quinazolines has been researched along with Ache in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.56) | 18.7374 |
| 1990's | 2 (3.70) | 18.2507 |
| 2000's | 19 (35.19) | 29.6817 |
| 2010's | 28 (51.85) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Caselli, G; Giacomoni, C; Lanza, M; Letari, O; Milia, C; Rovati, LC; Sabatini, C; Vellani, V | 1 |
| Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y | 1 |
| Feng, NP; He, ZH; Li, Z; Xia, Q; Zhang, HY; Zhang, K; Zhang, YT; Zhao, JH | 1 |
| Chen, Y; Jian, Z; Li, H; Liao, B; Liu, Q; Wang, K; Yang, T | 1 |
| Dravyakar, BR; Khan, T; Khedekar, PB; Patel, KN; Sherje, AP; Suvarna, V | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Kovalenko, S; Kramar, H; Stepaniuk, H; Taran, I; Voloshchuk, N | 1 |
| Christensen, SL; Kristensen, DM; Munro, G; Olesen, J; Petersen, S | 1 |
| Austin, M; Bauman, JE; Chai, X; Eaton, KD; Futran, N; Hayes, DN; Kurland, BF; Liao, JJ; Martins, RG; Mendez, E; Papagikos, MA; Parvathaneni, U; Raez, LE; Schmidt, R; Sharma, AK; Wallace, SG; Wang, DX; Yunus, F | 1 |
| Arndt, K; Corradini, L; Doods, H; Hirsch, S; Just, S | 1 |
| Jiang, J; Li, K; Wu, X; Yao, P; Zhang, J | 1 |
| Abbas, H; Blazeby, JM; Chatterjee, A; Dahle-Smith, A; Davoudianfar, M; Dutton, SJ; Falk, S; Ferry, DR; Fyfe, DW; Gamble, T; Garcia-Alonso, A; Harrison, M; Hubner, RA; Jankowski, J; Julier, P; Kerr, R; Mansoor, W; Peachey, L; Pearson, SR; Petty, RD; Thompson, J | 1 |
| Acosta, MC; Callejo, G; Castany, M; Castellanos, A; Gallar, J; Gasull, X; Giblin, JP; Gual, A; Luna, C | 1 |
| Byrne, FM; Chapman, V; Cheetham, S; Vickers, S | 1 |
| El Said, NO; El Wakeel, L; Kamal, KM; Morad, Ael R | 1 |
| Cho, KS; Choi, YD; Ham, WS; Kang, DH; Kwon, JK; Lee, H; Lee, JY; Oh, CK | 1 |
| Balboni, G; Byun, JS; Congiu, C; De Petrocellis, L; Deplano, A; Di Marzo, V; Garrido, M; Lee, JY; Messeguer, A; Onnis, V; Schiano Moriello, A; Sohn, JM; Vázquez-Romero, A; Zamponi, GW; Zhang, FX | 1 |
| Jia, S; Li, JX; Qiu, Y; Thorn, DA; Zhang, Y | 1 |
| Lan, Y; Peng, Y; Song, J; Songyang, Y; Zhang, L | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Curigliano, G; de Braud, F; De Cobelli, O; Sbanotto, A; Scardino, E; Spitaleri, G | 1 |
| Fujimoto, T; Ito, T; Kanda, S; Mori, S | 1 |
| Barreiro, EJ; Corrêa, RS; de Rezende, CM; Doriguetto, AC; Fraga, CA; Fumian, MM; Maia, RC; Mazzeu, EF; Miranda, AL; Silva, LL | 1 |
| Fischer, MJ; Messlinger, K; Sixt, ML | 1 |
| Ishar, MP; Paneerselvam, P; Raj, T; Rather, BA; Reddy, A; Sivakumar, S | 1 |
| Amonkar, MM; Bachelot, T; Johnston, S; Kaufman, B; Salazar, V; Sherrill, B; Viens, P; Wu, Y | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Cao, H; Chen, Z; Feng, EG; Jiang, H; Li, WG; Liu, H; Xu, TL; Yu, F; Yu, Y | 1 |
| Hojjati, M; Nguyen, S | 1 |
| Chau, LH; Fan, CW; Fung, BT; Li, JC; Li, MK; Tai, DC | 1 |
| Lin, TC; Wu, PY | 1 |
| Chen, F; Ding, JS; Li, D; Li, S | 1 |
| Hwang, EC; Hwang, IS; Jung, SI; Kang, TW; Kim, MK; Kim, SO; Kwon, DD; Lu, JW; Park, K; Ryu, SB; Yu, HS | 1 |
