quinazolines has been researched along with Disease Models, Animal in 478 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (1.26) | 18.7374 |
| 1990's | 15 (3.14) | 18.2507 |
| 2000's | 128 (26.78) | 29.6817 |
| 2010's | 285 (59.62) | 24.3611 |
| 2020's | 44 (9.21) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Gayyar, MMH; Alattar, A; Alshaman, R; Hamdan, AM | 1 |
| Beesley, J; Gause, WC; Haskó, G; Lovászi, M; Németh, ZH; Pacher, P | 1 |
| Chen, X; Fu, H; Gao, Z; He, Q; Jin, Y; Luo, P; Pan, Z; Shen, X; Xu, Z; Yan, H; Yang, B | 1 |
| Karpenko, O; Kovalenko, S; Krasovska, N; Nosulenko, I; Stavytskyi, V; Voskoboinik, O | 1 |
| Bomsel, M; Cohen, E; Delongchamps, NB; Edvinsson, L; Ganor, Y; Lopalco, L; Mariotton, J; Sams, A; Sanvito, F; Sennepin, A; Siracusano, G; Zerbib, M | 1 |
| Bhavan, PS; Chung, CL; Hou, SM; Hsia, CH; Hsia, CW; Huang, WC; Jayakumar, T; Sheu, JR; Wu, MP | 1 |
| Chung, JI; Jalin, AMA; Jin, S; Joung, C; Ju, C; Kim, BS; Kim, WK; Lee, KS; Lee, S; Pahk, K; Ryu, JM; Song, HY | 1 |
| Abelleira-Hervas, L; Aleksynas, R; Ashburner, N; Caselli, G; Liu, L; Mota, BC; Rovati, LC; Sastre, M | 1 |
| Li, J; Lu, T; Qin, Z; Sun, P | 1 |
| Cho, JE; Jang, MS; Jeon, S; Kim, HR; Kim, S; Ko, M; Lee, JY; Myung, S; Park, CM; Park, HG; Shin, YS; Song, JH | 1 |
| Ahnert, JR; Albacker, LA; Chen, T; Cross, JB; Diao, L; Elamin, YY; Frampton, GM; Han, H; He, J; Heymach, JV; Hu, L; Lanman, RB; Le, X; Li, S; Meric-Bernstam, F; Miller, VA; Negrao, MV; Nilsson, MB; Pisegna, M; Poteete, A; Raymond, VM; Robichaux, JP; Roeck, B; Routbort, M; Schrock, AB; Sun, H; Vijayan, RSK; Wang, J; Wong, KK; Yang, Z; Zhang, F | 1 |
| Benninger, F; Lenz, M; Maggio, N; Neufeld, MY; Shavit-Stein, E; Shimon, MB; Vlachos, A | 1 |
| Chen, Y; Han, M; Hu, L | 1 |
| Arima, S; Asano, D; Kaneko, Y; Kondo, R; Morita, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K | 1 |
| Bu, Y; Chang, F; Jia, F; Jia, Q; Liao, X; Ren, X; Song, G; Xiao, X; Xu, Z; Zhang, M | 1 |
| Dai, Y; Geng, X; Gong, J; Liu, D; Ma, Z; Meng, H; Song, G; Song, Z; Yang, T; Zhou, B | 1 |
| Chang, CH; Chang, CN; Chang, CY; Cheng, HM; Fang, WY; Kuo, YZ; Lin, JY; Pan, SC; Wu, LW | 1 |
| Baietti, MF; Criem, N; Impens, F; Lechat, B; Pandolfi, S; Quarck, R; Sablina, AA; Sewduth, RN; Sheryazdanova, A; Steklov, M; Zhao, P | 1 |
| Christensen, SL; Ernstsen, C; Kristensen, DM; Olesen, J | 1 |
| Das, D; Hong, J; Shi, J; Wang, J; Xie, L | 1 |
| Crish, JF; Elmquist, WF; Gampa, G; Hinojosa, AQ; Kenchappa, RS; Kim, M; Luu, A; Mohammad, AS; Parrish, KE; Rosenfeld, SS; Sarkaria, JN; West, R | 1 |
| Huang, W; Kong, H; Liu, P; Peng, LY; Xie, WP; Yang, MX; Yu, M; Zhou, H | 1 |
| Jiang, Q; Li, JJ; Li, XM; Lu, C; Tao, SY; Yan, B; Yao, J; Zhang, QY | 1 |
| Bogacka, J; Ciechanowska, A; Dobrogowski, J; Makuch, W; Mika, J; Pawlik, K; Popiolek-Barczyk, K; Przeklasa-Muszynska, A; Rojewska, E | 1 |
| Chen, YD; Han, B; Li, P; Liao, QF; Lin, L; Lin, YX; Tian, X; Wang, MX; Xie, ZY; Zhong, YP | 1 |
| Hanada, K; Itoh, K; Kato, T; Kawamura, Y; Kitayama, K; Kudo, N; Miura, N; Nakata, M; Narita, M; Nozaka, M; Tatara, Y; Tomita, H; Toyama, Y; Tsushima, M; Yokono, Y | 1 |
| Devi, RV; Singh, CB; Singh, OJ; Surbala, L | 1 |
| Cai, YT; Dong, YH; Jiang, L; Jin, J; Li, J; Li, Z; Liu, MM; Liu, XQ; Ma, TT; Meng, XM; Wang, JN; Wen, JG; Wu, MF; Wu, YG | 1 |
| Inoue, S; Koyama, Y; Naka, N; Nakagaki, T; Ogura, S; Oka, N; Terashi, M; Yamaki, K | 1 |
| Chen, H; Liang, D; Pan, L; Peng, Z; Tian, H; Zhang, R | 1 |
| Bogacka, J; Ciapała, K; Dobrogowski, J; Kwiatkowski, K; Mika, J; Pawlik, K; Przeklasa-Muszynska, A | 1 |
| Cai, X; Gao, J; Gu, Y; Guo, W; Sun, Y; Wang, B; Wang, Y; Wei, B; Xu, L; Xu, Q; Zhong, H | 1 |
| Guo, A; Ju, Y; Li, L; Li, W; Liu, W; Liu, X; Sang, A; Tu, Y; Zhou, Y; Zhu, M | 1 |
| Kaur, R; Sharma, V; Sharma, VL | 1 |
| Sun, J; Wu, JC; Xu, JC; Zhang, YF; Zhou, ZY | 1 |
| Chu, Y; Gu, P; Hui, X; Lin, S; Liu, X; Loomes, K; Mao, L; Nie, T; Tang, S; Wu, D; Xu, Y; Zhang, Y; Zhao, S; Zhao, X | 1 |
| Cui, Y; Wang, J; Wang, Q; Wu, X | 1 |
| Cai, E; Del Cid Pellitero, E; Durcan, TM; Fon, EA; Larroquette, F; Luo, W; Soubannier, V; Tavassoly, O; Thomas, RA | 1 |
| Chang, P; Chen, J; Gao, L; Li, J; Liu, F; Liu, X; Lu, M; Tang, H; Tang, Y; Wang, H; Yao, L | 1 |
| Borghi, MO; Cantone, MC; Carra, S; Dicitore, A; Gaudenzi, G; Ghilardi, A; Hofland, LJ; Persani, L; Plebani, A; Saronni, D; Vitale, G | 1 |
| Jin, Y; Lai, P; Li, S; Liu, C; Nie, D; Zhang, X; Zhou, M | 1 |
| Fang, Z; Han, J; Lin, J; Lin, Y; Peng, W; Qin, Y; Shi, X; Xiao, F; Xu, X; Zhang, Y; Zhao, L | 1 |
| Amin, KM; George, RF; Hegazy, GH; Ibrahim, NR; Mohamed, NM | 1 |
| Chou, CH; Yang, CR | 1 |
| Carlson, S; Gregory-Flores, A; Hinojo-Perez, A; Olson, A; Sharma, S; Thippeswamy, T | 1 |
| Cen, X; Hou, T; Najafov, A; Peng, D; Shan, B; Sun, Q; Sun, Y; Wang, Z; Xia, H; Xie, T; Xu, X; Xue, Y; Yi, C; Zhang, M; Zhao, Q | 1 |
| Amini, E; Faraj, FL; Gholami, K; Golpich, M; Rothan, HA; Teoh, TC; Yusof, R | 1 |
| Chen, SY; Chuang, YH; Cui, XB; Wang, YC | 1 |
| Hong, SK; Park, JI; Starenki, D; Wu, PK | 1 |
| Altman, MD; Andresen, B; Baker, J; Brubaker, JD; Chen, H; Chen, Y; Childers, M; Donofrio, A; Ferguson, H; Fischer, C; Fischmann, TO; Gibeau, C; Hicks, A; Jin, S; Kattar, S; Kleinschek, MA; Leccese, E; Lesburg, C; Li, C; Lim, J; Liu, D; Maclean, JKF; Mansoor, F; Moy, LY; Mulrooney, EF; Necheva, AS; Northrup, A; Presland, J; Rakhilina, L; Smith, GF; Torres, L; Yang, R; Zhang-Hoover, J | 1 |
| Chen, YW; Chiou, SP; Chou, TL; Ho, MY; Li, LT; Liang, YJ; Lin, CY; Lin, YJ; Wang, CY; Wang, IA; Wang, YH; Yu, J | 1 |
| Hao, Z; Liang, C; Sun, Y; Wang, C; Zhang, L; Zhou, J | 1 |
| Dallel, R; Descheemaeker, A; Luccarini, P | 1 |
| A Maklad, Y; Abuelizz, HA; Al-Salahi, R; Anouar, EH; Dib, RE; Marzouk, M; N Attia, H | 1 |
| Chen, XP; Hou, HH; Lin, SX; Sun, AS; Xu, Y; Zhang, F; Zhang, JY | 1 |
| Androphy, EJ; Calo, A; Cherry, JJ; Custer, SK; DiDonato, CJ; Du, S; Foley, TL; Gopalsamy, A; Gordo, SM; Gordon, W; Hosea, N; Jones, LH; Krizay, DK; LaRosa, G; Li, H; Mathur, S; Menard, CA; Patel, P; Potter, K; Ramos-Zayas, R; Reedich, EJ; Rietz, A; Rong, H; Tones, MA; Zhang, B | 1 |
| Chen, H; Hu, J; Liang, D; Liang, G; Liu, Z; Wang, J; Wang, W; Zhang, W; Zhao, L; Zhong, P | 1 |
| Hirata, M; Nezasa, KI; Shinonome, S; Tanaka, H; Tanaka, Y; Torii, M | 1 |
| Arima, S; Asano, D; Ishii, K; Kondo, R; Mori, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K; Ushikubo, H | 1 |
| Brownfoot, F; Campbell, L; Ellett, L; Hannan, NJ; Hastie, R; Horne, AW; Kaitu'u-Lino, TJ; Lim, E; Sluka, P; Tong, S | 1 |
| Antequera, D; Bartolome, F; Carro, E; de la Cueva, M; Fernandez, T; Gil, C; Martinez, A; Pascual, C | 1 |
| Baek, IH; Bhandary, B; Bhattarai, KR; Chae, HJ; Chai, OH; Handigund, M; Junjappa, RP; Kim, HK; Kim, HR; Lee, GH; Lee, HY; Lee, YC; Marahatta, A; Pyo, JS | 1 |
| Accogli, T; Ballerini, P; Bastie, JN; Buffière, A; Delva, L; Lucchi, G; Pflumio, F; Quéré, R; Saint-Paul, L; Uzan, B | 1 |
| Hao, L; Hu, H; Jiang, Q; Li, X; Wang, G; Yan, B; Yao, J; Zhu, Y | 1 |
| Bode, A; Grubbs, CJ; Juliana, MM; Lubet, RA; Moeinpour, F; Steele, VE | 1 |
| Arima, S; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Sawada, S | 1 |
| Altan, M; Brahmer, JR; Carter, BW; Chen, T; Doebele, RC; Elamin, YY; Estrada-Bernal, A; Goldberg, SB; Heymach, JV; Le, AT; Li, S; Liu, S; Lu, C; Nilsson, MB; Papadimitrakopoulou, V; Politi, K; Poteete, A; Roarty, E; Robichaux, JP; Sun, H; Tan, Z; Truini, A; Wong, KK; Zhang, S | 1 |
| Chang, E; Gambhir, SS; Hori, SS; Hughes, NP; Kani, K; Kjær, A; Lee, S; Mallick, P; Natarajan, A; Nielsen, CH; Wang, SX; Xu, L | 1 |
| An, C; Chen, P; Chen, Y; Lei, X; Ouyang, H; Pan, Z; Qin, T; Sun, H; Wu, H; Wu, Y; Yu, D; Yuan, C; Zhang, S; Zhang, X; Zou, W | 1 |
| Chemmalakuzhy, R; Lang, L; Shay, C; Teng, Y; Thakkar, P; Wang, X; Xiong, Y | 1 |
| Guan, JL; Haas, M; Paul, R; Wang, C; Yeo, SK | 1 |
| Heo, SH; Hong, M; Kim, I; Kim, SY; Kwon, TK; Lee, S; Oh, Y; Park, S; Sung, YH; Yi, GS | 1 |
| Cui, J; Li, T; Li, Y; Su, D; Zhang, Y | 1 |
| Luo, HS; Ren, HX; Tang, QC; Xia, H; Yan, L | 1 |
| Choi, JY; Choi, WR; Han, SB; Hong, JT; Jung, JK; Kim, KC; Yeo, IJ | 1 |
| Chaudhari, PS; Chitlange, SS; Nanda, RK | 1 |
| Cheng, G; Feng, L; Hu, Y; Wang, Q; Yu, X; Zeng, L; Zhang, L; Zhang, Y; Zhao, M | 1 |
| Bonner, M; Kim, JY; Liu, Z; Pangeni, R; Raz, DJ; Tong, TR; Wang, J; Wu, J; Yang, L; Yuan, YC; Yuchi, T; Yun, X; Zhang, K | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Al Kury, LT; Bogovyk, R; Fedoriuk, M; Isaeva, E; Krishtal, O; Nikolaienko, O; Savotchenko, A; Semenikhina, M | 1 |
| Ballatore, C; Brunden, KR; Cornec, AS; James, MJ; Koivula, P; Lee, VM; Oukoloff, K; Smith, AB; Trojanowski, JQ; Yao, Y; Zhang, B | 1 |
| Mohapatra, DP; Shepherd, AJ; Shutov, LP; Usachev, YM; Warwick, CA | 1 |
| Cervera, A; Gebreyohannes, YK; Hautaniemi, S; Icay, K; Joensuu, H; Kallioniemi, O; Keskitalo, S; Kulesskiy, E; Laakkonen, P; Laaksonen, M; Lehtonen, R; Mpindi, JP; Murumägi, A; Pulkka, OP; Schöffski, P; Sihto, H; Tynninen, O; Varjosalo, M; Wennerberg, K; Wozniak, A | 1 |
| Chen, M; Li, Y; Tang, F; Tong, M; Wen, H; Xiao, R; Zhang, G; Zhao, M | 1 |
| Bachovchin, KA; Bag, S; Buskes, MJ; Ferrins, L; Jalani, HB; Klug, DM; Mehta, N; Mensa-Wilmot, K; Momper, JD; Pollastri, MP; Rodriguez, A; Schneider, KM; Sciotti, RJ; Sharma, A; Singh, B; Tanghe, S | 1 |
| Berkel, TDM; Pandey, SC; Sakharkar, AJ; Teppen, T; Zhang, H | 1 |
| Greengard, P; Hu, Z; Lin, L; Liu, T; Ma, K; Matas, E; Seo, JS; Wang, J; Wang, ZJ; Yan, Z; Yang, F; Zhang, F; Zhong, P | 1 |
| Chen, Y; Wu, P | 1 |
| Chen, R; Hei, Y; Liu, W; Long, Q; Mao, X; Wang, J | 1 |
| Hall, MD; Hu, X; Jadhav, A; Maloney, DJ; Strovel, JW; Urban, DJ; Yang, SM; Yoshioka, M | 1 |
| Guo, Z; Huang, C; Huang, H; Jiang, L; Liao, Y; Liu, J; Liu, Y; Wang, X; Xia, X | 1 |
| Akumtoh, DN; Archer, J; Bakowski, MA; Chappell, L; Chatterjee, AK; Chounna, PW; Chu, XJ; Chunda, VC; Debec, A; Dubben, B; Ehrens, A; Fombad, FF; Frohberger, SJ; Gagaring, K; Gandjui, NV; Guo, H; Hoerauf, A; Hübner, MP; Hull, MV; Joseph, SB; Kuhen, KL; Kwenti, TDB; Landmann, F; Lenz, F; Liu, R; McNamara, CW; Metuge, HM; Murphy, E; Ndzeshang, BL; Njouendou, AJ; Olejniczak, J; Petrassi, HM; Pionnier, N; Roland, J; Schultz, PG; Shiroodi, RK; Sjoberg, H; Steven, A; Struever, D; Sullivan, W; Taylor, MJ; Tremblay, MS; Turner, JD; Wanji, S; White, PM; Woods, AK; Xiong, W; Yang, B | 1 |
| Carter, JJ; Cooper, SL; March, J; Woolard, J | 1 |
| Cai, G; Cai, J; Gao, R; Ji, Q; Li, C; Li, Q; Song, D; Sui, H; Teng, P; Wang, Y; Zhou, L | 1 |
| Aldousari, S; Chevalier, S; Kassouf, W; Mansure, JJ; Nassim, R; Rocha, J; Szymanski, K | 1 |
| Honda, Y; Ichihara, E; Kiura, K; Kubo, T; Kudo, K; Minami, D; Murakami, T; Ninomiya, T; Ochi, N; Takigawa, N; Tanimoto, M | 1 |
| Antequera, D; Bolos, M; Carro, E; Ferrer, I; Gil, C; Krzyzanowska, A; Martinez, A; Pascual, C; Perez, DI; Perez-Gonzalez, R; Pérez-Grijalba, V; Redondo, M; Sarasa, M | 1 |
| Harmann, LM; Meyer, J; Petersen, M; Routhu, KV; Sonin, DL; Strande, JL; Wakatsuki, T | 1 |
| Eda, T; Iwakura, Y; Mizuno, M; Nagata, K; Namba, H; Nawa, H; Okubo, T; Shibuya, M; Sotoyama, H; Wang, R | 1 |
| Chen, M; Dominguez, SL; Eastham-Anderson, J; Le Pichon, CE; Lewin-Koh, N; Ngu, H; Scearce-Levie, K; Solanoy, H; Watts, R | 1 |
| Asano, O; Hishinuma, I; Inoue, C; Ishii, N; Kusano, K; Miyazaki, K; Shirato, M; Takase, Y; Wakita, H; Yamamoto, E | 1 |
| Essenburg, C; Kaufman, D; Lewis, S; Staal, B; Vande Woude, GF; Zhang, YW | 1 |
| Bhave, S; Bruno, PA; Datta, J; Lang, JC; Mapp, AK; Pan, Q; Piao, L; Su, T; Taylor, CE; Teknos, TN; Xie, X; Zhang, M | 1 |
| Feng, Z; Gibbs, RM; Jacques, V; Ko, CP; Li, DK; Lin, MY; Miao, W; Pellizzoni, L; Plasterer, HL; Rucki, AA; Rusche, JR; Sharma, S; Sumner, CJ; Van Meerbeke, JP; Wee, CD; Xia, B | 1 |
| Fu, LX; Tang, DM; Wang, Y; Yan, HX; Yang, XN | 1 |
| Bail, S; Barlow, C; Cardona, H; DiDonato, CJ; Durens, M; Emery, C; Gogliotti, RG; Heier, CR; Jacques, V; Jarecki, J; Jorgensen, M; Kiledjian, M; Kuntz, N; Plasterer, HL; Rusche, J; Singh, J; Xia, B | 1 |
| Gallo, JM; Lv, H; Sharma, J | 1 |
| Abbas, Sel-S; Awadallah, FM; Ibrahim, NA; Kamel, G; Said, EG | 1 |
| Bahare, RS; Khan, SA; Malik, S | 1 |
| Gavine, P; Huang, XS; Ji, Q; Li, M; Su, X; Wu, YL; Xie, L; Yang, XN; Zhan, P; Zhang, J; Zhang, L; Zhang, XC; Zheng, L; Zhong, WZ; Zhou, M; Zhu, G | 1 |
| Daschil, N; Datta, S; Doppler, W; Hannesdóttir, L; Koller, JB; Müller-Holzner, E; Parajuli, N; Philipp, S; Sexl, V; Stoitzner, P; Tripp, CH; Tymoszuk, P; Villunger, A; Wasmer, MH; Wiegers, GJ | 1 |
| Barthwal, MK; Khaliq, T; Mishra, V; Narender, T; Palit, G; Pandey, HP; Singh, VK; Tiwari, S | 1 |
| Akamizu, T; Hattori, Y; Iwakura, H; Kawano, K; Maitani, Y | 1 |
| Garber, C; Keith, C; Kohn, E; Lam, G; Mascia, F; Steinberg, SM; Yuspa, SH | 1 |
| Bhatt, DK; Gupta, S; Hay-Schmidt, A; Jansen-Olesen, I; Olesen, J; Ploug, KB; Ramachandran, R | 1 |
| Chen, Y; Wang, M; Zhao, J; Zhong, W | 1 |
| Cagan, RL; Das, TK | 1 |
| Agar, JN; Agar, NY; Alberta, J; Davis, E; Easterling, ML; Ebling, MC; Ide, JL; Kellersberger, KA; Kesari, S; Liu, X; Marchionni, MA; Norton, I; Santagata, S; Sauvageot, CM; Stiles, CD; Stuart, DD; Wang, LY | 1 |
| Chang, C; Chen, CC; Chuang, WM; Hsieh, TF; Hung, XF; Lin, MH; Ma, WL; Shyr, CR; Tsai, YR; Zhang, C; Zhang, Q | 1 |
| Dai, B; Fang, B; Gao, W; Hofstetter, WL; Lu, H; Meng, J; Minna, J; Roth, JA; Swisher, SG; Wang, L; Wu, S | 1 |
| Becker, MA; Farzan, T; Haluska, P; Harrington, SC; Hou, X; Kalli, KR; Krempski, JW; Weroha, SJ; Wong, TW | 1 |
| Fujii, T; Fujiwara, M; Fukuda, S; Hotta, Y; Kanda, M; Kasuya, H; Kobayashi, D; Kodera, Y; Koike, M; Nakayama, G; Nomoto, S; Sahin, TT; Sugimoto, H; Tan, G; Tanaka, C; Tanaka, M; Tsurumaru, N; Yamada, S; Yamamura, K | 1 |
| Dosaka-Akita, H; Hirata, K; Kuge, Y; Shiga, T; Takei, T; Takeuchi, S; Tamaki, N; Zhao, S; Zhao, Y | 1 |
| Galichet, A; Müller, EJ; Rüegg, S; Sayar, BS; Schmidt, E; Sibilia, M; Siffert, M; Suter, MM | 1 |
| Bailey, ST; Bowman, T; Brown, M; Choi, YJ; Debajit, KB; Foley, KM; Iglehart, JD; Kochupurakkal, B; Maulik, G; Miron, A; Miron, PL; Rodig, SJ; Tian, R | 1 |
| Abrams, MB; Kjell, J; Olson, L; Pernold, K | 1 |
| Anagnostis, P; Karras, S; Krassas, GE | 1 |
| Ambrosini, G; de Stanchina, E; Musi, E; Schwartz, GK | 1 |
| Bokobza, SM; Devery, AM; Jiang, Y; Ryan, AJ; Weber, AM | 1 |
| Burda, WN; Fleeman, R; Manetsch, R; Shaw, LN; Van Horn, KS | 1 |
| Andoh, T; Kuraishi, Y; Yoshida, T | 1 |
| Croft, SL; Sanderson, L; Yardley, V | 1 |
| Bardeesy, N; Caravan, P; Chen, X; Crenshaw, A; DePeralta, DK; Fuchs, BC; Fujii, T; Golub, TR; Gupta, S; Hoshida, Y; Kuroda, T; Lanuti, M; Lauwers, GY; McGinn, CM; Onofrio, R; Schmitt, AD; Tanabe, KK; Taylor, B; Wei, L; Winckler, W; Yamada, S | 1 |
| Burghes, AH; Butchbach, ME; Gurney, ME; Singh, J | 1 |
| Adejumo, O; Allak, A; Hubbard, MA; Jameson, MJ; Khalil, AA; Maxwell, AK; Mendez, RE; Schoeff, SS; VanKoevering, KK | 1 |
| Li, JJ; Li, ZW; Mao, XQ; Shi, GF; Wang, F; Wang, L; Wang, Q; Wu, JJ; Zhang, JP; Zou, J | 1 |
| Diaz-Hernandez, M; Engel, T; Henshall, DC; Hessel, EV; Jimenez-Pacheco, A; Mesuret, G; Miras-Portugal, MT; Sanz-Rodriguez, A | 1 |
| Dohi, K; Frenkel, EP; Hirata, M; Hojo, K; Iguchi, M; Inoue, M; Ishioka, Y; Masuno, K; Matsuo, K; Nezasa, K; Sato, N; Shichijo, M; Shinonome, S; Sugimoto, T; Tanaka, H; Wada, T; Yamada, T; Yonezawa, S | 1 |
