Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and Cell Transformation, Neoplastic

quinazolines has been researched along with Cell Transformation, Neoplastic in 105 studies

Research

Studies (105)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (3.81)18.2507
2000's35 (33.33)29.6817
2010's65 (61.90)24.3611
2020's1 (0.95)2.80

Authors

AuthorsStudies
Lin, JY; Yeh, TH1
Cao, H; Fan, F; Feng, J; Hu, Y; Liu, S; Ma, R; Ni, J; Qin, X; Sha, H; Wu, J; Xu, X; Yan, D; Yu, S; Zang, J; Zhou, L1
Chen, YC; Chien, CC; Chiu, WT; Liu, KH; Wu, WS1
Fan, Y; Gong, L; Huang, Z; Xu, Y1
Chai, Y; Wu, Y; Yao, Y; Zhu, Z1
Cunha, SI; Jia, M; Souchelnytskyi, S1
Achenbach, H; Besses, C; Birgegård, G; Folkvaljon, F; Garmo, H; Griesshammer, M; Gugliotta, L; Harrison, CN; Holmberg, L; Kiladjian, JJ; Wu, J1
Ali, SM; Chung, JH; DiClemente, F; Dolfi, SC; Ganesan, S; Gay, LM; Hirshfield, KM; Kulkarni, A; Lee, E; Leyland-Jones, B; Lin, S; Liu, C; Paratala, BS; Petrosky, W; Pham, K; Rodriguez-Rodriguez, L; Ross, JS; Schrock, AB; Williams, CB; Williams, K; Yao, M; Yilmazel, B1
Lang, L; Teng, Y1
Brown, KK; Chan, H; Chheang, C; Daly, RJ; Huang, C; Lee, RS; Li, F; Ma, X; Mitchell, CA; Nguyen, E; Rodgers, SJ; Schittenhelm, RB; Simpson, KJ; Song, J; Wu, J; Zhang, L1
Brekken, RA; Buettner, R; Chatterjee, S; Christofori, G; Frasca, D; Heukamp, LC; Koker, M; König, K; Meder, L; Neumaier, B; Peifer, M; Rauh, D; Schöttle, J; Siobal, M; Thomas, RK; Ullrich, RT; Wieczorek, C; Wolf, J1
Deng, XB; Jin, ZR; Li, XQ; Liu, QZ; Liu, Y; Ma, L; Miao, XB; Sun, DX; Testa, JR; Wu, Y; Xiao, GH; Yao, KT; Zhang, G1
Alvarez-Larrán, A; Besses, C; Cervantes, F1
Carbonetti, G; Carlin, SD; Chiosis, G; de Stanchina, E; Divilov, V; Gomes-DaGama, EM; Holland, JP; Janjigian, YY; Lewis, JS; Viola-Villegas, N1
Fan, YX; Johnson, GR; Marino, MP; Ou, W; Reiser, J; Shen, Y; Wong, KK; Wong, L; Wu, WJ1
Hsu, JH; Li, MF; Shiau, EL; Wu, MT1
Bhave, S; Bruno, PA; Datta, J; Lang, JC; Mapp, AK; Pan, Q; Piao, L; Su, T; Taylor, CE; Teknos, TN; Xie, X; Zhang, M1
Barker, HE; Chang, J; Cox, TR; Erler, JT; Martens, JW; Nicolau, MM; Wetterskog, D1
Biddinger, P; Dillard, T; Hao, Z; Patel, V1
Fishbein, M; Marchevsky, A; Reckamp, KL; Saldivar, JS; Scher, KS1
Buchanan, G; Frydenberg, M; Furic, L; Larsson, O; Pedersen, J; Risbridger, GP; Taylor, RA; Wilkinson, SE1
Hellman, U; Kazi, JU; Lundby, A; Mohlin, S; Olsen, JV; Påhlman, S; Rönnstrand, L; Sun, J1
Takeuchi, S; Yano, S1
Chou, YH; Hsieh, MS; Hua, SF; Jhuang, JY1
Balanis, NG; Carlin, CR; Pascuzzi, PE; Schiemann, BJ; Schiemann, WP; Wendt, MK; Williams, WK1
Al-Ejeh, F; Bessette, DC; Chenevix-Trench, G; Cocciardi, S; Grimmond, SM; Khanna, KK; Lakhani, SR; McCart-Reed, A; Quinn, MC; Saunus, JM; Seidens, T; Shi, W; Simpson, PT; Tilch, E; Waddell, N; Wiegmans, AP1
Anto, RJ; Antony, J; Chandran, H; Joseph, SM; Katiki, MR; Murty, MS; Nath, LR; Nishanth, KS; Panakkal, EJ; Paul, A; Rajan, E; Ran, S; Saikia, M; Sankar, S; Shabna, A; Sridivya, I; Sriramya, I; Vinod, V1
Bertotti, A; Bose, R; Cottino, F; Galimi, F; Jacobs, SA; Jain, N; Kavuri, SM; Leto, SM; Migliardi, G; Monsey, J; Searleman, AC; Shen, W; Trusolino, L1
Fukuda, T; Gu, J; Hang, Q; Hou, S; Im, S; Isaji, T1
Choe, J; Han, M; Jeoung, D; Kim, H; Kim, Y; Kim, YM; Lee, H; Lee, YS; Park, D1
Banno, E; de Velasco, MA; Fujita, Y; Hamada, S; Hayashi, H; Nakahara, H; Nakamura, Y; Nishio, K; Nutahara, K; Okegawa, T; Sakai, K; Terashima, M; Togashi, Y; Tomida, S1
Ahmad, F; Dixit, D; Joshi, SD; Sen, E1
Goto, N; Inoue, T; Kashimoto, S; Kukimoto-Niino, M; Masuda, M; Mimata, A; Moriyama, H; Ohata, H; Ohbayashi, N; Okamoto, K; Sawa, M; Shirouzu, M; Uno, Y; Yamada, T1
