; Breast Neoplasms; Drug Design; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; Humans; Leukemia; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Nitriles; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Fusion Proteins; Sequence Alignment; Species Specificity; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2001 |
Management of patients with essential thrombocythemia: current concepts and perspectives.
Topics: Adult; Aged; Aspirin; Case Management; Clinical Trials as Topic; Diagnosis, Differential; Disease Progression; Female; Hemorrhagic Disorders; Humans; Hydroxyurea; Interferons; Leukemia; Male; Middle Aged; Pipobroman; Platelet Aggregation Inhibitors; Platelet Count; Pregnancy; Pregnancy Complications, Hematologic; Prospective Studies; Quinazolines; Risk; Safety; Thrombocythemia, Essential; Thrombophilia | 2001 |
1 trial(s) available for quinazolines and Leucocythaemia
| Article | Year |
|---|---|
Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Humans; Infant; Infusions, Intravenous; Leukemia; Male; Maximum Tolerated Dose; Quinazolines; Thiophenes; Treatment Outcome | 2005 |
45 other study(ies) available for quinazolines and Leucocythaemia
| Article | Year |
|---|---|
Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.
Topics: Adenine; Antidotes; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Molecular Docking Simulation; Quinazolines | 2022 |
In vitro and ex vivo anti‑tumor effect and mechanism of Tucatinib in leukemia stem cells and ABCG2‑overexpressing leukemia cells.
Topics: Adenosine Triphosphatases; Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzimidazoles; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Male; Mitoxantrone; Neoplasm Proteins; Neoplastic Stem Cells; Oxazoles; Pyridines; Quinazolines; Side-Population Cells; Tumor Cells, Cultured | 2021 |
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
Topics: Animals; Cell Line; CRISPR-Cas Systems; Endoribonucleases; Humans; Leukemia; Male; Metabolic Networks and Pathways; Mice, Inbred C57BL; Muscular Atrophy, Spinal; Quinazolines; RNA Precursors; RNA Splicing; RNA, Messenger | 2018 |
Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib.
Topics: Antineoplastic Agents; Apoptosis; Ascorbic Acid; Cell Survival; Cells, Cultured; Everolimus; Humans; Jurkat Cells; Leukemia; Lipid Peroxides; Lymphocytes; Organophosphates; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Vitamin K 3; Vitamins | 2018 |
Targeting the BET family for the treatment of leukemia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Cycle Proteins; Cell Proliferation; Gene Expression; Humans; Leukemia; Nuclear Proteins; Protein Serine-Threonine Kinases; Quinazolines; Quinazolinones; RNA-Binding Proteins; Transcription Factors; Triazoles | 2014 |
Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells.
Topics: Afatinib; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; DNA Methylation; Drug Synergism; Humans; Leukemia; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplastic Stem Cells; Promoter Regions, Genetic; Protein Kinase Inhibitors; Quinazolines; Random Allocation; Signal Transduction; Topotecan; Xenograft Model Antitumor Assays | 2014 |
Evodiamine inhibits the proliferation of leukemia cell line K562 by regulating peroxisome proliferators-activated receptor gamma (PPARγ) pathway.
Topics: Anilides; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia; PPAR gamma; Quinazolines | 2016 |
Docosahexaenoic Acid Sensitizes Leukemia Lymphocytes to Barasertib and Everolimus by ROS-dependent Mechanism Without Affecting the Level of ROS and Viability of Normal Lymphocytes.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Docosahexaenoic Acids; Everolimus; Humans; Jurkat Cells; Leukemia; Lymphocytes; Organophosphates; Quinazolines; Reactive Oxygen Species | 2016 |
Translational research: the full cycle.
Topics: AIDS Vaccines; Animals; Biomedical Research; Child; Clinical Trials as Topic; ErbB Receptors; Female; Gefitinib; Genetic Therapy; Humans; Interleukin Receptor Common gamma Subunit; Leukemia; Male; Pharmacogenetics; Quinazolines; Specimen Handling; Technology Transfer; Treatment Failure; X-Linked Combined Immunodeficiency Diseases | 2008 |
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression; HL-60 Cells; Humans; Imatinib Mesylate; Inhibitor of Differentiation Protein 1; K562 Cells; Leukemia; Leukemia, Experimental; Mice; Oncogenes; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; RNA, Small Interfering; Signal Transduction | 2008 |
Vandetanib mediates anti-leukemia activity by multiple mechanisms and interacts synergistically with DNA damaging agents.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia; Methotrexate; Piperidines; Protein Kinase Inhibitors; Quinazolines; Topoisomerase II Inhibitors | 2012 |
NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dogs; Female; Haplorhini; HL-60 Cells; Humans; Leukemia; Mice; Mice, Nude; Mice, SCID; Ovarian Neoplasms; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyrazoles; Quinazolines; Rats; Xenograft Model Antitumor Assays | 2012 |
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Inhibitory Concentration 50; Leukemia; Phytotherapy; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors | 2012 |
Novel nonclassical antifolate, 2-[N-(2´-Hydroxyethyl)amino]methyl-3H-quinazolin-4-one, with a potent antineoplastic activity toward leukemia cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Cisplatin; Dacarbazine; Female; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mitogen-Activated Protein Kinases; Quinazolines; Temozolomide; U937 Cells | 2012 |
A note on Evodia rutaecarpa.
