quinazolines has been researched along with Inflammation in 110 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.91) | 18.7374 |
| 1990's | 3 (2.73) | 18.2507 |
| 2000's | 28 (25.45) | 29.6817 |
| 2010's | 65 (59.09) | 24.3611 |
| 2020's | 13 (11.82) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Gayyar, MMH; Alattar, A; Alshaman, R; Hamdan, AM | 1 |
| Karpenko, O; Kovalenko, S; Krasovska, N; Nosulenko, I; Stavytskyi, V; Voskoboinik, O | 1 |
| Caselli, G; Giacomoni, C; Lanza, M; Letari, O; Milia, C; Rovati, LC; Sabatini, C; Vellani, V | 1 |
| Chen, Y; Han, M; Hu, L | 1 |
| Bellver-Sanchis, A; Griñán-Ferré, C; Kondengaden, SM; Marsal-García, L; Pallàs, M; Turga, RC; Vázquez, S | 1 |
| Han, X; Jiang, X; Li, N; Li, Y; Liu, C; Luo, J; Si, S; Wang, X; Xu, Y; Zuo, X | 1 |
| Elsner, P; Hesse-Macabata, J; Hipler, UC; Morgner, B; Wiegand, C | 1 |
| Cen, Y; Chen, ZB; He, M; Wa, QB; Yu, YB; Zhou, JW | 1 |
| Du, J; Fu, S; Gao, X; He, D; Hu, G; Huang, B; Liu, D; Meng, T; Su, Y; Zhang, Y; Zhou, A | 1 |
| Liu, L; Liu, S; Wang, Y; Yuan, Y | 1 |
| Evans, R; Raubo, P; Willis, P | 1 |
| Cui, Y; Wang, J; Wang, Q; Wu, X | 1 |
| Han, B; Huang, W; Li, X; Peng, C; Xie, X; Ye, C; Zhang, N; Zhao, Q; Zhu, HP | 1 |
| Kim, JB; Kim, SH; Lee, P; Yang, JY | 1 |
| Cao, W; De La Cruz, JA; Diebold, BA; Ganesh, T; Gangappa, S; Hofstetter, A; Kumar, A; Lambeth, JD; McCoy, J; Ranjan, P; Sambhara, S; Singh, N; Smith, SME | 1 |
| Fan, X; Liang, HP; Luo, L; Ma, W; Sun, Y; Tang, WQ; Yan, J; Yang, X; Yu, J; Zhu, JY | 1 |
| Altman, MD; Andresen, B; Baker, J; Brubaker, JD; Chen, H; Chen, Y; Childers, M; Donofrio, A; Ferguson, H; Fischer, C; Fischmann, TO; Gibeau, C; Hicks, A; Jin, S; Kattar, S; Kleinschek, MA; Leccese, E; Lesburg, C; Li, C; Lim, J; Liu, D; Maclean, JKF; Mansoor, F; Moy, LY; Mulrooney, EF; Necheva, AS; Northrup, A; Presland, J; Rakhilina, L; Smith, GF; Torres, L; Yang, R; Zhang-Hoover, J | 1 |
| Chen, HP; Chen, ZH; Li, ZY; Shen, HH; Wang, Y; Wu, YF; Xu, XC; Zhao, Y; Zhou, JS | 1 |
| Kouzaki, H; Ogawa, T; Shimizu, S; Shimizu, T; Takezawa-Yasuoka, K; Tojima, I | 1 |
| Han, J; Jiang, L; Jin, Z; Lou, D; Qian, Y; Xu, J; Yang, Y; Yu, Q; Zhou, L | 1 |
| Aki, A; Baba, D; Fukuda, T; Hashimoto, M; Ishiyama, T; Katagiri, T; Muramatsu, S; Tanaka, N; Ueda, K; Watanabe, K | 1 |
| Chen, H; Ju, X; Song, Z; Wang, Y; Wu, W; Yan, T; Yang, X; Zhang, Z | 1 |
| Bissonnette, R; Boguniewicz, M; Guttman-Yassky, E; Hanifin, JM; Kilty, I; Purohit, V; Tallman, AM; Wollenberg, A; Zielinski, MA | 1 |
| Azrad, M; Gavish, M; Veenman, L; Weizman, A; Zeineh, N | 1 |
| Xiao, H; Xu, J | 1 |
| Bhattacharjee, A; Biswas, K; Chatterjee, A; Gurung, AB; Joshi, SR; Pamay, P; Tripathy, D | 1 |
| Eraslan, E; Polat, E; Tanyeli, A; Yetim, Z | 1 |
| Amara, R; Gavish, M; Monga, S; Nagler, R; Weizman, A | 1 |
| Arndt, K; Corradini, L; Doods, H; Hirsch, S; Just, S | 1 |
| Hirata, K; Kimura, T; Kira, Y; Kudoh, S; Matsuura, K; Mitsuoka, S; Nagata, M; Nakai, T; Oka, T; Suzumura, T; Umekawa, K; Yoshimura, N | 1 |
| Deng, R; Li, DQ; Lin, J; Pflugfelder, SC; Su, Z; Zhang, L; Zhao, G | 1 |
| Ahn, M; Kim, SH; Koh, HW; Lee, SH; Lee, SM; Oh, YB; Park, BH | 1 |
| Fu, LX; Tang, DM; Wang, Y; Yan, HX; Yang, XN | 1 |
| Brown, C; De Souza, P; Fox, P; Gebski, V; Hudson, M; Lee, CK; Lord, S | 1 |
| Feddersen, CR; Fletcher, EV; Goel, A; Koch, AT; Love-Homan, L; Simons, AL; Sobhakumari, A | 1 |
| Andersen, HH; Kullander, K; Lagerström, MC; Rogoz, K | 1 |
| Gu, JA; Huang, SH; Huang, ST; Lee, CM; Lin, CM; Lin, FY; Rau, TG; Yang, CH; Yang, WC | 1 |
