quinazolines has been researched along with Abdominal Migraine in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.49) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 43 (64.18) | 29.6817 |
| 2010's | 19 (28.36) | 24.3611 |
| 2020's | 4 (5.97) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Fan, X; Pan, Q; Qin, G; Tian, R; Wang, Y; Wen, Q; Zhang, D; Zhang, Y; Zhou, J | 1 |
| Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y | 1 |
| Christensen, SL; Ernstsen, C; Kristensen, DM; Olesen, J | 1 |
| Dripps, I; Goadsby, PJ; Holland, PR; Pradhan, A; Saengjaroentham, C; Strother, LC; Sultan Jabir, MR | 1 |
| Dallel, R; Descheemaeker, A; Luccarini, P | 1 |
| Goadsby, PJ; Messina, R | 1 |
| Silberstein, SD; White, CS; Yuan, H | 1 |
| Hargreaves, R; Olesen, J | 1 |
| Christensen, SL; Kristensen, DM; Munro, G; Olesen, J; Petersen, S | 1 |
| Edvinsson, L; Warfvinge, K | 1 |
| Bhatt, DK; Gupta, S; Hay-Schmidt, A; Jansen-Olesen, I; Olesen, J; Ploug, KB; Ramachandran, R | 1 |
| Anderson, C; Bergeron, D; Binch, H; Decker, C; Garcia-Guzman, M; Hadida, S; Joshi, P; Moore, J; terHaar, E; Termin, A; Yoo, S | 1 |
| Gong, M; Li, J; Li, Z; Lu, X; Pan, X; Shang, Y; Wang, M; Wu, Y; Xu, Y; Zhai, Y | 1 |
| Gong, M; He, R; He, S; Lu, X; Pan, X; Wu, Y; Xu, Y | 1 |
| Farinelli, I; Martelletti, P; Missori, S | 1 |
| Stillman, MJ; Tepper, SJ | 1 |
| Davis, CD; Xu, C | 1 |
| Benemei, S; Capone, JG; Geppetti, P; Nicoletti, P | 1 |
| Tfelt-Hansen, P | 1 |
| Burgey, CS; Salvatore, CA; Williams, TM | 1 |
| Bhatt, DK; Boni, LJ; Gupta, S; Olesen, J | 1 |
| Nieber, K | 1 |
| Fischer, MJ; Messlinger, K; Sixt, ML | 1 |
| Tfelt-Hansen, PC | 1 |
| Olesen, J; Villalón, CM | 1 |
| Bigal, ME; Ho, TW | 1 |
| Vetter, C | 1 |
| Paone, DV; Staas, DD | 1 |
| Paemeleire, K; Schelstraete, C | 1 |
| Gingell, JJ; Hay, DL; Kane, SA; Moore, EL; Salvatore, CA | 1 |
| Edvinsson, L; Ho, TW | 1 |
| Durham, PL; Vause, CV | 1 |
| Fischer, MJ | 1 |
| Jensen, LT; Olesen, J; Petersen, KA; Tfelt-Hansen, P; Tvedskov, JF | 1 |
| Olesen, J; Tfelt-Hansen, P | 1 |
| Fischer, MJ; Lennerz, JK; Messlinger, K | 1 |
| Lionetto, L; Martelletti, P; Negro, A; Simmaco, M | 1 |
| Edvinsson, L | 2 |
| Hussar, DA | 1 |
| Durham, PL | 2 |
| Diener, HC; Goadsby, PJ; Hall, D; Husstedt, IW; Lesko, LM; Meier, U; Olesen, J; Pollentier, S | 1 |
| Dodick, DW; Lipton, RB | 1 |
| Brain, SD | 1 |
| Arulmani, U; Maassenvandenbrink, A; Saxena, PR; Villalón, CM | 1 |
| Herbert, MK; Holzer, P | 1 |
| Bigal, ME; Lipton, RB | 1 |
| Doods, H; Eberlein, W; Engel, W; Entzeroth, M; Hallermayer, G; Pieper, H; Rudolf, K | 1 |
| Kamikawa, Y; Kojima, S | 1 |
| Avezaat, CJ; Gupta, S; Maassenvandenbrink, A; Mehrotra, S; Saxena, PR; Villalón, CM | 1 |
| McCabe, JT; O'Sullivan, J | 1 |
| Roth, W; Schaefer, HG; Tillmann, C; Trocóniz, IF; Wolters, JM | 1 |
| Akerman, S; Goadsby, PJ; Gupta, S; Saxena, PR; van den Brink, AM; van den Maagdenberg, AM | 1 |
| Unger, J | 1 |
| Benemei, S; Capone, JA; Geppetti, P; Nicoletti, P | 1 |
| Recober, A; Russo, AF | 1 |
| Arndt, K; Doods, H; Just, S; Rudolf, K | 1 |
| Edvinsson, L; Kuris, A; Link, AS | 1 |
| Ashina, M; Jensen, RH | 1 |
| Cobaugh, DS | 1 |
| Doods, H; Eberlein, W; Engel, W; Entzeroth, M; Hallermayer, G; Rudolf, K; Wu, D | 1 |
| Tefferi, A; Wright, CA | 1 |
| Doods, H | 1 |
| Brain, SD; Hill, RG; Poyner, DR | 1 |
| Abounader, R; Doods, H; Hamel, E; Hébert, E; Moreno, MJ | 1 |
33 review(s) available for quinazolines and Abdominal Migraine
| Article | Year |
|---|---|
CGRP - a target for acute therapy in migraine: Clinical data.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials, Phase II as Topic; Dipeptides; Drug Delivery Systems; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2019 |
