Page last updated: 2024-08-21

quinazolines and Invasiveness, Neoplasm

quinazolines has been researched along with Invasiveness, Neoplasm in 217 studies

Research

Studies (217)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (1.84)	18.2507
2000's	81 (37.33)	29.6817
2010's	126 (58.06)	24.3611
2020's	6 (2.76)	2.80

Authors

Authors	Studies
Cui, Y; Dai, M; Hu, Y; Kong, W; Wang, X; Wu, H; Wu, J; Yu, B; Yu, X; Zhang, H; Zheng, Y	1
Abudula, M; Chen, Y; Chen, Z; Li, C; Yu, Y; Zhang, Y	1
Hu, ZY; Wang, GH	1
Lang, L; Shay, C; Teng, Y; Wang, X; Xiong, Y; Zhao, X	1
Huang, JJ; Jiang, WQ; Kipps, TJ; Lin, X; Wu, L; Zhang, J; Zhang, S	1
Chen, YJ; Jiang, HG; Jin, J; Li, J; Li, MY; Shu, Y; Wu, JN; Xiang, M; Zhu, YM	1
Bach, DH; Hu, R; Kim, D; Lee, SK; Luu, TT; Park, HJ	1
Crish, JF; Elmquist, WF; Gampa, G; Hinojosa, AQ; Kenchappa, RS; Kim, M; Luu, A; Mohammad, AS; Parrish, KE; Rosenfeld, SS; Sarkaria, JN; West, R	1
Tang, C; Wu, J; Xu, J	1
Ding, H; Liu, Y; Lu, H; Qin, X; Ren, T; Wang, S; Wu, Q; Zhang, Y; Zhao, Q	1
Jean-Claude, B; Thibault, B	1
Cao, Y; Jiang, AY; Jiang, XF; Jin, H; Wang, H; Wu, Y	1
Chen, CY; Lee, H; Lin, PL; Wang, L; Wu, DW; Wu, TC	1
Ding, L; He, QJ; Liang, GK; Tariq, M; Yang, B; Zhang, JQ	1
Gao, B; Guo, L; Hao, S; Jiang, Y; Luo, D; Tian, W; Yan, J; Zhang, S; Zhang, X	1
Li, C; Wei, G; Yang, C	1
Cheng, M; Guo, J; Hao, C; Pang, Y; Wang, J; Wang, K; Wu, T; Yin, W; Zhao, D; Zhu, M	1
Gao, H; Gui, S; Jin, L; Kang, J; Liu, Q; Yuan, T; Zhang, J; Zhang, Y	1
Hameed, I; Lin, JZ; Ren, ZY; Xu, Z; Yu, Y; Zhu, JG	1
Hu, J; Zhou, Y	1
Ohyashiki, K; Okabe, S; Tanaka, Y; Tauchi, T	1
Deng, X; Jiang, X; Liu, G; Wang, C; Wang, R; Xin, H; Yuan, C; Zhu, Y	1
Feng, J; Geng, R; Jin, Y; Liu, Y; Sun, J; Wei, Y; Zhao, F; Zhao, L; Zhu, B	1
Chen, DL; Chen, Y; Guo, XX; Jiang, R; Li, J; Li, XP; Lv, XT; Lv, YW; Ran, JH; Tian, K; Yuan, DZ; Zhou, P	1
Amini, A; Bhardwaj, V; Cascone, T; Cortez, MA; Evans, J; Heymach, JV; Komaki, RU; Welsh, JW	1
Leung, KN; Liao, X	1
Dong, Z; Kang, Y; Liu, G; Ma, X; Qian, Q; Zhang, X	1
Atoyan, R; Cai, X; Lai, CJ; Ma, AW; Pursell, NW; Samson, ME; Savagner, P; Selmi, A; Voi, M; Wang, J; Xu, W	1
Frasca, F; Gianì, F; Lotta, S; Messina, RL; Nicolosi, ML; Regalbuto, C; Vella, V; Vigneri, P; Vigneri, R	1
Chen, HJ; Fushiya, S; Hour, MJ; Jiang, YL; Lin, CM; Peng, SF; Tsai, SC; Yang, JS	1
Du, J; Lu, YY; Su, SB; Wang, XF; Zhang, H; Zhang, TL; Zhou, QM	1
He, CS; Wei, SH; Xie, M; Zhang, L	1
Higashiyama, S; Hosoi, H; Masui, T; Matsuura, N; Ota, I; Yane, K	1
Basu, D; Bewley, AF; Diehl, JA; Facompre, ND; Gimotty, PA; Herlyn, M; Montone, KT; Nakagawa, H; Rasanen, K; Rustgi, AK; Sperry, SM; Weinstein, GS	1
Deitz, S; Gore, J; Korc, M; Ouyang, H	1
Cecil, DL; Disis, ML; Gad, E; Herendeen, DR; Lai, VP; Lubet, RA; O'Meara, MM; Park, KH; Treuting, PM	1
Lin, J; Pan, W; Shi, H; Wu, H; Yu, H; Zhu, J	1
Alfieri, RR; Ardizzoni, A; Bonelli, M; Caffarra, C; Cavazzoni, A; Cretella, D; Fumarola, C; Galetti, M; Galvani, E; Gatti, R; Giovannetti, E; La Monica, S; Petronini, PG; Saccani, F; Sirangelo, R; Tiseo, M	1
Gao, S; Liu, ZL; Long, XH; Luo, QF; Peng, AF; Wen, HC; Zhang, GM; Zhang, L; Zhou, RP; Zhou, Y	1
Bode, AM; D'Alessio, A; De Luca, A; Gallo, M; Maiello, MR; Normanno, N	1
Herr, MJ; Jameson, JF; Jennings, LK; Mabry, SE	1
Capdevila, J; Filetti, S; Grande, E; Kreissl, MC; Newbold, K; Reinisch, W; Robert, C; Schlumberger, M; Tolstrup, LK; Zamorano, JL	1
Dandekar, G; Dandekar, T; Fecher, D; Göttlich, C; Nietzer, SL; Stratmann, AT; Walles, H; Walles, T; Wangorsch, G	1
Ding, X; Duan, W; Jin, X; Sun, Y; Wang, N; Wang, S; Xiang, L; Zhao, Z	1
Akashi, A; Funaki, S; Kadota, Y; Nakagiri, T; Okumura, M; Shiono, H; Takeuchi, Y	1
Downey, A; Levinson, B; Liebes, L; Muggia, F; Tiersten, A; Warner, E	1
Blumenschein, GR; El-Naggar, AK; Glisson, BS; Gonzalez-Angulo, AM; Jakob, JA; Kies, MS; Kupferman, ME; Lee, JJ; Liu, DD	1
Chen, L; Li, Q; Liu, XD; Wu, B; Xu, HF; Zhan, YH; Zhang, HH	1
Cai, H; Chen, X; Miao, L; Wang, Y; Xia, H; Zhuang, Z	1
Bianco, R; D'Amato, C; D'Amato, V; Damiano, V; De Placido, S; Formisano, L; Iommelli, F; Marciano, R; Nappi, L; Parsons, SJ; Raimondo, L; Rosa, R; Scorziello, A; Troncone, G; Veneziani, B	1
Dong, CS; Li, JH; Liu, QL; Liu, RJ; Luo, BH; Luo, GQ; Wang, JP; Wang, KS; Wen, JF; Xiao, H; Xiao, N; Xie, B; Xiong, F; Yang, XJ; Zhong, M	1
Fasching, PA; Gade, S; Loibl, S; Lübbe, K; Mau, C; Müller, V; Pantel, K; Schem, C; Schwarzenbach, H; Schwedler, K; Steinbach, B; Untch, M; von Minckwitz, G	1
Azim, HA; Barrios, CH; Baselga, J; Boyle, F; de Azambuja, E; Di Cosimo, S; Dreosti, L; Eidtmann, H; Eniu, A; Gelber, RD; Gorbunova, V; Holmes, AP; Holmes, E; Hsieh, RK; Huang, CS; Jackisch, C; Kim, SB; Kuemmel, S; Lang, I; Perez, EA; Piccart-Gebhart, M; Smith, I; Swaby, RF; Tavartkiladze, N; Untch, M; Vuylsteke, P; Xu, B	1
Atagi, S; Fukuoka, M; Goto, K; Harada, R; Hida, T; Hosomi, Y; Kato, T; Maemondo, M; Nagase, S; Nakagawa, K; Nishio, M; Okamoto, I; Seto, T; Tajima, K; Yamamoto, N; Yamanaka, T	1
Cayre, A; De Wever, O; Doan, VK; Dupouy, S; Forgez, P; Gompel, A; Kouchkar, A; Liu, J; Llorca, FP; Mourra, N; Wu, Z	1
Bubendorf, L; Erne, P; Frachet, A; Frismantiene, A; Kyriakakis, E; Maslova, K; Pfaff, D; Philippova, M; Resink, TJ; Ruiz, C; Vlajnic, T	1
Bellizzi, A; Cardone, RA; Forciniti, S; Greco, MR; Paradiso, A; Reshkin, SJ; Rubino, R; Zeeberg, K	1
George, VC; Kumar, DR; Kumar, RA; Suresh, PK	1
Fang, H; Lin, RY; Sun, MX; Tian, Y; Wang, Q; Wang, XY; Yu, JL; Zhao, YL	1
Foltz, G; Harrison, JK; Hothi, P; Law, BK; Luo, D; Pham, K; Reynolds, BA; Siemann, DW	1
Geater, SL; Massey, D; Mok, TS; Ou, SH; Schuler, M; Sequist, LV; Tsai, CM; Wu, YL; Yamamoto, N; Yang, JC; Yu, CJ; Zazulina, V; Zhou, C	1
Beeker, A; Kordes, S; Mathôt, RA; Pollak, MN; Punt, CJ; Richel, DJ; Weterman, MJ; Wilmink, JW; Zwinderman, AH	1
Blancafort, A; Brugada, R; Campuzano, Ò; Carrión-Salip, D; Giró-Perafita, A; Gómez-Miragaya, J; González-Suárez, E; Massaguer, A; Oliveras, G; Palafox, M; Palomeras, S; Puig, T; Turrado, C	1
Chu, W; Gao, L; Liu, J; Lv, B; Tan, G; Wang, R; Zhang, Y; Zhao, X; Zhen, Q	1
Cao, Q; Fu, SY; Li, Y; Wang, FY; Wang, LH; Wang, NN; Wang, YT; Wu, CF; Yang, JY	1
Hwang, SG; Kim, EM; Park, JK; Um, HD	1
Chang, GC; Chen, HW; Chen, JJ; Chen, MH; Lai, YH; Lin, SY; Wong, YH; Yang, CH; Yu, SL	1
Amoresano, A; Camorani, S; Carpentieri, A; Cerchia, L; Chiariello, M; Colecchia, D; Crescenzi, E; Fedele, M	1
Ai, P; Li, J; Peng, X; Wang, L; Zeng, Y; Zhang, Q	1
Guzzo, T; Keefe, S; Malkowicz, SB; Mamtani, R; Narayan, V; Vaughn, DJ	1
Bae, SY; Hong, JY; Jung, C; Kang, JI; Lee, HJ; Lee, SK; Park, HJ	1
Chen, SC; Goeldner, RG; Harbeck, N; Huang, CS; Hurvitz, S; Im, SA; Im, YH; Jassem, J; Jung, KH; Piccart-Gebhart, M; Ro, J; Shao, Z; Shen, K; Sun, Q; Uttenreuther-Fischer, M; Wojtukiewicz, M; Xu, B; Yeh, DC; Zhang, Q	1
Fahmy, O; Fend, F; Feyerabend, S; Gakis, G; Scharpf, M; Schubert, T; Schwentner, C; Stenzl, A	1
Jiang, T; Jiang, X; Pang, X; Pang, Z; Wan, X; Xu, W; Zhang, Q; Zhang, Z; Zhao, J; Zheng, X	1
Cheng, M; Conteh, AM; Craven, KE; Gore, J; Imasuen-Williams, IE; Korc, M	1
Huang, XX; Mao, SS; Wu, JS; Xiong, J; Yu, XN	1
He, X; Hong, S; Huang, Y; Ma, Y; Sheng, J; Yang, Y; Zhang, J; Zhang, L; Zhang, Y; Zhang, Z; Zhao, H; Zhou, T	1
Dowlati, A; Fu, P; Pennell, NA; Sharma, N; Yi, Q	1
Bi, M; Chen, W; Ding, F; Tang, C; Tang, DJ; Wang, J; Yu, H	1
Cheng, YD; Chung, JG; Hsia, TC; Hsiao, YT; Huang, AC; Kuo, CL; Lin, TS; Ma, YS; Peng, SF; Yang, MD	1
Chang, HM; Cheng, JC; Leung, PC; So, WK; Xiong, S	1
Chen, L; Gonzalez, FJ; Gu, J; Hu, CL; Hu, L; Li, L; Li, S; Lin, XM; Liu, JF; Tang, J; Wang, HY; Wang, RY; Wu, MC; Yan, XZ; Zhang, BH; Zhou, WP; Zhu, YJ	1
Harbeck, N; Wuerstlein, R	1
Alesi, GN; Chen, ZG; Chun, J; Fan, J; Jin, L; Kang, S; Kang, Y; Khuri, FR; Li, D; Magliocca, KR; Pan, C; Shin, DM	1
Natale, RB	2
Choi, YJ; Kim, CH; Lee, JC; Lee, JK; Na, II; Rho, JK; Ryoo, BY; Yang, SH	1
Bolognese, A; Caputo, M; Di Cello, P; Izzo, L; Izzo, P; Meloni, P; Pietrasanta, D	1
Braiteh, F; Johnson, FM; Kurzrock, R	1
Dacic, S; Dubey, S; Eickhoff, JC; Hoang, T; Kolesar, JM; Marcotte, SM; Schiller, JH; Siegfried, JM; Stabile, LP; Traynor, AM	1
Calvo, E; Chen, H; Dancey, JE; Lin, CC; Mays, T; Mita, AC; Mita, MM; O'Rourke, P; Papadopoulos, KP; Patnaik, A; Preston, GG; Rodon, J; Sarantopoulos, J; Takimoto, CH; Tolcher, AW; Yeh, IT	1
Anania, FA; Knight, BB; Merlin, D; O'Regan, RM; Saxena, NK; Sharma, D; Taliaferro-Smith, L	1
Heinemann, V	1
Evans, CP; Gandara, DR; Gautschi, O; Green, TP; Gumerlock, PH; Kung, HJ; Lara, PN; Mack, PC; Purnell, PR; Tepper, CG	1
Agulnik, M; Chen, EX; Cohen, EE; Cohen, RB; Dancey, J; Hayes, DN; Ho, J; Hotte, S; Laurie, S; Pond, GR; Siu, LL; Tsao, MS; Vidal, L; Winquist, E	1
Boyer, MJ; Davis, ID; Gurney, H; Kotasek, D; Pezaro, C; Rosenthal, MA; Solomon, B; Toner, GC; Underhill, C	1
Allen, J; Bermingham, A; Boyer, B; Carragher, N; Costello, GF; Curwen, J; Davies, BR; Elvin, P; Fennell, M; Green, TP; Hargreaves, J; Hennequin, LF; Hickinson, DM; Holdgate, GA; Jacobs, V; Logie, A; Plé, PA; Ward, WH; Whittaker, R; Wilkinson, RW	1
de Boüard, S; Guillamo, JS; Leuraud, P; Marie, Y; Marteau, L; Parienti, JJ; Peschanski, M; Poupon, MF; Raymond, E; Valable, S	1
Arteaga, CL; Boimel, PJ; Coniglio, SJ; Hynes, NE; Kedrin, D; Segall, JE; Wyckoff, J	1
Bromberg, ME; Colman, RW; Fusaro, M; Godoy, G; Kim, E; Liu, Y; Pixley, R	1
Dhruva, N; Socinski, MA	1
Cheng, LC; Chua, DT; Chung, LP; Ho, JC; Leung, EL; Sihoe, AD; Tam, IY; Tin, VP; Wong, MP	1
Jeibmann, A; Klämbt, C; Paulus, W; Witte, HT	1
Brown, AM; Ciardiello, F; Eckhardt, SG; Jürgensmeier, JM; Morelli, MP; Pitts, TM; Ryan, A; Tentler, JJ	1
Chan, AT; Chen, H; Cheng, SH; Lo, KW; Lui, VW; Ma, BB; Ng, MH; Poon, FF; Tao, Q; To, KF; Wong, E; Wong, SC	1
Boeck, S; Clemens, MR; Fischer von Weikersthal, L; Gauler, T; Geissler, M; Greten, TF; Hegewisch-Becker, S; Heinemann, V; Kettner, E; Klein, S; Kojouharoff, G; Märten, A; Neugebauer, S; Vehling-Kaiser, U; Waldschmidt, D; Winkelmann, C	1
Dieras, V; Florance, A; Gomez, HL; Johnston, S; Kennedy, MJ; Lichinitser, M; Maltzman, J; Manikhas, A; O'Rourke, L; Oliva, C; Pegram, M; Pippen, J; Pivot, X; Press, MF; Romieu, G; Sadeghi, S; Stein, S	1
