quinazolines has been researched along with Cirrhosis in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.00) | 18.2507 |
| 2000's | 15 (37.50) | 29.6817 |
| 2010's | 20 (50.00) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hanada, K; Itoh, K; Kato, T; Kawamura, Y; Kitayama, K; Kudo, N; Miura, N; Nakata, M; Narita, M; Nozaka, M; Tatara, Y; Tomita, H; Toyama, Y; Tsushima, M; Yokono, Y | 1 |
| Fukushima, K; Gatate, Y; Muramatsu, T; Naganuma, K; Nakano, S; Ohta, A; Shimizu, Y; Sujino, Y; Tanaka, R; Todo, M; Watanabe, A | 1 |
| Han, B; Huang, W; Li, X; Peng, C; Xie, X; Ye, C; Zhang, N; Zhao, Q; Zhu, HP | 1 |
| Begna, KH; Christopher Hook, C; Elliott, MA; Gangat, N; Hanson, CA; Ketterling, RP; Pardanani, A; Patnaik, MM; Szuber, N; Tefferi, A; Vallapureddy, RR; Wolanskyj, AP | 1 |
| Hryciw, DH; Jang, Y; Kruger, WA; Lee, A; Poronnik, P; Slattery, C | 1 |
| Harmann, LM; Meyer, J; Petersen, M; Routhu, KV; Sonin, DL; Strande, JL; Wakatsuki, T | 1 |
| Cooley, C; Dobberfuhl, AD; Goldschmeding, R; Higgins, PJ; Meldrum, KK; Overstreet, JM; Patel, S; Samarakoon, R | 1 |
| Alter, ML; Chaykovska, L; Hocher, B; Hohmann, M; Klein, T; Kraft, R; Kutil, B; Reichetzeder, C; Tsuprykov, O; von Websky, K | 1 |
| Hoving, S; Russell, NS; Seemann, I; Song, JY; Stewart, FA; te Poele, JA | 1 |
| He, J; Ishigaki, Y; Kanasaki, K; Kanasaki, M; Kitada, M; Koya, D; Nagai, T; Nakamura, Y; Shi, S; Srivastava, SP | 1 |
| Galvis-Carvajal, E; Gomer, RH; White, MJ | 1 |
| Carter, RL; Gold, JI; Grisanti, LA; Koch, WJ; Repas, AA; Talarico, JA; Tilley, DG | 1 |
| Hu, J; Li, X; Liang, D; Liang, G; Lin, F; Qian, Y; Wang, J; Xu, Z; Zeng, C; Zhong, P | 1 |
| Bao, W; Cheng, SB; Chin, YE; Liu, N; Qiu, A; Shi, Y; Wang, L; Xiong, C; Xu, L; Yan, H; Yang, T; Zhuang, S | 1 |
| Aksu, S; Büyükaşık, Y; Eliaçık, E; Göker, H; Haznedaroğlu, İC; Işık, A; Özcebe, OI; Sayınalp, N; Üner, A | 1 |
| Arihiro, K; Doi, S; Doi, T; Irifuku, T; Kohno, N; Masaki, T; Nakashima, A; Sasaki, K; Ueno, T; Yamada, K | 1 |
| Du, J; Li, D; Li, WQ; Li, XH; Li, YJ; Xiong, XM; Zhang, W | 1 |
| Crijns, HJ; De Boer, HC; De Jong, AM; Kamphuisen, PW; Kuiper, M; Lau, DH; Linz, D; Lumeij, S; Maass, AH; Rienstra, M; Schotten, U; Spronk, HM; Ten Cate, H; Van Gelder, IC; van Hunnik, A; van Zonneveld, AJ; Verheule, S; Zeemering, S | 1 |
| Bao, Y; Hu, J; Lan, J; Li, X; Liang, G; Peng, K; Qian, Y; Skibba, M; Zhao, Y; Zhong, P | 1 |
| Ellis, JL; Yin, C; Zhang, C | 1 |
| Dolman, ME; Fretz, MM; Goldschmeding, R; Hennink, WE; Kok, RJ; Lacombe, M; Nguyen, TQ; Pato, J; Prakash, J; Storm, G | 1 |
| Bartha, E; Habon, T; Halmosi, R; Hideg, K; Kálai, T; Kalman, E; Kiss, GN; Kulcsár, G; Sumegi, B; Toth, K | 1 |
| Kamiyama, K; Kimura, H; Li, X; Mikami, D; Okada, T; Takahashi, N; Torii, K; Yoshida, H | 1 |
| Bartha, E; Halmosi, R; Hideg, K; Kálai, T; Kereskai, L; Lantos, J; Magyar, K; Plozer, E; Solti, I; Sumegi, B; Szabados, E; Toth, K | 1 |
| Cheng, N; de Jong, MC; Jiang, L; Li, F; Li, N; Li, Q; Mao, H; Pawlik, TM; Zhou, Y | 1 |
| Cheng, N; Gao, WW; He, M; Wang, MW; Ye, RD; Zhang, M; Zhang, YY | 1 |
| Choi, SK; Galán, M; Henrion, D; Kassan, M; Matrougui, K; Partyka, M; Trebak, M | 1 |
| Lev, PR; Marta, RF; Molinas, FC; Vassallu, P | 1 |
| Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL | 1 |
| Bona, C; Kodera, T; McGaha, T; Phelps, R; Pines, M; Spiera, H | 1 |