Calcitonin Gene-Related Peptide Antagonists in the Treatment of Episodic Migraine.
Topics: Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Migraine Disorders; Piperazines; Quinazolines | 2019 |
Calcitonin Gene-Related Peptide Modulators - The History and Renaissance of a New Migraine Drug Class.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Spiro Compounds | 2019 |
CGRP receptor antagonism and migraine therapy.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Imidazoles; Migraine Disorders; Peptide Fragments; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2013 |
Proinflammatory mediators and migraine pathogenesis: moving towards CGRP as a target for a novel therapeutic class.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Clinical Trials as Topic; Dipeptides; Humans; Migraine Disorders; Piperazines; Quinazolines; Tryptamines | 2008 |
Clinical and preclinical rationale for CGRP-receptor antagonists in the treatment of migraine.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials as Topic; Dipeptides; Drug Evaluation, Preclinical; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines | 2008 |
The tortuous road to an ideal CGRP function blocker for the treatment of migraine.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Structure-Activity Relationship; Vasodilation | 2008 |
CGRP receptors in the control of pain and inflammation.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Imidazoles; Migraine Disorders; Neurogenic Inflammation; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2009 |
Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Drug Design; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Species Specificity; Structure-Activity Relationship | 2009 |
[CGRP antagonists: novel concept for treatment of migraine].
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Imidazoles; Migraine Disorders; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2009 |
The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs.
Topics: Analgesics; Animals; Azepines; Brain; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Drug Delivery Systems; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2009 |
Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Drug Design; Drug Industry; Humans; Imidazoles; Migraine Disorders; Patents as Topic; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2009 |
CGRP antagonists: hope for a new era in acute migraine treatment.
Topics: Azepines; Brain; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines | 2009 |
CGRP receptor antagonism and migraine.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Imidazoles; Migraine Disorders; Neurotransmitter Agents; Piperazines; Quinazolines | 2010 |
Calcitonin gene-related peptide receptor antagonists for migraine.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Indazoles; Migraine Disorders; Piperazines; Quinazolines; Quinazolinones; Treatment Outcome; Trigeminal Nerve | 2010 |
Possible site of action of CGRP antagonists in migraine.
Topics: Animals; Azepines; Blood-Brain Barrier; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide Receptor Antagonists; Cerebrovascular Circulation; Dipeptides; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Spiro Compounds | 2011 |
Neuropeptide effects in the trigeminal system: pathophysiology and clinical relevance in migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dura Mater; Humans; Membrane Potentials; Migraine Disorders; Neurokinin A; Neuropeptide Y; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Substance P; Trigeminal Ganglion; Trigeminal Nucleus, Spinal; Vasoactive Intestinal Peptide | 2011 |
CGRP receptor antagonists: an expanding drug class for acute migraine?
