quinazolines has been researched along with Acute Confusional Senile Dementia in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 25 (64.10) | 24.3611 |
| 2020's | 14 (35.90) | 2.80 |
| Authors | Studies |
|---|---|
| Gabr, MT; Hoda, N; Manzoor, S; Pal, K; Rasool, B | 1 |
| Emami, S; Haghighijoo, Z; Moosavi, F; Zamani, L | 1 |
| Hartikainen, S; Latvala, L; Murtola, TJ; Tiihonen, M; Tolppanen, AM | 1 |
| Abelleira-Hervas, L; Aleksynas, R; Ashburner, N; Caselli, G; Liu, L; Mota, BC; Rovati, LC; Sastre, M | 1 |
| Cheng, M; He, Y; Liu, J; Ma, C; Qin, F; Wang, H; Yang, C; Yang, J; Zhang, Y | 1 |
| Shaik Mohammad, F; Shama Bhat, G | 1 |
| Bellver-Sanchis, A; Griñán-Ferré, C; Kondengaden, SM; Marsal-García, L; Pallàs, M; Turga, RC; Vázquez, S | 1 |
| Gan, Q; Mcparland, L; Na, H; Qiu, WQ; Tian, H; Yang, JB; Yao, H; Zhang, Z | 1 |
| Dong, YH; Huang, XF; Ke, HM; Song, GQ; Wang, JH; Xu, DF | 1 |
| Dang Thi, TA; Le-Nhat-Thuy, G; Nguyen Hoang, S; Nguyen Thi, H; Nguyen Thi, N; Nguyen Thi, TH; Nguyen, TV; Pham-The, H | 1 |
| An, XW; Chen, C; Chen, F; Hu, N; Jia, XL; Li, XH; Liu, R; Sun, HT; Wang, JJ; Wang, Y; Zhao, B; Zheng, CG | 1 |
| Kumar, R; Pavlov, PF; Wang, L; Winblad, B | 1 |
| Chou, CH; Yang, CR | 1 |
| Jeripothula, M; Nerella, A | 1 |
| Cen, X; Hou, T; Najafov, A; Peng, D; Shan, B; Sun, Q; Sun, Y; Wang, Z; Xia, H; Xie, T; Xu, X; Xue, Y; Yi, C; Zhang, M; Zhao, Q | 1 |
| Nygaard, HB | 1 |
| Du, H; Ma, F | 1 |
| Smith, LM; Strittmatter, SM; Zhu, R | 1 |
| Antequera, D; Bartolome, F; Carro, E; de la Cueva, M; Fernandez, T; Gil, C; Martinez, A; Pascual, C | 1 |
| Bednarikova, Z; Gancar, M; Gazova, Z; Hu, CK; Li, MS; Linh, HQ; Thai, NQ | 1 |
| Li, Z; Liu, X; Lu, J; Wang, C; Wang, D; Wang, J; Zhang, J; Zhang, Y | 1 |
| Ballatore, C; Brunden, KR; Cornec, AS; James, MJ; Koivula, P; Lee, VM; Oukoloff, K; Smith, AB; Trojanowski, JQ; Yao, Y; Zhang, B | 1 |
| Du, H; Liu, X; Ma, F; Xie, J | 1 |
| Cao, LL; Guan, PP; Huang, XS; Liang, YY; Wang, P | 1 |
| Bezprozvanny, I; Chernyuk, D; Kabirova, M; Popugaeva, E; Zernov, N | 1 |
| Chen, JG; Li, X; Wu, YG | 1 |
| Chen, SB; Gu, LQ; He, Y; Huang, SL; Huang, ZH; Huang, ZS; Li, D; Tan, JH; Yao, PF | 1 |
| Antequera, D; Bolos, M; Carro, E; Ferrer, I; Gil, C; Krzyzanowska, A; Martinez, A; Pascual, C; Perez, DI; Perez-Gonzalez, R; Pérez-Grijalba, V; Redondo, M; Sarasa, M | 1 |
| Chu, C; Fu, P; Li, L; Ma, W; Shang, L; Wang, W; Zhang, X | 1 |
| Wadman, M | 1 |
| Gunther, EC; Haas, LT; Jeng, AT; Kaufman, AC; Kostylev, MA; Nygaard, HB; Robinson, SA; Salazar, SV; Strittmatter, SM; van Dyck, CH; Yang, J | 1 |
| Albuquerque, MG; Castro, HC; da Silva Lima, CH; de Alencastro, RB; Leal, FD; Rodrigues, CR | 1 |
| Abad, S; Auladell, C; Beas-Zarate, C; Camins, A; Ettcheto, M; Folch, J; García, ML; Olloquequi, J; Petrov, D; Sánchez-López, E | 1 |
| Li, H; Liu, JG; Wang, ZY; Yang, HM | 1 |
| Balboni, G; Carotti, A; Catto, M; Kim, HJ; Kim, JH; Lee, JY; Lee, KT; Nam, JH; Onnis, V; Park, B; Park, JH | 1 |
| Che, H; Fu, P; Gao, Y; Pan, Y; Wang, L; Wang, R; Zhang, L | 1 |
| Gao, K; Liu, JN; Ma, CM; Qin, C; Quan, XZ; Wang, DM; Yuan, SM; Zhang, LF | 1 |
| Gangarajula, S; Ghosh, AK; Huang, X; Kulkarni, S; Pandey, S; Rao, KV; Tang, J; Xu, X | 1 |
6 review(s) available for quinazolines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Enzyme Inhibitors; Humans; Monoamine Oxidase; Neuroprotective Agents; Phosphoric Diester Hydrolases; Quinazolines; tau Proteins | 2022 |
Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.