| Cadranel, J; Cong, XJ; Fairclough, D; Finnern, HW; Hirsh, V; Lorence, RM; Miller, VA; Palmer, M; Yang, JC | 1 |
| Kobayashi, Y | 1 |
| Alagarsamy, V; Murugananthan, G; Venkateshperumal, R | 1 |
| Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Hannick, SM; Honore, P; Jarvis, MF; Jinkerson, T; Koenig, JR; Lee, CH; Macri, BS; Marsh, KC; McDonald, HA; Oie, T; Perner, RJ; Schmidt, RG; Stewart, KD; Surowy, CS; Turner, S; Wetter, J; Wismer, CT; Zheng, GZ | 1 |
| Alcaraz, A; Elhilali, M; Emberton, M; Hartung, R; Harving, N; Matzkin, H; Vallancien, G; van Moorselaar, RJ | 1 |
| Bernard, PS; Blatter, HM; Chernov, HI; Plummer, AJ; Wilson, DE | 1 |
| Dolle, RE; Koblish, M; LaBuda, CJ; Little, PJ; Tuthill, P | 1 |
| Hough, LB; Lu, Q; Montero, MJ; Nalwalk, JW; Shan, Z; Svokos, K; Wentland, MP | 1 |
| Bevan, S; Christiansen, M; Copp, P; Culshaw, AJ; Davis, A; Davis, C; Dyson, A; Dziadulewicz, EK; Edwards, L; Eggelte, H; Fox, A; Gentry, C; Groarke, A; Hallett, A; Hart, TW; Hughes, GA; Knights, S; Kotsonis, P; Lee, W; Lyothier, I; McBryde, A; McIntyre, P; Paloumbis, G; Panesar, M; Patel, S; Seiler, MP; Yaqoob, M; Zimmermann, K | 1 |
| Elhilali, M; Emberton, M; Nickel, JC; Vallancien, G | 1 |
| Bakthavatchalam, R; Blum, CA; Blurton, P; Brian Jones, A; Brielmann, H; Burkamp, F; Chandrasekhar, J; Clarkson, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Hutchison, A; Zheng, X | 1 |
| Ayoub, J; Bezjak, A; Chan, RT; Clark, G; Cyjon, A; de Albuquerque Ribeiro, R; Fenton, D; Gerogianni, A; Laberge, F; Lago, S; Noble, J; Reck, M; Seymour, L; Shepherd, FA; Trajkovic, A; Tu, D; von Pawel, J; Zukin, M | 1 |
| Erschbamer, M; Olson, L; Pernold, K | 1 |
| Császár, I; Juhász, G; Kovács, Z; Nyitrai, G; Palkovits, M; Papp, E; Puskás, L | 1 |
| Bryans, R; Huskisson, EC; Scott, J | 1 |
| Borras-Blasco, J; Navarro-Ruiz, A; Vela-Casasempere, P | 1 |
| Hezky, P; Krejcí, I; Proska, J; Rádl, S | 1 |
| Clarke, S; Cunningham, D; Facchini, T; González Barón, M; James, R; Maroun, J; Maughan, TS; Schulz, J; Vincent, M; Zalcberg, J | 1 |
| Hosoi, E; Matsushita, K; Shohara, E; Sugimura, M; Tatsumi, Y | 1 |
| Beresford, R; Clissold, SP | 1 |
5 review(s) available for quinazolines and Ache
| Article | Year |
|---|---|
Combination of solifenacin and tamsulosin may provide additional beneficial effects for ureteral stent-related symptoms-outcomes from a network meta-analysis.
Topics: Drug Therapy, Combination; Humans; Lower Urinary Tract Symptoms; Network Meta-Analysis; Pain; Quinazolines; Randomized Controlled Trials as Topic; Solifenacin Succinate; Stents; Tamsulosin; Treatment Outcome; Urinary Catheterization; Urological Agents | 2019 |
The beneficial effect of alpha-blockers for ureteral stent-related discomfort: systematic review and network meta-analysis for alfuzosin versus tamsulosin versus placebo.
Topics: Adrenergic alpha-Antagonists; Bayes Theorem; Humans; Pain; Pain Measurement; Quinazolines; Randomized Controlled Trials as Topic; Stents; Sulfonamides; Tamsulosin; Treatment Outcome; Ureteral Obstruction | 2015 |
Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy.