Choi, YJ; Kim, CH; Lee, JC; Lee, JK; Lee, SS; Na, II; Rho, JK; Ryoo, BY; Yang, SH; Yoo, YD	1
Brown, G; Chau, I; Cunningham, D; Oates, J; Starling, N; Thomas, J; Thomas, K; Watkins, D; Webb, J	1
Arbushites, M; Di Leo, A; Finn, RS; Gagnon, R; Koehler, M; Press, MF	1
Cancello, G; Colleoni, M; Montagna, E; Rizzo, S; Scarano, E; Torrisi, R	1
Fielding, J; Godley, P; Grigson, G; Heathcote, S; Kim, W; Nielsen, M; Pruthi, RS; Rathmell, WK; Schultz, H; Smith, A; Wallen, EM; Whang, Y	1
Batra, SK; Depreux, P; Henichart, JP; Johansson, SL; Mimeault, M	1
Greten, TF; Manns, MP; Plentz, RR	1
Bai, L; Evans, CP; Gao, AC; Kung, HJ; Yang, JC; Yap, S	1
Huang, W; Jia, H; Ma, J; Tan, L; Wu, J; Yan, H; Yang, S; Zeng, M; Zhu, X; Zuo, Y	1
Chan, AT; Cheng, SH; Ho, K; Lau, CP; Lei, KI; Lui, VW; Mok, TS; Ng, MH; Tsang, CM; Tsao, SW	1
Bertran, E; Caja, L; Campbell, J; Fabregat, I; Fausto, N	1
Hui, RC; Ko, JH; Shih, YC; Yang, CH	1
Choi, YJ; Chung, JH; Kim, CH; Kim, HR; Lee, CT; Lee, JC; Lee, JS; Rho, JK; Xu, X; Yoon, HI	1
Angelo, A; Azzariti, A; Colucci, G; Porcelli, L; Quatrale, AE; Silvestris, N	1
Cabodi, S; Camacho-Leal, MP; Defilippi, P; Morello, V; Papotti, M; Repetto, D; Sigismund, S; Turco, E; Volante, M	1
Dyckhoff, G; Gottschling, S; Herpel, E; Kuhnt, T; Pelz, T; Penzel, R; Schnabel, PA; Thomas, M	1
Gooding, WE; Grandis, JR; Gubish, CT; Siegfried, JM; Stabile, LP; Xu, H	1
Cao, Z; Cheng, L; Dai, L; Deng, H; Deng, S; Feng, S; Li, W; Liu, S; Liu, Y; Ma, Y; Pan, Y; Shen, G; Shi, S; Tian, H; Wang, W; Wei, Y; Xie, H; Yang, S; Yang, Y; Zhang, N; Zhang, S; Zhao, C; Zhao, X; Zheng, R	1
Fujimoto-Ohuchi, K; Furugaki, K; Iwai, T; Kondoh, K; Mori, K; Moriya, Y; Yanagisawa, M; Yorozu, K	1
He, W; Jiang, G; Liu, M; Song, N; Zhang, P	1
Belousov, R; Colombo, C; Ghadimi, MP; Hornick, JL; Lazar, AJ; Lev, D; Liu, J; Lopez, G; Peng, T; Reynoso, D; Xie, X; Young, ED; Zhu, QS	1
Botti, G; D'Antonio, A; De Luca, A; Hendrix, MJ; Hsu, MY; Lamura, L; Margaryan, N; Mari, E; Normanno, N; Pirozzi, G; Roma, C; Salomon, DS; Strizzi, L	1
Egan, C; Koro, K; Magliocco, A; Parkin, S; Pohorelic, B; Singh, R; Yang, AD	1
Belani, C; Boinpally, R; Evans, J; Franke, A; Gail Eckhardt, S; Haluska, P; Leong, S; O'Bryant, CL; Ramalingam, S; Ramanathan, RK; Rosen, L; Venugopal, B; Witt, K	1
Li, DW; Liu, M; Luo, YG; Shi, XJ; Sun, XD; Sun, XO; Wu, XJ; Yao, CF; Yu, HY; Zhou, J	1
Chen, CH; Hsu, WM; Hu, RH; Huang, HC; Huang, J; Huang, MC; Huang, MJ; Lai, HS; Lee, JJ; Lee, PH; Liu, CH; Wu, YM	1
Belden, CJ; Fadul, CE; Harris, BT; Israel, MA; Pastel, DA; Paulsen, K; Ran, C; Roberts, DW; Valdes, PA	1
Constantinidou, A; Smith, I	1
Cheng, M; Guo, Q; Li, F; Peng, H; Wang, J; Wang, Y; Zhang, J; Zhao, D; Zhou, Y	1
Furukawa, M; Inoue, H; Kakudo, K; Nozaki, M; Ohnishi, Y	1
Chen, ZG; Fan, S; Khuri, FR; Koo, J; Li, Y; Owonikoko, TK; Ramalingam, SS; Sun, SY; Yue, P	1
Arozarena, I; Ehrhardt, M; Ferguson, J; Wellbrock, C	1
Kim, JJ	1
Abhold, EL; Altuna, X; Blair, KJ; Brumund, KT; Haas, M; Kiang, A; Kuo, SZ; Lopez, JP; Ongkeko, WM; Patel, A; Rahimy, E; Wang-Rodriguez, J; Weisman, RA; Yu, MA	1
Balwierz, A; Hielscher, T; Küblbeck, M; Pawitan, Y; Sahin, Ö; Ward, A; Wiemann, S; Zhang, JD	1
Asrani, K; Bremner, R; Cheng, E; Hostetter, G; Inge, L; Jameson, NM; Kingsley, CB; Loftus, JC; Tran, NL; Weiss, GJ; Whitsett, TG; Winkles, JA	1
Girard, L; Heymach, JV; Johnson, FM; Lippman, SM; Minna, JD; Peng, S; Saintigny, P; Sen, B; Wistuba, II; Zhang, L	1
Frampton, JE; Keating, GM; Lyseng-Williamson, KA	1
Deng, X; Erfani, SF; Hemler, ME; Hoff, J; Jin, H; Kaetzel, DM; Li, Q; Novak, M; Rabinovitz, I; Sharma, C; Sonnenberg, A; Stipp, CS; Yang, H; Yang, XH; Yi, Y; Zhou, P	1
Barker, P; Bodoky, G; Bondarenko, I; Cunningham, D; Karapetis, CS; Kocakova, I; Koski, SL; Mainwaring, P; Mookerjee, B; Robertson, J; Rougier, P; Salazar, R; Schmoll, HJ; Sobrero, A; Van Cutsem, E	1
Cheng, Y; Fielding, A; Hochhaus, A; Hoff, PM; Kim, TW; Koynov, KD; Kurteva, G; Li, J; Pestalozzi, BC; Pike, L; Pintér, T; Robertson, JD; Saunders, MP; Tebbutt, NC; van Eyll, B	1
Ai, Z; Teng, Y; Wang, J; Xu, Y; Yan, Y	1
Cui, K; Hao, A; Jin, G; Liu, Q; Nie, F; Wang, L; Wong, ST; Yao, L; Zhao, H	1
Barrick, B; Fraga, G; Matthys, B	1
Fang, X; Hu, Y; Li, M; Ma, S; Shen, H; Tan, C; Yuan, Y	1
Acierno, R; Alberti, S; del Boccio, P; Giannelli, G; Maffia, M; Pieragostino, D; Sacchetta, P; Salzet, M; Simeone, P; Tinelli, A; Toto, C; Vergara, D	1
Cai, Y; Chen, G; Jia, J; Liu, B; Liu, H; Liu, JY; Zhang, JL; Zhang, W; Zhao, YF; Zhong, HY	1
Chen, WS; Chen, YJ; Hsia, TC; Hsu, SC; Huang, CY; Huang, TC; Huang, WC; Hung, MC; Tsai, SL; Tu, CY; Wei, YL; Yeh, MH; Yen, CJ; Yu, MC; Yu, YL	1
Alfieri, R; Ardizzoni, A; Carmi, C; Cavazzoni, A; Dekker, H; Galvani, E; Giovannetti, E; Leon, LG; Mor, M; Peters, GJ; Petronini, PG; Saccani, F	1
Kassis, J; Klein, G; Maeda, A; Takada, K; Teramoto, N; Wells, A; Wu, C	1
Montgomery, RB	1
Bagheri-Yarmand, R; Barnes, CJ; Clayman, GL; Hong, WK; Kumar, R; Mandal, M; Yang, Z	1
Bartolini, S; Calandri, C; Cancellieri, A; Cappuzzo, F; Ceresoli, G; Crino, L; de Rosa, M; Gregorc, V; Lombardo, L; Magrini, E; Paties, CT; Rossi, E; Villa, E	1
Attoub, S; Bruyneel, E; Emami, S; Gespach, C; Mareel, M; May, FE; Nguyen, QD; Rodrigue, CM; Rodrigues, S; Thim, L; Westley, BR	1
Hashimoto, Y; Kakuta, H; Nagasawa, K; Tanatani, A	1
González, A; Guerrero, J; Martínez, J; Santibañez, JF	1
Adam, L; Bagheri-Yarmand, R; Barnes, CJ; Clayman, GL; El-Naggar, A; Hong, WK; Kumar, R; Lotan, R; Papadimitrakopoulou, VV; Wang, RA; Yang, Z	1
Allen, J; Costello, G; Curwen, J; Fennell, M; Green, TP; Hennequin, LF; Lambert-Van Der Brempt, C; Plé, PA	1
Averbuch, SD; Fandi, A; Gatzemeier, U; Giaccone, G; Grous, J; Herbst, RS; Johnson, DH; Manegold, C; Miller, V; Natale, RB; Ochs, JS; Pluzanska, A; Rennie, P; Rosell, R; Scagliotti, G; Schiller, JH; Von Pawel, J; Wolf, MK	1
Ogasawara, M; Suzuki, H	1
Büchler, MW; Friess, H; Giese, N; Kleeff, J; Korc, M; Li, J	1
Behnken, D; Coplin, MA; Gao, F; Govindan, R; Kommareddy, A; Read, W; Romvari, E	1
Barrow, D; Dutkowskil, C; Hiscox, S; Morgan, L; Nicholson, RI; Wakeling, A	1
Aoe, M; Doihara, H; Hara, H; Ishibe, Y; Shien, T; Shimizu, N; Taira, N; Takahashi, H; Teramoto, J; Yoshitomi, S	1
Baldi, E; Bonaccorsi, L; Carloni, V; Forti, G; Marchiani, S; Muratori, M	1
Condeelis, J; Coniglio, S; Eddy, R; Kempiak, S; Lorenz, M; Miki, H; Sarmiento, C; Segall, J; Symons, M; Takenawa, T; Yamaguchi, H	1
Aggarwal, BB; Kobayashi, Y; Takada, Y	1
Alleva, AM; Cole, GW; Maxhimer, JB; Nguyen, DM; Reddy, RM; Schrump, DS; Zuo, J	1
Angelucci, A; Biordi, L; Bologna, M; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Vicentini, C	1
Egami, H; Hirota, M; Ogawa, M; Takai, E; Tamori, Y; Tan, X	1
Amici, S; Gasparini, G; Gattuso, D; Gion, M; Longo, R; Sarmiento, R; Zancan, M	1
Matsumori, Y; Muguruma, H; Nakataki, E; Sone, S; Yano, S; Yoshizumi, M; Zheng, R	1
Allmer, C; Donehower, RC; Erlichman, C; Fitch, T; Kim, G; Mahoney, MR; Philip, PA; Picus, J; Pitot, HC; Thomas, J	1
Adam, L; Bar-Eli, M; Brown, G; Diehl, AJ; Dinney, CP; Kassouf, W; McConkey, DJ	1
Abe, M; Egami, H; Hirota, M; Nozawa, F; Ogawa, M; Tan, X	1
Antonaci, S; Azzariti, A; Giannelli, G; Paradiso, A; Porcelli, L; Sgarra, C	1
Barrow, D; Gee, J; Green, TP; Hiscox, S; Morgan, L; Nicholson, RI	1
Greten, TF	1
Halgunset, J; Larsson, E; Skogseth, H	1
Lipscomb, EA; Shin, S; Yoon, SO	1
Abbou, CC; Bakkar, A; Chopin, DK; Daher, A; de Medina, SG; Loric, S; Maillé, P; Nicolle, G; Radvanyi, F; Thiery, JP; Vacherot, F; Van der Kwast, T; Vermey, M; Vordos, D; Wallerand, H	1
Attoub, S; Bruyneel, E; Emami, S; Gespach, C; Grijelmo, C; Nguyen, QD; Rivat, C; Rodrigue, CM; Rodrigues, S	1
Antonaci, S; Giannelli, G	1
Allen, J; Breed, J; Costello, G; Curwen, J; Fennell, M; Green, TP; Hennequin, LF; Lambert-van der Brempt, C; Morgentin, R; Norman, RA; Olivier, A; Otterbein, L; Plé, PA; Warin, N	1
Clark, OH; Duh, QY; Park, JW; Rougier, JP; Werb, Z; Wong, M; Yeh, MW	1
Chopp, M; Hong, X; Jiang, F; Kalkanis, SN; Katakowski, M; Yang, H; Zhang, X; Zhang, ZG; Zheng, X	1
Batra, SK; Depreux, P; Henichart, JP; Johansson, SL; Lin, MF; Mimeault, M; Moore, E; Vankatraman, G	1
Dutta, PR; Maity, A	1
Jeon, NK; Kim, J; Lee, EJ; Whang, JH	1
Bedano, PM; Hanna, NH	1
Davies, AM; Ellis, P; Evans, WK; Haynes, AE; Lloyd, NS	1
Han, JY; Hong, EK; Kim, HT; Kim, HY; Lee, DH; Lee, JS; Nam, BH; Yu, SY	1
Ebi, H; Fujisaka, Y; Horiike, A; Jiang, H; Kawada, K; Minami, H; Murakami, H; Saijo, N; Sasaki, Y; Shimoyama, T; Shinkai, T; Tahara, M; Tamura, T; Yamada, Y; Yamamoto, N	1
Bhola, NE; Grandis, JR; Gubish, CT; Lui, VW; Mills, GB; Shin, D; Siegfried, JM; Siwak, DR; Thomas, SM; Zhang, Q	1
Bagnato, A; Di Castro, V; Natali, PG; Nicotra, MR; Rosanò, L; Spinella, F; Tortora, G	1
Barrow, D; Ellis, IO; Gee, JM; Hiscox, SE; Hutcheson, IR; Knowlden, JM; Nicholson, RI; Robertson, JF	1
Eniu, A	1
Ben Ahmed, S; Blackwell, K; Boussen, H; Citrin, DL; DeSilvio, ML; Harris, J; Johnston, S; Kaufman, B; Lombardi, DP; LoRusso, P; Salazar, V; Spector, NL; Trudeau, M; Westlund, RE; Zaks, TZ	1
Doyle, DM; Miller, KD	1
Batra, SK; Depreux, P; Hauke, R; Henichart, JP; Lin, MF; Mehta, PP; Mimeault, M	1
Arya, N; Burris, HA; Fleming, RA; Ho, PT; Jones, SF; Koch, KM; Lebowitz, PF; Loftiss, J; Overmoyer, B; Pandite, L; Paul, E; Peacock, NW; Pegram, MD; Silverman, P; Storniolo, AM	1
Green, TP; Hiscox, S; James, M; Jordan, NJ; Morgan, L; Nicholson, RI; Smith, C; Taylor, KM	1
Fridman, R; Kondapaka, SB; Reddy, KB	1
Klis, D; Liu, XP; Narla, RK; Uckun, FM	1
Aingorn, E; de-Groot, N; Elkin, M; Hochberg, A; Nagler, A; Pines, M; Reich, R; Vlodavsky, I	1
Greenberg, NM; Kassis, J; Kim, HG; Lo, H; Moellinger, J; Wells, A	1
Bennett, TA; Bergmann-Leitner, ES; Hacker, NF; Stetler-Stevenson, WG; Stromberg, K	1
Chakravarti, A; Dyson, NJ; Loeffler, JS	1
Assender, J; Barrow, D; Dewhurst, OL; Dutkowski, CM; Glynne-Jones, E; Goddard, L; Harper, ME; Nicholson, RI; Wakeling, AE	1
Archer, GE; Friedman, HS; Glazer, CA; Lal, A; Martinson, HM; Riggins, GJ; Sampson, JH	1