Chen, G; Gao, Y; Huang, C; Lu, Z; Shi, L; Song, Z; Wang, B; Wang, Y; Xu, D; Zhang, H; Zhang, W; Zhang, Y; Zhuang, N1
Gong, XL; Huang, C; Liu, H; Wen, B; Wu, LY1
Ellison, K; Hirsch, FR; Kim, J; Mitsudomi, T; Murakami, I; Rivard, CJ; Suda, K; Yu, H1
Peng, H; Xia, L; Xiaoli, Z; Zhiqiang, L1
Bullinger, L; Chen, J; Fröhling, S; Gilliland, DG; Golub, TR; Gu, TL; Lee, BH; Monti, S; Tam, WF; Wang, A1
Bernuau, D; Daniel, F; Güller, M; Legrand, A; Mauviel, A; Michel, L; Toualbi-Abed, K1
Ashton, GH; Baldeschi, C; Brunton, VG; Canel, M; Doyle, B; Frame, MC; Green, TP; Mackintosh, LJ; Mason, SM; Sansom, OJ; Serrels, A; Serrels, B1
Katayama, H; Kishino, D; Kiura, K; Kuyama, S; Ohashi, K; Okada, T; Sato, K; Takigawa, N; Tanimoto, M1
Hirano, S; Ichihara, E; Kiura, K; Kubo, T; Ohashi, K; Osawa, M; Takata, M; Takeda, H; Takigawa, N; Tanimoto, M; Yoshino, T1
Agrawal, NS; Cronin, JC; Cruz, P; Lin, JC; Prickett, TD; Rosenberg, SA; Samuels, Y; Wei, X; Wunderlich, JR; Yates, KE1
Ansaldi, F; Bagnasco, L; Ballestrero, A; Cea, M; Cirmena, G; Garuti, A; Grillo, V; Icardi, G; Moran, E; Nencioni, A; Parodi, S; Patrone, F; Rocco, I; Soncini, D; Zoppoli, G1
Chang, HC; Connolly, K; DiGiovanni, J; Kiguchi, K; Kitamura, T; Moore, T; Ruffino, L; Rumi, M; Treece, D1
Hart, JR; Hillmann, P; Hofmann, BT; Sun, M; Vogt, PK1
Bulfone, A; Cominelli, M; De Palma, M; Falini, A; Franzin, A; Galli, R; Mazzoleni, S; Pala, M; Poliani, PL; Politi, LS; Sergi Sergi, L1
Dempke, W; Zippel, R1
Chao, DC; Ho, TY; Hsiang, CY; Kao, ST; Li, CC; Liang, JA; Lin, LJ; Lo, HY; Wu, SL1
Durbin, JE; Koromilas, AE; Muller, WJ; Raven, JF; Tremblay, ML; Wang, S; Williams, V1
Chang, CS; Chao, DC; Ho, TY; Hsiang, CY; Huang, HC; Kao, ST; Liang, JA; Lin, LJ; Wu, SL1
Burga, LN; Hofstatter, EW; Hu, H; Juvekar, A; Troyan, SL; Tung, NM; Wulf, GM1
Fujita, Y; Hiroshima, K; Niijima, M; Nishio, K; Saitoh, M; Takiguchi, Y; Tatsumi, K1
Bareford, MD; Cruickshanks, N; Dai, Y; Dent, P; Grant, S; Hamed, HA; Hubbard, N; Mitchell, C; Tang, Y; Tye, G; Yacoub, A1
Bade, LK; Dehut, HA; Goldberg, JE; Hall, MK; Schwertfeger, KL1
Chao, YS; Cherniack, AD; Chiang, D; Cho, J; Dutt, A; Johnson, W; Kesari, S; Kwon, J; Meyerson, M; Onofrio, RC; Pastorino, S; Vandenberg, S; Verhaak, R; Watanabe, H; Xu, X; Yuza, Y; Zeng, Q1
Alder, H; Cascione, L; Condorelli, G; Croce, CM; Di Leva, G; Engelman, JA; Garofalo, M; Jeon, YJ; Lovat, F; Nephew, KP; Ngankeu, A; Nuovo, G; Ono, M; Rho, JK; Romano, G; Sun, J; Volinia, S1
Cheng, H; De Luo, B; Liu, ZG; Ren, Y; Zhang, YF; Zhu, H1
Bonfil, RD; Cher, ML; Conley-LaComb, MK; Heath, E; Jung, YS; Kim, CJ; Kim, HR; Najy, AJ; Saliganan, A; Won, JJ1
Chung, KF; Huang, CD; Huang, TT; Kuo, HP; Lee, KY; Lin, HC; Lin, SM; Lo, YL; Wang, CH1
Asaka, R; Hamanaka, W; Hatano, S; Ishikawa, Y; Lim Choi, Y; Mano, H; Nakagawa, K; Ninomiya, H; Okumura, S; Sakata, S; Satoh, Y; Soda, M; Suzuki, R; Takeuchi, K; Togashi, Y; Uehara, H1
Arai, Y; Chiku, S; Enari, M; Furuta, K; Harris, CC; Haugen, A; Hiramoto, M; Ichikawa, H; Iwakawa, R; Kohno, T; Nammo, T; Ogawa, S; Ogiwara, H; Oike, T; Okayama, H; Sakamoto, H; Schetter, AJ; Sekine, I; Shibata, T; Shimada, Y; Skaug, V; Totoki, Y; Tsuda, H; Tsuta, K; Watanabe, S; Yamanaka, I; Yasuda, K; Yokota, J; Yoshida, T1
Ansén, S; Bass, AJ; Beer, DG; Brace, LE; Brambilla, C; Brambilla, E; Brustugun, OT; Cho, J; Clement, JH; Deng, X; Dutt, A; Eck, MJ; Gabler, F; Gray, NS; Greulich, H; Groen, H; Hammerman, PS; Hanna, M; Hatton, C; Haura, EB; Helland, A; Heuckmann, JM; Heynck, S; Janne, PA; Johnson, BE; Koker, M; Lawrence, MS; Leenders, F; Lim, SM; Lin, W; Lorimier, P; Meyerson, M; Moch, H; Onofrio, RC; Peifer, M; Petersen, I; Querings, S; Ramos, AH; Rauh, D; Salvesen, HB; Seidel, D; Sietsma, H; Simard, JR; Soltermann, A; Sos, ML; Stoelben, E; Thomas, RK; Timens, W; Tsao, MS; Winckler, W; Wolf, J; Wong, KK; Woods, BA; Xu, C; Zander, T; Zhang, J; Zhou, W1