| Cao, H; Dubé, PE; Hao, X; Liu, L; Lu, N; Polk, DB; Ren, X; Rosen, MJ; Van Kaer, L; Wang, L; Washington, MK; Wilson, KT; Yan, F | 1 |
| Andoh, T; Kuraishi, Y; Yoshida, T | 1 |
| Ding, Y; Shen, Q; Wild, C; Ye, N; Zhou, J | 1 |
| Eräsalo, H; Hämäläinen, M; Laavola, M; Leppänen, T; Moilanen, E; Nieminen, R | 1 |
| Attwell, S; Azhar, S; Hansen, HC; Jahagirdar, R; Johansson, J; McLure, KG; Srivastava, RA; Tobin, J; Wagner, GS; Wong, NC; Wu, J; Young, PR; Yu, R; Zhang, H | 1 |
| Birklein, F; Hirsch, S | 1 |
| Corrêa, MF; dos Santos Fernandes, JP | 1 |
| Bian, K; Nie, XQ; Shi, HX; Yang, JW; Yuan, Y; Zhang, JY; Zhang, YJ | 1 |
| Guo, S; Li, Z; Liu, Y; Ren, G; Ren, J; Song, G; Wang, Y; Zhang, L | 1 |
| Chen, X; Gunawardena, HP; Jin, J; Liu, C; Liu, F; Wei, X; Wrobel, JA; Yu, Y; Zhou, L | 1 |
| Agdauletova, S; Daiber, A; Hausding, M; Klein, T; Kröller-Schön, S; Li, H; Mader, M; Mikhed, Y; Münzel, T; Oelze, M; Pfeffer, A; Schulz, E; Stamm, P; Steven, S; Sudowe, S; Welschof, P; Zinßius, E | 1 |
| Bao, W; Cheng, SB; Chin, YE; Liu, N; Qiu, A; Shi, Y; Wang, L; Xiong, C; Xu, L; Yan, H; Yang, T; Zhuang, S | 1 |
| de Jonge, WJ; Glowka, TR; Holzmann, B; Kalff, JC; Lysson, M; Schwandt, T; Stein, K; Steinebach, A; Tsujikawa, K; Wehner, S | 1 |
| Han, S; Jung, Y; Kang, C; Kim, E; Kim, W; Kwon, T; Lee, S; Yang, HJ; Youn, B; Youn, H | 1 |
| Garófalo, A; Giai, C; Gómez, MI; Gonzalez, CD; Ledo, C | 1 |
| Dhulap, S; Gavaraskar, K; Hirwani, RR | 1 |
| Gao, Y; Guo, L; Li, G; Liang, S; Liu, S; Lv, Q; Wang, S; Xie, J; Xu, H; Xue, Y; Ying, M; Zhang, X; Zou, L | 1 |
| Cho, SH; Jeong, JS; Kim, SR; Ko, YH; Kolliputi, N; Lee, KB; Lee, KS; Lee, YC; Park, HJ; Park, SC | 1 |
| Hayama, T; Kamio, N; Matsushima, K; Muromachi, K; Okabe, T | 1 |
| Aiuti, A; Ariganello, P; Attardi, E; Brigida, I; Cancrini, C; Chiriaco, M; Cittaro, D; Di Cesare, S; Di Matteo, G; Finocchi, A; Fraziano, M; Giannelli, S; Lazarevic, D; Palma, P; Rossi, P; Santilli, V; Scarselli, A; Stupka, E; Taus, F | 1 |
| Li, Y; Liu, D; Qu, S; Song, J; Song, L; Tang, H; Wu, Y | 1 |
| Fang, Q; Li, W; Li, X; Liang, G; Lin, F; Wang, L; Wang, Y; Zhang, Y; Zheng, C; Zhong, P; Zou, C | 1 |
| Barat, C; Dental, C; Ouellet, M; Proust, A; Tremblay, MJ | 1 |
| Hamid, Q; Hassan, M; Jo, T; Martin, JG; McGovern, T; Ramos-Barbón, D; Tamaoka, M; Tolloczko, B; Yoshizawa, Y | 1 |
| Aberg, A; Andersson, G; Andrews, G; Arvai, AS; Cheshire, DR; Connolly, S; Crane, BR; Garcin, ED; Gensmantel, NP; Getzoff, ED; Hamley, PJ; Kroeger, MD; Mallinder, PR; Mete, A; Nicholls, DJ; Rosenfeld, RJ; St-Gallay, SA; Stuehr, DJ; Tainer, JA; Tinker, AC; Wallace, AV | 1 |
| Cameron, DA; Hall, PS; Hanby, A | 1 |
| Demierre, MF; Goldberg, LJ; Pongpudpunth, M | 1 |
| Carvalheira, JB; Cintra, DE; de Souza, CT; Franchini, KG; Mourão, RH; Pauli, JR; Prada, PO; Rittner, R; Rocco, SA; Ropelle, ER; Saad, MJ; Schenka, A; Vassallo, J; Velloso, LA | 1 |
| Cristofanilli, M; Esteva, FJ; Hortobagyi, GN; Hung, MC; Krishnamurthy, S; LaFortune, TA; Liu, P; Lucci, A; Singh, B; Ueno, NT; Zhang, D | 1 |
| Ishar, MP; Paneerselvam, P; Raj, T; Rather, BA; Reddy, A; Sivakumar, S | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Ueno, NT; Yamauchi, H | 1 |
| Cristofanilli, M | 1 |
| Boussen, H; Cristofanilli, M; DeSilvio, M; Salazar, V; Spector, N; Zaks, T | 1 |
| Denny, WA; Ding, Y; Ferguson, LR; Lin, Z; Murray, PM | 1 |
| Giannis, A; Grisanti, S; Lüke, J; Lüke, M; Merz, H; Nassar, K; Tura, A | 1 |
