quinazolines has been researched along with Hypoxia in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, W; Li, S; Liao, H; Qiu, W; Yin, L; Zhan, J; Zhang, J | 1 |
| Carter, R; Hagan, AE; Lewis, AL; Lloyd, AW; Macfarlane, WM; Phillips, GJ; Sharma, RA; Westhorpe, A; Znati, SA | 1 |
| Chen, X; Liu, Y; Qi, C; Yang, P; Zhang, J | 1 |
| Chen, JL; Hu, X; Li, QY; Li, YL; Rao, MJ; Wu, LW; Yan, W; Zhang, B; Zhang, C; Zhang, NY | 1 |
| Cui, J; Duan, Y; Gou, W; Li, D; Li, Y; Liu, Q; Ning, H; Qin, Y; Wei, H | 1 |
| Hashimoto, M; Hidayat, M; Kobayashi, I; Moriyama, H; Moriyama, M; Murakami, A; Nara, T; Nurwidya, F; Sasaki, S; Shimada, N; Suina, K; Tajima, K; Takahashi, F; Takahashi, K; Yagishita, S; Yoshioka, Y | 1 |
| Du, J; Li, D; Li, WQ; Li, XH; Li, YJ; Xiong, XM; Zhang, W | 1 |
| Arima, S; Ishii, K; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Ushikubo, H | 1 |
| Cui, L; Dai, Z; Hu, GY; Jiang, DJ; Liu, SY; Xiao, J | 1 |
| Cao, PJ; Dhani, N; Do, T; Hedley, DW; Hill, RP; Magalhaes, JM; Pham, NA; Schwock, J | 1 |
| Angelillo-Scherrer, A; Hirt, L; Price, M; Thevenet, J | 1 |
| Bignon, YJ; Cayre, A; El Guerrab, A; Nemlin, CC; Penault-Llorca, F; Rossignol, F; Vigier, F; Zegrour, R | 1 |
| Chang, CY; Chang, SC; Chang, SJ; Chen, CY; Kuo, LC; Lai, YC; Liu, YC; Yu, CJ; Yuan, MK | 1 |
| Dempsey, EC; Fagan, KA; Karoor, V; Le, M; Merrick, D; Miller, YE | 1 |
| Feldkamp, T; Heemann, U; Herget-Rosenthal, S; Horbelt, M; Kribben, A; Lange, B; Philipp, T; Pietruck, F | 1 |
| Aono, Y; Azuma, M; Kanematsu, T; Miki, T; Sone, S; Uehara, H; Yamamoto, A; Yano, S | 1 |
| Bally, MB; Chia, S; Denyssevych, T; Dragowska, WH; Gelmon, K; Masin, D; Wallis, AE; Warburton, C; Yan, H | 1 |
| Binns, D; Cullinane, C; Hicks, RJ; McArthur, GA; Roselt, P; Solomon, B; Weibe, LI | 1 |
| Coppi, E; Corradetti, R; Pedata, F; Pugliese, AM; Spalluto, G | 1 |
| Delivoria-Papadopoulos, M; Heffernan, TM; Sacks, LM; Wagerle, LC | 1 |
| Howell, LL; Landrum, AM | 1 |
| Clarke, W; Cohen, AH; Fouty, B; Hanson, K; McMurty, IF; Morris, K; Rodman, DM | 1 |
| Fukuchi, Y; Hanasato, N; Kira, S; Nishino, M; Oka, M; Yamaguchi, K | 1 |
| Alfranca, A; Aragonés, J; Jones, DR; Landázuri, MO; Martin, S; Mérida, I; San Juan, MA; Vara, A; Vidal, F | 1 |
| Oka, M | 1 |
| Cai, YC; Dong, YM | 1 |
| Hara, H; Hori, M; Iemura, R; Ohtaka, H; Ozaki, A; Sukamoto, T | 2 |
| Fujimura, H; Kitani, T; Naitoh, Y; Yamada, T; Yamahara, J | 1 |
| Matsumoto, M; Minematsu, R; Miyake, K; Takeo, S; Tanonaka, K | 1 |
| Kunieda, T; Naito, M; Nakanishi, N; Obayashi, Y; Okubo, S; Yoshioka, T | 1 |
| McCormack, JJ; Webster, LK | 1 |
32 other study(ies) available for quinazolines and Hypoxia
| Article | Year |
|---|---|
Novel vandetanib derivative inhibited proliferation and promoted apoptosis of cancer cells under normoxia and hypoxia.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2022 |
Vandetanib-eluting radiopaque beads for chemoembolization: physicochemical evaluation and biological activity of vandetanib in hypoxia.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Chemoembolization, Therapeutic; Drug Liberation; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Liver Neoplasms; MAP Kinase Signaling System; Neovascularization, Pathologic; Piperidines; Quinazolines; Vascular Endothelial Growth Factors | 2021 |
Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation.