Argyle, DJ; Bergkvist, GT; Cervantes-Arias, A; Muirhead, R; Pang, LY; Yool, DA1
Boehm, JS; Butaney, M; Cheung, HW; Du, J; Engelman, JA; Golub, TR; Hahn, WC; He, F; Jänne, PA; Luo, B; Meyerson, M; Root, DE; Sequist, LV; Wang, X; Weir, BA1
Antoine, M; Belmont, L; Cadranel, J; Fallet, V; Lacave, R; Lavolé, A; Poulot, V; Ruppert, AM; Wislez, M1
Boerner, JL; Kuperwasser, C; List, K; Madden, JM; Mueller, KL; Zoratti, GL1
Brown, HA; Bruntz, RC; Bryson, BL; Cipriano, R; Graham, J; Jackson, MW; Miskimen, KL; Scott, SA; Stark, GR1
Chisholm, JW; Igal, RA; Nashed, M1
Barbacid, M; Guerra, C; Hernández-Porras, I; Navas, C; Schuhmacher, AJ; Sibilia, M1
Chen, C; Chuang, TH; Liao, D; Liu, Y; Luo, Y; Markowitz, D; Reisfeld, RA; Xiang, R; Yang, J1
Gonzalez, D; Nicholson, AG; Nutting, CM; O'Brien, M; Popat, S; Wotherspoon, A1
Montgomery, RB1
Bunn, PA; Franklin, W1
Carlomagno, F; Ciardiello, F; Fontanini, G; Fusco, A; Guida, T; Ryan, AJ; Santoro, M; Tortora, G; Vecchio, G; Vitagliano, D1
Arteaga, CL; Ritter, CA1
Dufresne, A; Gainet, M; Guardiola, E; Pivot, X1
Marmé, D1
Franklin, RA; McCubrey, JA; McMahon, M; Shelton, JG; Sreevalsan, T; Steelman, LS1
Berlin, JD; Lockhart, AC; Lockhart, C1
Jeng, YM; Lien, HC; Su, MC1
Alvarez, JV; Bulmer, SE; Chen, TH; Feng, W; Frank, DA; Greulich, H; Hahn, WC; Jänne, PA; Meyerson, M; Sellers, WR; Zappaterra, M1
Greulich, H; Griffin, JD; Jänne, PA; Jiang, J; Meyerson, M; Sellers, WR1
Gazdar, AF; Girard, L; Lee, W; Minna, JD; Peyton, M; Ramirez, RD; Sato, M; Shames, DS; Shay, JW; Sunaga, N; Vaughan, MB1
Furukawa, M; Greene, MI; Inoue, K; Kawase, I; Kijima, T; Kumagai, T; Nagatomo, I; Ogata, Y; Osaki, T; Saito, Y; Tachibana, I; Takahashi, R; Yamadori, T; Yano, Y; Yoneda, T; Yoshida, M1
Davies, GC; Lipkowitz, S; Rahman, L; Ryan, PE; Zajac-Kaye, M1
Cecere, F; Reguart, N; Rosell, R; Santarpia, M; Taron, M1
Avila, MA; Berasain, C; Castillo, J; Erroba, E; Lee, DC; Perugorría, MJ; Prieto, J; Santamaría, M1
Belldegrun, A; Figlin, R; Iwata, KK; Jin, Y; Lieberman, R; Pantuck, A; Rao, J; Zhang, ZF1
Carey, KD; Garton, AJ; Gibson, N; Haley, JD; Kahler, J; Park, F; Romero, MS; Ross, S; Sliwkowski, MX; Thomson, S1
Antonaci, S; Giannelli, G1
Chang, A; Zhang, X1
Bissonnette, M; Cerda, S; Cohen, G; Dougherty, U; Fichera, A; Gong, C; Hart, J; Jagadeeswaran, S; Joseph, L; Khare, S; Little, N; Mustafi, R; Sehdev, A; Tallerico, M; Tretiakova, M; Turner, JR; Yuan, W1
Ahlman, H; Bernhardt, P; Jansson, S; Johanson, V; Kölby, L; Nilsson, O; Persson, F; Stenman, G; Stridsberg, M; Swärd, C; Wängberg, B1
Chen, X; Li, N; Newman, RA; Sood, S; Sun, Z; Yang, CS; Yang, P1
Becker, JC; Schrama, D; Ugurel, S1
Boukouvala, S; Calkins, K; Cutler, RE; Fong, R; Funke, R; Gendreau, SB; Gerritsen, ME; Heuer, TS; Kim, YD; Lamb, P; Matthews, DJ; Miller, N; Trowe, T; Vysotskaia, V; Woolfrey, JR; Yang, JP1
Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM1
Coffey, RJ; Der, CJ; Gangarosa, LM; Graves-Deal, R; Oldham, SM; Sizemore, N1
Antonyak, MA; Moscatello, DK; Wong, AJ1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Zushi, S1
Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC1
Arteaga, CL; Coffey, RJ; Forbes, JT; Lenferink, AE; Shawver, LK; Simpson, JF1
Billestrup, N; Brender, C; Kaltoft, K; Mikkelsen, G; Nielsen, M; Odum, N; Wasik, M; Zhang, Q1
Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E1