| Asada, M; Funahashi, Y; Ito, K; Semba, T; Uenaka, T; Wakabayashi, T | 1 |
| Bartholomeusz, C; Hortobagyi, GN; Humphries, J; Lee, J; Mansour, O; Ordentlich, P; Ueno, NT | 1 |
| Altiok, S; Doshi, P; Fulp, W; Haura, EB; Sasser, K; Smith, MA; Song, L | 1 |
| Chang, FY; Chao, TT; Chen, KF; Chen, YL; Huang, YC; Lin, HI; Shiau, CW; Tsai, YT; Wang, CY; Yu, CJ | 1 |
| Alpini, G; DeMorrow, S; Frampton, G; Galindo, C; McMillin, M; Standeford, H; Thompson, M; Whittington, E | 1 |
| Brodsky, SV; Hebert, LA; Ivanov, I; Muni, N; Nadasdy, G; Nadasdy, T; Rovin, BH; Satoskar, AA; Vance, JC; Ware, KM | 1 |
| Jin, D; Sakonjo, H; Takai, S | 1 |
| Balansky, R; Camoirano, A; D'Agostini, F; De Flora, S; Ganchev, G; Iltcheva, M; Izzotti, A; La Maestra, S; Longobardi, M; Micale, RT; Steele, VE | 1 |
| Bateman, E; Bowen, JM; Boyle, FM; Keefe, DM; Mayo, BJ; Plews, E; Stringer, AM; Wignall, A | 1 |
| Hamada, T; Hayashi, S; Kadowaki, M; Kim, JH; Lee, J; Yamamoto, T; Yashiro, T | 1 |
| Birklein, F; Hirsch, S | 1 |
| Bender, C; Fichtner, I; Fröhlich, H; Herwig, R; Hülsmann, HJ; Jarahian, M; Korf, U; Kuner, R; Merk, J; Rolff, J; Sültmann, H; Thomas, M | 1 |
| Asano, D; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Borger, DR; Byron, VF; DiGloria, CM; Foster, R; Groeneweg, JW; Growdon, WB; Hernandez, SF; Kim, M; Lopez, H; Rueda, BR; Scialabba, V; Tambouret, R; Zhang, L | 1 |
| Bi, LL; Chen, YH; Gao, TM; Geng, F; Li, XW; Liu, F; Liu, JH; Lu, YS; Mei, L; Sun, XD; Wang, J; Zhang, J; Zhang, M | 1 |
| Bhagathavula, N; Dame, MK; Dawes, SM; Elder, JT; Fu, W; Gudjonsson, JE; Johnston, A; Lambert, S; Varani, J; Ward, NL; Warner, RL | 1 |
| Brown, D; Butowski, N; Cheng, SY; Giles, FJ; James, CD; Mazar, AP; Nicolaides, T; Ozawa, T; Parsa, AT; Raizer, JJ; Sarkaria, JN; Shen, W; Stegh, AH; Yao, TW; Yoshida, Y | 1 |
| Adler, KB; Arif, M; Chen, CH; Chiu, CL; Statt, S; Thai, P; Wu, R | 1 |
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| Ishii, N; Shirato, M; Wakita, H | 1 |
| Hasegawa, Y; Katayama, T; Kim-Mitsuyama, S; Koibuchi, N; Kusaka, H; Lin, B; Ma, M; Nakagawa, T; Sueta, D; Toyama, K; Uekawa, K | 1 |
| Cai, H; Cui, Y; Gu, Y; Guo, M; Hong, M; Liang, J; Long, J; Ni, L; Qing, W; Ren, Y; Sai, Y; Su, W; Sun, J; Sun, Q; Yang, H; Yang, Z; Yin, F; Zhang, M; Zhang, W; Zhang, Z; Zhou, F; Zhou, J | 1 |
| Gu, Q; Gui, Y; He, X; Lan, T; Li, W; Qi, C; Tang, F; Wang, L; Wu, T; Xing, L; Yang, Y; Zeng, C; Zhang, Q; Zheng, L | 1 |
| Choi, E; Daugherty, A; Eguchi, S; Elliott, KJ; Forrester, SJ; Fukuda, Y; Kawai, T; Kobayashi, T; Obama, T; Rizzo, V; Takayanagi, T; Taro, Y; Tsuji, T | 1 |
| Agdauletova, S; Daiber, A; Hausding, M; Klein, T; Kröller-Schön, S; Li, H; Mader, M; Mikhed, Y; Münzel, T; Oelze, M; Pfeffer, A; Schulz, E; Stamm, P; Steven, S; Sudowe, S; Welschof, P; Zinßius, E | 1 |
| Bergman, JM; Cabalu, TD; Coleman, PJ; Cui, D; Fox, SV; Garson, SL; Gilbert, KF; Gotter, AL; Harrell, CM; Kuduk, SD; Lemaire, W; Mercer, SP; Prueksaritanont, T; Renger, JJ; Roecker, AJ; Tannenbaum, PL; Winrow, CJ | 1 |
| Marchetti, D; Ngo, JA; Wetzel, MD; Zhang, L | 1 |
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| Abbas, AH; Abou El Ella, DA; Esmat, A; Ismail, NS; Serya, RA | 1 |
| Hu, J; Li, X; Liang, D; Liang, G; Lin, F; Qian, Y; Wang, J; Xu, Z; Zeng, C; Zhong, P | 1 |
| Bhat, WW; Ghosh, B; Lattoo, SK; Mabalirajan, U; Panda, L; Rasool, S; Rather, RA; Rayees, S; Satti, NK; Singh, G | 1 |
| Aguilar-Suárez, R; Correa-Basurto, J; Galindo-Sevilla, N; Hernández-Luis, F; Márquez-Navarro, A; Mendoza-Martínez, C; Montero-Cortes, MD; Nieto-Meneses, R; Nogueda-Torres, B; Rodriguez-Lezama, A; Rojas-Rojas, Á; Suárez-Contreras, E | 1 |
| Davisson, RL; Eguchi, S; Elliott, KJ; Forrester, SJ; Fukuda, Y; Kawai, T; Obama, T; Park, JY; Takayanagi, T; Tilley, DG; Tsuji, T | 1 |
| Cao, D; Chen, L; Li, D; Pei, H; Pu, Y; Tang, M; Xie, C | 1 |
| Jin, ZX; Liu, F; Liu, YX; Min, SY; Wang, L; Zhang, XX; Zhu, ZL; Zuo, Z | 1 |
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| Chamness, GC; Chang, JC; Contreras, A; De Angelis, C; Fu, X; Giuliano, M; Gray, JW; Gutierrez, C; Heiser, LM; Herrera, S; Hilsenbeck, SG; Hu, H; Lopez-Tarruella, S; Mao, S; Nardone, A; Osborne, CK; Pavlick, AC; Rimawi, MF; Schiff, R; Trivedi, MV; Wang, NJ; Wang, T; Wang, YC | 1 |
| Bronshtein, T; Haber, T; Machluf, M; Shivinsky, A | 1 |
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| Arribas, J; Aura, C; Boehm, M; Burgues, O; Cortés, J; Deeds, J; Lluch, A; Marangoni, E; Martínez-Barriocanal, Á; Morancho, B; Mosher, R; Navarro Jiménez, A; Nuciforo, P; Peg, V; Rubio, IT; Schlegel, R; Tabernero, J; Vicario, R; Zacarias-Fluck, M; Zhang, J | 1 |
| Halstead-Nussloch, G; Irie, HY; Ito, K; Katsyv, I; Olcott, W; Park, SH | 1 |
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| Appleton, CT; Beier, F; Mort, JS; Pest, MA; Pitelka, V; Usmani, SE | 1 |
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| Bertotti, A; Catalano, I; Leto, SM; Migliardi, G; Sassi, F; Throsby, M; Torri, V; Trusolino, L; Zanella, ER | 1 |
| Ambrose, A; Arun, BK; Brady, SW; Chang, CC; Dobbs, J; Ibarra-Drendall, C; Jain, S; Jia, W; Kyrish, M; Li, P; Richards-Kortum, R; Seewaldt, VL; Sistrunk, C; Tkaczyk, TS; Wang, H; Wang, X; Yu, D; Zhang, Q; Zhao, H | 1 |
| Chaplain, MAJ; Hill, L; Kapelyukh, Y; Wolf, R | 1 |
| Flores, J; Klebe, D; Krafft, PR; Lekic, T; Rolland, WB; Tang, J; Zhang, JH | 1 |
| Darras, FH; Decker, M; Khan, N; Nurulain, SM; Saad, A; Sadek, B | 1 |
| Ishii, K; Mori, A; Nakahara, T; Nakano, A; Sakamoto, K; Ushikubo, H | 1 |
| Fan, XX; Jiang, ZH; Leung, EL; Liu, L; Liu, ZQ; Lu, LL; Tin, VP; Wong, MP; Yao, XJ; Yau, LF; Zhou, YL | 1 |
| Clark, SW; Ma, Y; Mobley, BC; Sarkaria, JN; Tang, N; Thompson, RC; Wang, J | 1 |
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| Chen, K; Cheng, P; Gao, S; Hu, S; Huang, H; Sun, X; Yu, W | 1 |
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| Cao, YX; He, YY; Mao, S; Xiao, X; Xie, XX; Xin, MH; Xuan, W; Zhang, S; Zhang, SQ; Zuo, SJ | 1 |
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| Chen, KF; Chen, MH; Chen, YT; Chu, PY; Hsu, CC; Hsu, CJ; Hu, MH; Huang, CT; Lee, CH; Liu, CY; Shiau, CW; Tsai, WC; Tseng, LM; Wang, DS | 1 |
| De Andrade, JP; Gu, VW; Kulak, MV; Lorenzen, AW; Park, JM; Spanheimer, PM; Van Dorin, SE; Weigel, RJ; Woodfield, GW; Wu, VT | 1 |
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| Feng, Z; Ju, P; Owlanj, H; Tjandra, E; Yeap, Y; Zhang, S | 1 |
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| Amary, F; Barnard, M; Brüderlein, S; Cottone, L; Drewry, DH; Flanagan, AM; Guppy, N; Jorgensen, M; Leite, AP; Leithner, A; Möller, P; Pillay, N; Scheipl, S; Smith, JA; Strauss, SJ; Tirabosco, R; Turlais, F; Ye, H; Zuercher, WJ | 1 |
| Huang, HY; Ji, H; Wang, Y; Yang, L; Zhang, Z | 1 |
| Allemand, DH; Charreau, EH; Cidlowski, JA; Cordo Russo, RI; Cortese, E; De Martino, M; Elizalde, PV; Guzmán, P; Huang, TH; Izzo, F; Mercogliano, MF; Oakley, RH; Pereyra, MG; Proietti, CJ; Rivas, MA; Roa, JC; Schillaci, R; Venturutti, L; Yankilevich, P | 1 |
| Gao, X; Guo, Q; Han, Y; Hu, C; Liu, M; Wang, J; Wang, Y; Zhang, K | 1 |
| Banno, E; de Velasco, MA; Fujita, Y; Hamada, S; Hayashi, H; Nakahara, H; Nakamura, Y; Nishio, K; Nutahara, K; Okegawa, T; Sakai, K; Terashima, M; Togashi, Y; Tomida, S | 1 |
| Bird, BH; Dodd, KA; Erickson, BR; Shrivastava-Ranjan, P; Spiropoulou, CF | 1 |
| Conklin, DS; Khan, F; Kokabee, L; Sevinsky, CJ; Sun, Y; Wang, X; Wong, J | 1 |
| Aral, A; Can Basaklar, A; Damar, C; Gulbahar, O; Karabulut, R; Kaya, C; Kose, F; Poyraz, A; Sonmez, K; Turkyilmaz, Z | 1 |
| Ariza, L; Atencia-Cibreiro, G; Bosch, A; Calvo, AC; Corfas, G; Esteban-Pérez, J; García-Redondo, A; Gregorio, D; Leiva, T; Mancuso, R; Martínez-Muriana, A; Morell, M; Navarro, X; Osta, R | 1 |
| Bunn, PA; Chan, DC; Gao, D; Helfrich, BA; Kim, J; Tan, AC; Zhang, Z | 1 |
| Bao, S; Feng, SW; Guo, X; Lei, L; Liu, Y; Shen, R; Shen, X; Wang, F; Wang, N; Wang, W; Wang, X; Wang, Y; Wu, H; Xu, S | 1 |
| Darras, FH; Decker, M; Khan, N; Pockes, S; Sadek, B | 1 |
| Eigenmann, MJ; Frances, N; Hoffmann, G; Lavé, T; Walz, AC | 1 |
| Böhning, E; Calvisi, DF; Cigliano, A; Dombrowski, F; Evert, M; Günther, J; Merz, J; Peters, K; Pilo, MG; Ribback, S; Sailer, V; Steinmüller, F; Utpatel, K | 1 |
| Tan, Q; Zhang, J | 1 |
| Al-Masri, AA; El Eter, EA; Lateef, R; Mohamed, OY | 1 |
| Gao, DP; Gao, R; Ji, MH; Shen, JC; Yang, JJ; Yang, RH; Zhang, SG | 1 |
| Ding, Z; Does, MD; Gore, JC; Li, K; Manning, HC; Smith, RA; Waterton, JC; Xu, J; Zhao, P | 1 |
| Ahn, MJ; Bai, Y; Chen, K; Cheng, Z; Guo, Q; Kim, DW; Rabbie, S; Wang, Y; Xu, Y; Yang, JC; Yang, Z; Yin, X; Zhang, L; Zhang, X | 1 |
| Chen, L; Chen, Z; Fu, L; Li, F; Wang, F; Wang, X; Zhang, W | 1 |
| Avery, VM; Baell, JB; Bullen, HE; Cowman, AF; Crabb, BS; Curtis, JM; Di Rago, AE; Duffy, S; Gilson, PR; Hutton, CA; Jarman, KE; Jousset Subroux, H; Lowes, KN; Nguyen, W; Prinz, B; Sleebs, BE; Tan, C | 1 |
| Behnam, B; Gardaneh, M; Kaviani, A; Shojaei, S | 1 |
| Bachoo, RM; Cho, SK; Hatanpaa, KJ; Humphries, CG; Kim, RS; Kittler, R; Klingler, S; Kollipara, RK; Maher, EA; Mashimo, T; Mickey, B; Nannepaga, S; Piccirillo, S; Raisanen, J; Regmi, N; Singh, DK; Sirasanagandla, S; Sun, Y; Vemireddy, V; Wang, S; Yang, XL; Zheng, H | 1 |
| Flores, JJ; Klebe, D; Krafft, PR; Lekic, T; McBride, DW; Rolland, WB; Zhang, JH | 1 |
| Che, H; Fu, P; Gao, Y; Pan, Y; Wang, L; Wang, R; Zhang, L | 1 |
| Cherry, JJ; Fadeyi, O; Foley, TL; Gopalsamy, A; Jones, LH; Kyne, RE; LaRosa, G; Liu, S; Loria, PM; Maglich-Goodwin, J; Menard, C; Nabhan, JF; Narayanan, A; Noell, S; Parikh, MD; Petersen, DN; Ren, Y; Rong, H; Tones, MA | 1 |
| Barber, MM; Burda, WN; Flanigan, DL; Fleeman, R; Manetsch, R; Shaw, LN; Van Horn, KS | 1 |
| Ashton, S; Barry, ST; Caddy, J; Curtis, NJ; Derbyshire, N; Floc'h, N; Harris, E; Hattersley, M; Jacobs, VN; Maratea, K; Odedra, R; Pease, EJ; Pilling, JE; Taylor, P; Trueman, D; Wen, S | 1 |
| Heymach, JV; Nikolinakos, P | 1 |
| Bozec, A; Brunstein, MC; Etienne-Grimaldi, MC; Fischel, JL; Milano, G; Sudaka, A | 1 |
| Bronder, JL; Feigenbaum, L; Gril, B; Herring, JM; Liewehr, DJ; Merino, MJ; Palmieri, D; Rubin, SD; Steeg, PS; Steinberg, SM; Vega-Valle, E | 1 |
| Bartha, E; Habon, T; Halmosi, R; Hideg, K; Kálai, T; Kalman, E; Kiss, GN; Kulcsár, G; Sumegi, B; Toth, K | 1 |
| Bradley, DP; Jürgensmeier, JM; Kilburn, L; Lacey, T; Mills, J; Odedra, R; Scott, M; Tessier, JJ; Wedge, SR | 1 |
| Aberg, A; Andersson, G; Andrews, G; Arvai, AS; Cheshire, DR; Connolly, S; Crane, BR; Garcin, ED; Gensmantel, NP; Getzoff, ED; Hamley, PJ; Kroeger, MD; Mallinder, PR; Mete, A; Nicholls, DJ; Rosenfeld, RJ; St-Gallay, SA; Stuehr, DJ; Tainer, JA; Tinker, AC; Wallace, AV | 1 |
| Becker, M; Fichtner, I; Hammer, S; Hoffmann, J; Merk, J; Rolff, J; Sommer, A; Soong, R | 1 |
| Mark, M; Tadayyon, M; Thomas, L | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Kamijo, M; Matsuoka, N; Minoura, K; Mutoh, S; Shimoshige, Y; Takakura, S | 1 |
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| Castellino, S; Chism, JP; Demby, VE; John-Williams, LS; Olson, KL; Otto, V; Polli, JW; Woodard, SM; Yeager, RL | 1 |
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| Ashton, GH; Baldeschi, C; Brunton, VG; Canel, M; Doyle, B; Frame, MC; Green, TP; Mackintosh, LJ; Mason, SM; Sansom, OJ; Serrels, A; Serrels, B | 1 |
| Hamaguchi, W; Hattori, K; Igarashi, S; Ishikawa, N; Kawano, N; Koganemaru, Y; Masuda, N; Matsumoto, Y; Miyazaki, T; Ogino, S; Ohta, M; Takeuchi, M; Yamasaki, S; Yokoyama, K | 1 |
| Bissonette, R; Brown, PH; Hill, J; Hilsenbeck, SG; Kittrell, F; Medina, D; Zhang, Y | 1 |
| Abba, MC; Aldaz, CM; Bissonnette, RP; Brown, PH; Gaddis, S; Hill, J; Hu, Y; Kittrell, FS; Levy, CC; Medina, D | 1 |
| Davidson, CR; Hardie, WD; Ikegami, M; Korfhagen, TR; Le Cras, TD; Schmidt, SM; Whitsett, JA | 1 |
| JuanYin, J; Kelly, K; Koretsky, A; Munasinghe, J; Shapiro, E; Tracy, K; Zhang, L | 1 |
| Kabashima, K; Mori, T; Nakashima, D; Nishio, D; Tokura, Y | 1 |
| Aracil, M; Jimeno, J; Ling, YH; Perez-Soler, R; Zou, Y | 1 |
| Gerthoffer, WT; Karpurapu, M; Li, Q; Nakaoka, Y; Paria, BC; Rao, GN; Wang, D; Zhang, Q | 1 |
| Aliu, SO; Hann, BC; Hylton, NM; Li, KL; Moasser, MM; Wang, D; Wilmes, LJ | 1 |
| Cox, RA; Enkhbaatar, P; Hamahata, A; Hawkins, HK; Herndon, DN; Jacob, S; Lange, M; Mathew, BP; Traber, DL; Traber, LD | 1 |
| Chadjichristos, C; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Guerrot, D; Helle, F; Jouzel, C; Placier, S | 1 |
| Bhatt, DK; Boni, LJ; Gupta, S; Olesen, J | 1 |
| Bartha, E; Halmosi, R; Hideg, K; Kálai, T; Kereskai, L; Lantos, J; Magyar, K; Plozer, E; Solti, I; Sumegi, B; Szabados, E; Toth, K | 1 |
| Becker, M; Fichtner, I; Leschber, G; Merk, J; Rolff, J | 1 |
| España, A; López-Picazo, JM; López-Zabalza, MJ; Marquina, M; Pelacho, B; Pretel, M | 1 |
| Elenius, K; Grenman, R; Iivanainen, E; Kulmala, J; Lauttia, S; Salven, P; Tvorogov, D; Zhang, N | 1 |
| Gaballah, K; Hills, A; Oakley, R; Partridge, M; Ryan, A | 1 |
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| de Stanchina, E; Goel, A; Gong, Y; Koutcher, JA; Mellinghoff, IK; Ouerfelli, O; Pao, W; Politi, KA; Regales, L; Shen, R; Spassova, M; Vivanco, I; Zakowski, MF | 1 |
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| Andrésson, T; Burghes, AH; Butchbach, ME; Edwards, JD; Gurney, ME; Jarecki, J; Pellizzoni, L; Saieva, L; Simard, LR; Singh, J; Slominski, E; Thorsteinsdóttir, M; Thurmond, J; Zhang, J | 1 |
| Ahn, SK; Choi, H; Choi, NS; Hwang, IC; Im, DS; Kim, SJ; Kim, SW; Kim, YH; Lee, HW; Lee, J; Lee, KJ; Lee, SS; Moon, SK | 1 |
| Aihara, A; Arii, S; Ito, K; Kudo, A; Matsumura, S; Mitsunori, Y; Murakata, A; Nakamura, N; Noguchi, N; Tanaka, S; Yasen, M | 1 |
| Bosenberg, M; Bressel, A; Chin, L; Chiu, MI; Clark, SC; Depinho, RA; Heyer, J; Horner, JW; Jacks, T; Rancourt, R; Reddypalli, S; Rideout, WM; Robinson, MO; Woo, JK; Zhou, Y; Zi, T | 1 |
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| Cheng, N; de Jong, MC; Jiang, L; Li, F; Li, N; Li, Q; Mao, H; Pawlik, TM; Zhou, Y | 1 |
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| Ali, S; Banerjee, S; El-Rayes, BF; Philip, PA; Sarkar, FH; Schaffert, JM | 1 |
| Barabasz, A; Fadden, P; Foley, B; Hall, S; Huang, K; Rice, JW; Scott, A; Steed, P; Veal, JM | 1 |
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| Bai, L; Evans, CP; Gao, AC; Kung, HJ; Yang, JC; Yap, S | 1 |
| Bou Reslan, H; Cao, TC; Carano, RA; Cheng, JH; Clermont, AC; Devasthali, V; Forrest, WF; Fuh, G; Hamilton, P; Ho, CC; Johnson, L; Koeppen, H; Lee, CV; Lima, A; Molina, R; Nannini, MA; Plowman, GD; Singh, M; Thompson, JD; Yu, RX | 1 |
| Bailey, D; Campbell, S; Chatur, S; Chiacchia, FS; Genest, J; Gordon, A; Hafiane, A; Hansen, HC; Jahagirdar, R; Johansson, J; Krimbou, L; Wagner, GS; Wong, NC | 1 |
| Li, H; Wang, Q; Xia, D; Yao, Y; Zhou, J | 1 |
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16 review(s) available for quinazolines and Disease Models, Animal
| Article | Year |
|---|---|
A Drosophila approach to thyroid cancer therapeutics.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drosophila; Drug Evaluation, Preclinical; Humans; Piperidines; Proto-Oncogene Proteins c-ret; Quinazolines; Thyroid Neoplasms | 2013 |
