Page last updated: 2024-08-21

quinazolines and Chemical and Drug Induced Liver Injury

quinazolines has been researched along with Chemical and Drug Induced Liver Injury in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (7.04)	18.7374
1990's	0 (0.00)	18.2507
2000's	20 (28.17)	29.6817
2010's	44 (61.97)	24.3611
2020's	2 (2.82)	2.80

Authors

Authors	Studies
Bai, M; Li, C; Li, M; Li, Y; Liu, H; Lu, S; Ma, S; Su, P; Yin, X; Zhang, C	1
Aleo, MD; Barton, HA; Di, L; Generaux, G; Howell, BA; Lakhani, VV; Nadanaciva, S; Qiu, L; Riccardi, K; Shoda, LKM; Siler, SQ; Watkins, PB; Yang, Y	1
Kaur, R; Sharma, V; Sharma, VL	1
Hayashi, R; Inomata, M; Kambara, K; Kashii, T; Konishi, H; Miwa, T; Okazawa, S; Shimokawa, K; Tanaka, H; Tobe, K; Tokui, K; Yamada, T	1
Baba, T; Ikeda, S; Iwasawa, T; Kato, T; Ogura, T; Okudela, K; Sekine, A; Yamakawa, H; Yamanaka, Y	1
Dong, YZ; Li, F; Lin, ZJ; Zhang, B; Zhang, D; Zhang, XM	1
Hunt, CM; Spraggs, CF; Xu, CF	1
Chen, L; Huang, Y; Liu, J; Ma, Y; Wu, H; Zhao, H; Zhou, N	1
Kaniwa, N; Saito, Y	1
Agbor-Tarh, D; Aktas, B; Azim, HA; Baselga, J; Bradbury, I; de Azambuja, E; Di Cosimo, S; Dinh, P; Dreosti, L; Eidtmann, H; Greger, JG; Hsieh, RK; Huang, CS; Jackisch, C; Kim, SB; Piccart, M; Smith, I; Vuylsteke, P	1
Kutoh, E	1
Hong, W; Huang, Q; Liu, Y; Sun, X; Wu, J; Wu, W	1
Cardon, LR; Cox, CJ; Curran, J; Ejlertsen, B; Finkelstein, DM; Goss, PE; McDonnell, SK; Parham, LR; Rappold, E; Schaid, DJ; Spraggs, CF	1
Abdel-Rahman, O; Fouad, M	1
Hirata, T; Ito, T; Kurita, N; Shimizu, S; Uchihara, H	1
Fukuoka, M; Hasegawa, Y; Ozaki, T; Sugiura, T; Suzumura, T; Tsukuda, H; Yonesaka, K	1
Fontanella, C; Lederer, B; Loibl, S; Nekljudova, V; Untch, M; von Minckwitz, G	1
Agbor-Tarh, D; Azim, HA; Bradbury, I; de Azambuja, E	1
Chen, J; Hu, P; Jiang, J; Liu, DY; Tan, FL; Wang, YX; Wu, YW; Zhao, Q; Zheng, X	1
Iseri, K; Iyoda, M; Kuno, Y; Matsumoto, K; Saito, T; Shibata, T; Shindo-Hirai, Y; Suzuki, T; Wada, Y; Yamamoto, Y	1
Nakagawa, K; Okamoto, I; Takeda, M	1
Briley, LP; Cox, CJ; Dilthey, A; Iqbal, Z; King, KS; Li, L; McVean, G; Nelson, MR; Newcombe, PJ; Parham, LR; Shen, J; Slater, AJ; Spraggs, CF	1
An, LJ; He, LN; He, X; Wang, LL; Yang, AH; Zhai, YR; Zhang, FL; Zhang, SC	1
Hagihara, K; Hirasawa, M; Izumi, T; Okudaira, N	1
Dong, M; He, X; Li, J; Wang, J; Wang, Y; Wang, Z; Wu, Y	1
Atobe, O; Fujimori, A; Hachiya, T; Ikuyama, Y; Imai, A; Shiba, H; Sonehara, K	1
de la Cruz Merino, L; Marcos Rodríguez, JA; Romero Carreño, E; Santana Martínez, S	1
Hayashi, H; Kudo, K; Nakagawa, K; Takeda, M; Ueda, H	1
Goto, K; Kirita, K; Matsumoto, S; Niho, S; Ohmatsu, H; Sugiyama, E; Umemura, S; Yoh, K; Zenke, Y	1
Hotta, K; Ichihara, E; Kato, Y; Kiura, K; Kubo, T; Kudo, K; Minami, D; Ninomiya, K; Ninomiya, T; Oda, N; Ohashi, K; Sato, A; Tabata, M; Takigawa, N; Tanimoto, M; Yoshioka, H	1
Faulkner, L; Meng, X; Naisbitt, DJ; Park, BK; Spraggs, CF	1
Aklillu, E; Makonnen, E; Petros, Z	1
Bi, YA; Campbell, S; Davidson, R; Duignan, DB; Dunn, MC; Feng, B; Kostrubsky, VE; Mireles, R; Smith, AR; Wang, HF; Xu, JJ	1
Fimognari, FL; Franco, A; Pastorelli, R; Pellegrinotti, M; Repetto, L	1
Chatta, G; Evans, CP; Gandara, DR; Lara, PN; Longmate, J; Posadas, E; Quinn, DI; Stadler, W; Twardowski, P	1
Han, C; Isse, K; Li, G; Lim, K; Wu, T; Xu, L	1
Fukuoka, M; Nakagawa, K; Okamoto, I; Takeda, M	1
Ishikawa, H; Kato, T; Naito, T; Nakagaki, S; Ohashi, Y; Onishi, T; Sakurai, M; Shino, M; Suzuki, K; Takahashi, T; Yamamoto, N	1
Andrade, RJ; Hallal, H; López Martín, A; Titos-Arcos, JC	1
Chan, EC; Hanson, KL; Nelson, SD; New, LS; Takakusa, H; Wahlin, MD; Zhao, C	1
Azuma, J; Fujio, Y; Furukawa, M; Goya, S; Hirata, H; Kawase, I; Kida, H; Kijima, T; Minami, T; Nagatomo, I; Nonen, S; Otani, Y; Shimizu, T; Tachibana, I; Takahashi, R; Takeda, Y	1
Kalofonos, H; Koutras, A; Labropoulou-Karatza, C; Makatsoris, T; Onyenadum, A; Peroukides, S; Tsamandas, A	1
Chen, W; Han, C; Li, G; Wu, T	1