Reviews

12 review(s) available for quinazolines and Cell Transformation, Neoplastic

ArticleYear
Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies.
    Cells, 2019, 01-09, Volume: 8, Issue:1

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Fibroblast Growth Factors; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Molecular Targeted Therapy; Neoplasms; Quinazolines; Receptor, Fibroblast Growth Factor, Type 4; Signal Transduction

2019
[Treatment of essential thrombocythemia].
    Medicina clinica, 2013, Sep-21, Volume: 141, Issue:6

    Topics: Adult; Age Factors; Aged; Anticoagulants; Aspirin; Cell Transformation, Neoplastic; Disease Progression; Female; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Hydroxyurea; Intraoperative Complications; Janus Kinase 2; Leukemia, Myeloid, Acute; Life Expectancy; Male; Middle Aged; Mutation, Missense; Platelet Aggregation Inhibitors; Point Mutation; Pregnancy; Pregnancy Complications, Hematologic; Primary Myelofibrosis; Quinazolines; Risk Factors; Thrombocythemia, Essential; Thrombophilia

2013
Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: sensitivity and resistance.
    Respiratory investigation, 2014, Volume: 52, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Membrane Proteins; Molecular Targeted Therapy; Mutation; Polymorphism, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Quinazolines; Small Cell Lung Carcinoma

2014
[SRC kinases in tumor therapy].
    Medizinische Klinik (Munich, Germany : 1983), 2010, Volume: 105, Issue:10

    Topics: Aniline Compounds; Benzodioxoles; Cell Physiological Phenomena; Cell Transformation, Neoplastic; Clinical Trials, Phase II as Topic; Dasatinib; Disease Progression; DNA Mutational Analysis; Drug Delivery Systems; Enzyme Activation; Humans; Neoplasms; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Mas; Pyrimidines; Quinazolines; Quinolines; src-Family Kinases; Thiazoles

2010
Epidermal growth factor receptor expression, signal pathway, and inhibitors in non-small cell lung cancer.
    Seminars in oncology, 2002, Volume: 29, Issue:5 Suppl 14

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Cetuximab; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Panitumumab; Precancerous Conditions; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction

2002
The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors.
    Seminars in oncology, 2003, Volume: 30, Issue:1 Suppl 1

    Topics: Antineoplastic Agents; Cell Transformation, Neoplastic; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Neoplasm Metastasis; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction

2003
[Epidermal growth factor receptors (EGFR): a new target for anticancer therapy].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2003, Volume: 7, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biopsy; Cell Transformation, Neoplastic; Cetuximab; Clinical Trials as Topic; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Panitumumab; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Survival Analysis; Treatment Outcome

2003
The epidermal growth factor receptor as a target for colorectal cancer therapy.
    Seminars in oncology, 2005, Volume: 32, Issue:1

    Topics: Aminoquinolines; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Transformation, Neoplastic; Cetuximab; Colorectal Neoplasms; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lapatinib; Organic Chemicals; Panitumumab; Prognosis; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction

2005
Predicting the outcome of chemotherapy for lung cancer.
    Current opinion in pharmacology, 2006, Volume: 6, Issue:4

    Topics: 14-3-3 Proteins; Antineoplastic Agents; Cell Transformation, Neoplastic; Clinical Trials as Topic; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Epigenesis, Genetic; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Mesoderm; Mutation; Nuclear Proteins; Polymorphism, Genetic; Protein Kinase Inhibitors; Quinazolines; Smoking; Thioredoxins; Treatment Outcome; Y-Box-Binding Protein 1

2006
Novel concepts in hepatocellular carcinoma: from molecular research to clinical practice.
    Journal of clinical gastroenterology, 2006, Volume: 40, Issue:9

    Topics: Antineoplastic Agents; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Transformation, Neoplastic; ErbB Receptors; Gefitinib; Humans; Liver Cirrhosis; Neoplasm Invasiveness; Prognosis; Quinazolines

2006
Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer.
    Journal of medical genetics, 2007, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Clinical Trials, Phase II as Topic; DNA Mutational Analysis; DNA, Neoplasm; Double-Blind Method; Drug Delivery Systems; Drug Design; Drug Resistance, Neoplasm; ErbB Receptors; Ethnicity; Exons; Female; Gefitinib; Genes, erbB-1; Genes, p53; Genes, ras; Genotype; Humans; Lung Neoplasms; Male; Mutagenesis, Insertional; Mutation; Mutation, Missense; Protein Structure, Tertiary; Quinazolines; Randomized Controlled Trials as Topic; Sequence Deletion; Smoking

2007
Strategies to optimize the use of targeted agents for tumor therapy.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2008, Volume: 6, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cell Transformation, Neoplastic; Clinical Trials as Topic; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Synergism; Gefitinib; Gene Silencing; Humans; Neoplasms; Prognosis; Quinazolines

2008

Trials

1 trial(s) available for quinazolines and Cell Transformation, Neoplastic

ArticleYear
Leukemic transformation and second cancers in 3649 patients with high-risk essential thrombocythemia in the EXELS study.
    Leukemia research, 2018, Volume: 74

    Topics: Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasms, Second Primary; Quinazolines; Thrombocythemia, Essential

2018

Other Studies

92 other study(ies) available for quinazolines and Cell Transformation, Neoplastic

ArticleYear
Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Animals; Antigens, CD; Antineoplastic Agents, Phytogenic; Body Weight; Cachexia; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytokines; Dose-Response Relationship, Drug; Indole Alkaloids; Lymphocyte Count; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Organ Size; Prostatic Neoplasms; Quinazolines; Spleen; Th1-Th2 Balance; Tumor Necrosis Factor-alpha

2021
Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Gefitinib; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; Oligonucleotide Array Sequence Analysis; Quinazolines; Real-Time Polymerase Chain Reaction

2017
Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation.
    The American journal of Chinese medicine, 2017, Volume: 45, Issue:4

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Survival; Cell Transformation, Neoplastic; Evodia; Glioblastoma; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tumor Cells, Cultured

2017
A case of resistance to tyrosine kinase inhibitor therapy: small cell carcinoma transformation concomitant with plasma-genotyped T790M positivity.
    Anti-cancer drugs, 2017, Volume: 28, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Cisplatin; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mutation; Pemetrexed; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma

2017
Histologic transformation from adenocarcinoma to both small cell lung cancer and squamous cell carcinoma after treatment with gefitinib: A case report.
    Medicine, 2018, Volume: 97, Issue:18

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Fatal Outcome; Gefitinib; Humans; Lung Neoplasms; Male; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma

2018
Exposure to EGF and 17β‑estradiol irreversibly affects the proliferation and transformation of MCF7 cells but is not sufficient to promote tumor growth in a xenograft mouse model upon withdrawal of exposure.
    International journal of molecular medicine, 2018, Volume: 42, Issue:3

    Topics: Animals; Benzamides; Carcinogenesis; Cell Proliferation; Cell Transformation, Neoplastic; Dioxoles; Epidermal Growth Factor; Estradiol; Female; Gefitinib; Humans; MCF-7 Cells; Mice, SCID; Models, Biological; Neoplastic Stem Cells; Phenotype; Quinazolines; Spheroids, Cellular; Tamoxifen; Xenograft Model Antitumor Assays

2018
RET rearrangements are actionable alterations in breast cancer.
    Nature communications, 2018, 11-16, Volume: 9, Issue:1