Vandetanib for the treatment of thyroid cancer: an update.
Topics: Animals; Carcinoma, Neuroendocrine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Epidermal Growth Factor; Humans; Piperidines; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Thyroid Neoplasms; Transfection; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Benzodioxoles; Brain; Disease Models, Animal; Humans; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Quinazolines; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Synapses; Thiazoles | 2016 |
Evodiamine and Its Role in Chronic Diseases.
Topics: Analgesics; Animals; Anti-Allergic Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents, Phytogenic; Chronic Disease; Disease Models, Animal; Evodia; Humans; Molecular Structure; Phytotherapy; Plants, Medicinal; Quinazolines; Signal Transduction; Structure-Activity Relationship | 2016 |
The tyrosine kinase inhibitor cediranib for non-small cell lung cancer and other thoracic malignancies.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Neoplasm Staging; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Risk Assessment; Survival Analysis; Thoracic Neoplasms | 2008 |
Linagliptin, a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Topics: Animals; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hypoglycemic Agents; Linagliptin; Purines; Quinazolines; Species Specificity | 2009 |
Antiangiogenic therapies for malignant pleural mesothelioma.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cell Line, Tumor; Disease Models, Animal; Humans; Mesothelioma; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phenylurea Compounds; Piperidines; Pleural Effusion, Malignant; Pleural Neoplasms; Quinazolines; Quinolines; Thoracic Cavity; Vascular Endothelial Growth Factors | 2011 |
[Leptomeningeal meningitis related to breast cancer overexpressing HER2: is there a place for a more specific treatment?].
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blood-Brain Barrier; Breast Neoplasms; Disease Models, Animal; Female; Humans; Lapatinib; Meningeal Carcinomatosis; Meningeal Neoplasms; Primates; Quinazolines; Rats; Receptor, ErbB-2; Trastuzumab | 2011 |
Erlotinib: preclinical investigations.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Transplantation, Heterologous | 2003 |
Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Availability; Cetuximab; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors; Follow-Up Studies; Gefitinib; Humans; Infusions, Intravenous; Neoplasms; Quinazolines | 2004 |
The role of gefitinib in lung cancer treatment.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis | 2004 |
Role of microglia in multiple sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Acute Disseminated; Encephalomyelitis, Autoimmune, Experimental; Humans; Microglia; Models, Biological; Multiple Sclerosis; Quinazolines; T-Lymphocytes | 2005 |
ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety.
Topics: Animals; Anxiety; Cyclohexylamines; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immobility Response, Tonic; Maze Learning; Motor Activity; Quinazolines; Receptors, Somatostatin | 2005 |
[Anti-EGFR therapy: towards a "à la carte" targeting of hepatocellular carcinoma].
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cetuximab; Clinical Trials, Phase II as Topic; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Ligands; Liver Neoplasms; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rats; Signal Transduction; Transforming Growth Factor alpha | 2006 |
Role of prostaglandins in gastroprotection.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastric Mucosa; Humans; Prostaglandins; Quinazolines; Stomach Ulcer | 1998 |
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Chemoprevention; Clinical Trials as Topic; Combined Modality Therapy; Disease Models, Animal; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Lung Neoplasms; Quinazolines; Signal Transduction; Transplantation, Heterologous; Up-Regulation | 2002 |
4 trial(s) available for quinazolines and Disease Models, Animal
| Article | Year |
|---|---|
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.
Topics: Ado-Trastuzumab Emtansine; Adult; Animals; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Datasets as Topic; Disease Models, Animal; DNA Mutational Analysis; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Male; Mice; Mice, Transgenic; Mutation; Neoplasms; Progression-Free Survival; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2 | 2019 |
Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Chemokines; Disease Models, Animal; ErbB Receptors; Exanthema; Female; Gefitinib; Genes, erbB-1; Humans; Inflammation Mediators; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovarian Neoplasms; Quinazolines; RNA, Messenger; Skin; Translational Research, Biomedical | 2013 |
RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.
Topics: Animals; Apolipoprotein A-I; Cells, Cultured; Chlorocebus aethiops; Cholesterol, HDL; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hep G2 Cells; Humans; In Vitro Techniques; Macaca fascicularis; Male; Molecular Weight; Probability; Quinazolines; Quinazolinones; Random Allocation; Risk Assessment | 2010 |
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
458 other study(ies) available for quinazolines and Disease Models, Animal
| Article | Year |
|---|---|
QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model.
Topics: alpha-Fetoproteins; Animals; beta Catenin; Carcinoma, Hepatocellular; Disease Models, Animal; Glycogen Synthase Kinase 3; Hepatocytes; Inflammation; Liver; Liver Neoplasms; MAP Kinase Kinase Kinase 5; NF-kappa B; Organ Specificity; Phenyl Ethers; Quinazolines; Rats; Rats, Sprague-Dawley; Survival Analysis; TNF Receptor-Associated Factor 2; Tumor Necrosis Factor-alpha | 2021 |
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis.
Topics: Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Disease Models, Animal; Endotoxemia; Inosine; Inosine Monophosphate; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Pneumonia, Pneumococcal; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Signal Transduction; Streptococcus pneumoniae; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Diarylheptanoids; Disease Models, Animal; DNA Damage; HaCaT Cells; Humans; Keratinocytes; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; Piperidines; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Skin; Skin Diseases | 2021 |
Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification: A Novel Class of Anti-inflammatory Agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dicarboxylic Acids; Disease Models, Animal; Edema; Hydrazines; Inflammation; Quinazolines; Rats; Rats, Wistar | 2021 |
Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission.
Topics: Animals; Calcitonin Gene-Related Peptide; Dipeptides; Disease Models, Animal; Female; Healthy Volunteers; HEK293 Cells; HIV Infections; HIV-1; Humans; Mice; Mucous Membrane; Peptide Fragments; Primary Cell Culture; Quinazolines; T-Lymphocytes; Tissue Culture Techniques | 2021 |
Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.
Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Free Radical Scavengers; Free Radicals; Humans; I-kappa B Kinase; Imidazoles; Indole Alkaloids; Male; Mice, Inbred ICR; NF-kappa B; Nitriles; P-Selectin; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Protein Kinase Inhibitors; Pulmonary Embolism; Pyridines; Quinazolines; Sulfones; Thrombosis; Transcription Factor RelA | 2022 |
The Quinazoline Otaplimastat (SP-8203) Reduces the Hemorrhagic Transformation and Mortality Aggravated after Delayed rtPA-Induced Thrombolysis in Cerebral Ischemia.
Topics: Acetamides; Animals; Brain Ischemia; Cerebral Hemorrhage; Disease Models, Animal; Endothelial Cells; Fibrinolytic Agents; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Matrix Metalloproteinases; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator | 2022 |
I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Blood-Brain Barrier; Disease Models, Animal; Imidazoles; Imidazolines; Ligands; Mice; Mice, Transgenic; Quinazolines | 2022 |
Quinazoline alkylthio derivative targets norepinephrine and calcitonin gene-related peptide to improve behavior and radiographic score in the rat model of cervical vertigo.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Norepinephrine; Quinazolines; Rats; Vertigo | 2022 |
Novel SARS-CoV-2 entry inhibitors, 2-anilinoquinazolin-4(3H)-one derivatives, show potency as SARS-CoV-2 antivirals in a human ACE2 transgenic mouse model.
Topics: Acetamides; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; COVID-19; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Quinazolines; Rats; SARS-CoV-2 | 2023 |
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus.
Topics: Animals; Anticoagulants; Disease Models, Animal; Hippocampus; Male; Mice; Pilocarpine; Pyrroles; Quinazolines; Receptor, PAR-1; Status Epilepticus; Thrombin | 2019 |
Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Indole Alkaloids; Inflammation; Male; MAP Kinase Signaling System; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Changes in components of the neurovascular unit in the retina in a rat model of retinopathy of prematurity.
Topics: Animals; Disease Models, Animal; Female; Phenylurea Compounds; Pregnancy; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Retina; Retinal Neovascularization; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A | 2020 |
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; Benzodioxoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Computational Biology; Disease Models, Animal; Drug Antagonism; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation; Humans; Liver Neoplasms; Mice; Oxaliplatin; Quinazolines; Signal Transduction; Wnt Proteins; Xenograft Model Antitumor Assays | 2020 |
Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Necrosis; Pancreas; Pancreatitis; Paracrine Communication; Phosphatidylinositol 3-Kinase; Piperidines; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Resveratrol; Severity of Illness Index; Signal Transduction; Taurocholic Acid; Vascular Endothelial Growth Factor A | 2020 |
The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression.
Topics: Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Endothelial Cells; Humans; I-kappa B Kinase; Immunosuppressive Agents; Inflammation Mediators; Jurkat Cells; Keratinocytes; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Phenotype; Psoriasis; Quinazolines; Skin; Th17 Cells; U937 Cells | 2020 |
The Noonan Syndrome Gene
Topics: Animals; Blood Vessels; Carcinoma, Lewis Lung; Disease Models, Animal; Endosomal Sorting Complexes Required for Transport; Endosomes; Endothelial Cells; Haploinsufficiency; HeLa Cells; Hemorrhage; Humans; Lymphokines; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Noonan Syndrome; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Signal Transduction; Transcription Factors; Ubiquitination; Vascular Endothelial Growth Factor Receptor-2; Vascular Malformations | 2020 |
No central action of CGRP antagonising drugs in the GTN mouse model of migraine.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Injections, Intraventricular; Mice; Migraine Disorders; Nitroglycerin; Piperazines; Quinazolines; Vasodilator Agents | 2020 |
In vivo efficacy studies of novel quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors, in lung cancer xenografts (NCI-H1975) mice models.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Structure-Activity Relationship | 2020 |
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzamides; Blood-Brain Barrier; Brain; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Glioblastoma; Humans; Kinesins; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Proteins; Quinazolines; Tetrahydroisoquinolines; Xenograft Model Antitumor Assays | 2020 |
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Topics: Animals; Cell Movement; Cell Proliferation; Crown Ethers; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Hypertension, Pulmonary; In Vitro Techniques; MAP Kinase Signaling System; Microfilament Proteins; Monocrotaline; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Quinazolines; Rats; Signal Transduction; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Vimentin | 2020 |
SKLB1002, a potent inhibitor of VEGF receptor 2 signaling, inhibits endothelial angiogenic function in vitro and ocular angiogenesis in vivo.
Topics: Animals; Burns, Chemical; Cell Movement; Cell Proliferation; Cornea; Corneal Diseases; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred ICR; Neovascularization, Physiologic; Ophthalmic Solutions; Quinazolines; Signal Transduction; Thiadiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.
Topics: Analgesics, Opioid; Animals; Cold Temperature; Cytokines; Disease Models, Animal; Drug Synergism; Ganglia, Spinal; Hyperalgesia; Male; Mice; Morphine; Neuralgia; Peripheral Nerve Injuries; Quinazolines; Rats, Wistar; Receptors, CCR4; Sciatic Nerve; Spinal Cord; Touch | 2020 |
Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production.
Topics: Acetates; Animals; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Feces; Gastrointestinal Agents; Gastrointestinal Microbiome; Inflammation Mediators; Intestinal Mucosa; Lactobacillus acidophilus; Male; Metabolomics; Quinazolines; Rats, Sprague-Dawley; Ribotyping | 2020 |
Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Topics: Animals; Collagen Type III; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Macrophages; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Pyrroles; Quinazolines; Receptor, PAR-1; Renin; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Rutaecarpine exhibits anti-diabetic potential in high fat diet-multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Glucose; Homeostasis; Hypoglycemic Agents; Indole Alkaloids; Liver; Male; Mice, Inbred C57BL; Quinazolines | 2020 |
Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cisplatin; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Epithelial Cells; Humans; Indole Alkaloids; Kidney Tubules; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Oxidative Stress; Protein Binding; Quinazolines | 2020 |
Anti-allergic effect of the Src family kinase inhibitor saracatinib.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Benzodioxoles; Cell Line; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Immunoglobulin E; Male; Mast Cells; Mice; Mice, Hairless; Phosphorylation; Quinazolines; Rats; src-Family Kinases | 2020 |
JANEX-1 improves acute pulmonary embolism through VEGF and FAK in pulmonary artery smooth muscle cells.
Topics: Acute Disease; Animals; Cell Proliferation; Disease Models, Animal; Focal Adhesion Protein-Tyrosine Kinases; Janus Kinase 3; Lung; Male; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Pulmonary Artery; Pulmonary Embolism; Quinazolines; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2020 |
CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain.