Topics: Alzheimer Disease; Animals; Benzodioxoles; Cholinesterase Inhibitors; Cholinesterases; Curcumin; Humans; Molecular Targeted Therapy; Neurofibrillary Tangles; Neuroprotective Agents; Phosphorylation; Plaque, Amyloid; Protein Aggregation, Pathological; Protein Processing, Post-Translational; Quinazolines; Receptors, N-Methyl-D-Aspartate; tau Proteins; Thiadiazoles | 2021 |
Targeting Fyn Kinase in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzodioxoles; Enzyme Inhibitors; Humans; Prion Proteins; Proto-Oncogene Proteins c-fyn; Quinazolines | 2018 |
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Benzodioxoles; Brain; Disease Models, Animal; Humans; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Quinazolines; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Synapses; Thiazoles | 2016 |
Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.
Topics: Abietanes; Alkaloids; Alzheimer Disease; Curcuma; Curcumin; Drugs, Chinese Herbal; Epimedium; Evodia; Flavonoids; Ginsenosides; Humans; Huperzia; Panax; Phytotherapy; Plant Extracts; Quinazolines; Salvia miltiorrhiza; Scutellaria baicalensis; Sesquiterpenes | 2016 |
Rvx 208.
Topics: Acute Coronary Syndrome; Alzheimer Disease; Animals; Atherosclerosis; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Quinazolines; Quinazolinones | 2011 |
33 other study(ies) available for quinazolines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Quinazolines; Structure-Activity Relationship; tau Proteins | 2021 |
Use of α1-adrenoceptor antagonists tamsulosin and alfuzosin and the risk of Alzheimer's disease.
Topics: Adrenergic alpha-Antagonists; Alzheimer Disease; Case-Control Studies; Humans; Male; Quinazolines; Receptors, Adrenergic; Sulfonamides; Tamsulosin | 2022 |
I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Blood-Brain Barrier; Disease Models, Animal; Imidazoles; Imidazolines; Ligands; Mice; Mice, Transgenic; Quinazolines | 2022 |
Identification and in silicon binding study of a novel NR2B selective NMDAR antagonist.
Topics: Alzheimer Disease; Humans; Molecular Docking Simulation; Quinazolines; Receptors, N-Methyl-D-Aspartate; Silicon; Structure-Activity Relationship | 2023 |
Computational Fragment-Based Design of Phytochemical Derivatives as EGFR Inhibitors.
Topics: Alzheimer Disease; ErbB Receptors; Humans; Molecular Docking Simulation; Phytochemicals; Plant Extracts; Quinazolines | 2023 |
Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Cognitive Dysfunction; Gene Expression Regulation; Glucagon-Like Peptides; Hippocampus; Histone-Lysine N-Methyltransferase; Histones; Inflammation; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines | 2019 |
Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Female; Maze Learning; Mice; Mice, Transgenic; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Treatment Outcome | 2020 |
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinergic Antagonists; Cognitive Dysfunction; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Indole Alkaloids; Mice; Models, Molecular; Molecular Structure; Morris Water Maze Test; Phosphodiesterase 5 Inhibitors; Protein Conformation; Quinazolines; Scopolamine | 2020 |
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Sequence; Catalytic Domain; Cholinesterase Inhibitors; Click Chemistry; Drug Evaluation, Preclinical; Humans; Molecular Docking Simulation; Protein Conformation; Quinazolines; Structure-Activity Relationship; Triazoles | 2020 |
Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; Indole Alkaloids; Mice; Phosphorylation; Quinazolines; Sucrose | 2021 |
Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity.