Topics: Aged; Antineoplastic Agents; Diphosphonates; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Octreotide; Osteoarthropathy, Secondary Hypertrophic; Pain; Quinazolines; Rheumatology; Treatment Outcome; Vagotomy | 2011 |
Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. a review of phase II/III trials.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Diarrhea; Female; Humans; Leukopenia; Male; Middle Aged; Nausea; Neutropenia; Pain; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Vomiting | 2002 |
Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Humans; Kinetics; Pain; Prostaglandins; Quinazolines; Rheumatic Diseases | 1987 |
12 trial(s) available for quinazolines and Ache
| Article | Year |
|---|---|
Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Disease-Free Survival; Drug Administration Schedule; ErbB Receptors; Erlotinib Hydrochloride; Exanthema; Female; Head and Neck Neoplasms; Humans; In Situ Hybridization, Fluorescence; Male; Pain; Quinazolines; Remission Induction; Treatment Outcome | 2013 |
Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Deglutition Disorders; Diarrhea; Disease Progression; Disease-Free Survival; Double-Blind Method; Drug Eruptions; Eating; Esophageal Neoplasms; Fatigue; Female; Gefitinib; Humans; Male; Middle Aged; Pain; Proportional Hazards Models; Quality of Life; Quinazolines; Retreatment | 2014 |
Alfuzosin treatment improves the rate and time for stone expulsion in patients with distal uretral stones: a prospective randomized controlled study.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Female; Humans; Male; Middle Aged; Pain; Prospective Studies; Quinazolines; Time Factors; Ureteral Calculi; Young Adult | 2015 |
Health-related quality of life in patients with hormone refractory prostate cancer receiving gefitinib.
Topics: Activities of Daily Living; Adenocarcinoma; Administration, Oral; Aged; Analgesics; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gonadotropin-Releasing Hormone; Humans; Male; Middle Aged; Pain; Pain Measurement; Prostatic Neoplasms; Protein Kinase Inhibitors; Quality of Life; Quinazolines; Time Factors; Treatment Failure | 2009 |
Impact of lapatinib monotherapy on QOL and pain symptoms in patients with HER2+ relapsed or refractory inflammatory breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cohort Studies; Female; Genes, erbB-2; Humans; Lapatinib; Middle Aged; Pain; Quality of Life; Quinazolines | 2010 |
Medical expulsive therapy using alfuzosin for patient presenting with ureteral stone less than 10mm: a prospective randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Dextropropoxyphene; Diclofenac; Female; Humans; Male; Middle Aged; Pain; Prospective Studies; Quinazolines; Remission, Spontaneous; Severity of Illness Index; Ureteral Calculi; Young Adult | 2011 |
Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: results of a randomized phase IIb/III trial (LUX-Lung 1).
Topics: Adenocarcinoma; Afatinib; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cough; Double-Blind Method; Dyspnea; Erlotinib Hydrochloride; Fatigue; Female; Follow-Up Studies; Gefitinib; Humans; Longitudinal Studies; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pain; Prognosis; Quality of Life; Quinazolines; Salvage Therapy | 2013 |
Alfuzosin 10 mg once daily improves sexual function in men with lower urinary tract symptoms and concomitant sexual dysfunction.
Topics: Adrenergic alpha-Antagonists; Aged; Ejaculation; Humans; Male; Pain; Penile Erection; Quality of Life; Quinazolines; Sexual Dysfunction, Physiological; Treatment Outcome; Urinary Bladder Neck Obstruction; Urination Disorders | 2005 |
The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation.
Topics: Adrenergic alpha-Antagonists; Aged; Ejaculation; Humans; Male; Middle Aged; Pain; Prostatic Hyperplasia; Quality of Life; Quinazolines; Sexual Dysfunction, Physiological; Treatment Outcome; Urologic Diseases | 2006 |
Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21.
Topics: Adult; Aged; Antineoplastic Agents; Canada; Carcinoma, Non-Small-Cell Lung; Cough; Double-Blind Method; Dyspnea; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Pain; Protein Kinase Inhibitors; Quality of Life; Quinazolines; Surveys and Questionnaires; Survival Analysis; Treatment Outcome | 2006 |
Fluproquazone for osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Pain; Quinazolines; Quinazolinones; Random Allocation | 1981 |
Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Humans; Kinetics; Pain; Prostaglandins; Quinazolines; Rheumatic Diseases | 1987 |
38 other study(ies) available for quinazolines and Ache
| Article | Year |
|---|---|
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
Topics: Amino Acid Sequence; Analgesics; Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Freund's Adjuvant; Humans; Imidazoles; Imidazoline Receptors; Inflammation; Male; Pain; Phosphorylation; Protein Kinase C-epsilon; Quinazolines; Rats; Rats, Wistar; Sensory Receptor Cells | 2020 |
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.
Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroglycerin; Pain; Periaqueductal Gray; Quinazolines; Rats, Sprague-Dawley; Receptors, AMPA | 2020 |
Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models.
Topics: Analgesics; Animals; Dinoprostone; Drug Carriers; Emulsions; Guinea Pigs; Hyaluronic Acid; Hydrogels; Indole Alkaloids; Interleukin-6; Mice; Pain; Quinazolines; Skin Absorption; Tumor Necrosis Factor-alpha | 2017 |
Design and Development of Novel 2-(Morpholinyl)-N-substituted Phenylquinazolin-4-amines as Selective COX-II Inhibitor.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Drug Development; Humans; Mice; Molecular Docking Simulation; Pain; Quantitative Structure-Activity Relationship; Quinazolines; Rats, Wistar | 2019 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
EXPERIMENTAL STUDY OF PAIN-RELIEVING MECHANISMS OF 4-[4-OXO-(4H)-QUINAZOLIN-3-YL]-BENZOIC ACID (PK-66 COMPOUND).
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzoates; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Male; Pain; Quinazolines; Rats, Wistar | 2018 |
Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Drug Delivery Systems; Female; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; Oxidoreductases; Pain; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Rodentia | 2019 |
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Freund's Adjuvant; Inflammation; Ketorolac; Male; Morphine; Neurons; Osteoarthritis; Pain; Pain Measurement; Piperazines; Quinazolines; Rats; Rats, Wistar; Spinal Cord | 2013 |
Activation of spinal neuregulin 1-ErbB2 signaling pathway in a rat model of cancer-induced bone pain.
Topics: Animals; Carcinoma 256, Walker; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Neoplasm Transplantation; Neoplasms; Neuregulin-1; Pain; Quinazolines; Rats; Receptor, ErbB-2; Signal Transduction; Tibia | 2014 |
Acid-sensing ion channels detect moderate acidifications to induce ocular pain.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acids; Action Potentials; Amiloride; Animals; Blinking; Cnidarian Venoms; Cornea; Disease Models, Animal; Dry Eye Syndromes; Eye; Guanidines; Guinea Pigs; Hydrogen-Ion Concentration; Male; Nerve Fibers; Ocular Motility Disorders; Ovalbumin; Pain; Patch-Clamp Techniques; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Sensory Receptor Cells; Statistics, Nonparametric | 2015 |
Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
Topics: Animal Feed; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Glial Fibrillary Acidic Protein; Hypoglycemic Agents; Insulin; Linagliptin; Male; Metformin; Microscopy, Fluorescence; Neuroglia; Neurons; Pain; Pain Management; Pain Measurement; Pioglitazone; PPAR gamma; Purines; Quinazolines; Rats; Rats, Sprague-Dawley; Thiazolidinediones | 2015 |
Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.
Topics: Analgesics; Animals; Calcium; Capsaicin; Cell Line; Fever; HEK293 Cells; Humans; Pain; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Peptide; Triazines; TRPV Cation Channels | 2015 |
Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzofurans; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Injections, Intraventricular; Locomotion; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Synthesis and biological evaluation of novel 6,7-dihydro-5H-cyclopenta[d]pyrimidine and 5,6,7,8-tetrahydroquinazoline derivatives as sigma-1 (σ1) receptor antagonists for the treatment of pain.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Molecular Structure; Pain; Pyrimidines; Quinazolines; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2016 |
The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Topics: Animals; Antithrombins; Capillary Permeability; Central Nervous System Agents; Cervical Vertebrae; Disease Models, Animal; Fibrin; Hirudins; Hyperalgesia; Injections, Spinal; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrroles; Quinazolines; Radiculopathy; Rats, Sprague-Dawley; Receptor, PAR-1; Spinal Cord | 2017 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
[Potent and continuous relief of spinal bone pain due to metastasis of non-small cell lung cancer by treatment with gefitinib--a case report].
Topics: Aged; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Fatal Outcome; Female; Gefitinib; Humans; Lung Neoplasms; Pain; Quinazolines; Spine; Tomography, X-Ray Computed | 2009 |
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Female; Humans; Hydrazones; Male; Mice; Pain; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Rabbits; Rats; Rats, Wistar; Safrole | 2009 |
Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Dipeptides; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Migraine Disorders; Neurons; Pain; Piperazines; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Wistar; Trigeminal Nucleus, Spinal | 2009 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Inflammation; Male; Mice; Pain; Pain Measurement; Quinazolines; Structure-Activity Relationship | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
A nonproton ligand sensor in the acid-sensing ion channel.