| Jafar, AA; Kapavarapu, R; Krishna, GR; Kumar, KA; Kumar, KS; Kumar, PM; Pal, M; Parsa, KV; Priya, KK; Rambabu, D; Reddy, CM; Shivakumar, K; Sreenivasulu, M | 1 |
| Cheng, N; Gao, WW; He, M; Wang, MW; Ye, RD; Zhang, M; Zhang, YY | 1 |
| Li, Y; Wang, H; Xia, Y; Xu, W; Yan, J | 1 |
| Chan, J; Chen, X; Collins, T; Deignan, J; Du, X; Duquette, J; Fu, Z; Gustin, DJ; Henne, K; Johnson, M; Lemon, B; Li, AR; Ma, J; Medina, JC; Miao, S; Mihalic, J; Sullivan, T; Tonn, G | 1 |
| Faldyna, M; Kovaru, F; Kovaru, H; Leva, L; Matiasovic, J; Ondrackova, P | 1 |
| Engelmann-Pilger, K; Frank, S; Klein, T; Linke, A; Mark, M; Pfeilschifter, J; Schürmann, C; Steinmetz, C | 1 |
| Baeza-Squiban, A; Hamel, R; Marano, F; Ramgolam, K; Rumelhard, M | 1 |
| Fang, J; Guo, ZB; Lü, JG; Qu, WS; Tian, DS; Wang, W; Xie, MJ; Yu, ZY; Zhang, HQ; Zhang, Q | 1 |
| Banerjee, S; Bose, D; Chatterjee, N; Chattopadhyay, D; Das, S; Saha, KD | 1 |
| Burton, VJ; Butler, M; Parkinson, SJ; Pearson, R; Sanmugalingam, D; Smith, P; Watson, RP; Wilson, T | 1 |
| Brooks, MB | 1 |
| Elomaa, I; Joensuu, H; Orpana, A; Osterlund, P; Repo, H | 1 |
| Akçil, E; Koçak, M; Yavuz, G | 1 |
| Karasawa, A; Kusaka, H; Noji, T | 1 |
| Dick, K; Sadhu, C; Staunton, DE; Tino, WT | 1 |
| Hayashi, H; Isobe, Y; Nagasaki, T; Takahashi, H; Tobe, M; Tomizawa, H | 1 |
| Alagarsamy, V; Murugananthan, G; Venkateshperumal, R | 1 |
| Berente, Z; Gallyas, F; Osz, E; Radnai, B; Sumegi, B; Varbiro, G; Veres, B | 1 |
| Hall, MW; Hart, J; Kim, HJ; Knatz, N; Wewers, MD | 1 |
| Banasik, M; Dytnerska, K; Lewkowicz, N; Lewkowicz, P; Tchórzewski, H | 1 |
| Aggarwal, BB; Kobayashi, Y; Takada, Y | 1 |
| Allen, S; Marker, D; Michael, E; Nees, M; Smith, L; Woodworth, CD | 1 |
| Dolle, RE; Koblish, M; LaBuda, CJ; Little, PJ; Tuthill, P | 1 |
| Berman, A; Chow, CK; Denduluri, N; Swain, SM; Tan, AR; Walshe, J; Yang, SX | 1 |
| Graves, JE; Heffernan, MP; Jones, BF; Lind, AC | 1 |
| Campbell, D; Jackson, CJ; Xue, M | 1 |
| Tuma, RS | 1 |
| Hur, GY; In, KH; Jung, JY; Jung, KH; Kang, EH; Kang, KH; Kim, JH; Kim, SJ; Lee, EJ; Lee, KJ; Lee, SH; Lee, SY; Shim, JJ; Shin, C; Yoo, SH | 1 |
| Hermanns, JF; Piérard, GE; Quatresooz, P | 1 |
| Ben Ahmed, S; Blackwell, K; Boussen, H; Citrin, DL; DeSilvio, ML; Harris, J; Johnston, S; Kaufman, B; Lombardi, DP; LoRusso, P; Salazar, V; Spector, NL; Trudeau, M; Westlund, RE; Zaks, TZ | 1 |
| Hashizume, H; Kamio, N; Matsushima, K; Nakao, S; Sugiya, H | 1 |
| Bateman-Fite, R; Brackeen, MF; Clark, RL; Connolly, KM; Menius, JA; Noel, LS; Sekut, L; Stimpson, SA; Yarnall, D | 1 |
| Nagler, A; Nyska, A; Nyska, M; Pines, M; Porat, S; Rivlin, E; Shoshan, S | 1 |
| Chang, HW; Kang, SS; Kim, HP; Kudo, I; Moon, TC; Murakami, M; Son, KH | 1 |
| Alcaraz, MJ; Gonzalez-Tejero, A; Molina, P; Rioja, I; Tárraga, A; Terencio, MC; Ubeda, A | 1 |
| Baggiolini, M; Gubler, HU | 1 |
4 review(s) available for quinazolines and Inflammation
| Article | Year |
|---|---|
The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition.
Topics: Acetamides; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Dermatitis, Atopic; Drug Approval; Humans; Immune System; Inflammation; Phosphodiesterase Inhibitors; Phthalic Acids; Pyridines; Quinazolines; Risk; Skin; Thalidomide | 2019 |
Histamine H4 receptor ligands: future applications and state of art.
Topics: Animals; Drug Discovery; Humans; Imidazoles; Indoles; Inflammation; Ligands; Models, Molecular; Pyrimidines; Quinazolines; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship | 2015 |
Therapeutic and cosmetic applications of Evodiamine and its derivatives--A patent review.