Reviews

19 review(s) available for quinazolines and Invasiveness, Neoplasm

Article	Year
Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy. Cancer, 2013, May-15, Volume: 119, Issue:10 Topics: Anilides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Movement; DNA Damage; Epithelial-Mesenchymal Transition; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Proto-Oncogene Proteins c-met; Pyridines; Pyrrolidinones; Quinazolines; Quinolines; Radiation Tolerance; Signal Transduction; Up-Regulation	2013
Vandetanib in advanced medullary thyroid cancer: review of adverse event management strategies. Advances in therapy, 2013, Volume: 30, Issue:11 Topics: Carcinoma, Neuroendocrine; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Diseases; Humans; Male; Neoplasm Invasiveness; Neoplasm Staging; Patient Selection; Piperidines; Prognosis; Quinazolines; Risk Assessment; Thyroid Neoplasms; Treatment Outcome	2013
Neoadjuvant Therapy for HER2-positive Breast Cancer. Reviews on recent clinical trials, 2017, Volume: 12, Issue:2 Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Breast Neoplasms; Bridged-Ring Compounds; Disease-Free Survival; Female; Humans; Lapatinib; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Risk Assessment; Survival Analysis; Taxoids; Treatment Outcome	2017
Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2008, Volume: 3, Issue:6 Suppl 2 Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Neoplasm Invasiveness; Neoplasm Staging; Neovascularization, Pathologic; Piperidines; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Risk Assessment; Survival Analysis; Treatment Outcome	2008
[Medical-oncological aspects in the treatment of pancreatic cancer]. Der Radiologe, 2009, Volume: 49, Issue:2 Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Chemotherapy, Adjuvant; Deoxycytidine; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Palliative Care; Pancreatectomy; Pancreatic Neoplasms; Prognosis; Quinazolines; Radiotherapy, Adjuvant; Survival Rate	2009
Molecular therapy of pancreatic cancer. Minerva endocrinologica, 2010, Volume: 35, Issue:1 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Axitinib; Benzenesulfonates; Bevacizumab; Capecitabine; Carcinoma, Pancreatic Ductal; Cetuximab; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Deoxycytidine; ErbB Receptors; Erlotinib Hydrochloride; Fluorouracil; Gemcitabine; Humans; Imidazoles; Indazoles; Neoplasm Invasiveness; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Phthalazines; Prognosis; Pyridines; Quinazolines; Randomized Controlled Trials as Topic; Risk Assessment; Sorafenib; Survival Analysis; Treatment Outcome; Vascular Endothelial Growth Factor A	2010
ZD6474, a small molecule tyrosine kinase inhibitor, potentiates the anti-tumor and anti-metastasis effects of radiation for human nasopharyngeal carcinoma. Current cancer drug targets, 2010, Volume: 10, Issue:6 Topics: Animals; Apoptosis; Carcinoma; Chemotherapy, Adjuvant; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Piperidines; Protein Kinase Inhibitors; Quinazolines	2010
EGFR tyrosine kinases inhibitors in cancer treatment: in vitro and in vivo evidence. Frontiers in bioscience (Landmark edition), 2011, 01-01, Volume: 16, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Cell Division; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lapatinib; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction	2011
KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jul-20, Volume: 29, Issue:21 Topics: Antineoplastic Agents; Biopsy; Carcinoma, Squamous Cell; ErbB Receptors; Fatal Outcome; Female; Gefitinib; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms; Lymphatic Metastasis; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Staging; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Time Factors; Tomography, X-Ray Computed; Tonsillar Neoplasms; Treatment Outcome	2011
Genetics of glioblastoma: a window into its imaging and histopathologic variability. Radiographics : a review publication of the Radiological Society of North America, Inc, 2011, Volume: 31, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Proliferation; Cell Survival; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Magnetic Resonance Imaging; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylcholine; Protein Kinase Inhibitors; Quinazolines	2011
Is there a case for anti-HER2 therapy without chemotherapy in early breast cancer? Breast (Edinburgh, Scotland), 2011, Volume: 20 Suppl 3 Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Early Detection of Cancer; Evidence-Based Medicine; Female; Follow-Up Studies; Humans; Lapatinib; Middle Aged; Molecular Targeted Therapy; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Quinazolines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Risk Assessment; Survival Analysis; Treatment Outcome	2011
Recent advances in treatment of advanced urothelial carcinoma. Current urology reports, 2012, Volume: 13, Issue:2 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Carcinoma, Transitional Cell; Cetuximab; Cisplatin; Doxorubicin; Female; Gefitinib; Humans; Immunotherapy; Male; Methotrexate; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Quality Improvement; Quinazolines; Risk Assessment; Survival Analysis; Treatment Outcome; Urinary Bladder Neoplasms; Vinblastine	2012
Vandetanib: a guide to its use in advanced medullary thyroid cancer. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2012, Dec-01, Volume: 26, Issue:6 Topics: Carcinoma, Neuroendocrine; Disease-Free Survival; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Piperidines; Practice Guidelines as Topic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Thyroid Neoplasms	2012
Biologically targeted treatment of non-small-cell lung cancer: focus on epidermal growth factor receptor. Clinical lung cancer, 2003, Volume: 5 Suppl 1 Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Ligands; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines	2003
Novel concepts in hepatocellular carcinoma: from molecular research to clinical practice. Journal of clinical gastroenterology, 2006, Volume: 40, Issue:9 Topics: Antineoplastic Agents; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Transformation, Neoplastic; ErbB Receptors; Gefitinib; Humans; Liver Cirrhosis; Neoplasm Invasiveness; Prognosis; Quinazolines	2006
Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer letters, 2007, Sep-08, Volume: 254, Issue:2 Topics: Antineoplastic Agents; Cell Movement; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Morphogenesis; Neoplasm Invasiveness; Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction	2007
Salvage therapy in patients with advanced non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Docetaxel; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Salvage Therapy; Survival Analysis; Taxoids	2006
The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Glutamates; Guanine; Humans; Male; Maximum Tolerated Dose; Mesothelioma; Neoplasm Invasiveness; Patient Selection; Pemetrexed; Pleural Neoplasms; Practice Guidelines as Topic; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Treatment Outcome	2006
Integrating biological agents into systemic therapy of breast cancer: trastuzumab, lapatinib, bevacizumab. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2007, Volume: 12 Suppl 1 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Genetic Testing; Heart Diseases; Humans; Lapatinib; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Patient Selection; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Trastuzumab; Treatment Outcome; Vascular Endothelial Growth Factor A	2007