Topics: Animals; Apoptosis; beta Catenin; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Cerebrum; Endothelial Cells; Glucose; Hypoxia; Intercellular Signaling Peptides and Proteins; Lithium Chloride; Microvessels; Oxygen; Quinazolines; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway; Wnt3 Protein | 2017 |
Evodiamine induces apoptosis and promotes hepatocellular carcinoma cell death induced by vorinostat via downregulating HIF-1α under hypoxia.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Synergism; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Quinazolines; Vorinostat | 2018 |
Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.
Topics: Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Hypoxia; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2019 |
Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Exons; Female; Gefitinib; Gene Deletion; Glycoproteins; Humans; Hypoxia; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred NOD; Microscopy, Fluorescence; Mutation; Neoplasm Transplantation; Neoplastic Stem Cells; Octamer Transcription Factor-3; Peptides; Phenotype; Quinazolines; Real-Time Polymerase Chain Reaction | 2016 |
Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats.
Topics: Animals; Apoptosis; Calcitonin Gene-Related Peptide; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-3; Fibroblasts; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indole Alkaloids; Myocardium; Quinazolines; Signal Transduction; Transforming Growth Factor beta1; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2016 |
A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina.
Topics: Animals; Astrocytes; Cell Movement; Cell Proliferation; Endothelial Cells; Female; Hypoxia; Immunohistochemistry; In Situ Hybridization; Male; Mice; Phenylurea Compounds; Pregnancy; Quinazolines; Retina; Vascular Endothelial Growth Factor A | 2017 |
Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons.
Topics: Animals; Apoptosis; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Hippocampus; Hypoxia; In Situ Nick-End Labeling; Indole Alkaloids; Neural Inhibition; Neurons; Oxidative Stress; Oxygen; Pregnancy; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Vasodilator Agents | 2008 |
Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models.
Topics: Animals; Benzodioxoles; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hypoxia; Male; Mice; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphorylation; Quinazolines; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor | 2009 |
Coagulation factor Xa activates thrombin in ischemic neural tissue.
Topics: Animals; Animals, Newborn; Anticoagulants; Cell Death; Factor Xa; Fondaparinux; Gene Expression Regulation; Glucose; Hippocampus; Hypoxia; Ischemia; JNK Mitogen-Activated Protein Kinases; Organ Culture Techniques; Polysaccharides; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Serine; Signal Transduction; Thrombin | 2009 |
Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Cetuximab; DNA; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Flow Cytometry; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, Reporter; Green Fluorescent Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Lapatinib; Molecular Sequence Data; Neoplasm Metastasis; Quinazolines; Transcription, Genetic | 2011 |
Gefitinib-related interstitial lung disease in Taiwanese patients with non-small-cell lung cancer.
Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cough; Dyspnea; Female; Gefitinib; Hospital Mortality; Humans; Hypoxia; Incidence; Kaplan-Meier Estimate; Lung Diseases, Interstitial; Lung Neoplasms; Male; Middle Aged; Quinazolines; Retrospective Studies; Taiwan | 2013 |
Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism.
