Page last updated: 2024-10-16

quinacrine and Rida

quinacrine has been researched along with Rida in 4 studies

Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.

Research Excerpts

ExcerptRelevanceReference
"Quinacrine was reported to have a marked in vitro antiprion action in mouse neuroblastoma cells."2.71A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie. ( Andréoletti, O; Gayrard, V; Laroute, V; Picard-Hagen, N; Toutain, PL; Viguié, C, 2005)
"Treatment with quinacrine or pentosan polysulfate cleared the PrPSc from the ScGT1-1 cell cultures, and the increase in levels of monomeric SNAP-25 and synaptophysin was reversible."1.33Altered interaction and expression of proteins involved in neurosecretion in scrapie-infected GT1-1 cells. ( Löw, P; Sandberg, MK, 2005)
"Quinacrine treatment cleared PrP(Sc) and restored calcium responses in the ScGT1-1 cultures."1.32Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment. ( Kristensson, K; Sandberg, MK; Wallén, P; Wikström, MA, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
May, BC1
Witkop, J1
Sherrill, J1
Anderson, MO1
Madrid, PB1
Zorn, JA1
Prusiner, SB1
Cohen, FE1
Guy, RK1
Sandberg, MK2
Wallén, P1
Wikström, MA1
Kristensson, K1
Löw, P1
Gayrard, V1
Picard-Hagen, N1
Viguié, C1
Laroute, V1
Andréoletti, O1
Toutain, PL1

Trials

1 trial available for quinacrine and Rida

ArticleYear
A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie.
    British journal of pharmacology, 2005, Volume: 144, Issue:3

    Topics: Algorithms; Animals; Cell Line, Tumor; Culture Media; Extracellular Space; Female; Injections, Intra

2005

Other Studies

3 other studies available for quinacrine and Rida

ArticleYear
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
    Bioorganic & medicinal chemistry letters, 2006, Sep-15, Volume: 16, Issue:18

    Topics: Aminacrine; Cell Line; Cell Survival; Humans; Molecular Structure; Neuroblastoma; Scrapie; Structure

2006
Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.
    Neurobiology of disease, 2004, Volume: 15, Issue:1

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Line;

2004
Altered interaction and expression of proteins involved in neurosecretion in scrapie-infected GT1-1 cells.
    The Journal of biological chemistry, 2005, Jan-14, Volume: 280, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Surface; Cell Line; Cyclic AMP; Membrane Proteins; M

2005
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