quinazolines has been researched along with Cancer of Gastrointestinal Tract in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, Y; Han, X; Jiao, D; Ren, J; Wang, Y | 1 |
| Anjum, R; Barry, E; Bhavsar, D; Boyd, S; Brown, C; Campbell, A; Goldberg, K; Grondine, M; Guichard, S; Hardy, CJ; Hunt, T; Jones, RDO; Kettle, JG; Li, X; Moleva, O; Ogg, D; Overman, RC; Packer, MJ; Pearson, S; Schimpl, M; Shao, W; Smith, A; Smith, JM; Stead, D; Stokes, S; Tucker, M; Ye, Y | 1 |
| Braconi, C; Chau, I; Cunningham, D; Forster, M; Gerlinger, M; Kalaitzaki, E; Khan, K; Rane, JK; Rao, S; Starling, N; Valeri, N; Watkins, D | 1 |
| Adelstein, DJ; Bokar, JA; Dowlati, A; Fu, P; Halmos, B; Jia, Y; Juergens, R; Rodal, MB | 1 |
| Bertotti, A; Catalano, I; Leto, SM; Migliardi, G; Sassi, F; Throsby, M; Torri, V; Trusolino, L; Zanella, ER | 1 |
| Brown, AM; Ciardiello, F; Eckhardt, SG; Jürgensmeier, JM; Morelli, MP; Pitts, TM; Ryan, A; Tentler, JJ | 1 |
| Christensen, IJ; Ladekarl, M; Lassen, U; Olesen, RK; Pappot, H; Pfeiffer, P; Rohrberg, KS; Skov, BG; Sørensen, M; Westman, M | 1 |
| Dragnev, KH; Graham, RM; Memoli, VA; Petty, WJ; Swift, CB; Urbanic, JJ; Varela, VA; Voelzke, WR; Waller, LL | 1 |
| Cunningham, D; Yim, KL | 1 |
| Buysschaert, I; Carmeliet, P; Christensen, IJ; Høyer-Hansen, G; Ladekarl, M; Lassen, U; Olesen, RK; Pappot, H; Pfeiffer, P; Rohrberg, KS; Skov, BG; Sørensen, M | 1 |
| Alferez, DG; Anderson, E; Crafter, C; Goodlad, RA; Odedra, R; Ryan, AJ; Sini, P; Wedge, SR; Wilkinson, RW; Wright, NA | 1 |
| Aboagye, E; Boddy, AV; Calvert, AH; Gunn, RN; Hughes, AN; Newell, DR; Osman, S; Price, PM; Rafi, I; Taylor, GA; Wells, P | 1 |
| Gill, S; Goldberg, RM; Thomas, RR | 1 |
| Gerst, B; Höpfner, M; Scherübl, H; Sutter, AP; Zeitz, M | 1 |
| Biddle, A; Davis, TH; Desai, NB; Dmitrovsky, E; Dragnev, KH; Hamilton, M; Iwata, KK; Ma, Y; Memoli, N; Memoli, VA; Nugent, WC; Petty, WJ; Rigas, JR | 1 |
| Yatabe, Y | 1 |
| Ames, MM; Gilbert, JA; Lloyd, RV | 1 |
| Harmon, SJ; Hynes, JB; McGill, JE; Washtien, WL; Yang, YC | 1 |
| Allegra, CJ | 1 |
| Ogawa, M | 1 |
| Armand, JP; Cunningham, D; Kohne, CH; Misset, JL; van Cutsem, E | 1 |
| Adenis, A; Conroy, T; Paillot, B | 1 |
| Aherne, GW; Benepal, TS; Cunningham, D; Ford, HE; Gruia, G; Massey, A; Price, T; Rao, S; Ross, PJ; Vernillet, L | 1 |
| Antognoli, S; Baldelli, AM; Barni, S; Battelli, N; Cascinu, S; Catalano, V; Ferraù, F; Giordani, P; Graziano, F; Labianca, R; Maisano, R; Mari, D; Massacesi, C; Pessi, MA; Priolo, D; Rota, S; Santini, D; Siena, S; Silva, RR; Tonini, G; Zaniboni, A | 1 |
6 review(s) available for quinazolines and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Targeted drug therapies and cancer.
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Drug Delivery Systems; Erlotinib Hydrochloride; Gastrointestinal Neoplasms; Gefitinib; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2011 |
New targeted therapies in gastrointestinal cancers.