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Drug Design; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Tryptamines | 2012 |
New therapeutic target in primary headaches - blocking theCGRP receptor.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Animals; Calcitonin; Calcitonin Gene-Related Peptide Receptor Antagonists; Child; Clinical Trials as Topic; Drug Evaluation, Preclinical; Headache; Humans; Migraine Disorders; Neurotransmitter Agents; Piperazines; Protein Precursors; Quinazolines; Rats; Receptors, Calcitonin Gene-Related Peptide; Signal Transduction; Trigeminal Nerve; Vasodilation | 2003 |
CGRP antagonists in the acute treatment of migraine.
Topics: Acute Disease; Calcitonin Gene-Related Peptide; Cerebral Arteries; Humans; Migraine Disorders; Piperazines; Quinazolines; Trigeminal Nerve; Vasoconstriction; Vasoconstrictor Agents | 2004 |
CGRP receptor antagonists: a new choice for acute treatment of migraine?
Topics: Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Humans; Migraine Disorders; Piperazines; Quinazolines; Randomized Controlled Trials as Topic; Receptors, Calcitonin Gene-Related Peptide | 2004 |
Calcitonin gene-related peptide and its role in migraine pathophysiology.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Structure-Activity Relationship | 2004 |
[Innovative treatment of acute migraine pain with CGRP receptor antagonists].
Topics: Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperazines; Quinazolines; Vasodilator Agents | 2004 |
Headache: triumphs in translational research.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Headache; Humans; Migraine Disorders; Piperazines; Quinazolines; Vasoconstriction | 2005 |
Clinical data on the CGRP antagonist BIBN4096BS for treatment of migraine attacks.
Topics: Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Piperazines; Quinazolines | 2005 |
[Recent development of calcitonin gene-related peptide (CGRP) receptor antagonist].
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Drug Design; Humans; Irritable Bowel Syndrome; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Synaptic Transmission; Vasodilation | 2005 |
Migraine development, treatments, research advances, and anesthesia implications.
Topics: Acute Disease; Adult; Age Distribution; Age of Onset; Analgesics, Opioid; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Cortical Spreading Depression; Ergotamine; Female; Humans; Male; Middle Aged; Migraine Disorders; Nurse Anesthetists; Peptides; Piperazines; Prevalence; Primary Prevention; Quinazolines; Risk Factors; Serotonin Receptor Agonists; Sex Distribution; Trigeminal Nerve | 2006 |
Migraine headaches: a historical prospective, a glimpse into the future, and migraine epidemiology.
Topics: Benzamides; Benzopyrans; Calcitonin Gene-Related Peptide; Drug Therapy, Combination; Ergotamine; Global Health; Humans; Incidence; Indans; Migraine Disorders; Piperazines; Prevalence; Prospective Studies; Quinazolines; Randomized Controlled Trials as Topic; Spiro Compounds; Sumatriptan; Treatment Outcome; United States; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Pain pharmacology in migraine: focus on CGRP and CGRP receptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cerebral Arteries; Humans; Migraine Disorders; Nervous System; Neurons, Afferent; Nociceptors; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Vasodilation | 2007 |
CGRP antagonists: unravelling the role of CGRP in migraine.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Migraine Disorders; Models, Biological; Molecular Structure; Quinazolines | 2007 |
Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cerebral Arteries; Dipeptides; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Trigeminal Nerve; Tryptamines; Vasodilation | 2008 |
A single institutional experience with 43 pregnancies in essential thrombocythemia.
Topics: Abortion, Induced; Abortion, Spontaneous; Abruptio Placentae; Adult; Anticoagulants; Aspirin; Busulfan; Erythromelalgia; Female; Fetal Death; Follow-Up Studies; Heparin; Humans; Hydroxyurea; Migraine Disorders; Obstetric Labor, Premature; Phosphorus Radioisotopes; Platelet Aggregation Inhibitors; Platelet Count; Plateletpheresis; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Pregnancy Trimester, First; Pregnancy, Ectopic; Pregnancy, High-Risk; Quinazolines; Retrospective Studies; Risk; Thrombocythemia, Essential; Uterine Hemorrhage | 2001 |
Development of CGRP antagonists for the treatment of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Piperazines; Quinazolines | 2001 |
3 trial(s) available for quinazolines and Abdominal Migraine
| Article | Year |
|---|---|
CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine.
Topics: Adult; Calcitonin Gene-Related Peptide Receptor Antagonists; Cross-Over Studies; Dipeptides; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitroglycerin; Piperazines; Quinazolines; Vasodilator Agents | 2010 |
Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.