Topics: Alkaloids; Animals; Autoimmune Diseases; Cell Line, Tumor; Central Nervous System Diseases; Cosmetics; Evodia; Fruit; Humans; Inflammation; Metabolic Diseases; Molecular Structure; Neoplasms; Patents as Topic; Quinazolines | 2015 |
[Pharmacological study on the effects of the adenosine uptake inhibitor KF24345 on inflammatory diseases].
Topics: Acute Disease; Adenosine; Animals; Depression, Chemical; Erythrocytes; Glomerulonephritis; Humans; Inflammation; Leukopenia; Lipopolysaccharides; Mice; Neurotransmitter Uptake Inhibitors; Pancreatitis; Pyrimidinones; Quinazolines; Tumor Necrosis Factor-alpha | 2003 |
5 trial(s) available for quinazolines and Inflammation
| Article | Year |
|---|---|
Markers of systemic inflammation predict survival in patients with advanced renal cell cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Renal Cell; Female; Humans; Inflammation; Kaplan-Meier Estimate; Kidney Neoplasms; Lapatinib; Leukocyte Count; Male; Megestrol Acetate; Middle Aged; Platelet Count; Prognosis; Quinazolines; Serum Albumin; Tamoxifen; Young Adult | 2013 |
Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Blood Proteins; Carcinoma, Non-Small-Cell Lung; Crown Ethers; Disease Progression; Drug Monitoring; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunity, Humoral; Inflammation; Lung Neoplasms; Male; Middle Aged; Precision Medicine; Quinazolines; Time Factors | 2015 |
Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Administration Schedule; Early Termination of Clinical Trials; Female; Humans; Inflammation; Lapatinib; Middle Aged; Neoadjuvant Therapy; Paclitaxel; Quinazolines | 2010 |
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cohort Studies; Female; Humans; Immunoenzyme Techniques; Inflammation; Lapatinib; Lymphatic Metastasis; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Sensitivity and Specificity; Skin Neoplasms | 2008 |
101 other study(ies) available for quinazolines and Inflammation
| Article | Year |
|---|---|
QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model.
Topics: alpha-Fetoproteins; Animals; beta Catenin; Carcinoma, Hepatocellular; Disease Models, Animal; Glycogen Synthase Kinase 3; Hepatocytes; Inflammation; Liver; Liver Neoplasms; MAP Kinase Kinase Kinase 5; NF-kappa B; Organ Specificity; Phenyl Ethers; Quinazolines; Rats; Rats, Sprague-Dawley; Survival Analysis; TNF Receptor-Associated Factor 2; Tumor Necrosis Factor-alpha | 2021 |
Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification: A Novel Class of Anti-inflammatory Agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dicarboxylic Acids; Disease Models, Animal; Edema; Hydrazines; Inflammation; Quinazolines; Rats; Rats, Wistar | 2021 |
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
Topics: Amino Acid Sequence; Analgesics; Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Freund's Adjuvant; Humans; Imidazoles; Imidazoline Receptors; Inflammation; Male; Pain; Phosphorylation; Protein Kinase C-epsilon; Quinazolines; Rats; Rats, Wistar; Sensory Receptor Cells | 2020 |
Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Indole Alkaloids; Inflammation; Male; MAP Kinase Signaling System; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Cognitive Dysfunction; Gene Expression Regulation; Glucagon-Like Peptides; Hippocampus; Histone-Lysine N-Methyltransferase; Histones; Inflammation; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines | 2019 |
Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport.
Topics: Animals; Atherosclerosis; Biological Transport, Active; Cholesterol; Indole Alkaloids; Inflammasomes; Inflammation; Macrophages; Mice; Mice, Knockout, ApoE; NLR Family, Pyrin Domain-Containing 3 Protein; Quinazolines | 2020 |
Tryptanthrin promotes keratinocyte and fibroblast responses in vitro after infection with Trichophyton benhamiae DSM6916.
Topics: Antimicrobial Cationic Peptides; Cell Line; Cytokines; Epidermis; Fibroblasts; Humans; Immunity, Innate; Inflammation; Keratinocytes; Ki-67 Antigen; Quinazolines; Skin; Tinea; Toll-Like Receptor 2; Trichophyton | 2020 |
The role of quinazoline in ameliorating intervertebral disc degeneration by inhibiting oxidative stress and anti-inflammation via NF-κB/MAPKs signaling pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Dose-Response Relationship, Drug; Humans; Inflammation; Intervertebral Disc Degeneration; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; Protective Agents; Quinazolines; Reactive Oxygen Species; Structure-Activity Relationship | 2020 |
Evodiamine Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in BV-2 Cells via Regulating AKT/Nrf2-HO-1/NF-κB Signaling Axis.
Topics: Animals; Cell Line; Cell Nucleus; Cell Survival; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Lipopolysaccharides; Mice; Models, Biological; Neuroglia; Neurons; NF-E2-Related Factor 2; NF-kappa B; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrosine 3-Monooxygenase; Up-Regulation | 2021 |
Reduced expression of CYLD promotes cell survival and inflammation in gefitinib-treated NSCLC PC-9 cells: Targeting CYLD may be beneficial for acquired resistance to gefitinib therapy.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deubiquitinating Enzyme CYLD; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Genes, Tumor Suppressor; Humans; Inflammation; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines | 2020 |
The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors.
Topics: Administration, Inhalation; Alkanes; Amines; Animals; Anti-Inflammatory Agents; Benzamides; Dogs; Drug Evaluation, Preclinical; Humans; Inflammation; Mitogen-Activated Protein Kinase 14; Models, Molecular; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Quinazolines; Rats; Structure-Activity Relationship | 2020 |
Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway.
Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; HMGB1 Protein; Inflammation; NF-kappa B; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway.
Topics: Animals; Apelin; Apoptosis; Cytokines; Evodia; Fibrosis; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Pneumonia; Quinazolines; RAW 264.7 Cells | 2021 |
Evodiamine Inhibits
Topics: Antigens, Bacterial; Cell Nucleus; Cytokines; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Interleukin-8; MAP Kinase Signaling System; Microbial Sensitivity Tests; NF-kappa B; NF-kappa B p50 Subunit; Quinazolines; Signal Transduction; Subcellular Fractions; Type IV Secretion Systems | 2021 |
Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival.