Topics: Animals; Behavior, Animal; Biomarkers; Buprenorphine; Disease Models, Animal; Drug Synergism; Injections, Spinal; Male; Mice; Models, Animal; Morphine; Neuralgia; Pain Management; Quinazolines; Receptors, CCR4; Time Factors; Treatment Outcome | 2020 |
Combination of Fruquintinib and Anti-PD-1 for the Treatment of Colorectal Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzofurans; CD8 Antigens; Cell Line, Tumor; Chemotherapy, Adjuvant; Colectomy; Colorectal Neoplasms; Disease Models, Animal; Drug Synergism; Humans; Immune Checkpoint Inhibitors; Male; Mice; Mice, Knockout; Microsatellite Instability; Programmed Cell Death 1 Receptor; Quinazolines; Receptors, Vascular Endothelial Growth Factor; T-Lymphocytes, Regulatory; Treatment Outcome; Tumor Microenvironment; Young Adult | 2020 |
Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.
Topics: Animals; Benzofurans; Cell Movement; Cell Proliferation; Choroidal Neovascularization; Disease Models, Animal; Endothelial Cells; Humans; Macrophages; Male; Mice; Mice, Transgenic; Quinazolines; Vascular Endothelial Growth Factor A | 2020 |
Ameliorative potential of Adhatoda vasica against anti-tubercular drugs induced hepatic impairments in female Wistar rats in relation to oxidative stress and xeno-metabolism.
Topics: Alkaloids; Animals; Antitubercular Agents; Arylamine N-Acetyltransferase; Chemical and Drug Induced Liver Injury; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP2E1; Disease Models, Animal; Female; Free Radical Scavengers; Gene Expression Regulation; Glucuronosyltransferase; Isoniazid; Justicia; Oxidative Stress; Plant Extracts; Plant Leaves; Pregnane X Receptor; Pyrazinamide; Quinazolines; Rats, Wistar; Rifampin | 2021 |
Down-regulated microRNA-199a-3p enhances osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Kdm3a in ovariectomized rats.
Topics: Animals; Antigens, CD; Azepines; Bone and Bones; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Gene Knockdown Techniques; Gene Regulatory Networks; Genes, Reporter; Histone Demethylases; Humans; Kruppel-Like Transcription Factors; Mesenchymal Stem Cells; MicroRNAs; Mitogen-Activated Protein Kinase 1; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Quinazolines; Rats; Rats, Sprague-Dawley | 2021 |
The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis.
Topics: Adipocytes, Beige; Adipocytes, White; AMP-Activated Protein Kinases; Animals; Biological Products; Disease Models, Animal; DNA-Binding Proteins; Drug Evaluation, Preclinical; In Vitro Techniques; Indole Alkaloids; Male; Mice; Mice, Transgenic; Models, Biological; Obesity; Oxygen Consumption; Quinazolines; Signal Transduction; Thermogenesis; Transcription Factors | 2021 |
Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway.
Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; HMGB1 Protein; Inflammation; NF-kappa B; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation.
Topics: alpha-Synuclein; Animals; Blood-Brain Barrier; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Humans; Male; Mice; Mice, Inbred C57BL; Piperazines; Quinazolines; RNA, Small Interfering; Synucleinopathies | 2021 |
Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Adenine; Adenosine; Animals; Bronchoalveolar Lavage Fluid; Cadherins; Class I Phosphatidylinositol 3-Kinases; Claudins; Cytokines; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Quinazolines; Quinolines | 2021 |
Vandetanib versus Cabozantinib in Medullary Thyroid Carcinoma: A Focus on Anti-Angiogenic Effects in Zebrafish Model.
Topics: Angiogenesis Inhibitors; Anilides; Animals; Apoptosis; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Embryo, Nonmammalian; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Piperidines; Pyridines; Quinazolines; Thyroid Neoplasms; Zebrafish | 2021 |
Targeting protein lysine methyltransferase G9A impairs self-renewal of chronic myelogenous leukemia stem cells via upregulation of SOX6.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells; Primary Cell Culture; Quinazolines; SOXD Transcription Factors; Xenograft Model Antitumor Assays | 2021 |
Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Becaplermin; Cell Plasticity; Cells, Cultured; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phenotype; Phosphorylation; Plaque, Atherosclerotic; Quinazolines; Signal Transduction | 2021 |
Design, synthesis, and pharmacological characterization of some 2-substituted-3-phenyl-quinazolin-4(3H)-one derivatives as phosphodiesterase inhibitors.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Cognitive Dysfunction; Disease Models, Animal; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Phosphodiesterase Inhibitors; Quinazolines; Scopolamine; Structure-Activity Relationship; Sulfides | 2021 |
Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity.
Topics: Alzheimer Disease; Animals; Apoptosis; Brain; Cell Line; Cognition; Cognition Disorders; Disease Models, Animal; Humans; Male; Maze Learning; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neurons; Neuroprotection; Neuroprotective Agents; Okadaic Acid; Phosphorylation; Quinazolines; Spatial Memory; tau Proteins; Tauopathies | 2021 |
Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy.
Topics: Animals; Benzodioxoles; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Inflammation Mediators; Kainic Acid; Male; Proto-Oncogene Proteins c-fyn; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Telemetry | 2021 |
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Benzylamines; Cell Line, Tumor; Chaperone-Mediated Autophagy; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; HeLa Cells; HSC70 Heat-Shock Proteins; Humans; I-kappa B Kinase; Isoenzymes; Male; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; PC12 Cells; Phenylurea Compounds; Quinazolines; Rats; Signal Transduction | 2021 |
NMDA receptor antagonism with novel indolyl, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hippocampus; Indoles; Male; Malondialdehyde; Molecular Docking Simulation; Protein Binding; Quinazolines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2017 |
Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling.
Topics: Animals; Apoptosis; Becaplermin; Carotid Arteries; Carotid Artery Injuries; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Janus Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transfection; Vascular Remodeling | 2017 |
Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells.
Topics: Anilides; Animals; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Dynamics; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinazolines; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; High-Throughput Screening Assays; Imidazoles; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred Lew; Structure-Activity Relationship | 2017 |
Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Biomarkers; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Clonal Evolution; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glycosphingolipids; Humans; Isoenzymes; Mice; Neoplastic Stem Cells; Phenotype; Quinazolines; Receptors, Growth Factor; Retinal Dehydrogenase; Sialyltransferases; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response.
Topics: Animals; Biomarkers; Biopsy; Blood Urea Nitrogen; Cytokines; Disease Models, Animal; Indole Alkaloids; Inflammation Mediators; Kidney Diseases; Kidney Function Tests; Male; MAP Kinase Signaling System; Oxidative Stress; Phosphorylation; Protective Agents; Quinazolines; Rats; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2017 |
Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression.
Topics: Animals; Central Nervous System Sensitization; Dipeptides; Disease Models, Animal; Hyperalgesia; Isosorbide Dinitrate; Male; Migraine Disorders; Nitric Oxide Donors; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Sumatriptan; Vasoconstrictor Agents; Vasodilator Agents | 2018 |
Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Male; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Quinazolines; Seizures; Structure-Activity Relationship | 2017 |
Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model.
Topics: Actins; Animals; Carotid Arteries; Carotid Artery Injuries; Cyclic GMP; Disease Models, Animal; Gene Expression Regulation; Hyperplasia; Indole Alkaloids; Male; Nitric Oxide; Phosphorylation; Proliferating Cell Nuclear Antigen; Quinazolines; Rats, Sprague-Dawley; RNA, Messenger; Tunica Intima | 2018 |
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.
Topics: Animals; Cell Line; Disease Models, Animal; Endoribonucleases; Enzyme Inhibitors; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Mice; Mice, Knockout; Muscular Atrophy, Spinal; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Survival of Motor Neuron 2 Protein | 2017 |
Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; ErbB Receptors; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Quinazolines; Rats; Tyrphostins | 2018 |
Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Monitoring; Female; Humans; Lapatinib; Mass Spectrometry; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Tissue Distribution; Treatment Outcome; Xenograft Model Antitumor Assays | 2018 |
Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.
Topics: Animals; Capillaries; Cell Proliferation; Disease Models, Animal; N-Methylaspartate; Phenylurea Compounds; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A | 2018 |
Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Fertility; Gefitinib; Heterografts; Humans; Methotrexate; Mice; Microtubules; Miosis; Placenta; Pregnancy; Pregnancy, Ectopic; Quinazolines; Trophoblasts; Vinblastine; Vinorelbine | 2018 |
Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation; Hippocampus; Humans; Learning Disabilities; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Dynamics; Neurogenesis; Phosphodiesterase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction | 2018 |
PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis.
Topics: Adenine; Animals; Asthma; Disease Models, Animal; Endoplasmic Reticulum Stress; Lipid Peroxidation; Lipopolysaccharides; Membrane Proteins; Mice; Nerve Tissue Proteins; NF-kappa B; Ovalbumin; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Receptors, Cell Surface; Signal Transduction | 2018 |
Saracatinib impairs maintenance of human T-ALL by targeting the LCK tyrosine kinase in cells displaying high level of lipid rafts.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Disease Models, Animal; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Microdomains; Membrane Potential, Mitochondrial; Mice; Neoplastic Stem Cells; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2018 |
Gefitinib inhibits retina angiogenesis by affecting VEGF signaling pathway.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Cyclin E; Cyclin-Dependent Kinase 2; Disease Models, Animal; Gefitinib; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Oxygen; Platelet Endothelial Cell Adhesion Molecule-1; Quinazolines; Retinal Diseases; Retinal Vessels; Vascular Endothelial Growth Factor A | 2018 |
Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Heterocyclic Compounds, 3-Ring; Lapatinib; Male; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triazoles | 2018 |
Establishment of an abnormal vascular patterning model in the mouse retina.
Topics: Animals; Animals, Newborn; Choroid; Disease Models, Animal; Electroretinography; Female; Ischemia; Male; Mice, Inbred ICR; Phenylurea Compounds; Quinazolines; Retina; Retinal Vessels; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A | 2018 |
Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.
Topics: Afatinib; Animals; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Exons; Humans; Lung Neoplasms; Mice; Mutagenesis, Insertional; Mutation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Tumor Burden | 2018 |
A blood biomarker for monitoring response to anti-EGFR therapy.
Topics: Animals; Antineoplastic Agents; Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mice; Peroxiredoxin VI; Protein Kinase Inhibitors; Quinazolines; Treatment Outcome; Xenograft Model Antitumor Assays | 2018 |
Gefitinib for Epidermal Growth Factor Receptor Activated Osteoarthritis Subpopulation Treatment.
Topics: Animals; Cartilage, Articular; Collagen Type II; Disease Models, Animal; ErbB Receptors; Gefitinib; Humans; Mice; Mice, Transgenic; Osteoarthritis; Precision Medicine; Quinazolines; Signal Transduction | 2018 |
Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Disease Models, Animal; Drug Carriers; Enzyme Inhibitors; Head and Neck Neoplasms; Mice; Nanomedicine; Nanoparticles; Neoplasm Metastasis; Quinazolines; Snail Family Transcription Factors; src-Family Kinases; Vimentin | 2018 |
Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; BRCA1 Protein; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Intracellular Signaling Peptides and Proteins; Mammary Neoplasms, Animal; Metformin; Mice; Mitochondria; Models, Biological; Organelle Biogenesis; Oxidative Stress; Phosphorylation; Quinazolines; Substrate Specificity; TOR Serine-Threonine Kinases; Treatment Outcome | 2018 |
Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-de
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Azepines; Breast Neoplasms; Caspase 8; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Female; Heterografts; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Mice; Models, Biological; Quinazolines; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP | 2018 |
Efficacy of combined icotinib and pemetrexed in EGFR mutant lung adenocarcinoma cell line xenografts.
Topics: Adenocarcinoma of Lung; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crown Ethers; Disease Models, Animal; Drug Therapy, Combination; ErbB Receptors; Female; Humans; Mice; Mutation; Pemetrexed; Proto-Oncogene Proteins c-akt; Quinazolines; Xenograft Model Antitumor Assays | 2018 |
Evodiamine inhibits gastrointestinal motility via CCK and CCK1 receptor in water-avoidence stress rat model.
Topics: Animals; Avoidance Learning; Biomarkers; Disease Models, Animal; Gastrointestinal Motility; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Stress, Psychological | 2018 |
K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Avoidance Learning; Brain; Cell Line, Transformed; Chitinase-3-Like Protein 1; Disease Models, Animal; Drug Administration Schedule; Drug Delivery Systems; Encephalitis; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Microglia; NF-kappa B; Peptide Fragments; Quinazolines; Recognition, Psychology; Retention, Psychology | 2018 |
Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Carrageenan; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Male; Mice; Molecular Structure; Nitric Oxide; Picrates; Quinazolines; Rats, Wistar; Structure-Activity Relationship; Thiophenes | 2018 |
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Quinazolines; Rats; Remyelination; Signal Transduction; Time Factors | 2018 |
Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cytoskeletal Proteins; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Mice; Quinazolines; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2018 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Long-Term Potentiation; Male; Pilocarpine; Pyrroles; Quinazolines; Rats, Wistar; Receptor, PAR-1; Status Epilepticus | 2019 |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Brain; Disease Models, Animal; Humans; Mice; Microtubules; Neurons; Quinazolines; tau Proteins; Tauopathies; Triazoles | 2018 |
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
Anagrelide for Gastrointestinal Stromal Tumor.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cyclic Nucleotide Phosphodiesterases, Type 3; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gastrointestinal Stromal Tumors; High-Throughput Screening Assays; Humans; Mice; Platelet Aggregation Inhibitors; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2019 |
Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quinazolines; Signal Transduction; Skin; Skin Diseases; Th17 Cells; Toll-Like Receptor 7 | 2019 |
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Topics: Animals; Blood Proteins; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Half-Life; Hepatocytes; Humans; Lapatinib; Mice; Microsomes, Liver; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thermodynamics; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Water | 2019 |
Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Epigenesis, Genetic; Ethanol; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Male; Neuropeptide Y; Quinazolines; Rats; Rats, Sprague-Dawley | 2019 |
Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Female; Haploinsufficiency; Histone-Lysine N-Methyltransferase; Histones; Male; Methylation; Mice; Microfilament Proteins; Nerve Tissue Proteins; Prefrontal Cortex; Quinazolines | 2020 |
Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Ganglia, Spinal; Humans; Inflammation Mediators; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuralgia; Oxidative Stress; Paclitaxel; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Quinazolines; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Cells, Cultured; Uncoupling Protein 2 | 2019 |
Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Neuregulin-1; Neurons; Neuroprotective Agents; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-4; Spatial Learning; Temporal Lobe; Tyrphostins | 2019 |
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis; Cell Cycle Proteins; Disease Models, Animal; Half-Life; Humans; Kinetics; Mice; Neoplasms; Quinazolines; Structure-Activity Relationship; Transcription Factors | 2019 |
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer.
Topics: Animals; Apoptosis; Autophagy; Benzamides; Benzylamines; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease Models, Animal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Models, Biological; Molecular Targeted Therapy; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2019 |
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Discovery; Female; Filariasis; Filarioidea; High-Throughput Screening Assays; Mice; Phenotype; Quinazolines; Small Molecule Libraries; Wolbachia | 2019 |
Long-term cardiovascular effects of vandetanib and pazopanib in normotensive rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Drug Administration Schedule; Humans; Hypertension; Indazoles; Male; Piperidines; Pyrimidines; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides | 2019 |
Development of EGFR-targeted evodiamine nanoparticles for the treatment of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neoplasms, Experimental; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer.
Topics: Animals; Antineoplastic Agents; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; ErbB Receptors; Female; Gefitinib; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Mice; PPAR gamma; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tumor Burden; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model.
Topics: Afatinib; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Exons; Female; Gefitinib; Heterografts; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2 | 2013 |
Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Behavior; Cells, Cultured; Cognition; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Mice; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Signal Transduction; tau Proteins | 2013 |
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Imaging, Three-Dimensional; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Transforming Growth Factor beta; Ventricular Remodeling | 2013 |
ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Male; Motor Activity; Quinazolines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology | 2013 |
EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Biomarkers; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Humans; Longevity; Mice; Mice, Transgenic; Microglia; Motor Neurons; Neuromuscular Junction; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Spinal Cord; Staining and Labeling; Superoxide Dismutase; Superoxide Dismutase-1; Survival Analysis; Synapses; Time Factors | 2013 |
Antipruritic effect of the topical phosphodiesterase 4 inhibitor E6005 ameliorates skin lesions in a mouse atopic dermatitis model.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Cell Adhesion Molecules; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Humans; Lymphocytes; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Monocytes; Phosphodiesterase 4 Inhibitors; Phthalic Acids; Quinazolines; Rats; Rats, Sprague-Dawley; Skin; Tissue Distribution | 2013 |
Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridazines; Quinazolines; Signal Transduction; Small Cell Lung Carcinoma; Triazoles; Xenograft Model Antitumor Assays | 2013 |
Genetic and chemical targeting of epithelial-restricted with serine box reduces EGF receptor and potentiates the efficacy of afatinib.
Topics: Afatinib; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; DNA-Binding Proteins; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Head and Neck Neoplasms; Heterografts; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Quinazolines; Receptor, ErbB-2; Squamous Cell Carcinoma of Head and Neck; Transcription Factors | 2013 |
The DcpS inhibitor RG3039 improves motor function in SMA mice.
Topics: Animals; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endoribonucleases; Humans; Mice; Mice, Transgenic; Motor Neurons; Muscles; Muscular Atrophy, Spinal; Neuromuscular Junction; Quinazolines; Ribonucleoproteins, Small Nuclear; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Synaptic Transmission | 2013 |
A new selective vascular endothelial growth factor receptor 2 inhibitor ablates disease in a mouse model of psoriasis.
Topics: Animals; Capillary Permeability; Disease Models, Animal; Inflammation; Mice; Mice, Transgenic; Neovascularization, Pathologic; Psoriasis; Quinazolines; Skin; T-Lymphocytes; Thiadiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endoribonucleases; Female; Humans; Mice; Mice, Transgenic; Motor Neurons; Muscular Atrophy, Spinal; Quinazolines; Survival of Motor Neuron 2 Protein; Synapses | 2013 |
Intratumoral modeling of gefitinib pharmacokinetics and pharmacodynamics in an orthotopic mouse model of glioblastoma.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Glioblastoma; Humans; Male; Mice; Mice, Nude; Phosphorylation; Quinazolines; Xenograft Model Antitumor Assays | 2013 |
Design and synthesis of some 3-substituted-2-[(2,4-dichlorophenoxy)-methyl]quinazolin-4(3H)-one derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Female; Hydrazines; Lethal Dose 50; Male; Mice; Neurons; Pentylenetetrazole; Quinazolines; Quinazolinones; Seizures; Triazines | 2013 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Injections, Intraperitoneal; Mice; Molecular Structure; Quinazolines; Rats; Rats, Wistar; Seizures; Thiazoles; Thioamides | 2013 |
Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; DNA Mutational Analysis; ErbB Receptors; Female; Gefitinib; Genes, ras; Genetic Variation; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, SCID; Mutation; Neoplasm Transplantation; Proto-Oncogene Proteins c-met; Quinazolines; ras Proteins; Receptor, Fibroblast Growth Factor, Type 1; Xenograft Model Antitumor Assays | 2013 |
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response.
Topics: Animals; Antigens, Neoplasm; Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Chemotaxis; Disease Models, Animal; Doxorubicin; ErbB Receptors; Female; Humans; In Vitro Techniques; Interferon-gamma; Lapatinib; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, ErbB-2; STAT1 Transcription Factor | 2013 |
Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers.
Topics: Alcohols; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cold Temperature; Disease Models, Animal; H(+)-K(+)-Exchanging ATPase; Male; Molecular Structure; Omeprazole; Peganum; Plant Extracts; Pylorus; Quinazolines; Rats; Rats, Sprague-Dawley; Seeds; Stomach Ulcer; Sucralfate | 2013 |
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Gefitinib; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroblastoma; Polyethylene Glycols; Quinazolines; Transcriptome | 2013 |
Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Migraine Disorders; Neurokinin-1 Receptor Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitroglycerin; Piperazines; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Trigeminal Nerve; Vasodilator Agents; Wakefulness | 2014 |
Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gefitinib; Humans; Lung Neoplasms; Mice; Protein Kinase Inhibitors; Quinazolines | 2013 |
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.