Topics: Alzheimer Disease; Animals; Apoptosis; Brain; Cell Line; Cognition; Cognition Disorders; Disease Models, Animal; Humans; Male; Maze Learning; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neurons; Neuroprotection; Neuroprotective Agents; Okadaic Acid; Phosphorylation; Quinazolines; Spatial Memory; tau Proteins; Tauopathies | 2021 |
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Design; Electrophorus; Horses; Indoles; Kinetics; Mice; Molecular Docking Simulation; Neuroprotective Agents; Peptide Fragments; Protein Binding; Protein Multimerization; Quinazolines; Rats | 2021 |
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Benzylamines; Cell Line, Tumor; Chaperone-Mediated Autophagy; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; HeLa Cells; HSC70 Heat-Shock Proteins; Humans; I-kappa B Kinase; Isoenzymes; Male; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; PC12 Cells; Phenylurea Compounds; Quinazolines; Rats; Signal Transduction | 2021 |
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Kinetics; Ligands; Molecular Structure; Peptide Fragments; Protein Aggregates; Quinazolines; Structure-Activity Relationship | 2017 |
Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzodioxoles; Maze Learning; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Nootropic Agents; Proto-Oncogene Proteins c-fyn; Quinazolines; Recognition, Psychology; Spatial Learning; Spatial Memory; Spatial Navigation; Synapses | 2018 |
Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation; Hippocampus; Humans; Learning Disabilities; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Dynamics; Neurogenesis; Phosphodiesterase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction | 2018 |
Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Computer Simulation; Humans; In Vitro Techniques; Indazoles; Molecular Dynamics Simulation; Peptide Fragments; Pyridines; Quinazolines | 2018 |
Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Brain; Cell Line; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Quinazolines; Reactive Oxygen Species | 2018 |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Brain; Disease Models, Animal; Humans; Mice; Microtubules; Neurons; Quinazolines; tau Proteins; Tauopathies; Triazoles | 2018 |
Novel Deoxyvasicinone-Donepezil Hybrids as Potential Multitarget Drug Candidates for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Humans; In Vitro Techniques; Nootropic Agents; Quinazolines | 2019 |
Cyclooxygenase-2 is Essential for Mediating the Effects of Calcium Ions on Stimulating Phosphorylation of Tau at the Sites of Ser 396 and Ser 404.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blotting, Western; Calcium; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Lactones; Male; Maze Learning; Mice; Mice, Transgenic; Phosphorylation; Prostaglandin-E Synthases; Quinazolines; Real-Time Polymerase Chain Reaction; Serine; Sulfones; tau Proteins | 2019 |
Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium-Binding Proteins; Cells, Cultured; Gene Expression; Hippocampus; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Neurons; Phenyl Ethers; Presenilin-1; Quinazolines; Treatment Outcome | 2019 |
[Effect of rutaecarpine on Alzheimer's disease-like cognitive impairments induced by high glucose in rats].
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Glucose; Glycogen Synthase Kinase 3 beta; Indole Alkaloids; Male; Maze Learning; Phosphorylation; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; tau Proteins | 2019 |
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Biocatalysis; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indole Alkaloids; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Quinazolines | 2013 |
Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Behavior; Cells, Cultured; Cognition; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Mice; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Signal Transduction; tau Proteins | 2013 |
Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Cell Line, Tumor; Cognition; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Intracellular Space; Memory; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Quinazolines; Small Molecule Libraries | 2013 |
NIH gambles on recycled drugs.
Topics: Alzheimer Disease; Benzodioxoles; Drug Repositioning; Enzyme Inhibitors; Financing, Government; Humans; National Institutes of Health (U.S.); Quinazolines; United States | 2013 |
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Benzodioxoles; Disease Models, Animal; Focal Adhesion Kinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; Quinazolines; Signal Transduction | 2015 |
Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme.
Topics: Alzheimer Disease; Amines; Dyrk Kinases; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quantitative Structure-Activity Relationship; Quinazolines | 2015 |
3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Quinazolines | 2017 |
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Autophagy; Carbamazepine; Disease Models, Animal; Hippocampus; Male; Maze Learning; Mice; Neurons; Neuroprotective Agents; Plaque, Amyloid; Quinazolines; Random Allocation; Sirolimus; Spatial Memory | 2017 |
Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Disease Models, Animal; Maze Learning; Memory; Mice; Mice, Transgenic; Presenilin-1; Quinazolines; Random Allocation | 2011 |
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Pyrazoles; Quinazolines; Structure-Activity Relationship; Thiazoles | 2012 |