Trials

30 trial(s) available for quinazolines and Invasiveness, Neoplasm

Article	Year
N-cadherin expression is associated with acquisition of EMT phenotype and with enhanced invasion in erlotinib-resistant lung cancer cell lines. PloS one, 2013, Volume: 8, Issue:3 Topics: Adenocarcinoma; Adult; Aged; Antigens, CD; Cadherins; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Up-Regulation	2013
Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. Molecular oncology, 2014, Volume: 8, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Gefitinib; Humans; Lung Neoplasms; Models, Biological; Neoplasm Invasiveness; Neoplasm Proteins; Quinazolines; Signal Transduction; Swine; Tumor Microenvironment	2014
Continuous-infusion topotecan and erlotinib: a study in topotecan-pretreated ovarian cancer assessing shed collagen epitopes as a marker of invasiveness. The oncologist, 2014, Volume: 19, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Collagen; Epitopes; Erlotinib Hydrochloride; Female; Humans; Infusions, Intravenous; Neoplasm Invasiveness; Ovarian Neoplasms; Quinazolines; Topotecan	2014
Phase II study of gefitinib in patients with advanced salivary gland cancers. Head & neck, 2015, Volume: 37, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Adenoid Cystic; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gefitinib; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quinazolines; Remission Induction; Salivary Gland Neoplasms; Survival Analysis; Treatment Outcome	2015
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response. The Lancet. Oncology, 2014, Volume: 15, Issue:10 Topics: Administration, Oral; Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lapatinib; Maximum Tolerated Dose; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Quinazolines; Receptor, ErbB-2; Survival Analysis; Trastuzumab; Treatment Outcome	2014
Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study. The Lancet. Oncology, 2014, Volume: 15, Issue:11 Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Japan; Kaplan-Meier Estimate; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Quinazolines; Survival Analysis; Treatment Outcome	2014
Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6. The Lancet. Oncology, 2015, Volume: 16, Issue:7 Topics: Adult; Afatinib; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Staging; Quinazolines; Survival Analysis; Treatment Outcome	2015
Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial. The Lancet. Oncology, 2015, Volume: 16, Issue:7 Topics: Academic Medical Centers; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Confidence Intervals; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Follow-Up Studies; Gemcitabine; Humans; Male; Metformin; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Netherlands; Pancreatic Neoplasms; Quinazolines; Survival Analysis; Treatment Outcome	2015
Cisplatin, Gemcitabine, and Lapatinib as Neoadjuvant Therapy for Muscle-Invasive Bladder Cancer. Cancer research and treatment, 2016, Volume: 48, Issue:3 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cystectomy; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Humans; Lapatinib; Lymph Node Excision; Male; Maximum Tolerated Dose; Middle Aged; Muscle Neoplasms; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Prospective Studies; Quinazolines; Treatment Outcome; Urinary Bladder; Urinary Bladder Neoplasms	2016
Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial. The Lancet. Oncology, 2016, Volume: 17, Issue:3 Topics: Adult; Afatinib; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Mastectomy; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Quinazolines; Receptor, ErbB-2; Risk Assessment; Survival Analysis; Trastuzumab; Treatment Outcome; Vinblastine; Vinorelbine	2016
Interaction of Treatment and Biomarker in Advanced Non-small Cell Lung Cancer. Reviews on recent clinical trials, 2017, Volume: 12, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Docetaxel; ErbB Receptors; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pemetrexed; Proportional Hazards Models; Quinazolines; Risk Assessment; Survival Analysis; Taxoids; Treatment Outcome	2017
Phase I study of cetuximab, erlotinib, and bevacizumab in patients with advanced solid tumors. Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:6 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Drug Administration Schedule; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasms; Quinazolines; Treatment Outcome; Vascular Endothelial Growth Factor A	2009
Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib. Head & neck, 2009, Volume: 31, Issue:8 Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Adenoid Cystic; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Female; Follow-Up Studies; Gene Amplification; Humans; In Situ Hybridization, Fluorescence; Infusions, Intravenous; Lapatinib; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Probability; Prognosis; Quinazolines; Receptor, ErbB-2; Reference Values; Salivary Gland Neoplasms; Survival Analysis; Treatment Outcome	2009
An open-label, single-arm phase two trial of gefitinib in patients with advanced or metastatic castration-resistant prostate cancer. American journal of clinical oncology, 2009, Volume: 32, Issue:4 Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Gefitinib; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Orchiectomy; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Quinazolines; Risk Assessment; Single-Blind Method; Survival Analysis; Testosterone; Treatment Outcome	2009
Erlotinib 150 mg daily plus chemotherapy in advanced pancreatic cancer: an interim safety analysis of a multicenter, randomized, cross-over phase III trial of the 'Arbeitsgemeinschaft Internistische Onkologie'. Anti-cancer drugs, 2010, Volume: 21, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cross-Over Studies; Deoxycytidine; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Fluorouracil; Gemcitabine; Germany; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pancreas, Exocrine; Pancreatic Neoplasms; Prospective Studies; Quinazolines	2010
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Lapatinib; Letrozole; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Proportional Hazards Models; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Risk Assessment; Survival Analysis; Treatment Outcome; Triazoles	2009
Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33 Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Fluorouracil; Follow-Up Studies; Gemcitabine; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pancreatic Neoplasms; Probability; Quinazolines; Risk Assessment; Survival Analysis; Time Factors; Treatment Outcome	2009
Prognostic and predictive value of HER2 extracellular domain in metastatic breast cancer treated with lapatinib and paclitaxel in a randomized phase III study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Genes, erbB-2; Humans; In Situ Hybridization, Fluorescence; Kaplan-Meier Estimate; Lapatinib; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Paclitaxel; Predictive Value of Tests; Probability; Prognosis; Proportional Hazards Models; Quinazolines; Survival Analysis; Treatment Outcome	2009
A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: clinical and pathological results. BJU international, 2010, Volume: 106, Issue:3 Topics: Aged; Antineoplastic Agents; Cystectomy; Disease-Free Survival; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Humans; Male; Neoadjuvant Therapy; Neoplasm Invasiveness; Quinazolines; Treatment Outcome; Urinary Bladder Neoplasms	2010
An open-label study to describe pharmacokinetic parameters of erlotinib in patients with advanced solid tumors with adequate and moderately impaired hepatic function. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cohort Studies; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged; Neoplasm Invasiveness; Neoplasms; Protein Binding; Quinazolines	2012
Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III). Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Oct-10, Volume: 30, Issue:29 Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biopsy, Needle; Colorectal Neoplasms; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Fluorouracil; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Patient Selection; Proportional Hazards Models; Quinazolines; Risk Assessment; Survival Analysis; Treatment Outcome; Young Adult	2012
Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II). Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Oct-10, Volume: 30, Issue:29 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brazil; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Prognosis; Proportional Hazards Models; Pyridines; Quinazolines; Survival Analysis	2012
Gefitinib in pretreated non-small-cell lung cancer (NSCLC): analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-15, Volume: 21, Issue:14 Topics: Adult; Aged; Biomarkers, Tumor; Biopsy, Needle; Carcinoma, Non-Small-Cell Lung; Confidence Intervals; Disease Progression; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Preoperative Care; Probability; Prognosis; Prospective Studies; Quinazolines; Receptor, ErbB-2; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Treatment Outcome	2003
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Mar-01, Volume: 22, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Gefitinib; Gemcitabine; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Probability; Prognosis; Quinazolines; Reference Values; Survival Analysis; Treatment Outcome	2004
Gefitinib (ZD1839) combined with weekly epirubicin in patients with metastatic breast cancer: a phase I study with biological correlate. Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Epirubicin; ErbB Receptors; Female; Gefitinib; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Quinazolines; Receptor, ErbB-2	2005
Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Sep-20, Volume: 23, Issue:27 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Probability; Protein Kinase Inhibitors; Quinazolines; Survival Analysis; Treatment Outcome	2005
The role of gefitinib treatment for Korean never-smokers with advanced or metastatic adenocarcinoma of the lung: a prospective study. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:9 Topics: Adenocarcinoma; Administration, Oral; Aged; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gefitinib; Humans; Immunohistochemistry; Korea; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Probability; Prognosis; Proportional Hazards Models; Prospective Studies; Quality of Life; Quinazolines; Risk Assessment; Single-Blind Method; Smoking; Survival Rate; Treatment Outcome	2006
A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:9 Topics: Administration, Oral; Adult; Aged; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Japan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Risk Assessment; Survival Analysis; Thoracic Neoplasms; Treatment Outcome	2006
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Mar-01, Volume: 26, Issue:7 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cohort Studies; Female; Humans; Immunoenzyme Techniques; Inflammation; Lapatinib; Lymphatic Metastasis; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Sensitivity and Specificity; Skin Neoplasms	2008
Phase I dose escalation and pharmacokinetic study of lapatinib in combination with trastuzumab in patients with advanced ErbB2-positive breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jul-10, Volume: 26, Issue:20 Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lapatinib; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Quinazolines; Receptor, ErbB-2; Risk Assessment; Survival Analysis; Trastuzumab; Treatment Outcome	2008