Topics: Camptothecin; DNA Topoisomerases; Drug Resistance, Neoplasm; Humans; Leukemia; Phytotherapy; Quinazolines; Topoisomerase Inhibitors | 2012 |
Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones.
Topics: Animals; Antineoplastic Agents; Cell Division; Dogs; HL-60 Cells; Humans; Indicators and Reagents; K562 Cells; Leukemia; Leukemia L1210; Magnetic Resonance Spectroscopy; Quinazolines; Structure-Activity Relationship | 2004 |
[The present status of, and problems with the development of FLT3 kinase inhibitors].
Topics: Adult; Cell Cycle Proteins; Chaperonins; Child; fms-Like Tyrosine Kinase 3; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Mutation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Staurosporine | 2006 |
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, Human, Pair 20; Cytogenetic Analysis; Female; Follow-Up Studies; Humans; Hydroxyurea; Leukemia; Middle Aged; Quinazolines; Remission Induction; Thrombocythemia, Essential; Treatment Outcome | 2006 |
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Proliferation; Drug Synergism; Humans; Leukemia; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Piperidines; Quinazolines; Tumor Cells, Cultured | 2007 |
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Case-Control Studies; Cell Cycle; Cell Proliferation; Colony-Forming Units Assay; Daunorubicin; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Immunoblotting; Leukemia; Mice; Mice, Inbred BALB C; Organophosphates; Protein Serine-Threonine Kinases; Quinazolines; Thymidine; Transplantation, Heterologous; Tubulin Modulators; Vincristine | 2007 |
Synthesis and evaluation of 2,4-diaminoquinazoline antifolates with activity against methotrexate-resistant human tumor cells.
Topics: Animals; Cell Line; DNA, Neoplasm; Drug Resistance; Female; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines | 1984 |
Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; DNA Replication; Drug Resistance; Female; Humans; Kinetics; Leukemia; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Peptide Synthases; Quinazolines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1983 |
Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.
Topics: Animals; Antineoplastic Agents; DNA; Humans; Indoles; Isoindoles; Leukemia; Liver; Pyridones; Pyrimidines; Quinazolines; Rats; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1994 |
Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1993 |
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Humans; Leukemia; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Binding Sites; Cell Line; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Conformation; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured | 1996 |
Clinical trials referral resource. Clinical trials with tomudex.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leukemia; Male; Prostatic Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.
Topics: Biological Transport; Drug Resistance; Enzyme Inhibitors; Folic Acid; Gene Amplification; Genes; Humans; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
Topics: Biological Transport; Carrier Proteins; Folic Acid Antagonists; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Microscopy, Confocal; Quinazolines; Reduced Folate Carrier Protein; Thiophenes; Tumor Cells, Cultured | 1997 |
Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carrier Proteins; Drug Resistance, Neoplasm; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Peptide Synthases; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Leukemia; Models, Molecular; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Substrate Specificity; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Topics: Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Growth Inhibitors; Humans; Inhibitory Concentration 50; Leukemia; Methotrexate; Peptide Synthases; Purines; Quinazolines; RNA, Messenger; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Quinazolines; Thiophenes; Treatment Outcome; Trimetrexate | 1999 |
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Biological activity of some 4-anilinoquinazolines: cytotoxic, genotoxic and antiprotease effects, induction of necrosis and changes of actin cytoskeleton.
Topics: Animals; CHO Cells; Cricetinae; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia; Melanoma; Mice; Mutagenicity Tests; Necrosis; Protease Inhibitors; Quinazolines; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
[How should patients with essential thrombocythemia be treated?].
Topics: Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hydroxyurea; Leukemia; Platelet Aggregation Inhibitors; Quinazolines; Thrombocythemia, Essential | 2001 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cells, Cultured; Drug Carriers; Folic Acid; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase | 1990 |
Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake.
Topics: Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Leukemia; Methotrexate; Quinazolines; Receptors, Cell Surface; Trimetrexate; Tumor Cells, Cultured | 1989 |
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Doxorubicin; Drug Resistance; Humans; In Vitro Techniques; Leukemia; Membrane Glycoproteins; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured; Verapamil; Vincristine | 1989 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides | 1986 |
Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells.
Topics: Adolescent; Adult; Aged; Cell Line; Deoxyuridine; DNA, Neoplasm; Drug Resistance; Female; Humans; Leukemia; Male; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tritium | 1986 |
Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
Topics: Adenocarcinoma; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1987 |