Chang, SC; Hsu, SY; Kuo, LC; Lai, JI; Lai, YC; Lin, PC; Wang, WS	1
Borts, DJ; Bowers, GD; Castellino, S; Koch, K; MacLauchlin, C; O'Mara, M	1
Baykara, M; Benekli, M; Buyukberber, S; Coskun, U; Demirci, U; Kerem, M; Pasali, H; Pasaoglu, H; Uner, A; Yılmaz, G	1
Ishida, T; Iwasaku, M; Korogi, Y; Kunimasa, K; Masuda, G; Nishiyama, A; Takaiwa, T; Yoshioka, H	1
Dollery, CT; Hunt, CM; Parham, LR; Spraggs, CF	1
Chen, J; Dassarath, M; Gu, R; Wang, Q; Wu, G; Yang, K; Yin, Z	1
Hokkoku, K; Igarashi, S; Kitade, H; Mori, M; Nakai, M; Sagawa, M; Shintaku, K; Yamada, T; Yano, S	1
Binetti, P; La Cesa, A; Massacesi, C; Picardi, A; Santini, D; Tonini, G; Vincenzi, B	1
Bonsignori, M; Delprete, S; La Cesa, A; Marcucci, F; Massacesi, C; Rocchi, MB; Santini, D; Tonini, G; Vincenzi, B	1
Fujimura, M; Kasahara, K; Kimura, H; Kita, T; Nakao, S; Yoshimoto, A	1
Basar, O; Beyazit, Y; Köklü, S; Köksal, AS; Yolcu, OF; Yüksel, O	1
Bardag-Gorce, F; French, BA; French, SW; Li, J; Nan, L; Wilson, LT; Wu, Y	1
Hirashima, T; Kawahara, K; Kawase, I; Kobayashi, M; Matsui, K; Nakamura, Y; Nitta, T; Sasada, S; Takimoto, T	1
Anderson, F; Bebb, G; Davis, J; Ho, C; Murray, N	1
Aoe, M; Date, H; Fujiwara, Y; Hotta, K; Kiura, K; Matsuo, K; Tabata, M; Takigawa, N; Tanimoto, M; Tokumo, M; Toyooka, S	1
Eguchi, K; Seki, N; Shibakuki, R; Uematsu, K	1
Carlini, P; Ciccarese, M; Cognetti, F; Fabi, A; Felici, A; Ferretti, G; Milella, M; Nuzzo, C; Papaldo, P; Ruggeri, EM	1
Ramanarayanan, J; Scarpace, SL	1
Britten, CD; Gelmon, K; Guo, F; Letrent, SP; Munster, PN; Sharma, A; Tolcher, AW	1
Chang, R; Chang, YW; Dong, SH; Kim, BH; Kim, HJ; Kim, SY; Kim, YW	1
Saif, MW	1
Krishnan, GS; Ramanarayanan, J	1
Gascón, A; Pina, MA; Thomson, C; Valdearcos, S; Zabala, S	1
Calvert, AH; Cantwell, BM; Harris, AL; Kaye, SB; Macaulay, V; Milsted, RA; Smith, IE	1
Bishop, JA; Calvert, AH; Grzelakowska-Sztabert, B; Gumbrell, LA; Harland, SJ; Harrap, KR; Jackman, AL; Judson, IR; Newell, DR; Sikora, E	1
Alison, DL; Calvert, AH; Harland, SJ; Jackman, AL; Jones, TR; McElwain, TJ; Newell, DR; Robinson, BA; Siddik, ZH; Wiltshaw, E	1
Ochiai, T	1
Hori, M; Kowa, Y; Ochiai, T	1

Reviews

8 review(s) available for quinazolines and Chemical and Drug Induced Liver Injury

Article	Year
Genetic characterization to improve interpretation and clinical management of hepatotoxicity caused by tyrosine kinase inhibitors. Pharmacogenomics, 2013, Volume: 14, Issue:5 Topics: Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Gilbert Disease; Glucuronosyltransferase; Humans; Indazoles; Lapatinib; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Sulfonamides	2013
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury. Journal of human genetics, 2013, Volume: 58, Issue:6 Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carbamazepine; Chemical and Drug Induced Liver Injury; Diclofenac; Dideoxynucleosides; Drug Hypersensitivity; Floxacillin; Genetic Markers; HLA Antigens; HLA-A Antigens; HLA-B Antigens; HLA-DQ alpha-Chains; Humans; Lapatinib; Pharmacogenetics; Quinazolines; Skin; Stevens-Johnson Syndrome; Ticlopidine	2013
Probable linagliptin-induced liver toxicity: a case report. Diabetes & metabolism, 2014, Volume: 40, Issue:1 Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Fatigue; Female; Half-Life; Humans; Jaundice; Linagliptin; Metabolic Clearance Rate; Middle Aged; Nausea; Purines; Quinazolines	2014
Raltitrexed-based chemotherapy for advanced colorectal cancer. Clinics and research in hepatology and gastroenterology, 2014, Volume: 38, Issue:2 Topics: Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mucositis; Nausea; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Randomized Controlled Trials as Topic; Stomatitis; Thiophenes; Vomiting	2014