Topics: Cell Survival; Chemokine CCL2; Gene Expression Regulation; Humans; Inflammation; Inflammation Mediators; Influenza A virus; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Lung; Peroxidase; Quinazolines; Reactive Oxygen Species; Superoxides; Tumor Necrosis Factor-alpha | 2021 |
Evodiamine Inhibits Zymosan-Induced Inflammation In Vitro and In Vivo: Inactivation of NF-κB by Inhibiting IκBα Phosphorylation.
Topics: Cytokines; Humans; Inflammation; Intestinal Mucosa; Lung; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Quinazolines; Zymosan | 2017 |
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; High-Throughput Screening Assays; Imidazoles; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred Lew; Structure-Activity Relationship | 2017 |
Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.
Topics: Adenine; Animals; Autophagy; Benzylamines; Cell Line; Cytokines; Environmental Pollutants; Gene Expression Regulation; Humans; Inflammation; Mice; Mice, Inbred C57BL; Particulate Matter; Quinazolines | 2017 |
The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.
Topics: Administration, Intranasal; Animals; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Enzyme Inhibitors; Eosinophilia; Eosinophils; Epithelial Cells; ErbB Receptors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Nasal Mucosa; Neutrophil Infiltration; Quinazolines; Rats; Respiratory Mucosa; Thrombin; Tyrphostins | 2018 |
Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro.
Topics: Animals; Cell Proliferation; Cell Survival; Cytokines; ErbB Receptors; Extracellular Matrix; Gene Knockdown Techniques; Genes, src; Hepatic Stellate Cells; Inflammation; Lipopolysaccharides; Liver; Liver Cirrhosis; Male; NF-kappa B; Primary Cell Culture; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta; Tyrphostins | 2018 |
Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives.
Topics: Administration, Oral; Aminopyridines; Anemia; Animals; Binding Sites; Cell Line, Tumor; Drug Design; Hepcidins; Humans; Inflammation; Interleukin-6; Iron; Male; Mice, Inbred C57BL; Molecular Structure; Quinazolines; Structure-Activity Relationship | 2018 |
EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy.
Topics: Animals; Diabetic Retinopathy; Disease Progression; ErbB Receptors; Female; Inflammation; Macrophages; Male; Mice; Mitochondria; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Retinal Vessels; Tyrphostins | 2019 |
The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS.
Topics: Animals; Blotting, Western; Carbamates; Cell Line; Inflammation; Isoquinolines; Lipopolysaccharides; Mice; Microglia; Quinazolines; Receptors, GABA | 2019 |
Isaindigotone as an inhibitor of the lipopolysaccharide‑induced inflammatory reaction of BV‑2 cells and corresponding mechanisms.
Topics: Alkaloids; Anti-Inflammatory Agents; Cell Line; Cytokines; Drugs, Chinese Herbal; Inflammation; Inflammation Mediators; Lipopolysaccharides; Microglia; NF-kappa B; Quinazolines; Signal Transduction | 2019 |
Bioprospection of anti-inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15-lipoxygenase inhibitors.
Topics: Arachidonate 15-Lipoxygenase; Cyclooxygenase 2; HEK293 Cells; Humans; Indole Alkaloids; Inflammation; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Phytochemicals; Quinazolines; Quinine; Structure-Activity Relationship | 2019 |
Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Gene Expression Regulation; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kidney; Male; NF-kappa B; Oxidative Stress; Quinazolines; Rats; Rats, Wistar; Reactive Oxygen Species; Renal Artery; Reperfusion Injury; Surgical Instruments; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Inhibitory Effects of the Two Novel TSPO Ligands 2-Cl-MGV-1 and MGV-1 on LPS-induced Microglial Activation.
Topics: Animals; Carbamates; Cell Line; Cytokines; Inflammation; Ligands; Lipopolysaccharides; Microglia; Quinazolines; Reactive Oxygen Species; Receptors, GABA; Transcription Factor RelA | 2019 |
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Freund's Adjuvant; Inflammation; Ketorolac; Male; Morphine; Neurons; Osteoarthritis; Pain; Pain Measurement; Piperazines; Quinazolines; Rats; Rats, Wistar; Spinal Cord | 2013 |
Plasma RANTES, IL-10, and IL-8 levels in non-small-cell lung cancer patients treated with EGFR-TKIs.
Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chemokine CCL5; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Interleukin-10; Interleukin-8; Lung Neoplasms; Male; Middle Aged; Mutation; Quinazolines; Treatment Outcome | 2013 |
A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium.
Topics: Adult; Aged; Antibodies, Neutralizing; Cytokines; Epithelial Cells; Epithelium, Corneal; Gene Expression Regulation; Humans; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Interleukins; Middle Aged; NF-kappa B; Nitriles; Primary Cell Culture; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Sulfones | 2013 |
Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice.
Topics: Animals; Apoptosis; Cell Movement; Chemokines; Heart Function Tests; Inflammation; Janus Kinase 3; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Neutrophils; Quinazolines | 2013 |
A new selective vascular endothelial growth factor receptor 2 inhibitor ablates disease in a mouse model of psoriasis.
Topics: Animals; Capillary Permeability; Disease Models, Animal; Inflammation; Mice; Mice, Transgenic; Neovascularization, Pathologic; Psoriasis; Quinazolines; Skin; T-Lymphocytes; Thiadiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Cytokines; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Head and Neck Neoplasms; Humans; Inflammation; Lapatinib; NADPH Oxidase 4; NADPH Oxidases; Oligonucleotide Array Sequence Analysis; Panitumumab; Protein Kinase Inhibitors; Quinazolines; Squamous Cell Carcinoma of Head and Neck; Time Factors | 2013 |
Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia.