| Nagler, A; Pines, M; Snyder, D; Yarkoni, S | 1 |
| Ali-El-Dein, B; Bazeed, M; Hafez, AT; Jaidane, M; Mohsen, T; Ounaies, A | 1 |
| Felici, A; Flanders, KC; Fujii, M; Javelaud, D; Mauviel, A; Mitchell, JB; Piek, E; Reiss, M; Roberts, AB; Russo, A; Samuni, AM; Sowers, A; Xavier, S; Yarkoni, S | 1 |
| Doğusoy, G; Gümüştaş, K; Ozçelik, MF; Pekmezci, S; Saribeyoğlu, K; Unal, E | 1 |
| Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL | 1 |
| Bruno, W; Heller, L; Klitzman, B; Levin, LS; Meade, R; Olbrich, KC | 1 |
| Kakizoe, E; Okunishi, H; Shimoura, K; Shiota, N; Tanaka, T | 1 |
| Knopov, V; Levi-Schaffer, F; Nagler, A; Pines, M; Slavin, S | 1 |
| Nagler, A; Pines, M | 1 |
| Alexiev, R; Domb, A; Genina, O; Inbar, J; Nagler, A; Ohana, M; Pines, M | 1 |
3 review(s) available for quinazolines and Cirrhosis
| Article | Year |
|---|---|
Pharmacobiological Approach for the Clinical Development of Ruxolitinib in Myeloproliferative Neoplasms.
Topics: Bone Marrow; Combined Modality Therapy; Disease Progression; Female; Fibrosis; Humans; Hydroxyurea; Janus Kinase 2; Leukapheresis; Middle Aged; Myeloproliferative Disorders; Nitriles; Phlebotomy; Point Mutation; Polycythemia Vera; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinazolines; Splenectomy; Splenomegaly | 2015 |
Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.
Topics: Administration, Cutaneous; Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Collagen Type I; Fibrosis; Graft vs Host Disease; Humans; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic | 2003 |
Halofuginone: a novel antifibrotic therapy.
Topics: Animals; Collagen; Fibrosis; Humans; Liver Cirrhosis; Piperidines; Postoperative Complications; Protein Synthesis Inhibitors; Pulmonary Fibrosis; Quinazolines; Quinazolinones; Skin; Tissue Adhesions | 1998 |
1 trial(s) available for quinazolines and Cirrhosis
| Article | Year |
|---|---|
Variation of PDGF, TGFbeta, and bFGF levels in essential thrombocythemia patients treated with anagrelide.
Topics: Adolescent; Adult; Aged; Bone Marrow; Female; Fibroblast Growth Factor 2; Fibrosis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Platelet-Derived Growth Factor; Quinazolines; Reticulin; Thrombocytosis; Transforming Growth Factor beta | 2002 |
36 other study(ies) available for quinazolines and Cirrhosis
| Article | Year |
|---|---|
Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Topics: Animals; Collagen Type III; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Macrophages; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Pyrroles; Quinazolines; Receptor, PAR-1; Renin; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Acute Myocardial Infarction in an Adolescent Receiving Anagrelide for Essential Thrombocythemia with Underlying Persistent Coronary Endothelial Dysfunction.
Topics: Acetylcholine; Adolescent; Coronary Angiography; Coronary Vessels; Echocardiography; Endothelium, Vascular; Fibrinolytic Agents; Fibrosis; Heart Function Tests; Humans; Janus Kinase 2; Magnetic Resonance Imaging; Male; Nitroglycerin; Percutaneous Coronary Intervention; Quinazolines; Radionuclide Imaging; ST Elevation Myocardial Infarction; Thrombectomy; Thrombocythemia, Essential; Tomography, Optical Coherence; Tunica Intima; Vasodilator Agents | 2020 |
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway.