Does the use of lapatinib increase the risk of fatigue and hepatic toxicities in patients with solid tumors? A critical literature review and meta-analysis. Expert opinion on drug safety, 2014, Volume: 13, Issue:8 Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Fatigue; Humans; Lapatinib; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Risk	2014
Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2015, Volume: 88, Issue:1 Topics: Afatinib; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Mutation; Quinazolines	2015
Erlotinib-induced acute hepatitis in a patient with pancreatic cancer. Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:3 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Deoxycytidine; ErbB Receptors; Erlotinib Hydrochloride; Gemcitabine; Humans; Liver; Male; Middle Aged; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinazolines	2008
Review: hepatotoxicity and EGFR inhibition. Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; ErbB Receptors; Erlotinib Hydrochloride; Humans; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinazolines	2008

Trials

8 trial(s) available for quinazolines and Chemical and Drug Induced Liver Injury

Article	Year
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity. Pharmacology research & perspectives, 2019, Volume: 7, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver Injury; Computer Simulation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Healthy Volunteers; HEK293 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; Liver; Male; Middle Aged; Mitochondria; Models, Biological; Quinazolines; Rats; Species Specificity; Taurocholic Acid; Young Adult	2019
Pattern of rash, diarrhea, and hepatic toxicities secondary to lapatinib and their association with age and response to neoadjuvant therapy: analysis from the NeoALTTO trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, 12-20, Volume: 31, Issue:36 Topics: Adult; Age Factors; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Diarrhea; Drug Administration Schedule; Drug Eruptions; Female; Humans; Incidence; Lapatinib; Logistic Models; Middle Aged; Neoadjuvant Therapy; Paclitaxel; Quinazolines; Receptor, ErbB-2; Time Factors; Trastuzumab	2013
Prospective validation of HLA-DRB107:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Aug-01, Volume: 32, Issue:22* Topics: Adult; Aged; Alleles; Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Female; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Humans; Lapatinib; Middle Aged; Prospective Studies; Quinazolines; Reproducibility of Results; Risk Factors	2014
Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB107:01. The pharmacogenomics journal, 2016, Volume: 16, Issue:2* Topics: Alanine Transaminase; Alleles; Antineoplastic Agents; Breast Neoplasms; Case-Control Studies; Chemical and Drug Induced Liver Injury; ErbB Receptors; Female; Genome-Wide Association Study; HLA-DRB1 Chains; Humans; Hyperbilirubinemia; INDEL Mutation; Lapatinib; Polymorphism, Single Nucleotide; Quinazolines; Risk	2016
A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study. Anti-cancer drugs, 2009, Volume: 20, Issue:3 Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Benzodioxoles; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Disease-Free Survival; Drug Resistance, Neoplasm; Gastrointestinal Diseases; Humans; Lymphopenia; Male; Middle Aged; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; src-Family Kinases	2009
Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes. Clinical pharmacology and therapeutics, 2012, Volume: 91, Issue:4 Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Genotype; Gilbert Disease; Glucuronosyltransferase; HLA-DQ alpha-Chains; HLA-DRB1 Chains; Humans; Incidence; Lapatinib; Quinazolines	2012
Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors. Anti-cancer drugs, 2003, Volume: 14, Issue:7 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid Antagonists; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Predictive Value of Tests; Quinazolines; Thiophenes; Transaminases	2003
Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety. Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1 Topics: Adult; Aged; Algorithms; Antineoplastic Agents; Area Under Curve; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Half-Life; Humans; Liver Function Tests; Middle Aged; Neoplasm Metastasis; Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Tandem Mass Spectrometry	2008

Other Studies

55 other study(ies) available for quinazolines and Chemical and Drug Induced Liver Injury

Article	Year
Study on the hepatotoxicity and potential mechanism of gefitinib based on CYP450 in mice and AML12 cells. The Journal of pharmacy and pharmacology, 2023, Mar-12, Volume: 75, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Drug-Related Side Effects and Adverse Reactions; Gefitinib; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Quinazolines; RNA, Messenger	2023
Ameliorative potential of Adhatoda vasica against anti-tubercular drugs induced hepatic impairments in female Wistar rats in relation to oxidative stress and xeno-metabolism. Journal of ethnopharmacology, 2021, Apr-24, Volume: 270 Topics: Alkaloids; Animals; Antitubercular Agents; Arylamine N-Acetyltransferase; Chemical and Drug Induced Liver Injury; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP2E1; Disease Models, Animal; Female; Free Radical Scavengers; Gene Expression Regulation; Glucuronosyltransferase; Isoniazid; Justicia; Oxidative Stress; Plant Extracts; Plant Leaves; Pregnane X Receptor; Pyrazinamide; Quinazolines; Rats, Wistar; Rifampin	2021
[A Case of Lung Adenocarcinoma Presenting with Leptomeningeal Carcinomatosis Successfully Treated with Afatinib after Erlotinib-Induced Hepatotoxicity]. Gan to kagaku ryoho. Cancer & chemotherapy, 2017, Volume: 44, Issue:7 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Afatinib; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Male; Meningeal Carcinomatosis; Quinazolines; Treatment Outcome	2017
Afatinib Therapy for Brain Metastases Aggravated by a Reduction in the Dose of Erlotinib Due to the Development of Hepatotoxicity. Internal medicine (Tokyo, Japan), 2017, Nov-01, Volume: 56, Issue:21 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Afatinib; Aged, 80 and over; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Quinazolines	2017
Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs: A network pharmacology study and biology experiments. PloS one, 2019, Volume: 14, Issue:5 Topics: Alanine Transaminase; Alkaline Phosphatase; Antimetabolites; Aspartate Aminotransferases; Benzylisoquinolines; Cell Line; Chemical and Drug Induced Liver Injury; Computational Biology; Drugs, Chinese Herbal; Flavonoids; Gene Expression Regulation; Gout Suppressants; Hepatocytes; Humans; Hyperuricemia; Indole Alkaloids; L-Lactate Dehydrogenase; Liver; Mitogen-Activated Protein Kinase 14; Molecular Docking Simulation; Protein Binding; Quinazolines; Saponins; Uric Acid	2019
[The cost-effectiveness analysis of gefitinib or erlotinib in the treatment of advanced EGFR mutant non-small cell lung cancer patients]. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2013, Volume: 16, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Diarrhea; ErbB Receptors; Erlotinib Hydrochloride; Exanthema; Female; Follow-Up Studies; Gefitinib; Humans; Insurance, Health; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Mutation; Patient Outcome Assessment; Protein Kinase Inhibitors; Quinazolines	2013
Idiosyncratic liver injury induced by vildagliptin with successful switch to linagliptin in a hemodialyzed diabetic patient. Diabetes care, 2014, Volume: 37, Issue:9 Topics: Adamantane; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Hypoglycemic Agents; Linagliptin; Nitriles; Purines; Pyrrolidines; Quinazolines; Renal Dialysis; Vildagliptin	2014
