quinacrine has been researched along with Trypanosomiasis, African in 3 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compound was orally bioavailable and displayed good plasma and brain exposure in mice." | 1.40 | Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. ( Brun, R; Buckner, FS; Chatterjee, AK; Creason, SA; Duster, NA; Gelb, MH; Gillespie, JR; Glynne, R; Hulverson, MA; McQueen, J; Molteni, V; Nagendar, P; Nagle, A; Norcross, NR; Ranade, RM; Supek, F; Tatipaka, HB; Wenzler, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tatipaka, HB | 1 |
| Gillespie, JR | 2 |
| Chatterjee, AK | 1 |
| Norcross, NR | 1 |
| Hulverson, MA | 2 |
| Ranade, RM | 2 |
| Nagendar, P | 1 |
| Creason, SA | 2 |
| McQueen, J | 2 |
| Duster, NA | 1 |
| Nagle, A | 1 |
| Supek, F | 1 |
| Molteni, V | 1 |
| Wenzler, T | 1 |
| Brun, R | 1 |
| Glynne, R | 1 |
| Buckner, FS | 2 |
| Gelb, MH | 2 |
| Patrick, DA | 1 |
| Herbst, ZM | 1 |
| Tidwell, RR | 1 |
| Klein, P | 1 |
3 other studies available for quinacrine and Trypanosomiasis, African
| Article | Year |
|---|---|
Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability | 2014 |
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.
Topics: Benzothiazoles; Humans; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Ur | 2017 |
[On the ideological history of the early period of chemotherapy].
Topics: Animals; Arsphenamine; Birds; Drug Therapy; History, 20th Century; Humans; Malaria; Malaria, Avian; | 1966 |