Topics: Animals; Apelin; Apoptosis; Cytokines; Evodia; Fibrosis; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Pneumonia; Quinazolines; RAW 264.7 Cells | 2021 |
Decreased survival and increased rate of fibrotic progression in essential thrombocythemia chronicled after the FDA approval date of anagrelide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone Marrow; Disease Progression; Disease-Free Survival; Drug Approval; Female; Fibrosis; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mortality; Platelet Aggregation Inhibitors; Polycythemia Vera; Primary Myelofibrosis; Prognosis; Proportional Hazards Models; Quinazolines; Retrospective Studies; Severity of Illness Index; Thrombocythemia, Essential; Thrombosis; Treatment Outcome; Young Adult | 2019 |
γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells.
Topics: Amyloid Precursor Protein Secretases; Animals; Benzodiazepinones; Cattle; Cell Line; Culture Media, Serum-Free; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Fibronectins; Fibrosis; Humans; Kidney Tubules, Proximal; MAP Kinase Signaling System; Opossums; Proteolysis; Quinazolines; Serum Albumin, Bovine; Transforming Growth Factor beta1; Tyrphostins; Urothelium | 2013 |
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Imaging, Three-Dimensional; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Transforming Growth Factor beta; Ventricular Remodeling | 2013 |
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
Topics: Animals; Benzothiazoles; Connective Tissue Growth Factor; Endothelium, Vascular; ErbB Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Isoquinolines; Mice; Mink; Myocytes, Smooth Muscle; Pyridines; Pyrroles; Quinazolines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Serpin E2; Signal Transduction; Smad2 Protein; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
Effects of telmisartan and linagliptin when used in combination on blood pressure and oxidative stress in rats with 2-kidney-1-clip hypertension.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Benzoates; Blood Pressure; Cardiomegaly; Collagen Type I; Constriction, Pathologic; Cystatin C; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Fibrosis; Heart; Hypertension, Renovascular; Kidney; Linagliptin; Lipoproteins, LDL; Male; Oxidative Stress; Purines; Quinazolines; Random Allocation; Rats; Rats, Wistar; Surgical Instruments; Telmisartan | 2013 |
Radiation- and anthracycline-induced cardiac toxicity and the influence of ErbB2 blocking agents.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Cell Survival; Cells, Cultured; Coronary Vessels; Doxorubicin; Fibrosis; Heart Diseases; Humans; Lapatinib; Male; Mice; Mice, Inbred C57BL; Microvessels; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; Pericardium; Quinazolines; Radiation Injuries, Experimental; Receptor, ErbB-2; Trastuzumab; Ventricular Function, Left | 2013 |
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen.
Topics: Animals; Blotting, Western; Cell Line, Transformed; Cell Proliferation; Cells, Cultured; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Down-Regulation; Endothelial Cells; Fibrosis; Gene Expression Regulation; Genetic Pleiotropy; Immunohistochemistry; Linagliptin; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred NOD; MicroRNAs; Purines; Quinazolines; Streptozocin | 2014 |
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Topics: Albumins; Cell Differentiation; Cell Movement; Cells, Cultured; Cicatrix; Fibroblasts; Fibrosis; Humans; Interferon-gamma; Lactones; Leukocytes, Mononuclear; Monocytes; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Receptor, PAR-2; Serum Amyloid P-Component; Signal Transduction; Thrombin; Trypsin; Tryptases; Wound Healing | 2015 |
Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomegaly; Cells, Cultured; Chemokine CCL2; ErbB Receptors; Fibrosis; Gefitinib; Heart Ventricles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Myofibroblasts; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2015 |
EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; ErbB Receptors; Fibrosis; Male; Mice; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Ventricular Remodeling | 2015 |
EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.
Topics: Animals; Chemokines; Cytokines; Disease Progression; ErbB Receptors; Fibroblasts; Fibrosis; Gefitinib; Hyperuricemia; Inflammation; Kidney; Kidney Diseases; Male; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Uric Acid | 2015 |
Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression.
Topics: Actins; Animals; Antibodies, Neutralizing; Azepines; Cell Line; Enzyme Inhibitors; Fibroblasts; Fibronectins; Fibrosis; Glomerulonephritis, IGA; Glucuronidase; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Klotho Proteins; Lysine; Male; Methylation; Mice; Quinazolines; Rats; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1; Ureteral Obstruction | 2016 |
Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats.
Topics: Animals; Apoptosis; Calcitonin Gene-Related Peptide; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-3; Fibroblasts; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indole Alkaloids; Myocardium; Quinazolines; Signal Transduction; Transforming Growth Factor beta1; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2016 |
Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation.
Topics: Analysis of Variance; Animals; Antithrombins; Atrial Fibrillation; Cell Proliferation; Dabigatran; Female; Fibrinolytic Agents; Fibroblasts; Fibrosis; Goats; Heart Atria; Indazoles; Mice, Transgenic; Nadroparin; Peptide Hydrolases; Pyrroles; Quinazolines; Rats; Receptors, Thrombin; Thrombin; Thrombophilia; Urea | 2017 |
New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice.