Erlotinib is a well-tolerated alternate treatment for non-small cell lung cancer in cases of gefitinib-induced hepatotoxicity. Anticancer research, 2014, Volume: 34, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Drug Substitution; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Protein Kinase Inhibitors; Quinazolines; Treatment Outcome	2014
Does toxicity predict efficacy? Insight into the mechanism of action of lapatinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Oct-20, Volume: 32, Issue:30 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Female; Humans; Neoadjuvant Therapy; Quinazolines	2014
Reply to C. Fontanella et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Oct-20, Volume: 32, Issue:30 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Female; Humans; Neoadjuvant Therapy; Quinazolines	2014
Therapeutic effects and adverse drug reactions are affected by icotinib exposure and CYP2C19 and EGFR genotypes in Chinese non-small cell lung cancer patients. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:17 Topics: Adult; Aged; Antineoplastic Agents; Asian People; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; China; Chromatography, High Pressure Liquid; Crown Ethers; Cytochrome P-450 CYP2C19; Disease-Free Survival; Drug Eruptions; Female; Genes, erbB-1; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; Tandem Mass Spectrometry	2014
Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats. PloS one, 2014, Volume: 9, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line; Chemical and Drug Induced Liver Injury; Cisplatin; ErbB Receptors; Erlotinib Hydrochloride; Humans; Kidney Tubules, Proximal; Liver; Macrophages; Male; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger	2014
Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:11 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Indole Alkaloids; Quinazolines; Rats	2015
The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB107:01. PloS one, 2015, Volume: 10, Issue:6* Topics: Chemical and Drug Induced Liver Injury; HLA-DRB1 Chains; Humans; Lapatinib; Models, Molecular; Molecular Dynamics Simulation; Quinazolines; Tetanus Toxoid	2015
Observation of hepatotoxicity during long-term gefitinib administration in patients with non-small-cell lung cancer. Anti-cancer drugs, 2016, Volume: 27, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Retrospective Studies; Time Factors	2016
[Successful Treatment of Non-Small Cell Lung Cancer with Afatinib after Gefitinib-Induced Hepatotoxicity]. Gan to kagaku ryoho. Cancer & chemotherapy, 2016, Volume: 43, Issue:1 Topics: Afatinib; Aged; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Gefitinib; Humans; Liver Diseases; Lung Neoplasms; Male; Protein Kinase Inhibitors; Quinazolines	2016
[Hepatic toxicity in HER-2(+) breast cancer patient under treatment with capecitabine and lapatinib]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2016, Mar-01, Volume: 40, Issue:2 Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Chemical and Drug Induced Liver Injury; Female; Humans; Lapatinib; Quinazolines; Receptor, ErbB-2	2016
Successful treatment with afatinib after gefitinib- and erlotinib-induced hepatotoxicity. Investigational new drugs, 2016, Volume: 34, Issue:6 Topics: Adenocarcinoma; Afatinib; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Lung Neoplasms; Prognosis; Quinazolines; Radiation-Sensitizing Agents	2016
Successful treatment with afatinib after grade 3 hepatotoxicity induced by both gefitinib and erlotinib in EGFR mutation-positive non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2016, Volume: 99 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; ErbB Receptors; Gefitinib; Glucuronosyltransferase; Humans; Lung Neoplasms; Middle Aged; Mutation; Pharmacogenetics; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Protein Kinase Inhibitors; Quinazolines; Retreatment; Treatment Outcome	2016
Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Asian People; Body Mass Index; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; ErbB Receptors; Female; Gefitinib; Humans; Liver Function Tests; Lung Neoplasms; Male; Middle Aged; Mutation; Overweight; Quinazolines; Retrospective Studies; Risk Factors	2016
No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB107:01-Restricted Lapatinib-Induced Liver Injury. Chemical research in toxicology, 2016, 12-19, Volume: 29, Issue:12* Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; HLA-DRB1 Chains; Humans; Lapatinib; Lymphocyte Activation; Quinazolines; T-Lymphocytes	2016
Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation. Omics : a journal of integrative biology, 2017, Volume: 21, Issue:3 Topics: Amoxicillin-Potassium Clavulanate Combination; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Diclofenac; Floxacillin; Genome-Wide Association Study; Genotype; HLA-B Antigens; HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Lapatinib; Liver; Proteins; Quinazolines	2017
Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Calcium; Carrier Proteins; Cells, Cultured; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Fluoresceins; Hepatocytes; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Membrane Potentials; Mitochondrial Membranes; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Quinazolines; Receptor, ErbB-2	2009
Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer. The Annals of pharmacotherapy, 2009, Volume: 43, Issue:3 Topics: Acidosis, Lactic; Adenocarcinoma; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Erlotinib Hydrochloride; Fatal Outcome; Humans; Lung Neoplasms; Male; Metformin; Quinazolines	2009
Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3 Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; ErbB Receptors; fas Receptor; Fas-Associated Death Domain Protein; Hepatocytes; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitrobenzenes; Quinazolines; Sulfonamides; Tyrphostins; Up-Regulation	2009
Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-10, Volume: 28, Issue:17 Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Liver Neoplasms; Lung Neoplasms; Quinazolines	2010
[Safety analysis of eight patients treated with erlotinib after severe gefitinib-induced liver injury]. Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:7 Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Molecular Structure; Quinazolines	2010
[Recurrent hepatocellular lesion due to alfuzosin]. Gastroenterologia y hepatologia, 2011, Volume: 34, Issue:2 Topics: Adrenergic alpha-1 Receptor Antagonists; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Quinazolines; Recurrence	2011
Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:6 Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Activation; Escherichia coli; Ferricyanides; Humans; Lapatinib; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Protein Binding; Quinazolines	2011
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jul-01, Volume: 29, Issue:19 Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Japan; Liver; Lung Neoplasms; Mutation; Quinazolines; Transaminases; Treatment Outcome	2011
Lapatinib-induced hepatitis: a case report. World journal of gastroenterology, 2011, May-14, Volume: 17, Issue:18 Topics: Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Lapatinib; Middle Aged; Quinazolines	2011
Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury. Journal of hepatology, 2011, Volume: 55, Issue:6 Topics: Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; ErbB Receptors; fas Receptor; Female; Galactosamine; Gene Expression; Group IV Phospholipases A2; Hepatocytes; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinazolines; Recombinant Proteins; Tyrphostins	2011