Topics: Animals; Antineoplastic Agents; Biomarkers; Blood-Brain Barrier; Brain Neoplasms; Disease Models, Animal; Erlotinib Hydrochloride; Glioma; Heme; Heterografts; Humans; Mice; Molecular Imaging; Neovascularization, Pathologic; Optical Imaging; Permeability; Pharmaceutical Preparations; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase Inhibitors; Quinazolines; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation.
Topics: Androgens; Animals; Butylhydroxybutylnitrosamine; Carcinogenesis; Castration; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Urinary Bladder Neoplasms | 2013 |
IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Inhibitory Concentration 50; Insulin-Like Growth Factor Binding Protein 2; Lung Neoplasms; Mice; Mutation; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
Dual HER/VEGF receptor targeting inhibits in vivo ovarian cancer tumor growth.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Disease Progression; Female; Humans; Mice; Neoplasm Grading; Ovarian Neoplasms; Piperidines; Protein Kinase Inhibitors; Proteomics; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Triazines; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Combination treatment of human pancreatic cancer xenograft models with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib and oncolytic herpes simplex virus HF10.
Topics: Animals; Apoptosis; Cell Proliferation; Combined Modality Therapy; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Oncolytic Virotherapy; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Simplexvirus; Survival Rate; Tumor Cells, Cultured; Virus Internalization; Virus Replication; Xenograft Model Antitumor Assays | 2014 |
Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Female; Fluorodeoxyglucose F18; Gefitinib; Humans; Ki-67 Antigen; Mice; Neoplasms; Phosphorylation; Quinazolines; Radiopharmaceuticals; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus vulgaris in a non-linear, V-shaped relationship.
Topics: Animals; Animals, Newborn; Cells, Cultured; Desmoglein 1; Desmoglein 3; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Humans; Keratinocytes; Lapatinib; Mice; Mice, Inbred C57BL; Mice, Knockout; Nonlinear Dynamics; Pemphigus; Quinazolines | 2014 |
NF-κB activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Growth Processes; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; Mice; Mice, Nude; NF-kappa B; Quinazolines; Receptor, ErbB-2; Signal Transduction; Xenograft Model Antitumor Assays | 2014 |
Oral erlotinib, but not rapamycin, causes modest acceleration of bladder and hindlimb recovery from spinal cord injury in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Erlotinib Hydrochloride; Female; Hindlimb; Immunosuppressive Agents; Locomotion; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Recovery of Function; Sirolimus; Spinal Cord Injuries; Urinary Bladder | 2014 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, erbB-1; Heterografts; Histones; Humans; Lung Neoplasms; Mice; Mitogen-Activated Protein Kinase Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Quinazolines; Xenograft Model Antitumor Assays | 2014 |
Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines.
Topics: Animals; Anti-Bacterial Agents; Diamines; Disease Models, Animal; Hemolysis; Humans; Larva; Microbial Sensitivity Tests; Molecular Structure; Peritonitis; Quinazolines; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship | 2014 |
Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch-related responses in mice with chronic atopy-like dermatitis.
Topics: Animals; Antipruritics; Cyclic AMP; Dermatitis, Atopic; Disease Models, Animal; Inflammation; Male; Mice; Phosphodiesterase 4 Inhibitors; Phthalic Acids; Pruritus; Quinazolines; Signal Transduction; Skin | 2014 |
Activity of anti-cancer protein kinase inhibitors against Leishmania spp.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Disease Models, Animal; Drug Repositioning; Indoles; Inhibitory Concentration 50; Lapatinib; Leishmania; Leishmaniasis; Mice, Inbred BALB C; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Treatment Outcome | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Hepatic Stellate Cells; Hepatocytes; Humans; Ligation; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Phosphorylation; Prognosis; Quinazolines; Rats; Rats, Wistar; Transcriptome | 2014 |
The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice.
Topics: Animals; Brain; Diet; Disease Models, Animal; Female; Male; Mice; Muscular Atrophy, Spinal; Pregnancy; Prenatal Exposure Delayed Effects; Quinazolines; Severity of Illness Index; SMN Complex Proteins; Spinal Cord; Treatment Outcome | 2014 |
Nanoimmunoassay to Detect Responses in Head and Neck Cancer: Feasibility in a Mouse Model.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Feasibility Studies; Gefitinib; Head and Neck Neoplasms; Heterografts; Immunoassay; In Vitro Techniques; Mice; Nanotechnology; Quinazolines | 2014 |
Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Gliosis; Kidney Diseases; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Spinal Cord Injuries | 2014 |
P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage.
Topics: Amygdala; Animals; Animals, Newborn; Bumetanide; Cell Death; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Male; Purinergic P2X Receptor Antagonists; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Potassium Chloride Symporter Inhibitors; Status Epilepticus; Tetrazoles | 2014 |
Preclinical antitumor activity of S-222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Mice; Mice, Nude; Mice, SCID; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays | 2014 |
Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Indoles; Lung Neoplasms; Mice; Mice, Nude; Quinazolines; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Lapatinib; Mice; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, ErbB-2; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Female; Fibroblasts; Humans; Interleukin-6; Lung Neoplasms; Mice; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Serine; STAT3 Transcription Factor; Tyrosine | 2014 |
CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
Topics: Animals; Apoptosis; Autoantigens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Mice; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Transcription, Genetic | 2014 |
Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
Topics: Animals; Azoxymethane; Benzamides; Body Temperature; Body Weight; Carcinogens; Chemokine CCL2; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hepatic Encephalopathy; Liver; Male; Mice; Mice, Inbred C57BL; Microglia; Nervous System Diseases; Quinazolines; Signal Transduction; Time Factors; Up-Regulation | 2014 |
Oral warfarin and the thrombin inhibitor dabigatran increase blood pressure in rats: hidden danger of anticoagulants?
Topics: Acetylcysteine; Animals; Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzimidazoles; beta-Alanine; Blood Pressure; Dabigatran; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Nephrectomy; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Renal Insufficiency, Chronic; Vitamin K; Warfarin | 2015 |
Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.
Topics: Animals; Atherosclerosis; Blood Glucose; Carotid Arteries; Chemokine CCL2; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; In Vitro Techniques; Insulin; Linagliptin; Malondialdehyde; NADPH Oxidases; Purines; Pyrazines; Quinazolines; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Vasodilation | 2014 |
Assay of lapatinib in murine models of cigarette smoke carcinogenesis.
Topics: Animals; Antineoplastic Agents; Body Weight; Disease Models, Animal; DNA Adducts; DNA Damage; Erythrocytes; Gene Expression Regulation; Lapatinib; Lung; Lung Neoplasms; Mice; MicroRNAs; Protein Kinase Inhibitors; Quinazolines; Tobacco Smoke Pollution; Toxicity Tests, Subchronic | 2014 |
Determining the mechanisms of lapatinib-induced diarrhoea using a rat model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Disease Models, Animal; ErbB Receptors; Goblet Cells; Intestinal Mucosa; Intestines; Lapatinib; Male; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Receptor, ErbB-2 | 2014 |
CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Diarrhea; Disease Models, Animal; Food Hypersensitivity; Male; Mast Cells; Mastocytosis; Mice; Mice, Inbred BALB C; Microtubules; Neurotransmitter Agents; Ovalbumin; Piperazines; Quinazolines; Sensory Receptor Cells | 2014 |
[Pain-relieving effect of CGRP antagonism on inflammatory pain].
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Chronic Pain; Disease Models, Animal; Inflammation; Neurons; Pain Threshold; Piperazines; Quinazolines; Rats; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord | 2014 |
Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Mice; Protein Kinase Inhibitors; Pyrones; Quinazolines; Signal Transduction; Thiophenes; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina.
Topics: Age Factors; Animals; Animals, Newborn; Capillaries; Collagen Type IV; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Male; N-Methylaspartate; Neurotoxicity Syndromes; Phenylurea Compounds; Plant Lectins; Quinazolines; Rats; Rats, Sprague-Dawley; Rec A Recombinases; Retinal Degeneration; Statistics, Nonparametric; Vascular Endothelial Growth Factor A | 2015 |
Dual HER2 targeting impedes growth of HER2 gene-amplified uterine serous carcinoma xenografts.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Models, Animal; Female; Gene Amplification; Gene Expression; Humans; Lapatinib; Mice; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Tumor Burden; Uterine Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors.
Topics: Amygdala; Animals; Anxiety; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Feeding Behavior; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; GPI-Linked Proteins; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Nogo Receptor 1; Pyrimidines; Quinazolines; Reaction Time; Receptor, ErbB-4; Receptors, Cell Surface; Signal Transduction; Tyrphostins | 2015 |
Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture.
Topics: Animals; Biopsy; Dermatitis; Disease Models, Animal; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Humans; Hyperplasia; In Vitro Techniques; Interleukin-1; Mice; Mice, Transgenic; Organ Culture Techniques; Phenotype; Quinazolines; Receptor, TIE-2; Skin | 2015 |
NT113, a pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Amplification; Gene Expression; Glioblastoma; Humans; Lapatinib; Mice; Quinazolines; Tissue Distribution; Xenograft Model Antitumor Assays | 2014 |
Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications.
Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylinositol 3-Kinase; Phosphatidylinositol Phosphates; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction | 2014 |
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Erlotinib Hydrochloride; Humans; MAP Kinase Kinase Kinases; Mice, Transgenic; Morpholines; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines | 2015 |
Effect of the phosphodiesterase 4 inhibitor E6005 on nerve growth factor elevation in irritated skin of NC/Nga mice.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Humans; Mice; Nerve Growth Factor; Phosphodiesterase 4 Inhibitors; Phthalic Acids; Pruritus; Quinazolines | 2014 |
DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure.
Topics: Animals; Blood Glucose; Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Heart; Hypertension; Linagliptin; Male; Purines; Quinazolines; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary | 2014 |
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Epithelial Cells; Female; Humans; Inhibitory Concentration 50; Mice; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Tumor Burden; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3; Xenograft Model Antitumor Assays | 2014 |
Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages.
Topics: Adenine; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Carotid Artery Injuries; Carotid Artery, Common; Cell Line; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Ligation; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 12; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; RNA Interference; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2015 |
Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Cells, Cultured; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum Stress; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Matrix; Humans; Interleukin-6; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Time Factors | 2015 |
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endotoxemia; Glucagon-Like Peptide 1; Inflammation; Linagliptin; Lipopolysaccharides; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Purines; Pyrazines; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles | 2015 |
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Orexin Receptor Antagonists; Orexin Receptors; Pyrimidines; Quinazolines; Rats; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship | 2015 |
Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Gene Knockdown Techniques; Glucuronidase; Humans; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Neoplasm Metastasis; Neoplasms, Basal Cell; Protein Kinase Inhibitors; Quinazolines; Tumor Burden; Tumor Suppressor Proteins | 2015 |
The evidence of glioblastoma heterogeneity.
Topics: Animals; Antigens, CD; Brain Neoplasms; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Insulin-Like Growth Factor Binding Proteins; Kaplan-Meier Estimate; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Oligonucleotide Array Sequence Analysis; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured | 2015 |
Effects of lapatinib and trastuzumab on vascular endothelial growth factor in experimental corneal neovascularization.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Injections, Intraperitoneal; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Trastuzumab; Vascular Endothelial Growth Factor A | 2015 |
mTOR inhibition induces EGFR feedback activation in association with its resistance to human pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Forkhead Transcription Factors; Humans; Morpholines; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Burden; Up-Regulation; Xenograft Model Antitumor Assays | 2015 |
Acid-sensing ion channels detect moderate acidifications to induce ocular pain.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acids; Action Potentials; Amiloride; Animals; Blinking; Cnidarian Venoms; Cornea; Disease Models, Animal; Dry Eye Syndromes; Eye; Guanidines; Guinea Pigs; Hydrogen-Ion Concentration; Male; Nerve Fibers; Ocular Motility Disorders; Ovalbumin; Pain; Patch-Clamp Techniques; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Sensory Receptor Cells; Statistics, Nonparametric | 2015 |
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Benzodioxoles; Disease Models, Animal; Focal Adhesion Kinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; Quinazolines; Signal Transduction | 2015 |
Design, synthesis and biological evaluation of novel quinazoline-based anti-inflammatory agents acting as PDE4B inhibitors.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Design; Edema; Gastric Mucosa; Humans; Male; Molecular Docking Simulation; Phosphodiesterase 4 Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2015 |
EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; ErbB Receptors; Fibrosis; Male; Mice; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Ventricular Remodeling | 2015 |
Therapeutic effects of R8, a semi-synthetic analogue of Vasicine, on murine model of allergic airway inflammation via STAT6 inhibition.
Topics: Alkaloids; Animals; Anti-Asthmatic Agents; Asthma; Azepines; Cytokines; Disease Models, Animal; Gene Expression; Immunoglobulin E; Lung; Male; Mice, Inbred BALB C; Ovalbumin; Quinazolines; Quinazolinones; STAT6 Transcription Factor; Toxicity Tests | 2015 |
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Leishmania major; Malaria; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium vivax; Quinazolines; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells | 2015 |
Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Endothelium, Vascular; ErbB Receptors; Erlotinib Hydrochloride; Hypertension; Hypertrophy; Mice; Muscle, Smooth, Vascular; Phenylbutyrates; Quinazolines; Random Allocation; Role; Sensitivity and Specificity; Signal Transduction; Vascular Remodeling | 2015 |
Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-α mediated by TNF-α converting enzyme in murine collagen-induced arthritis model.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Arthritis, Experimental; Cell Line; Collagen; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred DBA; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2015 |
Vascular endothelial growth factor receptor-2 inhibitor cediranib causes regression of endometriotic lesions in a rat model.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Endometriosis; Female; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Topics: Amino Acyl-tRNA Synthetases; Animals; Antimalarials; Computer-Aided Design; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Liver; Malaria, Falciparum; Mice; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Plasmodium falciparum; Protozoan Proteins; Quinazolines; Quinazolinones; Structure-Activity Relationship; Time Factors | 2015 |
Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.
Topics: Animals; Antineoplastic Agents, Hormonal; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Lapatinib; Mice; Molecular Targeted Therapy; Neoadjuvant Therapy; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; Time Factors; Xenograft Model Antitumor Assays | 2015 |
The effect of AZD2171- or sTRAIL/Apo2L-loaded polylactic-co-glycolic acid microspheres on a subcutaneous glioblastoma model.
Topics: Animals; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, Animal; Glioblastoma; Glycolates; Humans; Lactic Acid; Male; Mice; Mice, Nude; Microspheres; Polyesters; Polymers; Protein Kinase Inhibitors; Quinazolines; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2015 |
The effect of the DcpS inhibitor D156844 on the protective action of follistatin in mice with spinal muscular atrophy.
Topics: Animals; Body Weight; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Endoribonucleases; Female; Follistatin; Kaplan-Meier Estimate; Male; Mice; Mice, Transgenic; Motor Activity; Muscular Atrophy, Spinal; Quinazolines; Recombinant Proteins; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein | 2015 |
DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Humans; Melanoma; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neovascularization, Pathologic; Plant Extracts; Plant Leaves; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Amplification; Gene Dosage; Humans; Lapatinib; Molecular Targeted Therapy; Quinazolines; Receptor, ErbB-2; Trastuzumab; Treatment Outcome; Xenograft Model Antitumor Assays | 2015 |
PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Membrane Proteins; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays | 2015 |
TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Focal Adhesion Protein-Tyrosine Kinases; Gefitinib; Humans; Lung Neoplasms; Mice; Morpholines; Mutation; Protein Binding; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors; Quinazolines; Receptor, IGF Type 1; Xenograft Model Antitumor Assays | 2015 |
Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
Topics: Animals; Benzoxazines; Cartilage, Articular; Chemokine CCL2; Disease Models, Animal; Disease Progression; Male; Osteoarthritis; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Transforming Growth Factor alpha; Tyrphostins; Up-Regulation; Wounds and Injuries | 2015 |
HER2 activating mutations are targets for colorectal cancer treatment.
Topics: Afatinib; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial Cells; ErbB Receptors; Humans; Molecular Targeted Therapy; Mucous Membrane; Mutation; Quinazolines; Quinolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays | 2015 |
Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.
Topics: Afatinib; Animals; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; ErbB Receptors; Gastrointestinal Neoplasms; Gene Amplification; Gene Expression; Gene Knockdown Techniques; Humans; Lapatinib; Mice; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Trastuzumab; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Breast Neoplasms; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Glucose; Humans; Mice; Protein Biosynthesis; Quinazolines; Receptors, Estrogen; src-Family Kinases | 2015 |
The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.
Topics: Angiogenesis Inhibitors; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; GABA Modulators; Gefitinib; Liver; Mice; Mice, Transgenic; Midazolam; Models, Biological; NADPH-Ferrihemoprotein Reductase; Protein Kinase Inhibitors; Quinazolines; Thalidomide | 2017 |
Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Brain; Cyclooxygenase 2; Disease Models, Animal; Intracranial Hemorrhages; Oligopeptides; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin | 2016 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Histamine H3 Antagonists; Indans; Male; Memory; Memory Disorders; Nootropic Agents; Phenoxypropanolamines; Piperidines; Pyrilamine; Pyrroles; Quinazolines; Random Allocation; Rats, Wistar; Receptors, Histamine H3 | 2016 |
Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats.
Topics: Animals; Animals, Newborn; Axitinib; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Imidazoles; Indazoles; Microscopy, Fluorescence; Phenylurea Compounds; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.
Topics: Animals; Apoptosis; Benzophenanthridines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Isoquinolines; Lung Neoplasms; Membrane Glycoproteins; Membrane Proteins; Methionine; Mice; Models, Biological; Models, Molecular; Molecular Conformation; NADPH Oxidase 2; NADPH Oxidases; Oxidation-Reduction; Protein Binding; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2016 |
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Insulin; Insulin-Like Growth Factor I; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzofurans; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Injections, Intraventricular; Locomotion; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.
Topics: Animals; Axons; Biotin; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Dextrans; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Male; Mutation; Myelin Basic Protein; Neurons; Phosphorylation; Protein Phosphatase 2; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sphingosine; Spinal Cord Injuries; Tyrphostins | 2015 |
Vandetanib as a potential new treatment for estrogen receptor-negative breast cancers.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Disease Models, Animal; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mice; Middle Aged; Molecular Targeted Therapy; Neoplasm Grading; Neoplasm Metastasis; Neovascularization, Pathologic; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Quinazolines; Receptors, Estrogen; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents.
Topics: Amines; Aniline Compounds; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Urea | 2016 |
The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma.
Topics: Airway Remodeling; Animals; Asthma; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Down-Regulation; Eosinophils; ErbB Receptors; Gefitinib; Inflammation; Interferon-gamma; Interleukin-13; Leukocyte Count; Male; Mice; Mice, Inbred BALB C; Mucin 5AC; Ovalbumin; Proto-Oncogene Proteins c-bcl-2; Quinazolines | 2016 |
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins | 2016 |
Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autoantigens; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Humans; Lapatinib; MCF-7 Cells; Membrane Proteins; Mice; Mice, Nude; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2016 |
EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Piperidines; Proto-Oncogene Proteins c-ret; Quinazolines; Transcription Factor AP-2; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Inhibition of Epidermal Growth Factor Receptor Improves Myelination and Attenuates Tissue Damage of Spinal Cord Injury.
Topics: Animals; Astrocytes; Axons; Disease Models, Animal; ErbB Receptors; Female; Mice; Myelin Sheath; Neuroglia; Oligodendroglia; Quinazolines; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2016 |
Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model.
Topics: Animals; Disease Models, Animal; Male; Myocardial Infarction; Neuregulin-1; Oncogene Proteins v-erbB; Physical Conditioning, Animal; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins | 2016 |
CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Variation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Quinazolines; Receptors, Androgen; Signal Transduction; Transcription, Genetic; Xenograft Model Antitumor Assays | 2016 |
Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats.
Topics: Animals; Apoptosis; Calcitonin Gene-Related Peptide; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-3; Fibroblasts; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indole Alkaloids; Myocardium; Quinazolines; Signal Transduction; Transforming Growth Factor beta1; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2016 |
Effects of Src-kinase inhibition in cancer-induced bone pain.