Topics: Androstanes; Animals; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Glutamic Acid; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Nerve Growth Factor; Neurons, Afferent; Piperazines; Quinazolines; Substance P; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2 | 2014 |
Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities.
Topics: Anti-Inflammatory Agents; Cardiovascular Diseases; Drugs, Chinese Herbal; Evodia; Gene Expression Regulation; Humans; Indole Alkaloids; Inflammation; Macrophages; Nitric Oxide Synthase Type II; Quinazolines; TRPV Cation Channels | 2013 |
Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
Topics: Adolescent; Adult; Aged; Animals; Cell Line; Colitis; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; ErbB Receptors; Female; Gene Expression Regulation; Humans; Immunity, Innate; Inflammation; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myeloid Cells; Neutrophils; NF-kappa B; Quinazolines; Regeneration; Signal Transduction; Spleen; Tumor Necrosis Factor-alpha; Tyrphostins; Young Adult | 2014 |
Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch-related responses in mice with chronic atopy-like dermatitis.
Topics: Animals; Antipruritics; Cyclic AMP; Dermatitis, Atopic; Disease Models, Animal; Inflammation; Male; Mice; Phosphodiesterase 4 Inhibitors; Phthalic Acids; Pruritus; Quinazolines; Signal Transduction; Skin | 2014 |
Small molecule inhibitors targeting activator protein 1 (AP-1).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzophenones; Biological Products; Humans; Inflammation; Isoxazoles; Maleimides; Molecular Targeted Therapy; Neoplasms; Organic Chemicals; Quinazolines; Signal Transduction; Small Molecule Libraries; Transcription Factor AP-1; Transcription Factors | 2014 |
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages.
Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors; Inflammation; Interleukin-6; Macrophages; Mice; Morpholines; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Tumor Necrosis Factor-alpha | 2015 |
A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.
Topics: Animals; Aorta; Aortic Diseases; Apolipoprotein A-I; Apolipoproteins E; Atherosclerosis; Betaine-Homocysteine S-Methyltransferase; Cell Line; Cholesterol, HDL; Cholesterol, LDL; Cytokines; Diet, Fat-Restricted; Diet, Western; Drug Evaluation, Preclinical; Endothelial Cells; Gene Expression Profiling; Humans; Hyperlipidemias; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinazolines; Quinazolinones; RNA, Messenger; U937 Cells | 2014 |
[Pain-relieving effect of CGRP antagonism on inflammatory pain].
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Chronic Pain; Disease Models, Animal; Inflammation; Neurons; Pain Threshold; Piperazines; Quinazolines; Rats; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord | 2014 |
[Effects of rutaecarpine on inflammatory cytokines in insulin resistant primary skeletal muscle cells].
Topics: Animals; Cell Proliferation; Cytokines; Female; Glucose; Indole Alkaloids; Inflammation; Insulin Resistance; Male; Muscle, Skeletal; Quinazolines; Rats | 2014 |
A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; Chromatin; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Female; Histone-Lysine N-Methyltransferase; Histones; Immune Tolerance; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; Proteomics; Proto-Oncogene Proteins c-myc; Quinazolines; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2014 |
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endotoxemia; Glucagon-Like Peptide 1; Inflammation; Linagliptin; Lipopolysaccharides; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Purines; Pyrazines; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles | 2015 |
EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.
Topics: Animals; Chemokines; Cytokines; Disease Progression; ErbB Receptors; Fibroblasts; Fibrosis; Gefitinib; Hyperuricemia; Inflammation; Kidney; Kidney Diseases; Male; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Uric Acid | 2015 |
The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus.
Topics: Animals; Gastrointestinal Transit; Ileus; Inflammation; Intestines; Laparotomy; Mice; Mice, Knockout; Muscle, Smooth; Piperazines; Postoperative Period; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2015 |
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation; Hedgehog Proteins; Humans; Inflammation; MAP Kinase Signaling System; Mice; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Skin Aging; Tissue Inhibitor of Metalloproteinase-1; Ultraviolet Rays | 2015 |
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.
Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Imidazoles; Immunoglobulin G; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Staphylococcal Infections; Staphylococcal Protein A; Staphylococcus aureus; Tyrphostins; Virulence Factors | 2015 |
Beneficial effects of evodiamine on P2X(4)-mediated inflammatory injury of human umbilical vein endothelial cells due to high glucose.
Topics: Drugs, Chinese Herbal; Endothelium, Vascular; Evodia; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; NF-kappa B; Nitric Oxide; Quinazolines; Reactive Oxygen Species; Receptors, Purinergic P2X4; Receptors, Tumor Necrosis Factor; Umbilical Veins; Up-Regulation | 2015 |
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress.
Topics: Adenine; Animals; Aspergillosis, Allergic Bronchopulmonary; Biomarkers; Blotting, Western; Bronchoalveolar Lavage; CCAAT-Enhancer-Binding Proteins; Endoplasmic Reticulum Stress; Female; Glutathione; Glutathione Disulfide; Immunoglobulin E; Inflammation; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Phosphatidylinositol 3-Kinases; Quinazolines; RNA, Small Interfering | 2016 |
Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease-Activated Receptor-1.
Topics: Cells, Cultured; Complement C3; Dental Pulp; Enkephalins; Humans; Inflammation; Kallikreins; Prostate-Specific Antigen; Protein Precursors; Pulpitis; Pyrroles; Quinazolines; Receptor, PAR-1; Renin | 2016 |
The case of an APDS patient: Defects in maturation and function and decreased in vitro anti-mycobacterial activity in the myeloid compartment.
Topics: Adenine; B-Lymphocytes; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Dendritic Cells; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Inflammation; Lymphopenia; Macrophages; Male; Mycobacterium bovis; Primary Immunodeficiency Diseases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases; Young Adult | 2017 |
The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma.