Successful treatment of erlotinib-induced acute hepatitis and acute interstitial pneumonitis with high-dose corticosteroid: a case report and literature review. International journal of clinical pharmacology and therapeutics, 2011, Volume: 49, Issue:7 Topics: Adenocarcinoma; Adrenal Cortex Hormones; Aged; Alanine Transaminase; Anti-Inflammatory Agents; Antineoplastic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; ErbB Receptors; Erlotinib Hydrochloride; Humans; Liver Function Tests; Lung Diseases, Interstitial; Lung Neoplasms; Male; Methylprednisolone; Muscle Weakness; Quinazolines; Radiography, Thoracic	2011
Human metabolism of lapatinib, a dual kinase inhibitor: implications for hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Lapatinib; Male; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Young Adult	2012
Hepatotoxicity associated with lapatinib in an experimental rat model. European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:2 Topics: Alanine Transaminase; Albumins; Analysis of Variance; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Lapatinib; Lipoproteins, VLDL; Liver; Liver Function Tests; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triglycerides	2012
Successful treatment of non-small cell lung cancer with gefitinib after severe erlotinib-related hepatotoxicity. Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:4 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Treatment Outcome	2012
Gefitinib-induced hepatotoxicity in patients treated for non-small cell lung cancer. Onkologie, 2012, Volume: 35, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Female; Gefitinib; Humans; Liver Neoplasms; Middle Aged; Quinazolines; Treatment Outcome	2012
[Efficacy of low-dose erlotinib against gefitinib-induced hepatotoxicity in a patient with lung adenocarcinoma harboring EGFR mutations]. Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged, 80 and over; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Quinazolines	2013
Severe liver dysfunction after raltitrexed administration in an HCV-positive colorectal cancer patient. Cancer investigation, 2003, Volume: 21, Issue:1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Chemical and Drug Induced Liver Injury; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Function Tests; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Viremia	2003
[Transient liver injury caused by gefitinib]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004, Volume: 42, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Female; Gefitinib; Humans; Liver; Lung Neoplasms; Male; Middle Aged; Quinazolines	2004
Alfuzosin-induced acute hepatitis in a patient with chronic liver disease. The Annals of pharmacotherapy, 2004, Volume: 38, Issue:9 Topics: Acute Disease; Adrenergic alpha-Antagonists; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Hepatitis B, Chronic; Humans; Liver; Liver Function Tests; Male; Quinazolines	2004
The p105/50 NF-kappaB pathway is essential for Mallory body formation. Experimental and molecular pathology, 2005, Volume: 78, Issue:3 Topics: Animals; Antigens, Nuclear; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlormethiazole; Chromosomal Proteins, Non-Histone; Dihydropyridines; Enzyme Inhibitors; Hepatocytes; Inclusion Bodies; JNK Mitogen-Activated Protein Kinases; Liver; Liver Diseases; Male; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Models, Biological; NF-kappa B; NF-kappa B p50 Subunit; Protein Precursors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction	2005
Gefitinib for previously untreated patients with non-small cell lung cancer (NSCLC)--a retrospective study of 12 patients treated in one institution. Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:12 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Quinazolines; Retrospective Studies	2005