Topics: Acute Disease; Adult; Calcitonin Gene-Related Peptide Receptor Antagonists; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperazines; Piperidines; Quinazolines; Time Factors | 2004 |
Modelling the anti-migraine effects of BIBN 4096 BS: a new calcitonin gene-related peptide receptor antagonist.
Topics: Adult; Aged; Algorithms; Biological Availability; Calcitonin Gene-Related Peptide Receptor Antagonists; Computer Simulation; Data Interpretation, Statistical; Dipeptides; Double-Blind Method; Female; Half-Life; Humans; Injections, Intravenous; Logistic Models; Male; Middle Aged; Migraine Disorders; Models, Statistical; Nonlinear Dynamics; Population; Quinazolines; Receptors, Drug; Software | 2006 |
31 other study(ies) available for quinazolines and Abdominal Migraine
| Article | Year |
|---|---|
Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperazines; Quinazolines; Rats; Receptors, Calcitonin Gene-Related Peptide; Synaptic Transmission | 2022 |
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.
Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroglycerin; Pain; Periaqueductal Gray; Quinazolines; Rats, Sprague-Dawley; Receptors, AMPA | 2020 |
No central action of CGRP antagonising drugs in the GTN mouse model of migraine.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Injections, Intraventricular; Mice; Migraine Disorders; Nitroglycerin; Piperazines; Quinazolines; Vasodilator Agents | 2020 |
Differential medication overuse risk of novel anti-migraine therapeutics.
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Carbazoles; Fluorobenzenes; Headache Disorders, Secondary; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; Pain Measurement; Piperazines; Quinazolines; Receptor, Serotonin, 5-HT1F; Receptors, Calcitonin Gene-Related Peptide; Receptors, Serotonin; Risk Factors | 2020 |
Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression.
Topics: Animals; Central Nervous System Sensitization; Dipeptides; Disease Models, Animal; Hyperalgesia; Isosorbide Dinitrate; Male; Migraine Disorders; Nitric Oxide Donors; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Sumatriptan; Vasoconstrictor Agents; Vasodilator Agents | 2018 |
Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Drug Delivery Systems; Female; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; Oxidoreductases; Pain; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Rodentia | 2019 |
Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Migraine Disorders; Neurokinin-1 Receptor Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitroglycerin; Piperazines; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Trigeminal Nerve; Vasodilator Agents; Wakefulness | 2014 |
Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists.
Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Dipeptides; Humans; Imidazoles; Inhibitory Concentration 50; Migraine Disorders; Molecular Structure; Molecular Weight; Piperazines; Protein Binding; Quinazolines; Quinazolinones; Rats; Receptors, Calcitonin Gene-Related Peptide; Thiazolidinediones; Urea | 2014 |
Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.
Topics: Animals; Brain; China; Drugs, Chinese Herbal; Ginsenosides; Humans; Indole Alkaloids; Limonins; Medicine, Chinese Traditional; Mice; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Quinazolines; Reserpine; Serotonin | 2015 |
Optimization of combinations of ginsenoside-Rg1, ginsenoside-Rb1, evodiamine and rutaecarpine for effective therapy of mouse migraine.
Topics: Animals; Dopamine; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Indole Alkaloids; Medicine, Chinese Traditional; Mice, Inbred ICR; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Phytotherapy; Quinazolines; Serotonin | 2016 |
Migraine and telcagepant [corrected].
Topics: Dipeptides; Humans; Migraine Disorders; Oxazolidinones; Piperazines; Quality of Life; Quinazolines; Treatment Outcome; Tryptamines | 2009 |
Improvement of the closed cranial window model in rats by intracarotid infusion of signalling molecules implicated in migraine.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Carotid Arteries; Cerebrovascular Circulation; Dipeptides; Disease Models, Animal; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Microscopy; Migraine Disorders; Piperazines; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents | 2010 |
Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Dipeptides; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Migraine Disorders; Neurons; Pain; Piperazines; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Wistar; Trigeminal Nucleus, Spinal | 2009 |
Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cerebral Arteries; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Serotonin Receptor Agonists; Treatment Failure; Tryptamines | 2009 |
Is there an inherent limit to acute migraine treatment efficacy?
