Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and Chordoma

quinazolines has been researched along with Chordoma in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's9 (69.23)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Asquith, CRM; Bieberich, AA; Crona, DJ; Fatig, RO; Laitinen, T; Maffuid, K; Morris, DC; Torrice, CD1
Asquith, CRM; Crona, DJ; Laitinen, T; Maffuid, KA; Tizzard, GJ; Torrice, CD; Zuercher, WJ1
Asquith, CRM; Drewry, DH; East, MP; Havener, TM; Johnson, GL; Laitinen, T; Morris, DC; Naegeli, KM; Wells, CI; Zuercher, WJ1
Bozzi, F; Casale, A; Casali, PG; Conca, E; Crippa, F; Gronchi, A; Lo Vullo, S; Mariani, L; Marrari, A; Messina, A; Morosi, C; Negri, T; Palassini, E; Palmerini, E; Pilotti, S; Stacchiotti, S; Tamborini, E1
Bettegowda, C; Burger, PC; Connis, N; Gallia, GL; Hann, CL; Jiao, Y; Ruzevick, J; Siu, IM; Xia, X; Zhao, Q1
Bozzi, F; Conca, E; Dagrada, G; Gronchi, A; Manenti, G; Messina, A; Panizza, P; Pierotti, MA; Pilotti, S; Stacchiotti, S; Tamborini, E1
Asklund, T; Henriksson, R; Riklund, K; Sandström, M; Shahidi, S1
Amary, F; Barnard, M; Brüderlein, S; Cottone, L; Drewry, DH; Flanagan, AM; Guppy, N; Jorgensen, M; Leite, AP; Leithner, A; Möller, P; Pillay, N; Scheipl, S; Smith, JA; Strauss, SJ; Tirabosco, R; Turlais, F; Ye, H; Zuercher, WJ1
Kjellén, E; Lindén, O; Stenberg, L1
Kotasek, D; Parnis, FX; Singhal, N1
Amary, MF; Athanasou, N; Bacsi, K; Berisha, F; Briggs, TR; Flanagan, AM; Halai, D; Hogendoorn, PC; Idowu, B; Kindblom, LG; Leithner, A; Liegl, B; Presneau, N; Shalaby, A; Tirabosco, R; Ye, H1
Bertucci, F; Chetaille, B; Guiramand, J; Launay, SG; Medina, F; Moureau-Zabotto, L; Nazarian, S; Perrot, D1
Debus, J; Hof, H; Welzel, T1

Reviews

1 review(s) available for quinazolines and Chordoma

ArticleYear
Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review.
    BMC cancer, 2011, Oct-04, Volume: 11

    Topics: Aged; Antineoplastic Agents; Benzamides; Bone Neoplasms; Chordoma; ErbB Receptors; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Male; Molecular Targeted Therapy; Neoplasm Staging; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Treatment Outcome

2011

Trials

1 trial(s) available for quinazolines and Chordoma

ArticleYear
Phase II study on lapatinib in advanced EGFR-positive chordoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Chordoma; Disease-Free Survival; Drug Administration Schedule; ErbB Receptors; Female; Humans; Lapatinib; Male; Middle Aged; Quinazolines; Sacrum; Skull Base; Treatment Outcome

2013

Other Studies

11 other study(ies) available for quinazolines and Chordoma

ArticleYear
Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform.
    Scientific reports, 2022, 07-27, Volume: 12, Issue:1

    Topics: Aniline Compounds; Chordoma; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Quinazolines

2022
Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma.
    ChemMedChem, 2019, 10-04, Volume: 14, Issue:19

    Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chordoma; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Lung Neoplasms; Models, Molecular; Molecular Targeted Therapy; Protein Binding; Protein Kinase Inhibitors; Quinazolines

2019
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
    Journal of medicinal chemistry, 2019, 05-09, Volume: 62, Issue:9

    Topics: Aminoquinolines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chordoma; Drug Design; ErbB Receptors; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines

2019
Erlotinib inhibits growth of a patient-derived chordoma xenograft.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Cell Line, Transformed; Cell Proliferation; Chordoma; ErbB Receptors; Erlotinib Hydrochloride; Genome-Wide Association Study; Heterografts; Humans; Mice; Neoplasm Transplantation; Protein Kinase Inhibitors; Quinazolines; Xenograft Model Antitumor Assays

2013
Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies.
    Neuro-oncology, 2014, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Bone Neoplasms; Chordoma; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; In Situ Hybridization, Fluorescence; Lapatinib; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Recurrence, Local; Quinazolines; Sacrum; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
Durable stabilization of three chordoma cases by bevacizumab and erlotinib.
    Acta oncologica (Stockholm, Sweden), 2014, Volume: 53, Issue:7

    Topics: Adult; Antibodies, Monoclonal, Humanized; Bevacizumab; Bone Neoplasms; Chordoma; Erlotinib Hydrochloride; Female; Humans; Male; Middle Aged; Quinazolines; Sacrum; Skull Neoplasms; Treatment Outcome

2014
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
    The Journal of pathology, 2016, Volume: 239, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chordoma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Mice; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays

2016
Regression of cervical spinal cord compression in a patient with chordoma following treatment with cetuximab and gefitinib.
    Acta oncologica (Stockholm, Sweden), 2009, Volume: 48, Issue:1

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cervical Vertebrae; Cetuximab; Chordoma; Female; Gefitinib; Humans; Middle Aged; Quinazolines; Spinal Cord Compression

2009
Response to erlotinib in a patient with treatment refractory chordoma.
    Anti-cancer drugs, 2009, Volume: 20, Issue:10

    Topics: Antineoplastic Agents; Chordoma; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Sacrococcygeal Region

2009
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
    The Journal of pathology, 2011, Volume: 223, Issue:3

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Proliferation; Chordoma; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; ErbB Receptors; Humans; In Situ Hybridization, Fluorescence; Mutation; Neoplasm Proteins; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Skull Base Neoplasms; Tumor Cells, Cultured; Tyrphostins

2011
Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma.
    Onkologie, 2006, Volume: 29, Issue:12

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cetuximab; Chordoma; Gefitinib; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Quinazolines; Sacrum; Spinal Neoplasms; Treatment Outcome

2006