    Topics: Anilides; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Nuclear Receptor Coactivators; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-ret; Pyridines; Quinazolines; ras Guanine Nucleotide Exchange Factors; Receptor, ErbB-2; Signal Transduction; Xenograft Model Antitumor Assays

2018
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.
    Nature communications, 2019, 01-17, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Immediate-Early Proteins; Mass Spectrometry; Mice, Inbred BALB C; Mice, Nude; Oncogenes; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Proteomics; Quinazolines; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2019
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:4

    Topics: Animals; Antineoplastic Agents; Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Transformation, Neoplastic; Diphenylamine; Feedback, Physiological; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidines; Quinazolines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2013
Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma.
    The FEBS journal, 2013, Volume: 280, Issue:9

    Topics: Animals; Antineoplastic Agents; beta Catenin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cisplatin; ErbB Receptors; Gefitinib; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nanog Homeobox Protein; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplastic Stem Cells; Proto-Oncogene Proteins c-akt; Quinazolines; Side-Population Cells; Signal Transduction; Spheroids, Cellular; Xenograft Model Antitumor Assays

2013
Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:6

    Topics: Afatinib; Animals; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Cell Transformation, Neoplastic; Fluorodeoxyglucose F18; Humans; Mice; Positron-Emission Tomography; Protein Kinase Inhibitors; Quinazolines; Radiochemistry; Receptor, ErbB-2; Stomach Neoplasms; Treatment Outcome

2013
Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.
    The Journal of biological chemistry, 2013, Jun-07, Volume: 288, Issue:23

    Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Amino Acid Substitution; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Female; Humans; Lapatinib; Lung Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Mutation, Missense; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; Receptor, ErbB-2; Signal Transduction; Substrate Specificity

2013
Recurrent respiratory papillomatosis with lung involvement and malignant transformation.
    Thorax, 2014, Volume: 69, Issue:3

    Topics: Bronchial Neoplasms; Bronchoscopy; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Chemoradiotherapy, Adjuvant; Contrast Media; Disease Progression; Erlotinib Hydrochloride; Humans; Male; Middle Aged; Papillomavirus Infections; Protein Kinase Inhibitors; Quinazolines; Respiratory Tract Infections; Tomography, X-Ray Computed; Treatment Outcome

2014
Genetic and chemical targeting of epithelial-restricted with serine box reduces EGF receptor and potentiates the efficacy of afatinib.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:8

    Topics: Afatinib; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; DNA-Binding Proteins; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Head and Neck Neoplasms; Heterografts; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Quinazolines; Receptor, ErbB-2; Squamous Cell Carcinoma of Head and Neck; Transcription Factors

2013
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.
    Breast cancer research : BCR, 2013, Volume: 15, Issue:4

    Topics: Acinar Cells; Amino Acid Oxidoreductases; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mammary Glands, Human; Morphogenesis; Neoplasm Metastasis; Phenotype; Prognosis; Quinazolines; Reactive Oxygen Species; Receptor, ErbB-2; Signal Transduction

2013
Suppression of respiratory papillomatosis with malignant transformation by erlotinib in a kidney transplant recipient.
    BMJ case reports, 2013, Aug-28, Volume: 2013

    Topics: Bronchoscopy; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Erlotinib Hydrochloride; Humans; Kidney Transplantation; Lung Neoplasms; Male; Middle Aged; Papillomavirus Infections; Protein Kinase Inhibitors; Quinazolines; Respiratory Tract Infections; Thoracic Surgery, Video-Assisted

2013
EGFR-mutated lung cancer with T790M-acquired resistance in the brain and histologic transformation in the lung.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2013, Sep-01, Volume: 11, Issue:9

    Topics: Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasms, Second Primary; Protein Kinase Inhibitors; Quinazolines

2013
Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.
    The Prostate, 2013, Volume: 73, Issue:16

    Topics: Animals; Benzamides; Cell Communication; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; Fibroblasts; Hedgehog Proteins; Heterografts; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Morpholines; Prostatic Neoplasms; Purines; Quinazolines; Signal Transduction; Stromal Cells

2013
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
    Oncogene, 2014, Nov-13, Volume: 33, Issue:46

    Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine

2014
Histologic evolution from adenocarcinoma to squamous cell carcinoma after gefitinib treatment.
    The Annals of thoracic surgery, 2015, Volume: 99, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female; Gefitinib; Humans; Lung Neoplasms; Middle Aged; Quinazolines

2015
The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6.
    Neoplasia (New York, N.Y.), 2015, Volume: 17, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Neoplasm Metastasis; Neoplasms, Basal Cell; Protein Kinase Inhibitors; Quinazolines; Tumor Burden; Tumor Suppressor Proteins

2015
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Class I Phosphatidylinositol 3-Kinases; DNA Copy Number Variations; Drug Resistance, Neoplasm; ErbB Receptors; Exome; Female; Gefitinib; Gene Expression; Humans; Mice; Mice, Nude; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases; Plasmids; Protein Kinase Inhibitors; Quinazolines; Transfection; Xenograft Model Antitumor Assays

2015
DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria.
    Scientific reports, 2015, Jun-10, Volume: 5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Humans; Melanoma; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neovascularization, Pathologic; Plant Extracts; Plant Leaves; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays

2015
HER2 activating mutations are targets for colorectal cancer treatment.
    Cancer discovery, 2015, Volume: 5, Issue:8

    Topics: Afatinib; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial Cells; ErbB Receptors; Humans; Molecular Targeted Therapy; Mucous Membrane; Mutation; Quinazolines; Quinolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays

2015
Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells.
    Scientific reports, 2016, Jan-05, Volume: 6

    Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Deletion; Gene Expression; Gene Knockout Techniques; Humans; Integrin beta1; Protein Kinase Inhibitors; Protein Subunits; Quinazolines; Signal Transduction; Tyrphostins

2016
miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; DEAD-box RNA Helicases; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neovascularization, Pathologic; Paclitaxel; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab

2016
Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:8

    Topics: Afatinib; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Esophageal Neoplasms; Female; Head and Neck Neoplasms; HEK293 Cells; Humans; Mice; Multigene Family; Mutation; NIH 3T3 Cells; Phosphorylation; Quinazolines; Receptor, ErbB-4; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays

2016
G9a inhibition induced PKM2 regulates autophagic responses.
    The international journal of biochemistry & cell biology, 2016, Volume: 78

    Topics: Adaptor Proteins, Signal Transducing; Autophagy; Azepines; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Microtubule-Associated Proteins; Phosphoproteins; Quinazolines; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Transcription Factors; Tumor Protein p73; YAP-Signaling Proteins

2016
TNIK inhibition abrogates colorectal cancer stemness.
    Nature communications, 2016, 08-26, Volume: 7

    Topics: Adenomatous Polyposis Coli Protein; Administration, Oral; Aged; Animals; Azoxymethane; beta Catenin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Crystallography, X-Ray; Female; Germinal Center Kinases; Humans; Imidazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Middle Aged; Mutation; Neoplastic Stem Cells; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Recombinant Proteins; Ubiquitin-Protein Ligases; Wnt Proteins; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2016
miR-127 promotes EMT and stem-like traits in lung cancer through a feed-forward regulatory loop.
    Oncogene, 2017, 03-23, Volume: 36, Issue:12

    Topics: 3' Untranslated Regions; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Movement; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; Models, Biological; Neoplastic Stem Cells; NF-kappa B; Quinazolines; RNA Interference; Signal Transduction; Tumor Necrosis Factor alpha-Induced Protein 3

2017
Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-β1.
    Oncology reports, 2017, Volume: 37, Issue:3

    Topics: Animals; Animals, Newborn; Berberine; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; MicroRNAs; Promoter Regions, Genetic; Quinazolines; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1

2017
Heterogeneity in Immune Marker Expression after Acquisition of Resistance to EGFR Kinase Inhibitors: Analysis of a Case with Small Cell Lung Cancer Transformation.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017, Volume: 12, Issue:6

    Topics: Adenocarcinoma; Aged; Biomarkers; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Mutation; Prognosis; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma

2017
Gefitinib enhances radiotherapeutic effects of
    Nuclear medicine and biology, 2017, Volume: 48

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Protein Transport; Quinazolines; Radiation Tolerance; Radiochemistry; Tissue Distribution

2017
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.
    Blood, 2008, Sep-01, Volume: 112, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression; HL-60 Cells; Humans; Imatinib Mesylate; Inhibitor of Differentiation Protein 1; K562 Cells; Leukemia; Leukemia, Experimental; Mice; Oncogenes; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; RNA, Small Interfering; Signal Transduction

2008
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.
    World journal of gastroenterology, 2008, Nov-07, Volume: 14, Issue:41

    Topics: Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cycloheximide; ErbB Receptors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocytes; Humans; Kinetics; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Transfection; Tyrphostins; Up-Regulation

2008
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.
    Carcinogenesis, 2009, Volume: 30, Issue:2

    Topics: Adult; Aged; Animals; Anticarcinogenic Agents; Benzodioxoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Keratinocytes; Keratosis; Male; Mice; Middle Aged; Papilloma; Precancerous Conditions; Quinazolines; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate

2009
Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.
    Lung cancer (Amsterdam, Netherlands), 2009, Volume: 65, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinogens, Environmental; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gefitinib; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Pulmonary Fibrosis; Quinazolines; Smoking; Tumor Burden

2009
Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.
    Cancer research, 2009, Sep-01, Volume: 69, Issue:17

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Disease Models, Animal; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Phosphorylation; Promoter Regions, Genetic; Pulmonary Surfactant-Associated Protein C; Quinazolines; Receptor, ErbB-3; Smoking

2009
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.
    Nature genetics, 2009, Volume: 41, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Humans; Lapatinib; Melanoma; Mice; Mutation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-4; RNA Interference; Skin Neoplasms

2009
Ras-induced resistance to lapatinib is overcome by MEK inhibition.
    Current cancer drug targets, 2010, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Butadienes; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Genes, ras; Humans; Immunoblotting; Lapatinib; Mitogen-Activated Protein Kinase Kinases; Mutation; Nitriles; Quinazolines; Receptor, ErbB-2; Signal Transduction

2010
Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:8

    Topics: Algorithms; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Drug Evaluation, Preclinical; ErbB Receptors; Gene Expression Regulation, Neoplastic; Mice; Mice, Transgenic; Neoplasms, Glandular and Epithelial; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Skin Neoplasms; Treatment Outcome

2010
Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-31, Volume: 107, Issue:35

    Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalytic Domain; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Class I Phosphatidylinositol 3-Kinases; Dioxoles; Fibroblasts; Humans; Immunoprecipitation; Morpholines; Mutation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Subunits; Pyrimidinones; Quinazolines; Thiazolidinediones; Transfection

2010
Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.
    Cancer research, 2010, Oct-01, Volume: 70, Issue:19

    Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Gene Silencing; Gene Transfer Techniques; Glioblastoma; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Quinazolines; RNA, Messenger; Tyrphostins

2010
Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Cell Line; Cell Transformation, Neoplastic; Evodia; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Phosphorylation; Plant Extracts; Quinazolines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection

2011
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation.
    Cell cycle (Georgetown, Tex.), 2011, Mar-01, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Disease Progression; Female; Gefitinib; Humans; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT1 Transcription Factor; Transplantation, Heterologous

2011
Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.
    Fitoterapia, 2011, Volume: 82, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Coptis; Drugs, Chinese Herbal; Evodia; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Plant Extracts; Quinazolines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2011
Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.
    Breast cancer research : BCR, 2011, Mar-11, Volume: 13, Issue:2

    Topics: Aldehyde Dehydrogenase 1 Family; Animals; BRCA1 Protein; Breast; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Genes, BRCA1; Genes, p53; Humans; Isoenzymes; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Receptors, Estrogen; Retinal Dehydrogenase; RNA Interference

2011
An early event of EGFR mutation in pleomorphic carcinoma of the lung.
    International journal of clinical oncology, 2011, Volume: 16, Issue:6

    Topics: Antineoplastic Agents; Carcinoma; Cell Transformation, Neoplastic; Disease-Free Survival; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Middle Aged; Point Mutation; Protein Kinase Inhibitors; Quinazolines

2011
Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzimidazoles; Benzodioxoles; Breast Neoplasms; Cell Death; Cell Line, Transformed; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dasatinib; Female; Fibroblasts; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Protease Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Quinazolines; Radiation Tolerance; src-Family Kinases; Thiazoles