Topics: Airway Remodeling; Animals; Asthma; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Down-Regulation; Eosinophils; ErbB Receptors; Gefitinib; Inflammation; Interferon-gamma; Interleukin-13; Leukocyte Count; Male; Mice; Mice, Inbred BALB C; Mucin 5AC; Ovalbumin; Proto-Oncogene Proteins c-bcl-2; Quinazolines | 2016 |
EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation.
Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; ErbB Receptors; Hyperlipidemias; Immunoblotting; Inflammation; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Obesity; Oxidative Stress; Phosphorylation; Quinazolines; Rats; RNA Interference; src-Family Kinases; Tyrphostins | 2016 |
HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.
Topics: Acetamides; Azacitidine; Azepines; Blood-Brain Barrier; Bryostatins; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CCL2; Cytokines; Decitabine; HIV-1; Humans; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Phorbol Esters; Quinazolines; Receptors, Cell Surface; Virus Latency | 2017 |
The epidermal growth factor receptor mediates allergic airway remodelling in the rat.
Topics: Allergens; Animals; Cell Proliferation; Cysteine; ErbB Receptors; Gene Expression Profiling; Goblet Cells; Hyperplasia; Inflammation; Leukotriene D4; Muscle, Smooth; Ovalbumin; Quinazolines; Rats; Receptors, Leukotriene; Tyrphostins | 2008 |
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Cattle; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Isoenzymes; Male; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nitric Oxide Synthase; Quinazolines; Rats | 2008 |
Lapatinib for inflammatory breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Genes, erbB-2; Humans; Inflammation; Lapatinib; Quinazolines | 2009 |
A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib.
Topics: Alopecia; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Inflammation; Lung Neoplasms; Middle Aged; Quinazolines | 2009 |
EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.
Topics: Adiponectin; Adipose Tissue; Animals; Blood Glucose; Dietary Fats; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Glucose Tolerance Test; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Leptin; Liver; Macrophages; Male; Mice; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Epithelium; ErbB Receptors; Erlotinib Hydrochloride; Humans; Inflammation; Lung Neoplasms; Male; Mesoderm; Mice; Mice, Nude; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Signal Transduction | 2009 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Inflammation; Male; Mice; Pain; Pain Measurement; Quinazolines; Structure-Activity Relationship | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Targeted therapy in inflammatory breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Inflammation; Quinazolines | 2010 |
Novel targeted therapies in inflammatory breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Delivery Systems; Fluorouracil; Humans; Inflammation; Lapatinib; Protein Kinase Inhibitors; Quinazolines | 2010 |
Quinazolines as novel anti-inflammatory histone deacetylase inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Proliferation; Epigenesis, Genetic; Gene Expression; Histone Deacetylase Inhibitors; Humans; Inflammation; Quinazolines; Structure-Activity Relationship | 2010 |
The effect of adjuvant dimethylenastron, a mitotic Kinesin Eg5 inhibitor, in experimental glaucoma filtration surgery.
Topics: Animals; Antimitotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Filtering Surgery; Inflammation; Injections, Intraocular; Intraocular Pressure; Postoperative Complications; Quinazolines; Rabbits; Thiones; Time Factors; Wound Healing | 2010 |
A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Green Chemistry Technology; Heterocyclic Compounds; Humans; Inflammation; Isoindoles; Quinazolines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2011 |
Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Bleomycin; Chemokines; Cytokines; Disease Models, Animal; Fibrosis; Inflammation; Lung Injury; Male; Mice; Mice, Inbred ICR; Quinazolines; Receptors, Formyl Peptide; Time Factors | 2011 |
Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.
Topics: ADAM Proteins; ADAM17 Protein; Antibodies, Neutralizing; Cell Line; Epithelial Cells; ErbB Receptors; Gene Transfer Techniques; Genetic Vectors; Humans; Inflammation; Interleukin-8; Lentivirus; Lipopolysaccharides; Lung; Phosphorylation; Quinazolines; Respiratory Mucosa; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins | 2012 |
Discovery of potent and specific CXCR3 antagonists.
Topics: Animals; Bleomycin; Chromosome Aberrations; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Dose-Response Relationship, Drug; Drug Design; Humans; Inflammation; Inhibitory Concentration 50; Leukocytes; Macaca fascicularis; Mice; Models, Chemical; Quinazolines; Quinazolinones; Receptors, CXCR3; Time Factors | 2012 |
The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Concanavalin A; Dose-Response Relationship, Drug; Flow Cytometry; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-2; Quinazolines; Swine; T-Lymphocyte Subsets; T-Lymphocytes; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice.
Topics: Animals; Chemokine CXCL2; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Epithelial Cells; Female; Glucagon-Like Peptide 1; Inflammation; Keratinocytes; Linagliptin; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Obese; Myofibroblasts; Neutrophils; Purines; Quinazolines; Wound Healing | 2012 |
Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.
Topics: ADAM Proteins; ADAM17 Protein; Airway Remodeling; Autocrine Communication; Bronchi; Cell Line; Epithelial Cells; ErbB Receptors; Gene Silencing; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Particle Size; Particulate Matter; Quinazolines; RNA, Small Interfering; Tyrphostins | 2012 |
Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Inflammation; Male; MAP Kinase Signaling System; Microglia; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord Injuries; Tyrphostins | 2012 |
Exploring the anti-inflammatory activity of a novel 2-phenylquinazoline analog with protection against inflammatory injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Capillary Permeability; Carrageenan; Cell Line; Cell Survival; Cytokines; Dinoprostone; Female; Formaldehyde; Inflammation; Lipopolysaccharides; Liver; Liver Function Tests; Macrophages; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; NF-kappa B; Nitric Oxide; Quinazolines; Shock, Septic; Survival | 2012 |
Erlotinib and gefitinib, epidermal growth factor receptor kinase inhibitors, may treat non-cancer-related tumor necrosis factor-α mediated inflammatory diseases.