Topics: Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials as Topic; Dipeptides; Drug Administration Schedule; Endpoint Determination; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Serotonin Receptor Agonists; Time Factors; Treatment Outcome; Tryptamines | 2009 |
[Migraine can signal a risk for heart and brain].
Topics: Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Female; Humans; Imidazoles; Migraine Disorders; Migraine with Aura; Myocardial Infarction; Piperazines; Quinazolines; Risk Factors; Stroke; Tryptamines | 2009 |
Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding.
Topics: Azepines; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcitonin Receptor-Like Protein; Crystallography, X-Ray; Dipeptides; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Migraine Disorders; Piperazines; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Quinazolines; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Proteins; Receptors, Calcitonin; Receptors, Calcitonin Gene-Related Peptide; Tryptophan | 2010 |
Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Treatment Outcome | 2010 |
New drugs 04, part 1.
Topics: Adalimumab; Alefacept; alpha-Galactosidase; Anisoles; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antioxidants; Antiprotozoal Agents; Antirheumatic Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Drug Approval; Drug Therapy; Fabry Disease; Gefitinib; Humans; Iduronidase; Indoles; Isoenzymes; Lentigo; Lung Neoplasms; Migraine Disorders; Mucopolysaccharidosis I; Nitro Compounds; Patient Education as Topic; Propylamines; Psoriasis; Pyrrolidines; Quinazolines; Recombinant Fusion Proteins; Serotonin Receptor Agonists; Thiazoles; Tryptamines | 2004 |
CGRP-receptor antagonists--a fresh approach to migraine therapy?
Topics: Acute Disease; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Female; Humans; Male; Migraine Disorders; Piperazines; Piperidines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide | 2004 |
New drug curbs migraine pain.
Topics: Analgesics; Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Piperazines; Quinazolines | 2004 |
Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Piperazines; Quinazolines; Synaptic Transmission | 2004 |
Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-l-lysyl]-4-(4-pyr
Topics: Acute Disease; Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Callithrix; Cell Line, Tumor; Cyclic AMP; Dipeptides; Humans; In Vitro Techniques; Migraine Disorders; Quinazolines; Rats; Spleen; Structure-Activity Relationship | 2005 |
Characterisation of CGRP receptors in the human isolated middle meningeal artery.
Topics: Calcitonin Gene-Related Peptide; Humans; In Vitro Techniques; Ligands; Meningeal Arteries; Migraine Disorders; Peptide Fragments; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilation; Vasodilator Agents | 2006 |
Intravital microscopy on a closed cranial window in mice: a model to study trigeminovascular mechanisms involved in migraine.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dura Mater; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Microscopy, Video; Migraine Disorders; Piperazines; Quinazolines; Serotonin Receptor Agonists; Skull; Sumatriptan; Trigeminal Caudal Nucleus; Vasodilation | 2006 |
Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment.
Topics: Analgesics; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dipeptides; Humans; Injections, Intravenous; Migraine Disorders; Molecular Structure; Patents as Topic; Piperazines; Protein Precursors; Quinazolines; Treatment Outcome | 2007 |
[A new therapeutic principle for migraine].
Topics: Azepines; Calcitonin Gene-Related Peptide; Humans; Imidazoles; Migraine Disorders; Piperazines; Quinazolines; Serotonin Receptor Agonists; Treatment Outcome; Triazoles; Tryptamines; Vasodilator Agents | 2008 |
Prazosin treatment of ergotamine-induced peripheral ischemia.
Topics: Adult; Arm; Ergotamine; Female; Humans; Ischemia; Leg; Migraine Disorders; Prazosin; Quinazolines | 1980 |
Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Callithrix; Cell Line; Cyclic AMP; Electric Stimulation; Face; Female; Humans; Kinetics; Male; Migraine Disorders; Piperazines; Quinazolines; Rats; Receptors, Calcitonin Gene-Related Peptide; Regional Blood Flow; Trigeminal Ganglion | 2000 |
CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Gene Transfer, Horizontal; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Knockout; Migraine Disorders; Piperazines; Quinazolines; Rabbits; Receptor Activity-Modifying Proteins; Receptors, Calcitonin Gene-Related Peptide; Species Specificity; Substance Withdrawal Syndrome | 2002 |
Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment.
Topics: Acute Disease; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Cerebral Arteries; Dose-Response Relationship, Drug; Female; Humans; Male; Migraine Disorders; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Vasodilation | 2002 |