2011
Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.
    Journal of cell science, 2011, Sep-15, Volume: 124, Issue:Pt 18

    Topics: Amphiregulin; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line; Cell Movement; Cell Transformation, Neoplastic; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Mammary Glands, Human; MAP Kinase Signaling System; Mice; Mice, Transgenic; Quinazolines; Receptor, Fibroblast Growth Factor, Type 1

2011
Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies.
    Cancer research, 2011, Dec-15, Volume: 71, Issue:24

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cetuximab; ErbB Receptors; Erlotinib Hydrochloride; Exons; Gene Deletion; Glioblastoma; Humans; Kaplan-Meier Estimate; Mice; Mice, SCID; Mutation; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tumor Burden; Xenograft Model Antitumor Assays

2011
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers.
    Nature medicine, 2011, Dec-11, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; MicroRNAs; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction

2011
Synergistic inhibitory effects by the combination of gefitinib and genistein on NSCLC with acquired drug-resistance in vitro and in vivo.
    Molecular biology reports, 2012, Volume: 39, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Gefitinib; Genistein; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mutation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays

2012
Cediranib inhibits both the intraosseous growth of PDGF D-positive prostate cancer cells and the associated bone reaction.
    The Prostate, 2012, Sep-01, Volume: 72, Issue:12

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Growth Inhibitors; Humans; Lymphokines; Male; Mice; Mice, SCID; Platelet-Derived Growth Factor; Prostatic Neoplasms; Quinazolines; Random Allocation; Xenograft Model Antitumor Assays

2012
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.
    The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:5

    Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adult; Antigens, CD34; Asthma; Blood Cells; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Collagen Type I; ErbB Receptors; Female; Fibroblasts; Follow-Up Studies; Gefitinib; Humans; Hydrogen Peroxide; Leukocyte Common Antigens; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Function Tests; Signal Transduction; Stem Cells; Tyrphostins

2012
RET, ROS1 and ALK fusions in lung cancer.
    Nature medicine, 2012, Feb-12, Volume: 18, Issue:3

    Topics: 3T3 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Age Factors; Aged; Aged, 80 and over; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Neoplasm Staging; Oncogene Proteins, Fusion; Piperidines; Prognosis; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Quinazolines; Receptor Protein-Tyrosine Kinases; Sex Factors

2012
KIF5B-RET fusions in lung adenocarcinoma.
    Nature medicine, 2012, Feb-12, Volume: 18, Issue:3

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anaplastic Lymphoma Kinase; Animals; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Humans; Japan; Kinesins; Lung Neoplasms; Mice; NIH 3T3 Cells; Norway; Oncogene Proteins, Fusion; Piperidines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; United States

2012
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
    Cancer discovery, 2011, Volume: 1, Issue:1

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Dasatinib; Discoidin Domain Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Mice, Nude; Mutation; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; src-Family Kinases; Thiazoles

2011
Identification of tumour initiating cells in feline head and neck squamous cell carcinoma and evidence for gefitinib induced epithelial to mesenchymal transition.
    Veterinary journal (London, England : 1997), 2012, Volume: 193, Issue:1

    Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Carcinoma, Squamous Cell; Cat Diseases; Cats; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Gefitinib; Glycoproteins; Head and Neck Neoplasms; Humans; Neoplastic Stem Cells; Peptides; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck

2012
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.
    Cancer discovery, 2011, Volume: 1, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenocarcinoma of Lung; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 22; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Amplification; Humans; Lung Neoplasms; Mutation; Neurofibromin 1; Nuclear Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shelterin Complex; Signal Transduction; SOS1 Protein; Telomere-Binding Proteins

2011
Secondary resistance to erlotinib: acquired T790M mutation and small-cell lung cancer transformation in the same patient.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2012, Volume: 7, Issue:6

    Topics: Adult; Biopsy; Bronchoscopy; Cell Transformation, Neoplastic; Diagnosis, Differential; DNA Mutational Analysis; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Fatal Outcome; Female; Follow-Up Studies; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines; Sequence Deletion; Small Cell Lung Carcinoma; Tomography, X-Ray Computed

2012
Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met.
    Breast cancer research : BCR, 2012, Jul-12, Volume: 14, Issue:4

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Coculture Techniques; Culture Media, Conditioned; Drug Resistance, Neoplasm; ErbB Receptors; Fibroblasts; Gefitinib; Gene Expression; Hepatocyte Growth Factor; Humans; Paracrine Communication; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Quinazolines; Triple Negative Breast Neoplasms

2012
FAM83B mediates EGFR- and RAS-driven oncogenic transformation.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:9

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Gene Knockdown Techniques; Humans; Mammary Glands, Human; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Sequence Data; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases; Transcriptome

2012
Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells.
    Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Lung Neoplasms; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Stearoyl-CoA Desaturase; TOR Serine-Threonine Kinases

2012
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
    Cancer cell, 2012, Sep-11, Volume: 22, Issue:3

    Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Genes, ras; Humans; Mice; Mice, Transgenic; Pancreas; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Signal Transduction; STAT3 Transcription Factor; Tumor Suppressor Protein p53

2012
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway.
    Stem cells (Dayton, Ohio), 2013, Volume: 31, Issue:2

    Topics: Animals; Antigens, Ly; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Communication; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Imidazoles; Macrophages; Mammary Neoplasms, Animal; Membrane Proteins; Mice; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factor-3; Oleanolic Acid; Quinazolines; RNA, Small Interfering; Signal Transduction; SOXB1 Transcription Factors; STAT3 Transcription Factor; Tyrphostins

2013
Transformation to "high grade" neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma.
    Lung cancer (Amsterdam, Netherlands), 2013, Volume: 80, Issue:1

    Topics: Adenocarcinoma; Carcinoma, Neuroendocrine; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Immunohistochemistry; Lung Neoplasms; Middle Aged; Mutation; Neoplasm Grading; Protein Kinase Inhibitors; Quinazolines; Small Cell Lung Carcinoma

2013
Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.
    International journal of cancer, 2002, Sep-10, Volume: 101, Issue:2

    Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line; Cell Size; Cell Transformation, Neoplastic; Dimerization; ErbB Receptors; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutation; Neoplasm Invasiveness; Phosphorylation; Proteins; Quinazolines; Tyrphostins