Topics: Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Inflammation; Quinazolines; Tumor Necrosis Factor-alpha | 2013 |
Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; Colorectal Neoplasms; Cross-Sectional Studies; Fatigue; Female; Fever; Fluorouracil; Humans; Inflammation; Interleukin-6; Liver Neoplasms; Longitudinal Studies; Lung Neoplasms; Male; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Necrosis Factor-alpha | 2002 |
Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Copper; Female; Guinea Pigs; Inflammation; Male; Models, Animal; Quinazolines; Trace Elements; Zinc | 2003 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Inflammation; Inhibitory Concentration 50; NF-kappa B; Quinazolines; Rats; Spleen; Structure-Activity Relationship; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Drug Administration Schedule; Female; Foot; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Male; Microbial Sensitivity Tests; Norfloxacin; Oxazines; Pain; Pain Measurement; Quinazolines; Rats; Rats, Wistar; Time Factors | 2003 |
Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice.
Topics: Animals; HeLa Cells; Humans; Inflammation; Kidney; Lipopolysaccharides; Liver; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Quinazolinones; Spleen; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2004 |
Janus kinase 3 down-regulates lipopolysaccharide-induced IL-1 beta-converting enzyme activation by autocrine IL-10.
Topics: Animals; Autocrine Communication; Caspase 1; Caspase Inhibitors; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Interleukin-10; Interleukin-4; Janus Kinase 3; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction | 2004 |
Epidermal growth factor enhances TNF-alpha-induced priming of human neutrophils.
Topics: CD11b Antigen; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Humans; Inflammation; Interleukin-8; Neutrophils; Phagocytosis; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Respiratory Burst; Tumor Necrosis Factor-alpha; Tyrphostins | 2005 |
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
Topics: Active Transport, Cell Nucleus; Alkaloids; Annexin A5; Apoptosis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Collagen; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Enzyme Activation; Evodia; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Kinase; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Indole Alkaloids; Inflammation; Laminin; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Proteoglycans; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Collagen; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunoprecipitation; Inflammation; NF-kappa B; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotide Probes; Phosphorylation; Polymerase Chain Reaction; Quinazolines; RNA; Tyrosine; Up-Regulation; Uterine Cervical Neoplasms | 2005 |
Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mononeuropathies; Nitric Oxide Synthase; Pain; Quinazolines; Rats; Rats, Sprague-Dawley | 2006 |
A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer.
Topics: Breast Neoplasms; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Female; Humans; Inflammation; Pilot Projects; Quinazolines; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor | 2005 |
Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib.
Topics: Aged; Alopecia; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Gefitinib; Humans; Inflammation; Lung Neoplasms; Quinazolines; Time Factors | 2006 |
Protein C is an autocrine growth factor for human skin keratinocytes.
Topics: Antibodies, Monoclonal; Antigens, CD; Autocrine Communication; Blood Coagulation; Cell Proliferation; Cells, Cultured; Endothelial Protein C Receptor; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Inflammation; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein C; Quinazolines; Receptors, Cell Surface; RNA, Small Interfering; Skin; Wound Healing | 2007 |
Lapatinib moves forward in inflammatory and early HER2-positive breast cancer trials.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Drug Approval; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Research Design; Trastuzumab; United States | 2007 |
Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation.
Topics: Animals; Antineoplastic Agents; Bronchoalveolar Lavage Fluid; Cytokines; Enzyme Activation; Eosinophils; ErbB Receptors; Gefitinib; Goblet Cells; Inflammation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Respiratory Hypersensitivity; Respiratory Mucosa | 2007 |
Lapatinib shows promise for inflammatory breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials, Phase II as Topic; Female; Humans; Inflammation; Lapatinib; Multicenter Studies as Topic; Quinazolines | 2007 |
Erlotinib-responsive actinic keratoses.
Topics: Carcinoma, Squamous Cell; ErbB Receptors; Erlotinib Hydrochloride; Humans; Inflammation; Keratosis; Male; Protein Kinase Inhibitors; Quinazolines; Radionuclide Imaging; Skin Neoplasms; Sunlight | 2007 |
Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp.
Topics: Adult; Calcium; Cells, Cultured; Dental Pulp; Dinoprostone; Fibrinolysin; Humans; Inflammation; Interleukin-8; Peptides; Pyrroles; Quinazolines; Receptor, PAR-1; RNA, Messenger | 2008 |
Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Female; Galactosamine; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyrrolidinones; Quinazolines; Rats; Rats, Inbred Lew; Rolipram; Shock, Septic; Tumor Necrosis Factor-alpha | 1995 |
Topically applied halofuginone, an inhibitor of collagen type I transcription, reduces peritendinous fibrous adhesions following surgery.
Topics: Animals; Chickens; Collagen; Gene Expression Regulation; Hydroxyproline; Inflammation; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Statistics, Nonparametric; Tendon Injuries; Tissue Adhesions | 1996 |
A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Fruit; Humans; Immunoblotting; Indole Alkaloids; Inflammation; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Plant Extracts; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Quinazolines; Rats; Rats, Sprague-Dawley; Transfection | 1999 |
Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.
Topics: Alkaloids; Animals; Brassicaceae; Cells, Cultured; Chromatography, Thin Layer; Dinoprostone; Free Radical Scavengers; Humans; Inflammation; Inflammation Mediators; Inhibitory Concentration 50; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neutrophils; Nitric Oxide Synthase; Plants, Medicinal; Quinazolines; Structure-Activity Relationship; Xanthine Oxidase | 2001 |
Pharmacological properties of proquazone.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclinical; Gastrointestinal Hemorrhage; Indomethacin; Inflammation; Quinazolines; Rats | 1978 |