Topics: Acid Sensing Ion Channels; Acids; Amiloride; Animals; Behavior, Animal; Biophysics; Calcium; Cells, Cultured; Cricetinae; Cricetulus; Disease Models, Animal; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Glutamates; Guanidines; Hydrogen-Ion Concentration; Ion Channel Gating; Ligands; Membrane Potentials; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Pain; Pain Measurement; Patch-Clamp Techniques; Protein Structure, Tertiary; Protons; Quinazolines; Rats; Sensory Receptor Cells; Sodium Channels; Sulfhydryl Reagents; Time Factors; Transfection | 2010 |
Painful annular pustular drug eruption induced by erlotinib in a patient with non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Drug Eruptions; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Middle Aged; Pain; Protein Kinase Inhibitors; Quinazolines | 2011 |
Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
Topics: Administration, Cutaneous; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Female; Indole Alkaloids; Male; Mice; Oleic Acid; Pain; Plant Extracts; Quinazolines; Sesquiterpenes; Skin; Swine | 2012 |
Effects of alfuzosin with methylprednisolone for spontaneous expulsion and pain control of lower ureteral stone.
Topics: Adolescent; Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Drug Therapy, Combination; Female; Humans; Male; Methylprednisolone; Middle Aged; Pain; Quinazolines; Ureteral Calculi | 2012 |
The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; Ileum; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Quinazolines | 2003 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Disease Models, Animal; Drug Administration Schedule; Female; Foot; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Male; Microbial Sensitivity Tests; Norfloxacin; Oxazines; Pain; Pain Measurement; Quinazolines; Rats; Rats, Wistar; Time Factors | 2003 |
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Biological Availability; Calcium; Cells, Cultured; Disease Models, Animal; Heterocyclic Compounds, 2-Ring; Humans; Hyperalgesia; Isoquinolines; Models, Molecular; Pain; Quinazolines; Quinolines; Rats; Receptors, Drug; Static Electricity; Structure-Activity Relationship; Urea | 2005 |
Analgetic activity of a quinazoline.
Topics: Aminopyrine; Analgesics; Animals; Dental Pulp; Hot Temperature; Male; Mice; Morphine; Pain; Quinazolines; Rats | 1967 |
Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mononeuropathies; Nitric Oxide Synthase; Pain; Quinazolines; Rats; Rats, Sprague-Dawley | 2006 |
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles | 2005 |
Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.
Topics: Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Disease Models, Animal; Humans; In Vitro Techniques; Mice; Micronucleus Tests; Microsomes, Liver; Pain; Quinazolines; Rats; Solubility; Structure-Activity Relationship; TRPV Cation Channels | 2006 |
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Topics: Administration, Oral; Amides; Analgesics, Non-Narcotic; Animals; Biological Availability; Humans; Molecular Conformation; Pain; Quinazolines; Rats; Solubility; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2006 |
Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; ErbB Receptors; Female; In Situ Hybridization; Motor Activity; Pain; Pain Measurement; Psychomotor Performance; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sensation; Serotonin; Spinal Cord Injuries; Time Factors; Tyrosine 3-Monooxygenase; Urinary Bladder | 2007 |
Suppression of spike-wave discharge activity and c-fos expression by 2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine (Q5) in vivo.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Gene Expression; Genes, fos; Immunohistochemistry; Nerve Net; Pain; Piperidines; Quinazolines; Rats; Rats, Inbred Strains; Stress, Psychological | 2007 |
Alfuzosin-associated dermatomyositis.
Topics: Adrenergic alpha-Antagonists; Aged; Dermatomyositis; Humans; Magnetic Resonance Imaging; Male; Muscle Weakness; Muscle, Skeletal; Pain; Prostatic Hyperplasia; Quinazolines | 1998 |
Synthesis and analgesic activity of some quinazoline analogs of anpirtoline.
Topics: Aminopyridines; Analgesics; Animals; Hot Temperature; Male; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Piperidines; Pyridines; Quinazolines; Reaction Time; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship; Tramadol | 2000 |
Extension of the jaw opening reflex and effects of a central muscle relaxant (afloqualone) in the rat.
Topics: Animals; Electric Stimulation; Electromyography; Male; Masticatory Muscles; Molecular Structure; Muscle Relaxants, Central; Neck Muscles; Pain; Quinazolines; Rats; Reflex; Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome | 1990 |