2002
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
    Cancer research, 2002, Dec-15, Volume: 62, Issue:24

    Topics: 3T3 Cells; Animals; Carcinoma, Papillary; Cell Transformation, Neoplastic; Drosophila Proteins; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Piperidines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Vascular Endothelial Growth Factor Receptor-2

2002
Protein kinase inhibitors: novel tools in cancer therapy.
    Der Urologe. Ausg. A, 2004, Volume: 43 Suppl 3

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cell Transformation, Neoplastic; Gefitinib; Humans; Lung Neoplasms; Neoplasms; Phthalazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Signal Transduction

2004
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
    Oncogene, 2004, Oct-14, Volume: 23, Issue:47

    Topics: 3T3 Cells; Animals; Apoptosis; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cytokines; DNA Replication; Enzyme Inhibitors; ErbB Receptors; Genes, erbB-1; Hematopoietic Stem Cells; Humans; MAP Kinase Signaling System; Mice; Quinazolines; Receptor, ErbB-2; Tyrphostins

2004
Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcinoma.
    Cancer letters, 2005, Jun-16, Volume: 224, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; DNA Mutational Analysis; DNA, Neoplasm; ErbB Receptors; Exons; Female; Gefitinib; Humans; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Point Mutation; Quinazolines; Sequence Analysis, DNA

2005
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
    PLoS medicine, 2005, Volume: 2, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Exons; Gefitinib; Genetic Therapy; Humans; Mice; Mice, Nude; Mutation; Neoplasms, Experimental; NIH 3T3 Cells; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT3 Transcription Factor; Transfection; Tumor Stem Cell Assay

2005
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
    Cancer research, 2005, Oct-01, Volume: 65, Issue:19

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Growth Processes; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Interleukin-3; Mice; Mutagenesis, Site-Directed; Mutation, Missense; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Transfection

2005
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
    Cancer research, 2006, Feb-15, Volume: 66, Issue:4

    Topics: Aged; Bronchi; Cell Adhesion; Cell Growth Processes; Cell Transformation, Neoplastic; Dual Specificity Phosphatase 6; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Genes, erbB-1; Genes, p16; Genes, p53; Genes, ras; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Oncogenes; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; STAT3 Transcription Factor; Telomerase; Transfection; Up-Regulation

2006
The gefitinib-sensitizing mutant epidermal growth factor receptor enables transformation of a mouse fibroblast cell line.
    DNA and cell biology, 2006, Volume: 25, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA; Enzyme Activation; ErbB Receptors; Fibroblasts; Gefitinib; Mice; Mitogen-Activated Protein Kinases; Mutation; Quinazolines; Transfection

2006
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
    Oncogene, 2006, Oct-19, Volume: 25, Issue:49

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; CHO Cells; Cricetinae; Down-Regulation; ErbB Receptors; Humans; Mice; NIH 3T3 Cells; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-cbl; Quinazolines; Transfection; Tyrphostins; Ubiquitin

2006
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
    Cancer research, 2006, Jun-15, Volume: 66, Issue:12

    Topics: Aged; Amphiregulin; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; EGF Family of Proteins; ErbB Receptors; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Quinazolines; RNA, Small Interfering; Signal Transduction; Up-Regulation

2006
Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:7

    Topics: Actins; Anticarcinogenic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; ErbB Receptors; Erlotinib Hydrochloride; Flavonoids; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Quinazolines; Urinary Bladder Neoplasms

2006
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib.
    Cancer research, 2006, Aug-15, Volume: 66, Issue:16

    Topics: Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Erlotinib Hydrochloride; Genetic Vectors; Humans; Kinetics; Mutagenesis; Mutation; Protein Kinase Inhibitors; Quinazolines; Sequence Deletion

2006
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
    Cancer research, 2007, Jan-15, Volume: 67, Issue:2

    Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, ras; Male; Mice; Mice, Inbred A; Mutation; Quinazolines; Signal Transduction; Up-Regulation

2007
A transplantable human medullary thyroid carcinoma as a model for RET tyrosine kinase-driven tumorigenesis.
    Endocrine-related cancer, 2007, Volume: 14, Issue:2

    Topics: Aged; Animals; Calcitonin; Carcinoma, Medullary; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromogranin A; Disease Models, Animal; ErbB Receptors; Humans; Karyotyping; Male; Mice; Mice, Nude; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Quinazolines; Thyroid Neoplasms; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays

2007
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases.
    Oral oncology, 2008, Volume: 44, Issue:7

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cheek; Cricetinae; Dinoprostone; ErbB Receptors; Humans; Male; Mouth Mucosa; Mouth Neoplasms; Quinazolines; Receptor, ErbB-2

2008
EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Apr-15, Volume: 14, Issue:8

    Topics: Antineoplastic Agents; Cell Survival; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Humans; Lapatinib; Mutation; Phosphorylation; Protein Conformation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2

2008
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
    Science (New York, N.Y.), 1994, Aug-19, Volume: 265, Issue:5175

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine

1994
A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.
    The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; ErbB Receptors; Intestinal Mucosa; Ligands; Oncogene Protein pp60(v-src); Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Rats; RNA, Messenger; Transforming Growth Factor alpha; Up-Regulation

1997
Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: 3T3 Cells; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activation; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Transfection; Tyrphostins

1998
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells.
    International journal of cancer, 1998, Oct-29, Volume: 78, Issue:3

    Topics: Acute-Phase Proteins; Animals; bcl-X Protein; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Intestinal Mucosa; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins

1998
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
    The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Aug-15, Volume: 97, Issue:17

    Topics: Animals; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dimerization; DNA; Down-Regulation; ErbB Receptors; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nitriles; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins

2000
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
    Blood, 2001, Feb-15, Volume: 97, Issue:4

    Topics: Cell Transformation, Neoplastic; Dimethyl Sulfoxide; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Interferon-alpha; Interferon-gamma; Jurkat Cells; Leukemia-Lymphoma, Adult T-Cell; Mutation; Mycosis Fungoides; Neoplasm Proteins; Protein Biosynthesis; Proteins; Quinazolines; Recombinant Fusion Proteins; Repressor Proteins; RNA, Messenger; RNA, Neoplasm; Sezary Syndrome; Skin Neoplasms; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrphostins

2001
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
    The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins

2001