Topics: Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Blotting, Western; Butylated Hydroxytoluene; Carcinogens; Cell Proliferation; Cytokines; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Hypoxia; Immunoenzyme Techniques; Lung Neoplasms; Methylcholanthrene; Mice; Neovascularization, Pathologic; Piperidines; Proto-Oncogene Proteins c-myc; Pulmonary Alveoli; Quinazolines; Sleep Apnea Syndromes; Urethane; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; Hemolysis; Hypotonic Solutions; Hypoxia; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Male; Potassium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Triazoles | 2003 |
A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa").
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aged; Antineoplastic Agents; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Hypoxia; Lung Neoplasms; Middle Aged; Quinazolines; Radiography; Sputum | 2003 |
Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Female; Flow Cytometry; Gefitinib; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, SCID; Neoplasm Transplantation; Phosphorylation; Quinazolines; Receptor, ErbB-2; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab | 2004 |
Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Fluorine Radioisotopes; Gefitinib; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxidation-Reduction; Oxygen; Positron-Emission Tomography; Quinazolines; Tissue Distribution | 2005 |
A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
Topics: Action Potentials; Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Hippocampus; Hypoglycemia; Hypoxia; Male; Pyridines; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Synaptic Transmission; Time Factors; Triazoles | 2006 |
Sympathetic effect on cerebral blood flow regulation in hypoxic newborn lambs.
Topics: Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Ganglia, Sympathetic; Hematocrit; Hypoxia; Oxygen; Partial Pressure; Prazosin; Quinazolines; Sheep | 1983 |
Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys.
Topics: Adenosine; Animals; Hypoxia; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinazolines; Respiration; Rolipram; Triazoles | 1995 |
Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Channel Blockers; Cyclic GMP; Diltiazem; Hemodynamics; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Nitric Oxide; Perfusion; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Circulation; Purinones; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation | 1996 |
[E 4021, a cGMP phosphodiesterase inhibitor, is a selective pulmonary vasodilator in chronically hypoxic pulmonary hypertensive rats].
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Lung; Male; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
Topics: Cell Nucleus; Diacylglycerol Kinase; Diglycerides; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Luciferases; Nuclear Proteins; Oxygen; Phosphatidic Acids; Phospholipids; Piperidines; Plasmids; Pyrimidinones; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2001 |
Phosphodiesterase 5 inhibition restores impaired ACh relaxation in hypertensive conduit pulmonary arteries.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Hypertension; Hypoxia; In Vitro Techniques; Male; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2001 |
[Synthesis of 3-[4-[(3-alkylamino-2-hydroxy)propoxy]phenyl (benzyl)]-substituted 4(3H)-quinazolines as antimyocardial ischemic agents].
Topics: Adrenergic beta-Antagonists; Amines; Animals; Benzyl Compounds; Hypoxia; Mice; Quinazolines | 1990 |
Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Hypoxia; Male; Mice; Mice, Inbred Strains; Piperazines; Quinazolines; Structure-Activity Relationship | 1990 |
Novel 4-substituted 2-piperazinylquinazolines as potent anticonvulsive and antihypoxic agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Hypoxia; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Piperazines; Quinazolines | 1990 |
Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.
Topics: Alkaloids; Animals; Anticonvulsants; Atmospheric Pressure; Dihydroergotoxine; Hypoxia; Male; Mice; Pentobarbital; Plant Extracts; Plants, Medicinal; Potassium Cyanide; Quinazolines; Sleep; Vinca Alkaloids | 1989 |
Cardioprotective action of alpha-blocking agents, phentolamine and bunazosin, on hypoxic and reoxygenated myocardium.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Energy Metabolism; Heart; Hypoxia; Male; Myocardial Contraction; Myocardium; Oxygen; Phentolamine; Quinazolines; Rabbits | 1988 |
Effects of selective alpha 1-adrenoceptor blockade in dogs with hypoxic pulmonary vasoconstriction.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Gas Analysis; Dogs; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Pulmonary Circulation; Quinazolines; Vasoconstriction | 1988 |
Influence of hypoxia on the metabolism and biliary excretion of trimetrexate by the isolated perfused rat liver.
Topics: Animals; Bile; Half-Life; Hypoxia; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Quinazolines; Rats; Rats, Inbred Strains; Trimetrexate | 1986 |