Topics: Animals; Behavior, Animal; Benzodioxoles; Bone Neoplasms; Bone Remodeling; Bone Resorption; Cancer Pain; Disease Models, Animal; Hyperalgesia; Male; Neurons; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; src-Family Kinases | 2016 |
SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma.
Topics: Administration, Oral; Animals; Benzodioxoles; Bone and Bones; Cell Differentiation; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Myeloma; Osteoblasts; Osteoclasts; Osteolysis; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogenes; Quinazolines; src-Family Kinases | 2016 |
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chordoma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Mice; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2016 |
Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance.
Topics: Animals; Antineoplastic Agents, Immunological; Cell Line, Tumor; Cetuximab; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Heterografts; Humans; Lung Neoplasms; Nanomedicine; Quinazolines; Silicon Dioxide; Treatment Outcome | 2016 |
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclins; Disease Models, Animal; DNA Helicases; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lapatinib; Male; Mice; MicroRNAs; Models, Biological; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Quinazolines; Receptor, ErbB-2; RNA Interference; RNA-Binding Proteins; Stomach Neoplasms; Trastuzumab | 2016 |
Evodiamine sensitizes BGC-823 gastric cancer cells to radiotherapy in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; Male; Mice; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Radiation-Sensitizing Agents; Receptor, ErbB-2; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC.
Topics: Afatinib; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Esophageal Neoplasms; Female; Head and Neck Neoplasms; HEK293 Cells; Humans; Mice; Multigene Family; Mutation; NIH 3T3 Cells; Phosphorylation; Quinazolines; Receptor, ErbB-4; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2016 |
Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome.
Topics: Animals; Capillary Permeability; Cricetinae; Disease Models, Animal; Endothelial Cells; Hantavirus Pulmonary Syndrome; Orthohantavirus; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Quinazolines; Vascular Endothelial Growth Factor A; Viral Load | 2016 |
Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Epidermal Growth Factor; Female; Gene Expression; Humans; Lapatinib; MAP Kinase Signaling System; Mice; Neuregulin-1; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction.
Topics: Animals; beta 2-Microglobulin; Disease Models, Animal; Electrolytes; Kidney; Kidney Pelvis; Male; Quinazolines; Random Allocation; Rats; Rats, Long-Evans; Renal Artery; Transforming Growth Factor beta1; Ultrasonography, Doppler; Ureteral Obstruction | 2016 |
Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1(G93A) ALS mice and after partial muscle denervation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cell Survival; Disease Models, Animal; Lapatinib; Mice, Transgenic; Motor Neurons; Muscle Denervation; Neuregulin-1; Neurogenesis; Neuromuscular Junction; Quinazolines; Superoxide Dismutase-1 | 2016 |
Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Aurora Kinase B; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Amplification; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, myc; Histones; Humans; Lung Neoplasms; Mice; Organophosphates; Phosphorylation; Polyploidy; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Dopaminergic inhibition by G9a/Glp complex on tyrosine hydroxylase in nerve injury-induced hypersensitivity.
Topics: Animals; Azepines; Brain; Chromatography, High Pressure Liquid; CpG Islands; Disease Models, Animal; DNA Methylation; Dopamine; Down-Regulation; Histone-Lysine N-Methyltransferase; Hypersensitivity; Male; Mice; Mice, Inbred C57BL; Pain Measurement; Pain Threshold; Quinazolines; Sciatic Neuropathy; Signal Transduction; Tyrosine 3-Monooxygenase | 2016 |
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Histamine H3 Antagonists; Male; Pyrroles; Pyrrolidines; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Scopolamine | 2016 |
Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib.
Topics: Algorithms; Animals; Antineoplastic Agents; Biomarkers; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Mice; Models, Biological; Protein Kinase Inhibitors; Quinazolines; Xenograft Model Antitumor Assays | 2016 |
The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Immunohistochemistry; Islets of Langerhans Transplantation; Liver Neoplasms, Experimental; Male; Nitrosamines; Protein Kinase Inhibitors; Quinazolines; ras Proteins; Rats; Rats, Inbred Lew; Sodium-Glucose Transporter 1; Thyroid Epithelial Cells; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha | 2016 |
SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Pyrroles; Quinazolines; Rats; Rats, Wistar; Receptor, PAR-1 | 2016 |
Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme Inhibitors; Gamma Rhythm; Hippocampus; Interneurons; Mice; Neuregulin-1; Parvalbumins; Quinazolines; Receptor, ErbB-4; Sepsis-Associated Encephalopathy; Signal Transduction; Tyrphostins | 2017 |
A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-Gaussian diffusion MRI.
Topics: Animals; Bayes Theorem; Colonic Neoplasms; Diffusion Magnetic Resonance Imaging; Dimethyl Sulfoxide; Disease Models, Animal; Female; Humans; Mice; Mice, Nude; Models, Statistical; Organophosphates; Protein Kinase Inhibitors; Quinazolines | 2017 |
AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases.
Topics: Aged; Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Central Nervous System Neoplasms; Disease Models, Animal; ErbB Receptors; Female; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mice, Nude; Middle Aged; Mutation; Neoplasm Metastasis; Piperazines; Protein Kinase Inhibitors; Quinazolines; Spinal Cord | 2016 |
ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterografts; Lapatinib; Mice, Nude; Mitoxantrone; Neoplasm Proteins; Neoplasm Transplantation; Quinazolines; Topotecan | 2017 |
The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Topics: Animals; Antithrombins; Capillary Permeability; Central Nervous System Agents; Cervical Vertebrae; Disease Models, Animal; Fibrin; Hirudins; Hyperalgesia; Injections, Spinal; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrroles; Quinazolines; Radiculopathy; Rats, Sprague-Dawley; Receptor, PAR-1; Spinal Cord | 2017 |
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Mice; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship | 2017 |
GDNF induces RET-SRC-HER2-dependent growth in trastuzumab-sensitive but SRC-independent growth in resistant breast tumor cells.
Topics: Animals; Antineoplastic Agents, Immunological; Apoptosis; Benzodioxoles; Biomarkers; Breast Neoplasms; CD24 Antigen; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Humans; Hyaluronan Receptors; Mice; Phosphorylation; Proto-Oncogene Proteins c-ret; Quinazolines; Receptor, ErbB-2; src-Family Kinases; Trastuzumab; Xenograft Model Antitumor Assays | 2017 |
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.
Topics: Animals; Astrocytes; Brain; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Grading; Oligodendrocyte Transcription Factor 2; Plasmids; Plicamycin; Quinazolines; Receptor, Platelet-Derived Growth Factor alpha; RNA Interference; SOXB1 Transcription Factors; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups.
Topics: Administration, Intranasal; Animals; Animals, Newborn; Antithrombins; Dabigatran; Disease Models, Animal; Extracellular Matrix; Hydrocephalus; Injections, Intraperitoneal; Intracranial Hemorrhages; Maze Learning; Oligopeptides; Pyrroles; Quinazolines; Receptor, PAR-1; Rotarod Performance Test | 2017 |
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Autophagy; Carbamazepine; Disease Models, Animal; Hippocampus; Male; Maze Learning; Mice; Neurons; Neuroprotective Agents; Plaque, Amyloid; Quinazolines; Random Allocation; Sirolimus; Spatial Memory | 2017 |
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Topics: Animals; Disease Models, Animal; Drug Design; Endoribonucleases; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Molecular Docking Simulation; Muscular Atrophy, Spinal; Quinazolines; RNA, Messenger; Survival of Motor Neuron 2 Protein | 2017 |
Characterizing the Antimicrobial Activity of
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Biofilms; Cell Line, Tumor; Cell Survival; Diamines; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Folic Acid Antagonists; Hep G2 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Peritonitis; Quinazolines; Tetrahydrofolate Dehydrogenase | 2017 |
Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Bone Marrow; Cell Line, Tumor; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Mice; Nanoparticles; Organophosphates; Polyploidy; Protein Kinase Inhibitors; Quinazolines; Rats; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Drug Therapy, Combination; ErbB Receptors; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Quinazolines; Radiotherapy; Xenograft Model Antitumor Assays | 2008 |
Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoblotting; Immunochemistry; Lapatinib; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Research Design; RNA, Small Interfering; Signal Transduction; Transfection; Xenograft Model Antitumor Assays | 2008 |
Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Disease Models, Animal; Echocardiography; Enalapril; Enzyme Inhibitors; Fibrosis; Heart Failure; Male; Myocardial Infarction; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Remodeling | 2008 |
Examining the acute effects of cediranib (RECENTIN, AZD2171) treatment in tumor models: a dynamic contrast-enhanced MRI study using gadopentate.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Colorectal Neoplasms; Contrast Media; Disease Models, Animal; Dose-Response Relationship, Drug; Gadolinium DTPA; Glioma; Humans; Magnetic Resonance Imaging; Quinazolines; Rats; Rats, Nude; Treatment Outcome | 2009 |
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Cattle; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Isoenzymes; Male; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nitric Oxide Synthase; Quinazolines; Rats | 2008 |
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.
Topics: Adenocarcinoma; Adult; Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carboplatin; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cetuximab; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Etoposide; Female; Gemcitabine; Gene Expression Profiling; Genes, ras; Humans; Immunoblotting; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Middle Aged; Mutation; Oligonucleotide Array Sequence Analysis; Paclitaxel; Polymerase Chain Reaction; Prognosis; Protein Kinase Inhibitors; Quinazolines; Radiation-Sensitizing Agents; Small Cell Lung Carcinoma; Tumor Suppressor Protein p53; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays | 2008 |
Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide-1 and improves glycemic contro
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Female; Glucagon-Like Peptide 1; Glycemic Index; Humans; Hypoglycemic Agents; Linagliptin; Male; Mice; Purines; Quinazolines; Rats; Rats, Zucker; Tumor Cells, Cultured | 2009 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Cell Death; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Male; Nerve Degeneration; Polymers; Quinazolines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sural Nerve; Treatment Outcome; Wallerian Degeneration | 2009 |
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Carboxypeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Hypertrophy; Indole Alkaloids; Kallikreins; Losartan; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2009 |
An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}meth
Topics: Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Breast Neoplasms; Central Nervous System; Cricetinae; Disease Models, Animal; Drug Synergism; Female; Humans; Lapatinib; Male; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Tissue Distribution | 2009 |
Stretching the search for therapeutic targets in acute lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Protein Kinase Inhibitors; Quinazolines; Respiratory Distress Syndrome; Tyrphostins | 2008 |
Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Intubation, Intratracheal; Mice; Mice, Inbred Strains; Neutrophils; Permeability; Protein Tyrosine Phosphatases; Pulmonary Alveoli; Quinazolines; Signal Transduction; Tyrphostins; Ventilator-Induced Lung Injury; Ventilators, Mechanical | 2008 |
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.
Topics: Adult; Aged; Animals; Anticarcinogenic Agents; Benzodioxoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Keratinocytes; Keratosis; Male; Mice; Middle Aged; Papilloma; Precancerous Conditions; Quinazolines; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2009 |
Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines.
Topics: Administration, Oral; Amines; Animals; Anti-Inflammatory Agents; Chemotaxis; Dermatitis; Disease Models, Animal; Humans; Mice; Piperidines; Quinazolines; Receptors, CCR4; Structure-Activity Relationship | 2009 |
Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Immunoenzyme Techniques; Incidence; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Knockout; Pyrazoles; Quinazolines; Sulfonamides; Tetrahydronaphthalenes; Tumor Suppressor Protein p53 | 2009 |
Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Biomarkers, Tumor; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Gene Expression Profiling; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Pyrazoles; Quinazolines; Sulfonamides; Tetrahydronaphthalenes; Tumor Protein, Translationally-Controlled 1; Tumor Suppressor Protein p53 | 2009 |
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
Topics: Animals; Carrier Proteins; Collagen; Disease Models, Animal; Disease Progression; Doxycycline; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation; Humans; Lung; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Quinazolines; Respiratory Mechanics; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha; Uteroglobin | 2009 |
Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model.
Topics: Animals; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Disease Models, Animal; Ferric Compounds; Humans; Magnetic Resonance Imaging; Male; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Quinazolines; Vascular Endothelial Growth Factor A | 2009 |
Induction of eosinophil-infiltrating drug photoallergy in mice.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemokine CCL24; Cytokines; Dermatitis, Photoallergic; Disease Models, Animal; Drug Hypersensitivity; Eosinophils; Female; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Photosensitizing Agents; Quinazolines; Skin; Ultraviolet Rays | 2009 |
Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Survival; Depsipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Mice, Nude; Oncogene Proteins v-erbB; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
Topics: Angioplasty, Balloon; Animals; Carotid Artery Diseases; Carotid Stenosis; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Fibrinolytic Agents; Gene Transfer Techniques; Genetic Therapy; Guanine Nucleotide Exchange Factors; Hirudins; Humans; Muscle, Smooth, Vascular; Mutation; p21-Activated Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; rac1 GTP-Binding Protein; Rats; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Stress Fibers; Thrombin; Time Factors; Transfection; Tyrphostins | 2009 |
MRI methods for evaluating the effects of tyrosine kinase inhibitor administration used to enhance chemotherapy efficiency in a breast tumor xenograft model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gefitinib; Humans; Magnetic Resonance Imaging; Mice; Mice, Nude; Outcome Assessment, Health Care; Prognosis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines | 2009 |
Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury.
Topics: Acute Lung Injury; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Infusions, Intravenous; Lung; Lymph; Microcirculation; Piperazines; Pulmonary Edema; Pulmonary Gas Exchange; Quinazolines; Sheep; Smoke Inhalation Injury; Trachea; Treatment Outcome | 2009 |
Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism.
Topics: Animals; Arterioles; Blood Pressure; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Hypertension; Kidney; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Quinazolines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasoconstriction | 2009 |
Improvement of the closed cranial window model in rats by intracarotid infusion of signalling molecules implicated in migraine.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Carotid Arteries; Cerebrovascular Circulation; Dipeptides; Disease Models, Animal; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Microscopy; Migraine Disorders; Piperazines; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents | 2010 |
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Cardiovascular Agents; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Male; Myocardium; Natriuretic Peptide, Brain; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Inbred SHR; Signal Transduction; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Patient-derived xenografts of non-small-cell lung cancer: a pre-clinical model to evaluate adjuvant chemotherapy?
Topics: Adult; Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cetuximab; Chemotherapy, Adjuvant; Disease Models, Animal; Drug Evaluation, Preclinical; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mice, SCID; Middle Aged; Neoplasm Proteins; Quinazolines; Treatment Outcome; Xenograft Model Antitumor Assays | 2009 |
An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.
Topics: Acantholysis; Animals; Apoptosis; Betacellulin; Carrier Proteins; Disease Models, Animal; Enzyme Activation; Epidermal Growth Factor; Epidermis; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Intradermal Tests; Isoenzymes; Mice; Mice, Inbred C57BL; Pemphigus; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Sirolimus; src-Family Kinases; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha | 2009 |
The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels.
Topics: Animals; Antigens; Antineoplastic Agents; Blood Vessels; Bone Marrow Cells; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; ErbB Receptors; Gefitinib; Humans; Image Processing, Computer-Assisted; Melanoma; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Pericytes; Protein Kinase Inhibitors; Proteoglycans; Quinazolines; Skin Neoplasms | 2009 |
The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Neoplasm, Residual; Neoplasms, Experimental; Quinazolines; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Disease Models, Animal; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Phosphorylation; Promoter Regions, Genetic; Pulmonary Surfactant-Associated Protein C; Quinazolines; Receptor, ErbB-3; Smoking | 2009 |
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
Topics: Afatinib; Amphiregulin; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Disease Models, Animal; Drug Resistance, Neoplasm; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Profiling; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Mice; Mice, Nude; Mice, Transgenic; Mutation; Neoplasm Transplantation; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured | 2009 |
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erlotinib Hydrochloride; Gefitinib; Gene Expression; Humans; Hypertension, Pulmonary; Lapatinib; Male; Mice; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pulmonary Wedge Pressure; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Resistance | 2010 |
Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy.
Topics: Animals; Cell Survival; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscular Atrophy, Spinal; Phenotype; Promoter Regions, Genetic; Quinazolines; Survival of Motor Neuron 2 Protein | 2010 |
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).
Topics: Administration, Oral; Animals; Carbamates; Catalytic Domain; Computer Simulation; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Enzyme Inhibitors; Erectile Dysfunction; Humans; Male; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Quinazolines; Rabbits; Rats | 2010 |
The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma.
Topics: Animals; Aurora Kinase B; Aurora Kinases; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Histones; Humans; Liver Neoplasms; Mice; Mice, Nude; Organophosphates; Phosphorylation; Protein Serine-Threonine Kinases; Quinazolines; Treatment Outcome; Xenograft Model Antitumor Assays | 2010 |
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas.
Topics: Adenocarcinoma; Animals; Chimera; Disease Models, Animal; Embryonic Stem Cells; ErbB Receptors; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Phenotype; Piperazines; Proto-Oncogene Proteins p21(ras); Quinazolines; Respiratory Insufficiency; Signal Transduction | 2010 |
Antitumor and antiangiogenic activity of cediranib in a preclinical model of renal cell carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Disease Models, Animal; Female; Immunoenzyme Techniques; Kidney Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2009 |
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
Topics: Acetic Acid; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Cytopathogenic Effect, Viral; Dermis; Disease Models, Animal; Fibroblasts; Humans; Lung; Mice; Mice, SCID; Quinazolines; Transplantation, Heterologous; Treatment Outcome; Virus Replication | 2010 |
Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cholangitis; Collagen Type I; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fibrosis; Gene Expression; In Situ Nick-End Labeling; Ki-67 Antigen; Lithiasis; Male; Mucin 5AC; Quinazolines; Rats; Rats, Sprague-Dawley; Recurrence; Tyrphostins | 2011 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Inflammation; Male; Mice; Pain; Pain Measurement; Quinazolines; Structure-Activity Relationship | 2010 |
The influence of inhibition of the epidermal growth factor receptor on tympanic membrane wound healing in rats.
Topics: Administration, Topical; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred Lew; Tympanic Membrane; Tympanic Membrane Perforation; Wound Healing | 2010 |
Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Gefitinib; Naproxen; Quinazolines; Rats; Rats, Inbred F344; Research Design; Resveratrol; Stilbenes; Urinary Bladder Neoplasms | 2010 |
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging.
Topics: Adenocarcinoma; Amino Acid Substitution; Animals; Antineoplastic Agents; Aspartic Acid; Cyclin-Dependent Kinases; Diagnostic Imaging; Disease Models, Animal; Drug Evaluation, Preclinical; Genes, ras; Glycine; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Mutant Proteins; Pyrazoles; Quinazolines; Treatment Outcome | 2010 |
Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Deoxycytidine; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Indoles; Mice; Mice, SCID; NF-kappa B; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Treatment Outcome; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2010 |
Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mice; Mice, Nude; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2009 |
Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.
Topics: Animals; Biphenyl Compounds; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Excitatory Postsynaptic Potentials; Hippocampus; Lidocaine; Male; N-Methylaspartate; Neuronal Plasticity; Prefrontal Cortex; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sulfonamides; Synaptic Transmission; Time Factors | 2011 |
EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma.
Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Separation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Interleukin-6; Lung; Ovalbumin; Quinazolines; Rats; Rats, Inbred BN; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tyrphostins | 2010 |
A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study.
Topics: Animals; Anxiety; Axons; Behavior, Animal; Brain Injuries; Disease Models, Animal; Enzyme Inhibitors; Immunohistochemistry; Infusions, Intraventricular; Male; Neuroprotective Agents; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Rats; Rats, Wistar | 2010 |
Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Bone and Bones; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Male; Mice; Neoplasm Invasiveness; Osteoclasts; Osteogenesis; Osteolysis; Protein Kinase Inhibitors; Quinazolines; Radiography; RANK Ligand; Signal Transduction; src-Family Kinases; Xenograft Model Antitumor Assays | 2010 |
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Deoxycytidine; Disease Models, Animal; Erlotinib Hydrochloride; Gemcitabine; Genetic Engineering; Humans; Lung Neoplasms; Mice; Mutation; Neoplasms; Proto-Oncogene Proteins p21(ras); Quinazolines; Survival Analysis; Vascular Endothelial Growth Factor A | 2010 |
The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.
