Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and African Sleeping Sickness

quinazolines has been researched along with African Sleeping Sickness in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Bishop, OT; Boyom, FF; Dize, D; Duffy, J; Fokou, PVT; Keumoe, R; Kouipou Toghueo, RM; Laleu, B; Njanpa, CN; Tata, RB; Tchatat, MB; Tchuenguia, VC; Yamthe, LT1
Bachovchin, KA; Brady, KG; Erath, J; Gallerstein, MF; Leed, SE; Mensa-Wilmot, K; Pollastri, MP; Rodriguez, A; Sciotti, RJ; Tanghe, S; Woodring, JL1
Bachovchin, KA; Bag, S; Buskes, MJ; Ferrins, L; Jalani, HB; Klug, DM; Mehta, N; Mensa-Wilmot, K; Momper, JD; Pollastri, MP; Rodriguez, A; Schneider, KM; Sciotti, RJ; Sharma, A; Singh, B; Tanghe, S1
Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C1
Behera, R; Mensa-Wilmot, K; Thomas, SM1
Behera, R; Guyett, PJ; Mensa-Wilmot, K; Ogata, Y; Pollastri, M1
Barrett, MP; Clark, RL; Clements, CJ; Huggan, JK; Mackay, SP; Owusu-Dapaah, G; Rathnam, RP; Spencer, J1

Other Studies

7 other study(ies) available for quinazolines and African Sleeping Sickness

ArticleYear
Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of
    Molecules (Basel, Switzerland), 2022, Oct-04, Volume: 27, Issue:19

    Topics: Animals; Humans; Iron; Ligands; Quinazolines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African

2022
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
    European journal of medicinal chemistry, 2017, Dec-01, Volume: 141

    Topics: Aniline Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African

2017
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
    Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2

    Topics: Animals; Blood Proteins; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Half-Life; Hepatocytes; Humans; Lapatinib; Mice; Microsomes, Liver; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thermodynamics; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Water

2019
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
    Journal of medicinal chemistry, 2013, May-23, Volume: 56, Issue:10

    Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2013
New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:4

    Topics: Animals; Axitinib; Benzamides; Erlotinib Hydrochloride; Female; HeLa Cells; Humans; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lapatinib; Mice; Morpholines; Piperazines; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Trypanosomiasis, African

2014
Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:2

    Topics: Chromatography, Affinity; Endocytosis; ErbB Receptors; Humans; Lapatinib; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Peptides; Phosphorylation; Proteomics; Protozoan Proteins; Quinazolines; Signal Transduction; Tandem Mass Spectrometry; Trypanosoma brucei brucei; Trypanosomiasis, African

2017
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
    Bioorganic & medicinal chemistry, 2012, Oct-15, Volume: 20, Issue:20

    Topics: Animals; Benzodiazepines; Humans; Microbial Sensitivity Tests; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2012