Side effects related to cancer treatment: CASE 1. Hepatitis following treatment with gefitinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Nov-20, Volume: 23, Issue:33 Topics: Adenocarcinoma, Bronchiolo-Alveolar; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Female; Gefitinib; Humans; Lung Neoplasms; Middle Aged; Quinazolines	2005
Relationship between epidermal growth factor receptor gene mutations and the severity of adverse events by gefitinib in patients with advanced non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2006, Volume: 52, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Diarrhea; ErbB Receptors; Exanthema; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Prognosis; Quinazolines; Retrospective Studies	2006
Promising new treatment schedule for gefitinib responders after severe hepatotoxicity with daily administration. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-01, Volume: 24, Issue:19 Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Gefitinib; Humans; Liver; Lung Neoplasms; Middle Aged; Quinazolines	2006
Liver toxicity after treatment with gefitinib and anastrozole: drug-drug interactions through cytochrome p450? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Dec-10, Volume: 24, Issue:35 Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Gefitinib; Humans; Isoenzymes; Lymphatic Metastasis; Middle Aged; Nitriles; Quinazolines; Triazoles	2006
Acute drug induced hepatitis due to erlotinib. JOP : Journal of the pancreas, 2007, Jan-09, Volume: 8, Issue:1 Topics: Adenocarcinoma; Aged; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinazolines	2007
Alfuzosin-induced acute liver injury. The Korean journal of hepatology, 2007, Volume: 13, Issue:3 Topics: Acute Disease; Adrenergic alpha-Antagonists; Chemical and Drug Induced Liver Injury; Dysuria; Humans; Liver Diseases; Liver Function Tests; Male; Middle Aged; Prostatic Hyperplasia; Quinazolines	2007
Alfuzosin-induced hepatotoxicity. Journal of clinical pharmacy and therapeutics, 2000, Volume: 25, Issue:1 Topics: Acute Disease; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Humans; Hypertension; Male; Middle Aged; Quinazolines	2000
Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717) in advanced breast cancer. European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Folic Acid; Folic Acid Antagonists; Humans; Middle Aged; Quinazolines; Thymidylate Synthase	1988
Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717). NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diuresis; Drug Evaluation; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Middle Aged; Quinazolines; Thymidylate Synthase	1987
A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:8 Topics: Acetylglucosaminidase; Acid Phosphatase; Alanine Transaminase; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Folic Acid; Folic Acid Antagonists; Glomerular Filtration Rate; Hematologic Diseases; Hyperbilirubinemia; Kidney Diseases; Leucyl Aminopeptidase; Neoplasms; Quinazolines; Skin Diseases; Thymidylate Synthase	1986
Effects of 1-morpholinoacetyl-2-methyl-3-phenyl-4-oxo-1,2,3,4-tetrahydro quinazoline hydrochloride (HQ-275) on alpha-naphtyl isothio-cyanate- and/or thioacetamide-induced liver damage in rats. Japanese journal of pharmacology, 1974, Volume: 24, Issue:3 Topics: Acetamides; Adenosine Triphosphatases; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Body Temperature; Chemical and Drug Induced Liver Injury; Cholesterol; Histocytochemistry; Liver; Male; Morpholines; Potassium; Quinazolines; Rats; Sodium; Thioacetamide; Thiocyanates; Time Factors; Water	1974
Effects of 1-morpholinoacetyl-2-methyl-3-phenyl-4-oxo-1, 2, 3, 4-tetrahydroquinazoline hydrochloride (HQ-275) on acute experimental hepatic injury induced by carbon tetrachloride in rats. Japanese journal of pharmacology, 1973, Volume: 23, Issue:3 Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Liver; Male; Quinazolines; Rats; Sulfobromophthalein	1973