Topics: Adoptive Transfer; Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Blotting, Western; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-17; Lung; Male; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Helper-Inducer; Tyrphostins | 2010 |
Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Disease Models, Animal; ErbB Receptors; Humans; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, ErbB-2; Signal Transduction; Tyrphostins | 2010 |
Targeted molecular therapy of head and neck squamous cell carcinoma with the tyrosine kinase inhibitor vandetanib in a mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Disease Models, Animal; ErbB Receptors; Flow Cytometry; Head and Neck Neoplasms; Humans; Male; Mice; Mice, Nude; Molecular Targeted Therapy; Paclitaxel; Piperidines; Protein-Tyrosine Kinases; Quinazolines; Random Allocation; Sensitivity and Specificity; Survival Rate; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2011 |
Calcitonin gene-related peptide as a regulator of neuronal CaMKII-CREB, microglial p38-NFκB and astroglial ERK-Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Male; Morphine; Nerve Tissue Proteins; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Physical Stimulation; Piperazines; Protein Serine-Threonine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; STAT3 Transcription Factor | 2010 |
Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model.
Topics: Adenoma; Animals; Antineoplastic Agents; beta Catenin; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; ErbB Receptors; Genes, APC; Intestine, Small; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase Inhibitors; Quinazolines; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Clinical Trials, Phase II as Topic; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunohistochemistry; Immunosuppressive Agents; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Neuroendocrine Tumors; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Repressor Proteins; RNA Interference; Signal Transduction; Sirolimus; Survival Analysis; Survivin; TOR Serine-Threonine Kinases; Treatment Outcome | 2010 |
Small tumors, intermediate models, big hopes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Neuroendocrine Tumors; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Sirolimus; Survival Analysis; TOR Serine-Threonine Kinases; Treatment Outcome | 2010 |
A nonproton ligand sensor in the acid-sensing ion channel.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Animals; Behavior, Animal; Biophysics; Calcium; Cells, Cultured; Cricetinae; Cricetulus; Disease Models, Animal; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Glutamates; Guanidines; Hydrogen-Ion Concentration; Ion Channel Gating; Ligands; Membrane Potentials; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Pain; Pain Measurement; Patch-Clamp Techniques; Protein Structure, Tertiary; Protons; Quinazolines; Rats; Sensory Receptor Cells; Sodium Channels; Sulfhydryl Reagents; Time Factors; Transfection | 2010 |
EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium.
Topics: Acute Lung Injury; Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Gene Expression; Mice; Mice, Inbred C57BL; Naphthalenes; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; Treatment Outcome | 2011 |
Absorption of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase: comparative studies using in vitro, in situ and in vivo models.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Biological Transport; Caco-2 Cells; Disease Models, Animal; Epithelial Cells; ErbB Receptors; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Molecular Targeted Therapy; Permeability; Protein Kinase Inhibitors; Quinazolines; Rats | 2010 |
The effect of adjuvant dimethylenastron, a mitotic Kinesin Eg5 inhibitor, in experimental glaucoma filtration surgery.
Topics: Animals; Antimitotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Filtering Surgery; Inflammation; Injections, Intraocular; Intraocular Pressure; Postoperative Complications; Quinazolines; Rabbits; Thiones; Time Factors; Wound Healing | 2010 |
Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Immunohistochemistry; Mice; Mice, Inbred CBA; Mouth Neoplasms; Neovascularization, Pathologic; Piperidines; Quinazolines; Quinolones; Receptors, Vascular Endothelial Growth Factor | 2010 |
The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Disease Progression; ErbB Receptors; Fluorescent Antibody Technique; Gefitinib; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Vandetanib improves anti-tumor effects of L19mTNFalpha in xenograft models of esophageal cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disease Models, Animal; Esophageal Neoplasms; Fibronectins; Humans; Mice; Mice, SCID; Piperidines; Quinazolines; Recombinant Fusion Proteins; Single-Chain Antibodies; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2011 |
Impact of the Src inhibitor saracatinib on the metastatic phenotype of a fibrosarcoma (KHT) tumor model.
Topics: Animals; Apoptosis; Benzodioxoles; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Fibrosarcoma; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Lung Neoplasms; Mice; Mice, Inbred C3H; Phosphorylation; Quinazolines; Sarcoma, Experimental; src-Family Kinases; Survival Rate; Tumor Cells, Cultured | 2010 |
Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Carcinogens; Carcinoma, Squamous Cell; Commiphora; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Immunoenzyme Techniques; Mice; Mice, Inbred CBA; Mouth Neoplasms; Plant Extracts; Plant Gums; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; STAT3 Transcription Factor | 2011 |
Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Disease Models, Animal; Maze Learning; Memory; Mice; Mice, Transgenic; Presenilin-1; Quinazolines; Random Allocation | 2011 |
Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
Topics: Animals; Biomarkers, Tumor; Capillary Permeability; Cell Line, Tumor; Cell Proliferation; Diffusion; Disease Models, Animal; Extracellular Space; Glioma; Humans; Magnetic Resonance Imaging; Mice; Protein Kinase Inhibitors; Quinazolines; Receptors, Vascular Endothelial Growth Factor | 2011 |
Antitumor effects of carnertinib in castration resistant prostate cancer models: a comparative study with erlotinib.
Topics: Androgen Antagonists; Anilides; Animals; Apoptosis; Cell Division; Cell Line; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial Cells; Erlotinib Hydrochloride; Humans; Male; Mice, Nude; Morpholines; Nitriles; Orchiectomy; Prostate; Prostatic Neoplasms, Castration-Resistant; Protein Kinase Inhibitors; Quinazolines; Tosyl Compounds; Xenograft Model Antitumor Assays | 2011 |
Studies on the inhibition of feline EGFR in squamous cell carcinoma: enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cats; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Conserved Sequence; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Quinazolines; Radiation Tolerance; RNA Interference; Signal Transduction | 2011 |
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.
Topics: Animals; Antineoplastic Agents; Atropine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Cisplatin; Cricetinae; Cricetulus; Dipeptides; Disease Models, Animal; Drug Interactions; Ganglia, Spinal; Gene Expression Regulation; Guinea Pigs; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Piperazines; Pulmonary Artery; Quinazolines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensory Receptor Cells; Spectrometry, Mass, Electrospray Ionization; Superoxides; Tissue Culture Techniques; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Transfection; TRPV Cation Channels | 2011 |
Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Bleomycin; Chemokines; Cytokines; Disease Models, Animal; Fibrosis; Inflammation; Lung Injury; Male; Mice; Mice, Inbred ICR; Quinazolines; Receptors, Formyl Peptide; Time Factors | 2011 |
Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Endothelial Cells; ErbB Receptors; Female; Humans; Mice; Mice, SCID; Neoplasms; Phenotype; Piperidines; Quinazolines; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2011 |
EGFR inhibition fails to suppress vascular proliferation and tumor growth in a Ewing's sarcoma model.
Topics: Angiography; Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Humans; In Vitro Techniques; Mice; Mice, Nude; Neovascularization, Pathologic; Quinazolines; Sarcoma, Ewing; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2012 |
Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.
Topics: Animals; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mice; Neoplasm Invasiveness; Osteoblasts; Osteolysis; Protein Kinase Inhibitors; Quinazolines | 2011 |
Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Heart Failure; HSP72 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Male; MAP Kinase Signaling System; Mice; Myocytes, Cardiac; Phosphorylation; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Spin Labels | 2011 |
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.
Topics: Animals; Apoptosis; Calcium; Cells, Cultured; Disease Models, Animal; Drosophila; Fura-2; Glutamic Acid; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; NF-kappa B; Nuclear Proteins; Phenyl Ethers; Quinazolines; RNA Interference; RNA, Small Interfering; TRPC Cation Channels | 2011 |
DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Mice; Mice, Nude; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-3; Signal Transduction; Stomach Neoplasms | 2011 |
Targeting ErbB3-mediated stromal-epithelial interactions in pancreatic ductal adenocarcinoma.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Fibroblasts; Humans; Immunohistochemistry; Mice; Mice, SCID; Neuregulin-1; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transplantation, Heterologous | 2011 |
The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival.
Topics: Acute Disease; Animals; Disease Models, Animal; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Kidney; Liver; Male; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Heterotopic; Transplantation, Homologous | 2011 |
Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Invasiveness; Quinazolines; Sarcoma; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2011 |
Phenylbutyrate suppresses distinct skin reactions that are enhanced by blockade of epidermal growth factor receptor signaling.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemokine CCL2; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; ErbB Receptors; Forkhead Transcription Factors; Histone Deacetylase Inhibitors; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Mast Cells; Mice; Mice, Inbred BALB C; Phenylbutyrates; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Skin; Stem Cell Factor; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Selective elimination of alloreactivity in vitro and in vivo while sparing other T-cell-mediated immune responses.
Topics: Animals; Disease Models, Animal; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunity, Cellular; Immunotherapy; Isoantigens; Mice; Mice, Inbred BALB C; Quinazolines; T-Lymphocytes; Transplantation, Homologous | 2012 |
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Permeability; Quinazolines; Stroke | 2012 |
Hepatotoxicity associated with lapatinib in an experimental rat model.
Topics: Alanine Transaminase; Albumins; Analysis of Variance; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Lapatinib; Lipoproteins, VLDL; Liver; Liver Function Tests; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triglycerides | 2012 |
Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
Topics: Animals; Area Under Curve; Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Regulation; Glomerular Filtration Rate; Glucagon-Like Peptide 1; Heart; Humans; Kidney Failure, Chronic; Linagliptin; Myocardium; Natriuretic Peptide, Brain; Nephrectomy; Piperidines; Purines; Pyrazines; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles; Uracil; Uremia | 2011 |
Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Separation; Cerebellar Neoplasms; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Medulloblastoma; Mice; Mice, Transgenic; Piperazines; Quinazolines; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; Down-Regulation; Electric Stimulation; Epilepsy; ErbB Receptors; Female; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kv1.1 Potassium Channel; Male; Mice; Mice, Transgenic; Neuregulin-1; Neurons; Parvalbumins; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Potassium Channel Blockers; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Signal Transduction; Tyrphostins | 2011 |
Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model.
Topics: Animals; Cell Line; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Enzyme Activation; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Gene Deletion; Kidney Tubules, Proximal; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Recovery of Function; Reperfusion Injury; Time Factors | 2012 |
Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats.
Topics: Animals; Disease Models, Animal; ErbB Receptors; Gefitinib; Male; Protein Kinase Inhibitors; Pulmonary Fibrosis; Quinazolines; Radiation Pneumonitis; Rats; Rats, Wistar | 2012 |
Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
Topics: Administration, Cutaneous; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Female; Indole Alkaloids; Male; Mice; Oleic Acid; Pain; Plant Extracts; Quinazolines; Sesquiterpenes; Skin; Swine | 2012 |
Epidermal growth factor receptor signaling pathway involved in progestin-resistance of human endometrial carcinoma: In a mouse model.
Topics: Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Therapy, Combination; Endometrial Neoplasms; ErbB Receptors; Female; Gefitinib; Humans; Immunohistochemistry; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Phosphorylation; Quinazolines; Receptors, Progesterone; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine.
Topics: Adiposity; Animals; Appetite Depressants; Body Composition; Cyclobutanes; Disease Models, Animal; Female; Linagliptin; Obesity; Purines; Quinazolines; Rats; Rats, Wistar | 2012 |
Trigeminal nerve injury ErbB3/ErbB2 promotes mechanical hypersensitivity.
Topics: Animals; Blotting, Western; Disease Models, Animal; Hyperalgesia; Lapatinib; Male; Neuralgia; Pain Threshold; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred F344; Receptor, ErbB-2; Receptor, ErbB-3; Trigeminal Nerve Injuries; Vibrissae | 2012 |
The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice.
Topics: Age of Onset; Animals; Diabetes Mellitus, Type 1; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Female; Insulin; Insulin-Secreting Cells; Linagliptin; Mice; Mice, Inbred NOD; Purines; Quinazolines | 2012 |
Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colorectal Neoplasms; Diet; Disease Models, Animal; ErbB Receptors; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines; Sex Factors; Tyrphostins | 2012 |
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.
Topics: Animals; Benzamides; Benzimidazoles; Case-Control Studies; Crk-Associated Substrate Protein; Disease Models, Animal; Endothelial Cells; Epidermal Growth Factor; Familial Primary Pulmonary Hypertension; Fibroblast Growth Factor 2; Gefitinib; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Mice; Monocrotaline; Myocytes, Smooth Muscle; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Quinazolines; Quinolones; Rats; Signal Transduction | 2012 |
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Topics: Animals; Astrocytes; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Glioblastoma; Humans; Mice; Mice, Mutant Strains; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrosine | 2012 |
Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Disease Models, Animal; Lapatinib; Male; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases | 2012 |
Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Enzyme Activation; Estradiol; Estrogens; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Ovarian Neoplasms; Protein Binding; Protein Transport; Quinazolines; Receptors, Estrogen; src-Family Kinases; Xenograft Model Antitumor Assays | 2012 |
Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation.
Topics: Animals; Aorta; Capillary Permeability; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Hepatocyte Growth Factor; Humans; Inositol Polyphosphate 5-Phosphatases; Kidney; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Phosphoric Monoester Hydrolases; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; RNA Interference; Systemic Inflammatory Response Syndrome; Transfection; Vascular Cell Adhesion Molecule-1 | 2012 |
Modulating antiangiogenic resistance by inhibiting the signal transducer and activator of transcription 3 pathway in glioblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Drug Interactions; Female; Glioblastoma; Humans; Immunohistochemistry; Intermediate Filament Proteins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Nude; Nerve Tissue Proteins; Nestin; Pyrazoles; Pyrimidines; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2012 |
Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer.
Topics: Animals; Antipsychotic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Gefitinib; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Quinazolines; Random Allocation; Sensitivity and Specificity; Trifluoperazine; Tumor Cells, Cultured | 2012 |
Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
Topics: Animals; Apolipoproteins E; Blotting, Western; Coronary Artery Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty Liver; Hyperlipidemias; Male; Mice; Mice, Knockout; Quinazolines; TRPV Cation Channels | 2013 |
Hantavirus treatments advance amidst outbreak in US park.
Topics: Animals; California; Cricetinae; Disease Models, Animal; Disease Outbreaks; Hantavirus Pulmonary Syndrome; Humans; Mesocricetus; Orthohantavirus; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; United States; Viral Vaccines | 2012 |
[Personalised treatment of lung cancer].
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Positron-Emission Tomography; Precision Medicine; Quinazolines | 2012 |
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Brain Neoplasms; Breast Neoplasms; Cell Death; Cell Proliferation; Diagnostic Imaging; Disease Models, Animal; Female; Gene Amplification; Humans; Killer Cells, Natural; Lapatinib; Mice; Molecular Targeted Therapy; Necrosis; Neovascularization, Pathologic; Quinazolines; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Survival Analysis; Trastuzumab; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
A novel approach to develop anti-virulence agents against group A streptococcus.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Humans; Mice; Mice, Transgenic; Quinazolines; Streptococcal Infections; Streptococcus pyogenes; Streptokinase; Virulence; Virulence Factors | 2012 |
Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Benzamides; Caspase 3; Disease Models, Animal; Esophageal Neoplasms; Gastroesophageal Reflux; Gene Expression; Hedgehog Proteins; Immunoenzyme Techniques; Ki-67 Antigen; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled; RNA, Messenger; Smoothened Receptor | 2013 |
DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Benzoates; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptidyl Peptidase 4; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Linagliptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Purines; Quinazolines; Streptozocin; Telmisartan; Treatment Outcome | 2012 |
Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Humans; Imidazoles; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Quinazolines; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Triazines; Xenograft Model Antitumor Assays | 2012 |
Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Histocytochemistry; Hyperthermia, Induced; Immunohistochemistry; Mice, Inbred BALB C; Necrosis; Platelet Endothelial Cell Adhesion Molecule-1; Quinazolines; Thiadiazoles; Treatment Outcome | 2014 |
Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Intravitreal Injections; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Oxygen; Protein Kinase Inhibitors; Quinazolines; Retinal Diseases; Signal Transduction; Tissue Inhibitor of Metalloproteinase-3 | 2013 |
Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease.
Topics: Animals; Antineoplastic Agents; Chemokine CCL2; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation; Lipopolysaccharides; Lung Diseases, Interstitial; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain; Disease Models, Animal; Drug Design; gamma-Aminobutyric Acid; Mice; Molecular Structure; Quinazolines; Seizures; Structure-Activity Relationship; Swimming | 2013 |
Labeled EGFr-TK irreversible inhibitor (ML03): in vitro and in vivo properties, potential as PET biomarker for cancer and feasibility as anticancer drug.
Topics: Acrylamides; Animals; Antineoplastic Agents; Blotting, Western; Carbon Radioisotopes; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Humans; Isotope Labeling; Liver; Male; Neoplasm Transplantation; Neoplasms, Experimental; Phosphorylation; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured | 2002 |
Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa).
Topics: Animals; Antineoplastic Agents; bcl-X Protein; Blotting, Western; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gefitinib; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Radiation, Ionizing; Survival Rate; Tumor Cells, Cultured | 2002 |
Studies with CWR22 xenografts in nude mice suggest that ZD1839 may have a role in the treatment of both androgen-dependent and androgen-independent human prostate cancer.
Topics: Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carboplatin; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Humans; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Paclitaxel; Prostatic Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Receptors, Androgen; Testosterone; Tosyl Compounds; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Effect of halofuginone on the development of tight skin (TSK) syndrome.
Topics: Animals; Animals, Newborn; Collagen; Disease Models, Animal; Fibrosis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic; Skin Diseases | 2002 |
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Female; Furans; Lipopolysaccharides; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Quinazolines; Sepsis; Sulfonamides | 2003 |
Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Disease Models, Animal; Female; Folic Acid Antagonists; Glutamic Acid; In Vitro Techniques; Inflammatory Bowel Diseases; Liver; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Quinazolines; Rats; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2003 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis.
Topics: Animals; Bleomycin; Cell Division; Disease Models, Animal; ErbB Receptors; Gefitinib; Male; Mice; Mice, Inbred ICR; Phosphorylation; Pulmonary Fibrosis; Quinazolines | 2003 |
EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats.
Topics: Animals; Disease Models, Animal; ErbB Receptors; Gastric Lavage; Injections, Intraperitoneal; Male; Polycystic Kidney Diseases; Quinazolines; Rats; Rats, Sprague-Dawley | 2003 |
The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Disease Models, Animal; Drug Design; Humans; Jurkat Cells; NF-kappa B; Quinazolines; Rats; Structure-Activity Relationship; Transcription Factor AP-1; Transcriptional Activation | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Drug Administration Schedule; Female; Foot; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Male; Microbial Sensitivity Tests; Norfloxacin; Oxazines; Pain; Pain Measurement; Quinazolines; Rats; Rats, Wistar; Time Factors | 2003 |
Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice.
Topics: Animals; Antineoplastic Agents; Biological Availability; Carbon Radioisotopes; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Liposomes; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Quinazolines; Thymidylate Synthase; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2004 |
Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; PC12 Cells; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Quinazolinones; Rats | 2004 |
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vascular Resistance | 2004 |
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Angiotensin II; Animals; Antioxidants; Aorta; Bacterial Toxins; Cardiomyopathy, Hypertrophic; Cytochromes b; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Hypertension, Renovascular; Indoles; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Organ Culture Techniques; Polyethylene Glycols; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Superoxide Dismutase; Superoxides; Tyrphostins; Vasodilation; Vasodilator Agents | 2004 |
[The effect of IRESSA on H22 mouse hepatocellular carcinoma].
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cisplatin; Disease Models, Animal; Gefitinib; Liver Neoplasms; Mice; Quinazolines; Random Allocation; Treatment Outcome | 2004 |
The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Glioma; Piperidines; Protein-Tyrosine Kinases; Quinazolines; Rats | 2004 |
Phospholipid mediators and MgATPase modulation causes changes in the cardiovascular effects of vasopressin in lithium carbonate-induced polyuric rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Lithium Carbonate; Lypressin; Mice; Motor Activity; Neomycin; Phospholipids; Piperidines; Polyuria; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Sphingosine | 2004 |
Halofuginone can worsen liver fibrosis in bile duct obstructed rats.