Other Studies

168 other study(ies) available for quinazolines and Invasiveness, Neoplasm

Article	Year
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer science, 2019, Volume: 110, Issue:11 Topics: Acetylation; Animals; Azepines; Cadherins; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Histocompatibility Antigens; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Liver; Liver Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Snail Family Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta	2019
Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC. Respiratory research, 2019, Oct-12, Volume: 20, Issue:1 Topics: Antineoplastic Agents, Immunological; Bronchoalveolar Lavage Fluid; Cell Line, Tumor; Cell Movement; Crown Ethers; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Exosomes; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Invasiveness; Oncogenes; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Messenger	2019
Icotinib inhibits proliferation and epithelial-mesenchymal transition of non-small cell lung cancer A549 cells. Mathematical biosciences and engineering : MBE, 2019, 08-21, Volume: 16, Issue:6 Topics: A549 Cells; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Crown Ethers; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; ErbB Receptors; Humans; Lung Neoplasms; Mutation; Neoplasm Invasiveness; Quinazolines	2019
Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma. Journal of hematology & oncology, 2019, 12-05, Volume: 12, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodioxoles; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Drug Delivery Systems; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; src-Family Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Aurora B induces epithelial-mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis. Oncogene, 2020, Volume: 39, Issue:12 Topics: Animals; Aurora Kinase B; Breast Neoplasms; Carcinoma, Ductal; Cell Line, Tumor; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Neoplasm Invasiveness; Neoplasm Metastasis; Octamer Transcription Factor-3; Organophosphates; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Quinazolines; Signal Transduction; Snail Family Transcription Factors; Triple Negative Breast Neoplasms	2020
Bisdemethoxycurcumin Enhances the Sensitivity of Non-small Cell Lung Cancer Cells to Icotinib via Dual Induction of Autophagy and Apoptosis. International journal of biological sciences, 2020, Volume: 16, Issue:9 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Crown Ethers; Diarylheptanoids; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Histone Deacetylase Inhibitors; Humans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Reactive Oxygen Species; Sp Transcription Factors; Voltage-Dependent Anion Channel 1	2020
Overexpression of AGR2 Is Associated With Drug Resistance in Mutant Non-small Cell Lung Cancers. Anticancer research, 2020, Volume: 40, Issue:4 Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Mucoproteins; Mutation; Neoplasm Invasiveness; Oncogene Proteins; Protein Kinase Inhibitors; Quinazolines	2020
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma. Scientific reports, 2020, 04-16, Volume: 10, Issue:1 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzamides; Blood-Brain Barrier; Brain; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Glioblastoma; Humans; Kinesins; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Proteins; Quinazolines; Tetrahydroisoquinolines; Xenograft Model Antitumor Assays	2020
Effect of isofebrifugine on the proliferation and invasion of human gastric cancer cells via MMP. Cellular and molecular biology (Noisy-le-Grand, France), 2020, Apr-20, Volume: 66, Issue:1 Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Piperidines; Quinazolines; RNA, Messenger; Stomach Neoplasms	2020
A novel 4-aminoquinazoline derivative, DHW-208, suppresses the growth of human breast cancer cells by targeting the PI3K/AKT/mTOR pathway. Cell death & disease, 2020, 06-30, Volume: 11, Issue:6 Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Mice, Nude; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2020
Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells. Journal of ovarian research, 2017, Apr-26, Volume: 10, Issue:1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Cell Movement; Cell Survival; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Female; Gefitinib; Humans; MAP Kinase Signaling System; Molecular Targeted Therapy; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Quinazolines; src-Family Kinases; Tumor Cells, Cultured	2017
Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt/mTOR/STAT3 pathway. Molecular medicine reports, 2017, Volume: 16, Issue:3 Topics: Apoptosis; Artemisinins; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin B1; Down-Regulation; Drug Synergism; Gefitinib; Humans; Lung Neoplasms; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Up-Regulation	2017
An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signalling. European journal of cancer (Oxford, England : 1990), 2017, Volume: 85 Topics: A549 Cells; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Bcl-2-Like Protein 11; Carcinoma, Non-Small-Cell Lung; CCAAT-Enhancer-Binding Protein-beta; Cell Movement; Disease-Free Survival; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Protein Stability; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Up-Regulation; Xenograft Model Antitumor Assays	2017
Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway. Acta pharmacologica Sinica, 2017, Volume: 38, Issue:11 Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Movement; Cell Plasticity; Cell Proliferation; Dose-Response Relationship, Drug; Gefitinib; Interleukin-13; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Phenotype; Protein Kinase Inhibitors; Quinazolines; RAW 264.7 Cells; Signal Transduction; STAT6 Transcription Factor	2017
PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo. Journal of cellular biochemistry, 2018, Volume: 119, Issue:5 Topics: Adenine; Cell Line, Tumor; Cell Movement; Humans; Neoplasm Invasiveness; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Thyroid Neoplasms	2018
Vandetanib inhibits cisplatin‑resistant neuroblastoma tumor growth and invasion. Oncology reports, 2018, Volume: 39, Issue:4 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Neoplasm Invasiveness; Neuroblastoma; Piperidines; Proto-Oncogene Proteins c-ret; Quinazolines; Receptors, CXCR4; Signal Transduction	2018
Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity. Molecules (Basel, Switzerland), 2018, Feb-14, Volume: 23, Issue:2 Topics: A549 Cells; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Neoplasm Invasiveness; p21-Activated Kinases; Quinazolines	2018
Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas. Science China. Life sciences, 2018, Volume: 61, Issue:8 Topics: Adenoma; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Growth Hormone-Secreting Pituitary Adenoma; Humans; Mice; Neoplasm Invasiveness; Quinazolines; Rats; RNA Interference; Signal Transduction; Tyrphostins	2018
Efficacy of gefitinib‑celecoxib combination therapy in docetaxel‑resistant prostate cancer. Oncology reports, 2018, Volume: 40, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Celecoxib; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Docetaxel; Drug Resistance, Neoplasm; Gefitinib; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Prostatic Neoplasms; Quinazolines; Taxoids; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2018
Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway. Medical science monitor : international medical journal of experimental and clinical research, 2018, 08-23, Volume: 24 Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Osteosarcoma; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction	2018
Copanlisib, a novel phosphoinositide 3-kinase inhibitor, combined with carfilzomib inhibits multiple myeloma cell proliferation. Annals of hematology, 2019, Volume: 98, Issue:3 Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Chemokine CXCL12; Chemotaxis; Drug Synergism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Multiple Myeloma; Neoplasm Invasiveness; Neoplasm Proteins; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Proteasome Inhibitors; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Stromal Cells	2019
IFT80 Improves Invasion Ability in Gastric Cancer Cell Line via ift80/p75NGFR/MMP9 Signaling. International journal of molecular sciences, 2018, Nov-16, Volume: 19, Issue:11 Topics: Apoptosis; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cilia; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Nerve Tissue Proteins; Quinazolines; Receptors, Nerve Growth Factor; Signal Transduction; Stomach Neoplasms	2018
Induction of phosphatase shatterproof 2 by evodiamine suppresses the proliferation and invasion of human cholangiocarcinoma. The international journal of biochemistry & cell biology, 2019, Volume: 108 Topics: Animals; Antineoplastic Agents; Bile Duct Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Enzyme Induction; Humans; Interleukin-6; Mice; Neoplasm Invasiveness; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays	2019
Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer. Anti-cancer drugs, 2019, Volume: 30, Issue:6 Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Sirtuin 1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. Chemico-biological interactions, 2013, Apr-25, Volume: 203, Issue:2 Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-myc; Quinazolines; Resting Phase, Cell Cycle	2013
Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion. Molecular cancer therapeutics, 2013, Volume: 12, Issue:6 Topics: Cadherins; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms	2013
Thyroid cancer cell resistance to gefitinib depends on the constitutive oncogenic activation of the ERK pathway. The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, ras; Humans; MAP Kinase Signaling System; Mutation; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins B-raf; Quinazolines; Thyroid Neoplasms	2013
Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. International journal of oncology, 2013, Volume: 43, Issue:1 Topics: Cell Movement; Colorectal Neoplasms; ErbB Receptors; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Quinazolines; Quinazolinones; Signal Transduction; Styrenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcriptional Activation	2013
Evodiamine induces apoptosis and inhibits metastasis in MDA‑MB-231 human breast cancer cells in vitro and in vivo. Oncology reports, 2013, Volume: 30, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptors, Urokinase Plasminogen Activator; Resting Phase, Cell Cycle; Urokinase-Type Plasminogen Activator	2013
Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo. European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:16 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dipeptides; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; Receptor, Notch1; RNA Interference; Signal Transduction; Time Factors; Transfection; Xenograft Model Antitumor Assays	2013
Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells. Oncology reports, 2013, Volume: 30, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Diphtheria Toxin; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Receptor, ErbB-4; RNA, Messenger; Thyroid Neoplasms; Tyrphostins	2013
EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomas. Molecular cancer therapeutics, 2013, Volume: 12, Issue:10 Topics: Antibodies, Monoclonal, Humanized; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Lineage; Cetuximab; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Mesoderm; Neoplasm Invasiveness; Quinazolines; Spheroids, Cellular; Xenograft Model Antitumor Assays	2013
microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions. Oncogene, 2014, Sep-18, Volume: 33, Issue:38 Topics: Acetyltransferases; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Epidermal Growth Factor; Erlotinib Hydrochloride; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Transplantation; Pancreatic Neoplasms; Quinazolines; RNA Interference; Signal Transduction; Transcription Factors; Transforming Growth Factor beta	2014
A multiantigen vaccine targeting neu, IGFBP-2, and IGF-IR prevents tumor progression in mice with preinvasive breast disease. Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:12 Topics: Adoptive Transfer; Animals; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Female; Insulin-Like Growth Factor Binding Protein 2; Lapatinib; Lymphocytes, Tumor-Infiltrating; Mammary Neoplasms, Animal; Mice; Mice, Transgenic; Neoplasm Invasiveness; Precancerous Conditions; Quinazolines; Receptor, ErbB-2; Receptor, IGF Type 1; T-Lymphocytes; Tetrahydronaphthalenes; Tumor Cells, Cultured; Vaccines, Subunit	2013
Combined inhibition of epidermal growth factor receptor and cyclooxygenase-2 leads to greater anti-tumor activity of docetaxel in advanced prostate cancer. PloS one, 2013, Volume: 8, Issue:10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Proliferation; Cyclooxygenase 2; Docetaxel; ErbB Receptors; Flow Cytometry; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; NF-kappa B; Nitrobenzenes; Prostatic Neoplasms; Quinazolines; Sulfonamides; Taxoids; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2013
Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification. PloS one, 2013, Volume: 8, Issue:10 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Gefitinib; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Quinazolines	2013
Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitro. Oncology reports, 2014, Volume: 31, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fatty Acid Synthase, Type I; Humans; Lapatinib; Neoplasm Invasiveness; Osteosarcoma; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction	2014
Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib. Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:1 Topics: Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptors, CXCR4; Signal Transduction; src-Family Kinases	2014
Pro-MMP-9 upregulation in HT1080 cells expressing CD9 is regulated by epidermal growth factor receptor. Biochemical and biophysical research communications, 2013, Dec-06, Volume: 442, Issue:1-2 Topics: Cell Line, Tumor; ErbB Receptors; Gefitinib; Gene Knockdown Techniques; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Quinazolines; Tetraspanin 29; Up-Regulation	2013
Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14. Oncology reports, 2014, Volume: 31, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Down-Regulation; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 14; Neoplasm Invasiveness; Neuroblastoma; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-ret; Quinazolines; Receptors, CXCR4	2014
Does gefitinib have effects on EGFR mutation-positive thymoma? -Case report of thymoma recurrence. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2014, Volume: 20 Suppl Topics: Antineoplastic Agents; Combined Modality Therapy; ErbB Receptors; Fatal Outcome; Female; Gefitinib; Humans; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Quinazolines; Reoperation; Thoracic Surgery, Video-Assisted; Thymoma; Thymus Neoplasms	2014
Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Calcium-Binding Proteins; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; EGF Family of Proteins; Endothelial Growth Factors; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Gefitinib; Humans; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; RNA Interference; RNA, Small Interfering; Xenograft Model Antitumor Assays	2014
Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. Cell death & disease, 2014, May-15, Volume: 5 Topics: Animals; Antineoplastic Agents; Apoptosis; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cyclin B1; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gefitinib; HEK293 Cells; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Quinazolines; Receptor Protein-Tyrosine Kinases; RNA Interference; Time Factors; Transfection; Tumor Burden; Wnt Proteins; Wnt-5a Protein; Xenograft Model Antitumor Assays	2014
Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models. Breast cancer research : BCR, 2014, May-05, Volume: 16, Issue:3 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzodioxoles; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Lapatinib; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Transplantation, Heterologous	2014
Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells. PloS one, 2014, Volume: 9, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Stomach Neoplasms; Transcription Factors; Tyrphostins; Vimentin	2014
Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial. Breast cancer research and treatment, 2014, Volume: 147, Issue:1 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Case-Control Studies; Female; Follow-Up Studies; Humans; Lapatinib; MicroRNAs; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quinazolines; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Translational Research, Biomedical; Trastuzumab	2014
Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice. Oncotarget, 2014, Sep-30, Volume: 5, Issue:18 Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; ErbB Receptors; Female; Humans; Lapatinib; MCF-7 Cells; Metformin; Middle Aged; Neoplasm Invasiveness; Neurotensin; Quinazolines; Receptor Cross-Talk; Receptor, ErbB-2; Receptor, ErbB-3; Receptors, Neurotensin; Signal Transduction; Time Factors; Transfection; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays	2014
EGFR and IGF-1R in regulation of prostate cancer cell phenotype and polarity: opposing functions and modulation by T-cadherin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:2 Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Survival; Collagen; Drug Combinations; ErbB Receptors; Gefitinib; Gene Silencing; Golgi Apparatus; Humans; Laminin; Male; Neoplasm Invasiveness; Phenotype; Phosphorylation; Prostate; Prostatic Neoplasms; Proteoglycans; Pyrimidines; Pyrroles; Quinazolines; Receptor, IGF Type 1	2015
The scaffolding protein NHERF1 sensitizes EGFR-dependent tumor growth, motility and invadopodia function to gefitinib treatment in breast cancer cells. International journal of oncology, 2015, Volume: 46, Issue:3 Topics: Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Neoplasm Invasiveness; Phosphoproteins; Plakins; Protein Transport; Pseudopodia; Quinazolines; Sodium-Hydrogen Exchangers; Triple Negative Breast Neoplasms; Tumor Cells, Cultured	2015
Cancer-specific chemoprevention and anti-metastatic potentials of Rheum emodi rhizome ethyl acetate extracts and identification of active principles through HPLC and GC-MS analysis. Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:1 Topics: Acetates; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatography, High Pressure Liquid; Cyclopropanes; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Neoplasm Invasiveness; Neoplasm Metastasis; Phytotherapy; Plants, Medicinal; Polyphenols; Quinazolines; Rheum; Rhizome; Solvents; Time Factors	2015
Efficacy and survival-associated factors with gefitinib combined with cisplatin and gemcitabine for advanced non- small cell lung cancer. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:24 Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cisplatin; Deoxycytidine; Female; Follow-Up Studies; Gefitinib; Gemcitabine; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quinazolines; Remission Induction; Survival Rate; Young Adult	2014
VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner. Cancer letters, 2015, Apr-28, Volume: 360, Issue:1 Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Benzylamines; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cyclams; Female; Glioblastoma; Heterocyclic Compounds; Humans; Interleukin-2 Receptor alpha Subunit; Male; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; Neoplasm Invasiveness; Piperidines; Protein Kinase Inhibitors; Quinazolines; Receptor Cross-Talk; Receptors, CXCR4; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; Up-Regulation; Xenograft Model Antitumor Assays	2015
Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs. PloS one, 2015, Volume: 10, Issue:6 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Catechin; Cell Adhesion; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fatty Acid Synthase, Type I; Female; Gallic Acid; Humans; Lapatinib; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Naphthalenes; Neoplasm Invasiveness; Neoplasm Transplantation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Sirolimus; Trastuzumab	2015
MicroRNA-200a Targets EGFR and c-Met to Inhibit Migration, Invasion, and Gefitinib Resistance in Non-Small Cell Lung Cancer. Cytogenetic and genome research, 2015, Volume: 146, Issue:1 Topics: 3' Untranslated Regions; Antineoplastic Agents; Base Sequence; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met; Quinazolines; RNA Interference	2015
Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas. Cancer letters, 2015, Dec-01, Volume: 369, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Movement; Disulfiram; Drug Synergism; ErbB Receptors; Gefitinib; Glioma; Gluconates; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Signal Transduction; src-Family Kinases; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2015
Src and epidermal growth factor receptor mediate the pro-invasive activity of Bcl-w. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Cell Line, Tumor; Cell Movement; Disease Progression; ErbB Receptors; Gefitinib; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; src-Family Kinases	2016
Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways. Oncotarget, 2015, Sep-22, Volume: 6, Issue:28 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computer-Aided Design; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Drug Synergism; Gefitinib; Humans; Lung Neoplasms; Mice, SCID; Molecular Docking Simulation; Molecular Structure; Molecular Targeted Therapy; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; src-Family Kinases; Structure-Activity Relationship; Time Factors; Xenograft Model Antitumor Assays	2015
Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells. Oncotarget, 2015, Nov-10, Volume: 6, Issue:35 Topics: Antineoplastic Agents; Apoptosis; Aptamers, Nucleotide; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Immunoenzyme Techniques; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Phosphorylation; Quinazolines; Real-Time Polymerase Chain Reaction; Receptor, Platelet-Derived Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured	2015
Evodiamine inhibits the migration and invasion of nasopharyngeal carcinoma cells in vitro via repressing MMP-2 expression. Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:6 Topics: Blotting, Western; Carcinoma; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Structure; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction	2015
Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PloS one, 2015, Volume: 10, Issue:12 Topics: Actin Cytoskeleton; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diterpenes; Female; Gefitinib; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2015
Ten Years of Complete Remission of Pulmonary Metastasis after Post-Cystectomy Palliative Cisplatin-Gemcitabine Chemotherapy with Gefitinib for Muscle Invasive Bladder Cancer: A Case Report. Urologia internationalis, 2016, Volume: 97, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cystectomy; Deoxycytidine; Gefitinib; Gemcitabine; Humans; Male; Middle Aged; Neoplasm Invasiveness; Quinazolines; Urinary Bladder Neoplasms	2016
Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain. Oncotarget, 2016, Jun-07, Volume: 7, Issue:23 Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Drug Carriers; Drug Compounding; Drug Stability; Female; Lapatinib; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Invasiveness; Phosphatidylcholines; Protein Kinase Inhibitors; Quinazolines; Serum Albumin, Human; Tissue Distribution; Triple Negative Breast Neoplasms	2016
Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model. Cancer letters, 2016, 08-28, Volume: 379, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Movement; Cyclin-Dependent Kinase Inhibitor p16; ErbB Receptors; Female; Gene Expression Profiling; Genes, Retinoblastoma; Genetic Predisposition to Disease; Humans; Lapatinib; Lymphangiogenesis; Male; Mice, Transgenic; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenotype; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Pyrazoles; Quinazolines; Quinolines; Receptor, ErbB-2; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta	2016
Effect of saracatinib on pulmonary metastases from hepatocellular carcinoma. Oncology reports, 2016, Volume: 36, Issue:3 Topics: Animals; Benzodioxoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Quinazolines; Signal Transduction; src-Family Kinases; Xenograft Model Antitumor Assays	2016
Optimal tumor shrinkage predicts long-term outcome in advanced nonsmall cell lung cancer (NSCLC) treated with target therapy: Result from 3 clinical trials of advanced NSCLC by 1 institution. Medicine, 2016, Volume: 95, Issue:31 Topics: Academic Medical Centers; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; China; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Follow-Up Studies; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Staging; Predictive Value of Tests; Quinazolines; Response Evaluation Criteria in Solid Tumors; ROC Curve; Survival Analysis; Time Factors; Treatment Outcome	2016
miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog. Biochemical and biophysical research communications, 2016, Nov-18, Volume: 480, Issue:3 Topics: A549 Cells; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gefitinib; Humans; Lung Neoplasms; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; PTEN Phosphohydrolase; Quinazolines	2016
Bufalin inhibits gefitinib resistant NCI-H460 human lung cancer cell migration and invasion in vitro. Journal of ethnopharmacology, 2016, Dec-24, Volume: 194 Topics: Antineoplastic Agents; Bufanolides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Quinazolines; rhoA GTP-Binding Protein; Signal Transduction; SOS1 Protein	2016
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells. Oncotarget, 2016, Dec-06, Volume: 7, Issue:49 Topics: Amphiregulin; Antigens, CD; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease-Free Survival; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Ligands; Membrane Proteins; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Binding; Quinazolines; RNA Interference; Signal Transduction; Snail Family Transcription Factors; Time Factors; Tyrphostins	2016
Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. Gastroenterology, 2017, Volume: 152, Issue:5 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Movement; Choline Kinase; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Hep G2 Cells; Humans; Immunoblotting; Immunohistochemistry; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Neoplasm Invasiveness; Neoplasm Transplantation; Quinazolines; RNA, Messenger; TOR Serine-Threonine Kinases; Wound Healing; Xenograft Model Antitumor Assays	2017
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene, 2017, 07-06, Volume: 36, Issue:27 Topics: Animals; Anoikis; Antineoplastic Agents; Benzodioxoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lymphatic Metastasis; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Reactive Oxygen Species; Receptor, ErbB-2; src-Family Kinases	2017
Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line. Lung cancer (Amsterdam, Netherlands), 2009, Volume: 63, Issue:2 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Epithelium; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mesoderm; Neoplasm Invasiveness; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Transforming Growth Factor beta1	2009
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer. Nature clinical practice. Urology, 2008, Volume: 5, Issue:7 Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cecal Neoplasms; Cetuximab; Chemotherapy, Adjuvant; Colectomy; Female; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Leucovorin; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Quinazolines; Retroperitoneal Neoplasms; Sacrum; Thiophenes; Tomography, X-Ray Computed; Urinary Bladder Neoplasms	2008
Trichomegaly of the eyelashes after lung cancer treatment with the epidermal growth factor receptor inhibitor erlotinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jul-10, Volume: 26, Issue:20 Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Brain Neoplasms; Carcinoma, Bronchogenic; ErbB Receptors; Erlotinib Hydrochloride; Eyelashes; Female; Follow-Up Studies; Humans; Hypertrichosis; Lung Neoplasms; Magnetic Resonance Imaging; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Quinazolines; Risk Assessment	2008
Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2009, Volume: 64, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Estradiol; Female; Fulvestrant; Gefitinib; Humans; Lung Neoplasms; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pilot Projects; Postmenopause; Prognosis; Quinazolines; Safety; Survival Rate; Treatment Outcome	2009
Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. Cancer research, 2008, Dec-01, Volume: 68, Issue:23 Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Insulin-Like Growth Factor I; Lapatinib; Leptin; Neoplasm Invasiveness; Quinazolines; Receptor Cross-Talk; Receptor, IGF Type 1; Receptors, Leptin; Signal Transduction; Transcriptional Activation	2008
The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2009, Volume: 4, Issue:4 Topics: Benzodioxoles; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyrosine Kinases; Humans; Janus Kinase 3; Lung Neoplasms; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation-Sensitizing Agents; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor	2009
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Molecular oncology, 2009, Volume: 3, Issue:3 Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Clinical Trials, Phase II as Topic; Focal Adhesion Kinase 1; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; NIH 3T3 Cells; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Nude; src-Family Kinases; Transplantation, Heterologous; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays	2009
Molecular mechanisms underlying effects of epidermal growth factor receptor inhibition on invasion, proliferation, and angiogenesis in experimental glioma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jun-01, Volume: 15, Issue:11 Topics: Animals; Antineoplastic Agents; Blotting, Western; Brain; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Glioma; Humans; Mice; Mice, Nude; Mutation; Neoplasm Invasiveness; Neovascularization, Pathologic; Organ Culture Techniques; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; RNA Interference; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2009
ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jun-01, Volume: 15, Issue:11 Topics: Animals; Benzothiazoles; Cell Line, Tumor; Cell Movement; ErbB Receptors; Female; Gefitinib; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tyrphostins; Xenograft Model Antitumor Assays	2009
Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene, 2009, Jul-30, Volume: 28, Issue:30 Topics: Cell Line, Tumor; Cell Movement; ErbB Receptors; Fibroblast Growth Factor 2; Humans; Kininogen, High-Molecular-Weight; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Protein Structure, Tertiary; Quinazolines; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tyrphostins	2009
Carcinomatous meningitis in non-small-cell lung cancer: response to high-dose erlotinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Aug-01, Volume: 27, Issue:22 Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Carcinoma, Non-Small-Cell Lung; Disease Progression; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Fatal Outcome; Female; Humans; Immunohistochemistry; Lung Neoplasms; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningitis; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Quinazolines; Risk Assessment; Tomography, X-Ray Computed	2009
SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Molecular cancer research : MCR, 2009, Volume: 7, Issue:6 Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; ErbB Receptors; Gefitinib; Gene Amplification; Humans; Immunohistochemistry; Lung Neoplasms; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Reproducibility of Results; RNA, Small Interfering; src-Family Kinases	2009
Modeling glioma growth and invasion in Drosophila melanogaster. Neoplasia (New York, N.Y.), 2009, Volume: 11, Issue:9 Topics: Animals; Brain Neoplasms; Drosophila melanogaster; ErbB Receptors; Eye; Gefitinib; Glioma; Humans; Immunoenzyme Techniques; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured	2009
Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Molecular cancer therapeutics, 2009, Volume: 8, Issue:9 Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gastrointestinal Neoplasms; Gene Expression Profiling; Humans; Neoplasm Invasiveness; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3	2009
Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response. Investigational new drugs, 2010, Volume: 28, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Pharmacological; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Mutational Analysis; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins	2010
The role of MET activation in determining the sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors. Molecular cancer research : MCR, 2009, Volume: 7, Issue:10 Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Amplification; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Quinazolines	2009
Lapatinib and metronomic capecitabine combination in an HER2-positive inflammatory breast cancer patient: a case report. Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Volume: 21, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Carcinoma, Papillary; Deoxycytidine; Female; Fluorouracil; Humans; Lapatinib; Middle Aged; Neoplasm Invasiveness; Quinazolines; Receptor, ErbB-2; Treatment Outcome	2010
Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells. Molecular cancer therapeutics, 2010, Volume: 9, Issue:3 Topics: Adenocarcinoma; Apoptosis; Cell Fractionation; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Docetaxel; Drug Evaluation, Preclinical; ErbB Receptors; Gefitinib; Humans; Male; Neoplasm Invasiveness; Phosphorylation; Prostate; Prostatic Neoplasms; Quinazolines; Taxoids; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1	2010
Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model. Molecular cancer therapeutics, 2010, Volume: 9, Issue:6 Topics: Animals; Antineoplastic Agents; Benzodioxoles; Bone and Bones; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Male; Mice; Neoplasm Invasiveness; Osteoclasts; Osteogenesis; Osteolysis; Protein Kinase Inhibitors; Quinazolines; Radiography; RANK Ligand; Signal Transduction; src-Family Kinases; Xenograft Model Antitumor Assays	2010
Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells. Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: Anoikis; Antineoplastic Agents; Carcinoma; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Lapatinib; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2	2011
The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. Journal of cellular physiology, 2011, Volume: 226, Issue:5 Topics: Antigens, CD; Apoptosis; Apoptosis Regulatory Proteins; Cadherins; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; ErbB Receptors; Gefitinib; Gene Expression Regulation; Hepatocytes; Humans; Liver; Liver Neoplasms; Mesenchymal Stem Cells; Neoplasm Invasiveness; Phenotype; Protein Kinase Inhibitors; Quinazolines; Recombinant Proteins; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1	2011
Necrotizing vasculitis triggered by gefitinib: an unusual clinical presentation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Mar-01, Volume: 29, Issue:7 Topics: Antineoplastic Agents; Biopsy, Needle; Carcinoma, Non-Small-Cell Lung; Follow-Up Studies; Gefitinib; Humans; Immunohistochemistry; Lower Extremity; Lung Neoplasms; Male; Middle Aged; Necrosis; Neoplasm Invasiveness; Neoplasm Staging; Prednisolone; Quinazolines; Risk Assessment; Skin Diseases, Vascular; Treatment Outcome; Vasculitis	2011
Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs. Lung cancer (Amsterdam, Netherlands), 2011, Volume: 73, Issue:2 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carboplatin; Carcinoma, Acinar Cell; Cell Line, Tumor; Cell Movement; Cell Shape; Deoxycytidine; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gemcitabine; Gene Expression Profiling; Humans; Lung Neoplasms; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms; Quinazolines; Sequence Deletion	2011
β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene, 2011, Sep-29, Volume: 30, Issue:39 Topics: Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Integrin beta1; Lung Neoplasms; Membrane Proteins; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Transplantation, Heterologous	2011
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jul-01, Volume: 17, Issue:13 Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gefitinib; Head and Neck Neoplasms; Hepatocyte Growth Factor; Humans; Mice; Mice, SCID; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms, Squamous Cell; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Transforming Growth Factor alpha; Wound Healing; Xenograft Model Antitumor Assays	2011
SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jul-01, Volume: 17, Issue:13 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Endothelial Cells; Female; Hep G2 Cells; Humans; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Quinazolines; Signal Transduction; Thiadiazoles; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays; Zebrafish	2011
Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292. Clinical & experimental metastasis, 2011, Volume: 28, Issue:7 Topics: Animals; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mice; Neoplasm Invasiveness; Osteoblasts; Osteolysis; Protein Kinase Inhibitors; Quinazolines	2011
Surgical resection of locally advanced pulmonary adenocarcinoma after gefitinib therapy. The Annals of thoracic surgery, 2011, Volume: 92, Issue:1 Topics: Adenocarcinoma; Administration, Oral; Biopsy, Needle; Female; Follow-Up Studies; Gefitinib; Genes, erbB-1; Humans; Immunohistochemistry; Lung Neoplasms; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Pneumonectomy; Positron-Emission Tomography; Quinazolines; Risk Assessment; Tomography, X-Ray Computed; Treatment Outcome	2011
Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Sep-15, Volume: 17, Issue:18 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Invasiveness; Quinazolines; Sarcoma; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2011
Expression and functional role of CRIPTO-1 in cutaneous melanoma. British journal of cancer, 2011, Sep-27, Volume: 105, Issue:7 Topics: Activin Receptors, Type I; Benzamides; Benzodioxoles; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Dioxoles; Flow Cytometry; GPI-Linked Proteins; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Melanoma; Neoplasm Invasiveness; Neoplasm Proteins; Protein-Tyrosine Kinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Smad Proteins; src-Family Kinases; Tumor Cells, Cultured	2011
Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment. Breast cancer research and treatment, 2012, Volume: 133, Issue:1 Topics: Benzodioxoles; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Coculture Techniques; Culture Media, Conditioned; Enzyme Activation; Female; Gene Expression Profiling; Humans; Male; Mesenchymal Stem Cells; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; src-Family Kinases; Tumor Microenvironment	2012
Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta pharmacologica Sinica, 2011, Volume: 32, Issue:12 Topics: Allosteric Regulation; Cell Line, Tumor; Cell Movement; Humans; Kinesins; Neoplasm Invasiveness; Pancreatic Neoplasms; Quinazolines; Thiones	2011
Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor. Cancer research, 2011, Dec-01, Volume: 71, Issue:23 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Knockdown Techniques; Glycosylation; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mucins; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Polypeptide N-acetylgalactosaminyltransferase; Quinazolines; RNA, Messenger	2011
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer letters, 2012, Apr-01, Volume: 317, Issue:1 Topics: Actin Depolymerizing Factors; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; ErbB Receptors; Humans; Lim Kinases; MAP Kinase Kinase 1; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Molecular Structure; Neoplasm Invasiveness; p21-Activated Kinases; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pseudopodia; Quinazolines; Signal Transduction; Stomach Neoplasms; Structure-Activity Relationship; Transfection	2012
Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma. Oncology reports, 2012, Volume: 27, Issue:4 Topics: ADAM Proteins; ADAM17 Protein; Autocrine Communication; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Tongue Neoplasms; Tyrphostins	2012
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer biology & therapy, 2012, Volume: 13, Issue:5 Topics: Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; DNA-Binding Proteins; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Neoplasm Invasiveness; Prognosis; Protein Kinase Inhibitors; Quinazolines; Transcription Factors; Transfection	2012
Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene, 2013, Jan-03, Volume: 32, Issue:1 Topics: Benzimidazoles; Benzodioxoles; Cell Adhesion; Cell Division; Collagen; Humans; Integrin beta1; MAP Kinase Kinase Kinases; Melanoma; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; src-Family Kinases	2013
EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells. PloS one, 2012, Volume: 7, Issue:2 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cisplatin; ErbB Receptors; Flow Cytometry; Gefitinib; Head and Neck Neoplasms; Humans; Hyaluronan Receptors; Neoplasm Invasiveness; Neoplastic Stem Cells; Quinazolines; Signal Transduction	2012
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene, 2013, Feb-28, Volume: 32, Issue:9 Topics: Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; MicroRNAs; Neoplasm Invasiveness; Quinazolines; RNA-Binding Proteins; Tamoxifen	2013
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. The American journal of pathology, 2012, Volume: 181, Issue:1 Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Movement; ErbB Receptors; Erlotinib Hydrochloride; Gene Knockdown Techniques; Genes, ras; Humans; Lung Neoplasms; Mice; Mice, SCID; Mutation; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Receptors, Tumor Necrosis Factor; Signal Transduction; Tumor Cells, Cultured; TWEAK Receptor	2012
Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion. Molecular cancer therapeutics, 2012, Volume: 11, Issue:9 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Disease-Free Survival; Ephrins; Epithelial Cells; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Multivariate Analysis; Mutation, Missense; Neoplasm Invasiveness; Occludin; Proportional Hazards Models; Quinazolines; Receptor, EphA4	2012
Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:8 Topics: Animals; Butadienes; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Focal Adhesion Kinase 1; Humans; Integrin alpha6beta4; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tetraspanin 24; Transendothelial and Transepithelial Migration	2012
Influence of epidermal growth factor receptor inhibitor AG1478 on epithelial-mesenchymal transition in endometrial carcinoma cells. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2012, Volume: 22, Issue:9 Topics: Carcinoma; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endometrial Neoplasms; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured; Tyrphostins	2012
Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion. Journal of neuroscience research, 2013, Volume: 91, Issue:1 Topics: Animals; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Glioblastoma; Humans; Male; Mice; Mice, SCID; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Array Analysis; Quinazolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays	2013
Ulcerated plaques in the pelvic region of an adult female. Dermatology online journal, 2012, Oct-15, Volume: 18, Issue:10 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Deoxycytidine; Female; Fluorouracil; Genital Neoplasms, Female; Humans; Lapatinib; Middle Aged; Neoplasm Invasiveness; Quinazolines; Skin Neoplasms; Skin Ulcer	2012
Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib. World journal of surgical oncology, 2012, Nov-07, Volume: 10 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Gefitinib; Glutamates; Guanine; Humans; Lung Neoplasms; Lymph Nodes; Magnetic Resonance Imaging; Male; Meningeal Carcinomatosis; Middle Aged; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Staging; Pemetrexed; Pneumonectomy; Quinazolines; Radiotherapy, Adjuvant; Time Factors; Tomography, X-Ray Computed; Treatment Outcome	2012
Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature. Molecular bioSystems, 2013, Volume: 9, Issue:6 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Expression Profiling; Humans; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; Niacinamide; Phenylurea Compounds; Piperidines; Protein Interaction Maps; Protein Kinases; Proteome; Proteomics; Quinazolines; Sorafenib	2013
Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma. PloS one, 2012, Volume: 7, Issue:12 Topics: Animals; Anoikis; Antineoplastic Agents; Apoptosis; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Salivary Gland Neoplasms; Snail Family Transcription Factors; Transcription Factors	2012
Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Molecular pharmacology, 2013, Volume: 83, Issue:4 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; ErbB Receptors; Female; Gene Expression Regulation, Enzymologic; Humans; Lapatinib; Mice; Neoplasm Invasiveness; Quinazolines; Receptor, ErbB-2; Severe Combined Immunodeficiency; Up-Regulation; Xenograft Model Antitumor Assays	2013
Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer. Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:1 Topics: Adenocarcinoma; Amides; Animals; Antineoplastic Agents; Apoptosis; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays	2013
EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. International journal of cancer, 2002, Jun-10, Volume: 99, Issue:5 Topics: Carcinoma, Signet Ring Cell; Cell Movement; Collagen; Drug Combinations; Enzyme Inhibitors; ErbB Receptors; Estrenes; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Herpesvirus 4, Human; Humans; Integrins; Isoenzymes; Laminin; Neoplasm Invasiveness; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrrolidinones; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Type C Phospholipases	2002
Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function. International journal of cancer, 2002, Sep-10, Volume: 101, Issue:2 Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line; Cell Size; Cell Transformation, Neoplastic; Dimerization; ErbB Receptors; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutation; Neoplasm Invasiveness; Phosphorylation; Proteins; Quinazolines; Tyrphostins	2002
Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). Molecular cancer therapeutics, 2003, Volume: 2, Issue:4 Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Keratinocytes; MAP Kinase Signaling System; Microscopy, Fluorescence; Neoplasm Invasiveness; p21-Activated Kinases; Phenotype; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Skin Neoplasms	2003
Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells. Oncogene, 2003, Jul-17, Volume: 22, Issue:29 Topics: Amphiregulin; Animals; Cells, Cultured; Colonic Neoplasms; Dogs; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, src; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Mucins; Muscle Proteins; Mutation; Neoplasm Invasiveness; Neuropeptides; Peptides; Phosphatidylinositol 3-Kinases; Proteins; Quinazolines; Receptors, Thromboxane; Signal Transduction; Transforming Growth Factor alpha; Trefoil Factor-1; Trefoil Factor-2; Trefoil Factor-3; Tumor Suppressor Proteins	2003
Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton. Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:11 Topics: Aminopeptidases; Animals; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Electrochemistry; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mice; Neoplasm Invasiveness; Protease Inhibitors; Puromycin; Quinazolines; Structure-Activity Relationship	2003
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Experimental cell research, 2004, Jan-01, Volume: 292, Issue:1 Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Genes, src; Humans; Kinetics; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcriptional Activation; Tyrphostins; Urokinase-Type Plasminogen Activator	2004
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2 Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; CSK Tyrosine-Protein Kinase; Cytoskeleton; Disease Progression; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; p21-Activated Kinases; Phenotype; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; src-Family Kinases; Transfection; Vinculin	2004
Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4 Topics: 3T3 Cells; Aniline Compounds; Animals; Antineoplastic Agents; CSK Tyrosine-Protein Kinase; Dioxoles; Mice; Models, Molecular; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Nude; src-Family Kinases; Structure-Activity Relationship; Tyrosine; Xenograft Model Antitumor Assays	2004
Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Evodia; Hepatocyte Growth Factor; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Plant Extracts; Quinazolines	2004
Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. International journal of oncology, 2004, Volume: 25, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; ErbB Receptors; Gefitinib; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Quinazolines	2004
Single agent gefitinib as first line therapy in patients with advanced non-small cell lung cancer: Washington University experience. Lung cancer (Amsterdam, Netherlands), 2004, Volume: 45, Issue:2 Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gefitinib; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Quinazolines; Retrospective Studies; Risk Assessment; Statistics, Nonparametric; Survival Analysis; Treatment Outcome	2004
Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839). Clinical & experimental metastasis, 2004, Volume: 21, Issue:3 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Drug Resistance, Neoplasm; Gefitinib; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; Phenotype; Quinazolines; Tamoxifen	2004
PLC and PI3K pathways are important in the inhibition of EGF-induced cell migration by gefitinib ('Iressa', ZD1839). Breast cancer (Tokyo, Japan), 2004, Volume: 11, Issue:4 Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Neoplasm Invasiveness; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Type C Phospholipases	2004
Signaling mechanisms that mediate invasion in prostate cancer cells. Annals of the New York Academy of Sciences, 2004, Volume: 1028 Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Immunoprecipitation; Laminin; Male; Neoplasm Invasiveness; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Proteoglycans; Quinazolines; Receptors, Androgen; Signal Transduction; Transfection; Tyrosine	2004
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. The Journal of cell biology, 2005, Jan-31, Volume: 168, Issue:3 Topics: Actin Depolymerizing Factors; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Fibronectins; GRB2 Adaptor Protein; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Neoplasm Invasiveness; Nerve Tissue Proteins; Oncogene Proteins; Quinazolines; Rats; RNA, Small Interfering; Transfection; Tyrphostins; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal	2005
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. The Journal of biological chemistry, 2005, Apr-29, Volume: 280, Issue:17 Topics: Active Transport, Cell Nucleus; Alkaloids; Annexin A5; Apoptosis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Collagen; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Enzyme Activation; Evodia; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Kinase; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Indole Alkaloids; Inflammation; Laminin; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Proteoglycans; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation	2005
The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro. The Journal of thoracic and cardiovascular surgery, 2005, Volume: 129, Issue:5 Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Cocarcinogenesis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Humans; Laminin; Mesothelioma; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Pleural Neoplasms; Proteoglycans; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A	2005
Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. EGF-receptor inhibition may prevent tumor cell dissemination. Thrombosis and haemostasis, 2005, Volume: 93, Issue:5 Topics: Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Inhibitory Concentration 50; Laminin; Male; MAP Kinase Signaling System; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Proteoglycans; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins; Urokinase-Type Plasminogen Activator	2005
Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells. International journal of oncology, 2005, Volume: 27, Issue:3 Topics: Animals; BALB 3T3 Cells; Cell Line, Tumor; Cell Movement; Culture Media, Conditioned; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Tight Junctions; Tyrphostins; Zonula Occludens-1 Protein	2005
SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells. Clinical & experimental metastasis, 2005, Volume: 22, Issue:3 Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Injections, Subcutaneous; Lung Neoplasms; Male; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Piperidines; Proto-Oncogene Mas; Quinazolines; src-Family Kinases; Transplantation, Heterologous; Vascular Endothelial Growth Factor A	2005
Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells. Cancer research, 2005, Nov-15, Volume: 65, Issue:22 Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Induction; ErbB Receptors; Gefitinib; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Platelet-Derived Growth Factor; Urinary Bladder Neoplasms	2005
Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway. Journal of clinical pathology, 2005, Volume: 58, Issue:12 Topics: Adenocarcinoma; Adult; Aged; Blotting, Western; Butadienes; Culture Media, Conditioned; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Male; Matrix Metalloproteinase 7; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Tight Junctions; Tumor Cells, Cultured; Tyrphostins	2005
ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells. Biochemical pharmacology, 2006, Feb-14, Volume: 71, Issue:4 Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Adhesion Molecules; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Humans; Immunoprecipitation; Inhibitory Concentration 50; Kalinin; Liver Neoplasms; Neoplasm Invasiveness; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Time Factors	2006
Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast cancer research and treatment, 2006, Volume: 97, Issue:3 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Female; Focal Adhesion Kinase 1; Gefitinib; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; Paxillin; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; src-Family Kinases; Tamoxifen	2006
[Molecular therapy for HCC?]. Zeitschrift fur Gastroenterologie, 2006, Volume: 44, Issue:2 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Clinical Trials as Topic; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Probability; Protein Kinase Inhibitors; Quinazolines; Survival Analysis; Treatment Outcome	2006
The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:1 Topics: Basement Membrane; Biological Assay; Carcinoma; Cell Movement; Collagen; Drug Combinations; Genistein; Humans; Laminin; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Plasminogen; Plasminogen Activators; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteoglycans; Quinazolines; Tyrphostins	2006
A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. Cancer research, 2006, Mar-01, Volume: 66, Issue:5 Topics: Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Eukaryotic Initiation Factor-4E; Humans; Integrin alpha6beta4; Neoplasm Invasiveness; Phosphorylation; Protein Biosynthesis; Quinazolines; ras Proteins; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Transcriptional Activation; Transfection; Tyrphostins	2006
Gefitinib inhibits the growth and invasion of urothelial carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal growth factor receptor activation. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, May-01, Volume: 12, Issue:9 Topics: Cell Division; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Gefitinib; Humans; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Urologic Neoplasms	2006
Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Molecular cancer therapeutics, 2006, Volume: 5, Issue:8 Topics: Animals; Cisplatin; Colonic Neoplasms; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Semaphorin-3A; Signal Transduction; Triazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2006
N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. Journal of medicinal chemistry, 2006, Nov-02, Volume: 49, Issue:22 Topics: 3T3 Cells; Animals; Antineoplastic Agents; Benzodioxoles; Cell Proliferation; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Dogs; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Male; Mice; Mice, Nude; Models, Molecular; Neoplasm Invasiveness; Protein-Tyrosine Kinases; Quinazolines; Rats; Solubility; src-Family Kinases; Structure-Activity Relationship; Thermodynamics; Transplantation, Heterologous	2006
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocrine-related cancer, 2006, Volume: 13, Issue:4 Topics: Adenocarcinoma, Follicular; Aprotinin; Blotting, Western; Carcinoma, Papillary; Cell Differentiation; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Protease Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Tetracyclines; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrphostins	2006
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness. Cancer science, 2007, Volume: 98, Issue:5 Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Inhibitors; Gene Expression; Glioma; Gliosarcoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Tyrphostins	2007
Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells. Molecular cancer therapeutics, 2007, Volume: 6, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Cytochromes c; Docetaxel; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Quinazolines; Signal Transduction; Taxoids; Tumor Cells, Cultured; Veratrum Alkaloids	2007
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses proliferation and invasion of human oral squamous carcinoma cells via p53 independent and MMP, uPAR dependent mechanism. Annals of the New York Academy of Sciences, 2007, Volume: 1095 Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Gefitinib; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tongue Neoplasms; Tumor Suppressor Protein p53	2007
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer. Molecular cancer therapeutics, 2007, Volume: 6, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; G1 Phase; Head and Neck Neoplasms; Humans; Indoles; Neoplasm Invasiveness; Quinazolines; Receptors, Bombesin; Signal Transduction; Tumor Stem Cell Assay	2007
Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity. Cancer research, 2007, Jul-01, Volume: 67, Issue:13 Topics: Animals; Antineoplastic Agents; Cadherins; Cell Line, Tumor; ErbB Receptors; Female; Gefitinib; Humans; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Ovarian Neoplasms; Pyrrolidines; Quinazolines; Receptor, Endothelin A	2007
Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. Breast cancer research : BCR, 2007, Volume: 9, Issue:4 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dimerization; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neuregulin-1; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Tamoxifen; Trastuzumab	2007
Development of new targeted therapies for breast cancer. Breast cancer (Tokyo, Japan), 2008, Volume: 15, Issue:1 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Delivery Systems; Female; Humans; Lapatinib; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Trastuzumab	2008
Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades. Growth factors (Chur, Switzerland), 2007, Volume: 25, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Synergism; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Mitoxantrone; Neoplasm Invasiveness; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Quinazolines; Signal Transduction; Veratrum Alkaloids	2007
Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast cancer research and treatment, 2009, Volume: 115, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogens; Focal Adhesion Protein-Tyrosine Kinases; Humans; Neoplasm Invasiveness; Phosphorylation; Quinazolines; src-Family Kinases; Treatment Outcome	2009
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. International journal of cancer, 1997, Mar-17, Volume: 70, Issue:6 Topics: Amphiregulin; Antineoplastic Agents; Breast Neoplasms; Cell Division; Collagenases; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gelatinases; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Tumor Cells, Cultured; Up-Regulation	1997
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154). Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:10 Topics: Actins; Antineoplastic Agents; Cell Adhesion; Epidermal Growth Factor; Glioblastoma; Humans; Integrins; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured	1998
Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8 Topics: Animals; Antineoplastic Agents; Carcinoma; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Gelatin; Humans; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C3H; Neoplasm Invasiveness; Neoplasm Transplantation; Piperidines; Promoter Regions, Genetic; Proteoglycans; Quinazolines; Quinazolinones; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1999
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8 Topics: Adenocarcinoma; Animals; Autocrine Communication; Breast Neoplasms; Cell Line; Diffusion Chambers, Culture; Epidermal Growth Factor; ErbB Receptors; Estrenes; Female; Humans; Immunoblotting; Isoenzymes; Male; Mice; Neoplasm Invasiveness; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Prostatic Neoplasms; Pyrrolidinones; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Type C Phospholipases	1999
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. Journal of the National Cancer Institute, 2001, Sep-19, Volume: 93, Issue:18 Topics: Antigens, CD; Autocrine Communication; Carcinoma; Cell Adhesion; Cell Movement; Cell Size; DNA, Antisense; DNA, Complementary; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha3; Integrin alpha6; Integrins; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Phenotype; Quinazolines; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured	2001
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer research, 2002, Jan-01, Volume: 62, Issue:1 Topics: Apoptosis; Arabidopsis Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Plant Proteins; Potassium Channels; Quinazolines; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrphostins	2002
Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor. The Prostate, 2002, Jun-01, Volume: 52, Issue:1 Topics: Adenocarcinoma; Apoptosis; Blotting, Northern; Blotting, Western; Cell Count; Cell Cycle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Quinazolines; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured	2002
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer research, 2002, Jun-15, Volume: 62, Issue:12 Topics: Animals; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Transfection; Tumor Cells, Cultured; Tyrphostins; Up-Regulation	2002