Topics: Angiotensin II; Animals; Apoptosis; ErbB Receptors; Fibrosis; Kidney; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2016 |
Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish.
Topics: Animals; Cell Count; Cell Proliferation; Ethanol; Extracellular Matrix Proteins; Fatty Liver; Fibrosis; Gene Expression Regulation; Hepatic Stellate Cells; Larva; Ligands; Liver; Liver Diseases, Alcoholic; Liver Regeneration; Mutation; Neovascularization, Physiologic; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Zebrafish; Zebrafish Proteins | 2016 |
Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
Topics: Cells, Cultured; Chemistry, Pharmaceutical; Drug Carriers; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Fibrosis; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Kinetics; Muramidase; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Quinazolines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2008 |
Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Disease Models, Animal; Echocardiography; Enalapril; Enzyme Inhibitors; Fibrosis; Heart Failure; Male; Myocardial Infarction; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Remodeling | 2008 |
Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Cells, Cultured; Dexamethasone; Fibrosis; Humans; Kidney Tubules, Proximal; Plasminogen Activator Inhibitor 1; Protein-Tyrosine Kinases; Quinazolines; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrphostins | 2009 |
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Cardiovascular Agents; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Male; Myocardium; Natriuretic Peptide, Brain; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Inbred SHR; Signal Transduction; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cholangitis; Collagen Type I; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fibrosis; Gene Expression; In Situ Nick-End Labeling; Ki-67 Antigen; Lithiasis; Male; Mucin 5AC; Quinazolines; Rats; Rats, Sprague-Dawley; Recurrence; Tyrphostins | 2011 |
Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Bleomycin; Chemokines; Cytokines; Disease Models, Animal; Fibrosis; Inflammation; Lung Injury; Male; Mice; Mice, Inbred ICR; Quinazolines; Receptors, Formyl Peptide; Time Factors | 2011 |
A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus.
Topics: Animals; Blotting, Western; Cholagogues and Choleretics; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; ErbB Receptors; Fibrosis; Gene Expression; Heart; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Myocardium; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin; Taurochenodeoxycholic Acid; Transcription Factor CHOP; Tyrphostins; Vasodilation | 2012 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction | 2003 |
Effect of halofuginone on the development of tight skin (TSK) syndrome.
Topics: Animals; Animals, Newborn; Collagen; Disease Models, Animal; Fibrosis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Scleroderma, Systemic; Skin Diseases | 2002 |
The use of halofuginone in limiting urethral stricture formation and recurrence: an experimental study in rabbits.
Topics: Administration, Oral; Animals; Electrocoagulation; Fibrosis; Male; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rabbits; Secondary Prevention; Urethra; Urethral Stricture | 2003 |
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
Topics: Animals; Blotting, Northern; Blotting, Western; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cells, Cultured; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Fibrosis; Gene Deletion; Genes, Reporter; Humans; Immunoblotting; MAP Kinase Signaling System; Mice; Mice, Inbred C3H; Microscopy, Confocal; Microscopy, Fluorescence; Piperidines; Plasmids; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Radiation Pneumonitis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Time Factors; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of esophageal strictures related to caustic injury.
Topics: Animals; Burns, Chemical; Caustics; Collagen Type I; Esophageal Stenosis; Esophagus; Fibrosis; Injections, Intraperitoneal; Male; Models, Animal; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Sodium Hydroxide | 2004 |
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; Gefitinib; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Hypertension; Ischemia; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteinuria; Quinazolines; Rats; Rats, Sprague-Dawley | 2004 |
Halofuginone inhibits collagen deposition in fibrous capsules around implants.
Topics: Animals; Collagen Type I; Colorimetry; Fibrosis; Male; Muscles; Piperidines; Prostheses and Implants; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Silicone Elastomers; Subcutaneous Tissue; Transforming Growth Factor beta | 2005 |
Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice.
Topics: Animals; Cell Proliferation; Chymases; Fibrosis; Immunohistochemistry; Mast Cells; Mice; Mice, Inbred C57BL; Protease Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scleroderma, Systemic; Serine Endopeptidases; Skin; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone.
Topics: Animals; Collagen; Disease Models, Animal; Fibrosis; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Osmolar Concentration; Piperidines; Quinazolines; Quinazolinones; Scleroderma, Localized; Skin | 1996 |
Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone.
Topics: Administration, Topical; Animals; Cell Division; Collagen; Disease Models, Animal; Fibrosis; Male; Mast Cells; Mice; Piperidines; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Skin | 2001 |