Topics: Aminopyrine; Animals; Bile Ducts; Breath Tests; Cholestasis, Extrahepatic; Collagen Type I; Collagen Type III; Disease Models, Animal; Ligation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Piperidines; Portal Pressure; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats.
Topics: Aminoquinolines; Aniline Compounds; Animals; Cyclic AMP; Disease Models, Animal; ErbB Receptors; Female; Injections, Intraperitoneal; Intubation, Gastrointestinal; Kidney; Male; Organic Chemicals; Polycystic Kidney, Autosomal Recessive; Quinazolines; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Vasopressin; Severity of Illness Index | 2004 |
In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Cell Line, Transformed; Disease Models, Animal; Female; Liver Neoplasms; Mice; Mice, SCID; Microscopy, Video; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Organophosphorus Compounds; Piperidines; Quinazolines | 2004 |
Highly selective inhibition of inducible nitric oxide synthase ameliorates experimental acute pancreatitis.
Topics: Acute Disease; Amino Acids; Amylases; Animals; Central Venous Pressure; Disease Models, Animal; Enzyme Inhibitors; Female; Hematocrit; Lipase; Lysine; Male; Nitric Oxide Synthase Type II; Pancreatitis; Quinazolines; Trichosurus; Water-Electrolyte Balance | 2005 |
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Biological Availability; Calcium; Cells, Cultured; Disease Models, Animal; Heterocyclic Compounds, 2-Ring; Humans; Hyperalgesia; Isoquinolines; Models, Molecular; Pain; Quinazolines; Quinolines; Rats; Receptors, Drug; Static Electricity; Structure-Activity Relationship; Urea | 2005 |
Enhanced platelet aggregability in dogs following myocardial infarction.
Topics: Animals; Blood Platelets; Carrier Proteins; Collagen; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Extracellular Matrix Proteins; Glycoproteins; Ligation; Myocardial Infarction; Platelet Aggregation; Quinazolines; Sulfinpyrazone | 1977 |
EGF receptor transactivation in angiotensin II and endothelin control of vascular protein synthesis in vivo.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Endothelins; ErbB Receptors; Heart Rate; Hypertension; Infusion Pumps, Implantable; Mesenteric Arteries; Protein Biosynthesis; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrphostins | 2004 |
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.
Topics: Animals; Carcinoma, Papillary; Disease Models, Animal; Drosophila; Drosophila Proteins; ErbB Receptors; Eye Abnormalities; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Piperidines; Protein Isoforms; Proto-Oncogene Proteins c-ret; Quinazolines; raf Kinases; ras Proteins; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 2005 |
The protective effects of rutaecarpine on gastric mucosa injury in rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Evodia; Female; Gastric Mucosa; Indole Alkaloids; Male; Phytotherapy; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2005 |
Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Cineangiography; Coronary Angiography; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Enzyme Inhibitors; Female; Heart Failure; Injections, Intra-Arterial; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Propranolol; Quinazolines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vascular Resistance; Vasodilation; Yohimbine | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Blotting, Western; Body Weight; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gallbladder; Gallbladder Neoplasms; Gefitinib; Humans; In Situ Nick-End Labeling; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neoplasms, Experimental; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Tolonium Chloride | 2005 |
Antiangiogenic effect of ZD1839 against murine renal cell carcinoma (RENCA) in an orthotopic mouse model.
Topics: Animals; Biopsy, Needle; Blotting, Western; Carcinoma, Renal Cell; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gefitinib; Immunohistochemistry; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Quinazolines; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured | 2005 |
Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mononeuropathies; Nitric Oxide Synthase; Pain; Quinazolines; Rats; Rats, Sprague-Dawley | 2006 |
SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Injections, Subcutaneous; Lung Neoplasms; Male; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Piperidines; Proto-Oncogene Mas; Quinazolines; src-Family Kinases; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2005 |
Involvement of dorsolateral periaqueductal gray cholecystokinin-2 receptors in the regulation of a panic-related behavior in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cholecystokinin; Disease Models, Animal; Exploratory Behavior; Fear; Male; Maze Learning; Motor Activity; Neural Pathways; Panic Disorder; Periaqueductal Gray; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Tetragastrin | 2005 |
Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives.
Topics: Animals; Antimalarials; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Quinazolines | 2005 |
[Enhanced expression of EGFR, TGF-alpha, EGF in hyperplastic parathyroid glands in established stage of renal failure in rats].
Topics: Animals; Cell Proliferation; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Hyperplasia; Intracellular Signaling Peptides and Proteins; Male; Parathyroid Glands; Parathyroid Hormone; Phosphorus, Dietary; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Time Factors; Transforming Growth Factor alpha | 2005 |
Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.
Topics: Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Disease Models, Animal; Humans; In Vitro Techniques; Mice; Micronucleus Tests; Microsomes, Liver; Pain; Quinazolines; Rats; Solubility; Structure-Activity Relationship; TRPV Cation Channels | 2006 |
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Quinazolines; Raloxifene Hydrochloride; RNA, Messenger; Structure-Activity Relationship; Transplantation, Heterologous; Trastuzumab; Xenograft Model Antitumor Assays | 2006 |
Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.
Topics: Adult; Aged; Animals; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Amplification; Glioblastoma; Humans; Male; Mice; Mice, Nude; Middle Aged; Quinazolines; Survival Rate; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2006 |
New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Malaria; Maximum Tolerated Dose; Parasitemia; Plasmodium berghei; Prodrugs; Pyrroles; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Therapeutic Equivalency | 2006 |
EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Survival Rate; Thiophenes | 2006 |
Halofuginone prevents subglottic stenosis in a canine model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dogs; Fibroblasts; Follow-Up Studies; Humans; In Vitro Techniques; Laryngostenosis; Mitomycin; Nucleic Acid Synthesis Inhibitors; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Treatment Outcome | 2006 |
Gefitinib prevents bleomycin-induced lung fibrosis in mice.
Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Gefitinib; Humans; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pulmonary Fibrosis; Quinazolines; Tyrphostins | 2006 |
Inhibitor of vascular endothelial growth factor receptor tyrosine kinase attenuates cellular proliferation and differentiation to mature neurons in the hippocampal dentate gyrus after transient forebrain ischemia in the adult rat.
Topics: Animals; Antigens, Surface; Bromodeoxyuridine; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Immunohistochemistry; Ischemic Attack, Transient; Male; Membrane Glycoproteins; Neurons; Phosphopyruvate Hydratase; Quinazolines; Rats; Rats, Wistar; Reperfusion; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A | 2006 |
Erlotinib prevents pulmonary metastasis in curatively resected breast carcinoma using a mouse model.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Protein Kinase Inhibitors; Quinazolines | 2006 |
Increased calcitonin gene-related peptide in neuroma and invading macrophages is involved in the up-regulation of interleukin-6 and thermal hyperalgesia in a rat model of mononeuropathy.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Hyperalgesia; Immunohistochemistry; In Vitro Techniques; Interleukin-6; Macrophages; Male; Membrane Proteins; Neuroma; Pain Measurement; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Neuropathy; Tumor Necrosis Factors; Up-Regulation | 2006 |
Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.
Topics: Adenine; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cinnamates; Class I Phosphatidylinositol 3-Kinases; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Leukocyte Count; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphoinositide-3 Kinase Inhibitors; Pneumonia; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2006 |
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Hydrogen Peroxide; Male; Middle Cerebral Artery; Molsidomine; NAD; Neuroprotective Agents; PC12 Cells; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2006 |
Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib.
Topics: Animals; Bile Ducts, Intrahepatic; Dilatation, Pathologic; Disease Models, Animal; ErbB Receptors; Gefitinib; Liver; Liver Diseases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Polycystic Kidney Diseases; Protein Kinase Inhibitors; Quinazolines; Rats | 2006 |
Intravital microscopy on a closed cranial window in mice: a model to study trigeminovascular mechanisms involved in migraine.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dura Mater; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Microscopy, Video; Migraine Disorders; Piperazines; Quinazolines; Serotonin Receptor Agonists; Skull; Sumatriptan; Trigeminal Caudal Nucleus; Vasodilation | 2006 |
Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Deoxycytidine; Deoxycytidine Kinase; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gemcitabine; Gene Expression Profiling; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Piperidines; Polymerase Chain Reaction; Predictive Value of Tests; Quinazolines; Radiation, Ionizing; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Transplantation, Heterologous | 2006 |
Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.
Topics: Animals; Antineoplastic Agents; Chemoprevention; Disease Models, Animal; ErbB Receptors; Female; Gefitinib; Gene Expression; Genes, ras; Lung Neoplasms; Mice; Mutation; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Quinazolines | 2006 |
In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents.
Topics: Alkaloids; Animals; Anti-Allergic Agents; Behavior, Animal; Cell Degranulation; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Interleukin-4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Plant Extracts; Pruritus; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2007 |
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, ras; Male; Mice; Mice, Inbred A; Mutation; Quinazolines; Signal Transduction; Up-Regulation | 2007 |
An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.
Topics: Administration, Oral; Administration, Topical; Animals; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Female; Human papillomavirus 11; Humans; Immunocompromised Host; Mice; Mice, Inbred BALB C; Mice, Nude; Quinazolines; Transplantation, Heterologous; Tumor Virus Infections; Virus Replication; Warts | 2007 |
Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: an investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol).
Topics: Animals; Calibration; Cell Proliferation; Colonic Neoplasms; Contrast Media; Disease Models, Animal; Heart Ventricles; Hemodynamics; Heterocyclic Compounds; Humans; Magnetic Resonance Imaging; Male; Neoplasm Transplantation; Organometallic Compounds; Piperidines; Quinazolines; Rats; Rats, Nude | 2008 |
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.
Topics: Androstadienes; Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hirudins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Recombinant Proteins; Research Design; RNA, Messenger; Signal Transduction; Thrombin; Time Factors; Ventricular Function, Left; Wortmannin | 2007 |
Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; ErbB Receptors; Female; In Situ Hybridization; Motor Activity; Pain; Pain Measurement; Psychomotor Performance; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sensation; Serotonin; Spinal Cord Injuries; Time Factors; Tyrosine 3-Monooxygenase; Urinary Bladder | 2007 |
A transplantable human medullary thyroid carcinoma as a model for RET tyrosine kinase-driven tumorigenesis.
Topics: Aged; Animals; Calcitonin; Carcinoma, Medullary; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromogranin A; Disease Models, Animal; ErbB Receptors; Humans; Karyotyping; Male; Mice; Mice, Nude; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Quinazolines; Thyroid Neoplasms; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays | 2007 |
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.
Topics: Adenocarcinoma; Animals; Apoptosis; bcl-Associated Death Protein; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Flow Cytometry; Fluorescent Antibody Technique; Humans; Lung Neoplasms; Mice; Mutation; Quinazolines; Sensitivity and Specificity | 2007 |
[Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Male; Mouth Neoplasms; Protein-Tyrosine Kinases; Quinazolines | 2007 |
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hindlimb; Humans; Janus Kinase 3; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Quinazolines; Signal Transduction; Systemic Inflammatory Response Syndrome; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice.
Topics: Adenoma; Animals; Antineoplastic Agents; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Injections, Intraperitoneal; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Quinazolines; Sex Factors | 2008 |
Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Hypertrophy; Hypotension; Indole Alkaloids; Losartan; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Quinazolines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Vasodilator Agents | 2007 |
Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; Humans; Mice; Neovascularization, Pathologic; Piperidines; Quinazolines; Temozolomide; Xenograft Model Antitumor Assays | 2008 |
Protective effects of carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Antioxidants; Carbazoles; Cardiotonic Agents; Carvedilol; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Interleukins; Male; Malondialdehyde; Metoprolol; Mice; Mice, Inbred BALB C; Myocarditis; Propanolamines; Quinazolines; Superoxide Dismutase; Up-Regulation | 2008 |
EGFR activation increases parathyroid hyperplasia and calcitriol resistance in kidney disease.
Topics: Animals; Calcitriol; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Disease Models, Animal; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Female; Genes, Reporter; Humans; Hyperparathyroidism, Secondary; Hyperplasia; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Renal Insufficiency, Chronic; Transforming Growth Factor alpha | 2008 |
Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Male; Mice; Mice, Nude; Models, Biological; Mutation; Pharmacogenetics; Quinazolines; Xenograft Model Antitumor Assays | 2008 |
Using fluorodeoxythymidine to monitor anti-EGFR inhibitor therapy in squamous cell carcinoma xenografts.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; Dideoxynucleosides; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Fluorine Radioisotopes; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Positron-Emission Tomography; Protein Kinase Inhibitors; Quinazolines | 2008 |
Comparative effect of alfuzosin and tamsulosin on the contractile response of isolated rabbit prostatic and iris dilator smooth muscles: possible model for intraoperative floppy-iris syndrome.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Intraoperative Complications; Iris; Iris Diseases; Male; Muscle, Smooth; Phenylephrine; Prostate; Quinazolines; Rabbits; Sulfonamides; Sympathomimetics; Syndrome; Tamsulosin | 2008 |
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Topics: Afatinib; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Survival; Disease Models, Animal; ErbB Receptors; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, Transgenic; NIH 3T3 Cells; Phosphorylation; Quinazolines; Receptor, ErbB-2; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Disparate effects of prazosin and propranolol on lipid metabolism in a rat model.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypertension; Lipid Metabolism; Lipoproteins, VLDL; Male; Prazosin; Propranolol; Quinazolines; Rats; Rats, Inbred Strains; Triglycerides | 1983 |
The 5-HT2 receptor antagonist, pelanserin, inhibits alpha 1-adrenoceptor-mediated vasoconstriction in vitro.
Topics: Animals; Aorta; Blood Pressure; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Mesenteric Arteries; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Tail; Vasoconstriction | 1995 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Histamine; Indomethacin; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship | 1995 |
Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone.
Topics: Animals; Collagen; Disease Models, Animal; Fibrosis; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Osmolar Concentration; Piperidines; Quinazolines; Quinazolinones; Scleroderma, Localized; Skin | 1996 |
Pharmacological activity of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension; Injections, Intravenous; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phosphatidylinositols; Prazosin; Quinazolines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Serotonin Antagonists; Vasoconstriction | 1996 |
A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Organ Size; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar | 1996 |
Studies on disease-modifying antirheumatic drugs: synthesis of novel quinoline and quinazoline derivatives and their anti-inflammatory effect.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Bone Resorption; Dinoprostone; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Pregnancy; Quinazolines; Quinolines; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.
Topics: Animals; Antigens, CD19; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Cell Lineage; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors; Humans; Immunotoxins; Mice; Mice, SCID; N-Glycosyl Hydrolases; Plant Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Ribosome Inactivating Proteins, Type 1; Survival Analysis; Thiophenes; Thymidylate Synthase | 1998 |
Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar; Receptors, Endothelin | 1998 |
Portal hypotensive effects of combined terlipressin and DL-028, a synthetic alpha 1 adrenoceptor antagonist administration on anesthetized portal hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Disease Models, Animal; Drug Therapy, Combination; Hypertension, Portal; Lypressin; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Terlipressin; Venous Pressure | 1999 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.
Topics: Animals; Cell Division; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Kidney Tubules, Collecting; Mice; Mice, Mutant Strains; Nephrons; Organ Culture Techniques; Phosphorylation; Polycystic Kidney Diseases; Protein-Tyrosine Kinases; Quinazolines | 1999 |
The cGMP-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fetus; Humans; Infant, Newborn; Infusions, Intravenous; Nitric Oxide; Persistent Fetal Circulation Syndrome; Phosphodiesterase Inhibitors; Piperidines; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Quinazolines; Sheep; Statistics, Nonparametric; Vasodilation | 1999 |
Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mice; Mice, Inbred BALB C; Polycystic Kidney Diseases; Protein-Tyrosine Kinases; Quinazolines | 2000 |
A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Genetic Variation; Genistein; Heterozygote; Humans; Janus Kinase 3; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Motor Neuron Disease; Neuroprotective Agents; Paralysis; Protein-Tyrosine Kinases; Quinazolines; Superoxide Dismutase | 2000 |
The effect of halofuginone, an inhibitor of collagen type i synthesis, on urethral stricture formation: in vivo and in vitro study in a rat model.
Topics: Animals; Collagen; Disease Models, Animal; Immunohistochemistry; In Situ Hybridization; Male; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Urethral Stricture | 2000 |
The effects of zenarestat, an aldose reductase inhibitor, on peripheral neuropathy in Zucker diabetic fatty rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Male; Quinazolines; Rats; Rats, Zucker | 2000 |
Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Calcium; Disease Models, Animal; Inhibitory Concentration 50; Isomerism; Neuromuscular Blocking Agents; Protein Binding; Pyridines; Quinazolines; Quinazolinones; Rats; Receptors, AMPA; Seizures; Solubility; Structure-Activity Relationship; Synaptic Transmission | 2001 |
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Endothelial Growth Factors; ErbB Receptors; Female; Fibroblast Growth Factor 2; Gefitinib; Growth Substances; Humans; Immunohistochemistry; Inhibitory Concentration 50; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines; Transforming Growth Factor alpha; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.
Topics: Animals; Antineoplastic Agents; Cell Division; Disease Models, Animal; ErbB Receptors; Mice; Mice, SCID; Pyrimidines; Quinazolines; Receptor, ErbB-2; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules.
Topics: Animals; Antineoplastic Agents; Deoxyribonucleotides; Disease Models, Animal; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Infusion Pumps; Injections, Intraperitoneal; Injections, Subcutaneous; Lymphoma; Mice; Mice, Inbred DBA; Nucleoside-Phosphate Kinase; Quinazolines; Time Factors; Tissue Distribution | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
ZD-1839 (AstraZeneca).
Topics: Anemia; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Diarrhea; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Tolerance; Drugs, Investigational; Economics, Pharmaceutical; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Nausea; Pancreatic Neoplasms; Quinazolines; Tumor Cells, Cultured | 2001 |
Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone.
Topics: Administration, Topical; Animals; Cell Division; Collagen; Disease Models, Animal; Fibrosis; Male; Mast Cells; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Skin | 2001 |
Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
Topics: Animals; Axons; Carbazoles; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Indole Alkaloids; Lymnaea; Nerve Crush; Nerve Regeneration; Neurons; Organ Culture Techniques; Quinazolines; Reproducibility of Results | 2001 |
Effects of intracavernous administration of adrenomedullin on erectile function in rats.
Topics: Adrenomedullin; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Erectile Dysfunction; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penile Erection; Peptides; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Rats; Rats, Wistar | 2001 |
Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Ascorbic Acid; Carbazoles; Cardiac Catheterization; Carvedilol; Coronary Disease; Coronary Stenosis; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; Hemodynamics; Male; Metoprolol; Norepinephrine; Propanolamines; Propranolol; Quinazolines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Stroke Volume; Survival Rate; Thiobarbituric Acid Reactive Substances; Ventricular Function, Left; Ventricular Remodeling | 2002 |
Analysis of the effect of halofuginone on bleomycin-induced scleroderma.
Topics: Animals; Bleomycin; Collagen; Disease Models, Animal; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic; Specific Pathogen-Free Organisms; Treatment Outcome | 2002 |
Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). III. Methods employed in the search for new blood schizonticidal drugs.
Topics: Animals; Antimalarials; Aotus trivirgatus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Female; Guanidines; Haplorhini; Hydroxamic Acids; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines | 1978 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Male; Myocardial Infarction; Necrosis; Phenoxybenzamine; Platelet Aggregation; Propranolol; Quinazolines | 1976 |
The effect of alpha 1-blocker, bunazosin on a murine model of congestive heart failure induced by viral myocarditis.
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Encephalomyocarditis virus; Enterovirus Infections; Heart Failure; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Quinazolines | 1992 |
Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes.
Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Disease Models, Animal; Female; Fluorenes; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydantoins; Lens, Crystalline; Naphthalenes; Organ Size; Quinazolines; Random Allocation; Rats; Rats, Inbred BN | 1991 |
[Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs].
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dobutamine; Dogs; Heart Failure; Hemodynamics; Isoproterenol; Prazosin; Quinazolines | 1988 |
Correlation of plasma serotonin changes with platelet aggregation in an in vivo dog model of spontaneous occlusive coronary thrombus formation.
Topics: Adenosine Diphosphate; Animals; Arteries; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Electric Stimulation; Female; Male; Microscopy, Electron, Scanning; Platelet Aggregation; Quinazolines; Serotonin | 1986 |