Topics: Adult; Aged; Antibodies, Monoclonal; Drug Therapy, Combination; ErbB Receptors; Erlotinib Hydrochloride; Female; Gastrointestinal Neoplasms; Gefitinib; Humans; Immunotherapy; Male; Middle Aged; Neoplasm Staging; Panitumumab; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Treatment Outcome | 2003 |
[Molecular diagnosis of solid tumors].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Gastrointestinal Neoplasms; Gefitinib; Humans; Lung Neoplasms; Quinazolines; Trastuzumab | 2005 |
New systemic drugs in the treatment of gastrointestinal cancer.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Docetaxel; Gastrointestinal Neoplasms; Humans; Irinotecan; Paclitaxel; Quinazolines; Taxoids; Thiophenes; Thymidylate Synthase | 1996 |
Clinical advances with topoisomerase I inhibitors in gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Docetaxel; Enzyme Inhibitors; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Platinum; Quinazolines; Taxoids; Thiophenes; Topoisomerase I Inhibitors | 1999 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine | 1999 |
5 trial(s) available for quinazolines and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
A Phase I study of the combination of oxaliplatin/docetaxel and vandetanib for the treatment of advanced gastroesophageal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Dose-Response Relationship, Drug; Gastrointestinal Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Piperidines; Protein Kinase Inhibitors; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Taxoids | 2013 |
Biomarkers in tissue from patients with upper gastrointestinal cancers treated with erlotinib and bevacizumab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Biomarkers, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Survival Analysis; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Therapy, Combination; ErbB Receptors; Erlotinib Hydrochloride; Female; Follow-Up Studies; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Quinazolines; Survival Analysis; Treatment Outcome | 2012 |
Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinoma.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Gastrointestinal Neoplasms; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2000 |
Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Italy; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Quinazolines; Risk Assessment; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
13 other study(ies) available for quinazolines and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Preliminary outcomes of raltitrexed eluting bead-transarterial chemoembolization using Callispheres® beads for gastrointestinal adenocarcinoma liver metastasis.
Topics: Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Male; Microspheres; Middle Aged; Quinazolines; Retrospective Studies; Thiophenes; Treatment Outcome | 2022 |
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
Topics: Drug Discovery; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Models, Molecular; Mutant Proteins; Mutation; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Quinazolines; Tissue Distribution; Triazoles; Tumor Cells, Cultured | 2018 |
Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Prognosis; Quinazolines; Retrospective Studies; Safety; Survival Rate; Thiophenes | 2019 |
Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.
Topics: Afatinib; Animals; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; ErbB Receptors; Gastrointestinal Neoplasms; Gene Amplification; Gene Expression; Gene Knockdown Techniques; Humans; Lapatinib; Mice; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Trastuzumab; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gastrointestinal Neoplasms; Gene Expression Profiling; Humans; Neoplasm Invasiveness; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3 | 2009 |
High cyclin D3 expression confers erlotinib resistance in aerodigestive tract cancer.
Topics: Animals; Biomarkers, Pharmacological; Carcinoma; Cyclin D1; Cyclin D3; Cyclin E; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gastrointestinal Neoplasms; Gene Expression Profiling; Humans; Immunohistochemistry; Mice; NIH 3T3 Cells; Quinazolines | 2011 |
Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.
Topics: Animals; Aurora Kinase B; Cell Proliferation; Colorectal Neoplasms; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histones; Humans; Mice; Phosphorylation; Quinazolines; Xenograft Model Antitumor Assays | 2012 |
2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Radioisotopes; Case-Control Studies; Enzyme Inhibitors; Female; Gastrointestinal Neoplasms; Humans; Liver; Male; Middle Aged; Quinazolines; Regression Analysis; Thymidine; Thymidylate Synthase; Tomography, Emission-Computed | 2003 |
A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839).
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoid Tumor; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Fluorescent Antibody Technique; Gastrointestinal Neoplasms; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Insulinoma; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers.
Topics: Biomarkers, Tumor; Bronchi; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Cyclin D1; DNA; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Exons; G1 Phase; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Immunoblotting; Immunohistochemistry; Ki-67 Antigen; Kinetics; Luciferases; Necrosis; Neoplasms; Quinazolines; Sequence Analysis, DNA; Time Factors; Transcriptional Activation | 2004 |
Lack of mutations in EGFR in gastroenteropancreatic neuroendocrine tumors.
Topics: Antineoplastic Agents; DNA Mutational Analysis; Drug Resistance, Neoplasm; ErbB Receptors; Gastrointestinal Neoplasms; Gefitinib; Humans; Molecular Sequence Data; Mutation; Neuroendocrine Tumors; Pancreatic Neoplasms; Polymorphism, Genetic; Protein Kinase Inhibitors; Quinazolines | 2005 |
Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogues.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Methotrexate; Quinazolines; Stereoisomerism; Structure-Activity Relationship | 1984 |
New therapeutic strategies for patients with gastrointestinal malignancies using biochemical modulation of fluorouracil.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Gene Expression Regulation, Enzymologic; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thymidylate Synthase | 1995 |