quinacrine and Rida
quinacrine has been researched along with Rida in 4 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine was reported to have a marked in vitro antiprion action in mouse neuroblastoma cells." | 2.71 | A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie. ( Andréoletti, O; Gayrard, V; Laroute, V; Picard-Hagen, N; Toutain, PL; Viguié, C, 2005) |
| "Treatment with quinacrine or pentosan polysulfate cleared the PrPSc from the ScGT1-1 cell cultures, and the increase in levels of monomeric SNAP-25 and synaptophysin was reversible." | 1.33 | Altered interaction and expression of proteins involved in neurosecretion in scrapie-infected GT1-1 cells. ( Löw, P; Sandberg, MK, 2005) |
| "Quinacrine treatment cleared PrP(Sc) and restored calcium responses in the ScGT1-1 cultures." | 1.32 | Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment. ( Kristensson, K; Sandberg, MK; Wallén, P; Wikström, MA, 2004) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| May, BC | 1 |
| Witkop, J | 1 |
| Sherrill, J | 1 |
| Anderson, MO | 1 |
| Madrid, PB | 1 |
| Zorn, JA | 1 |
| Prusiner, SB | 1 |
| Cohen, FE | 1 |
| Guy, RK | 1 |
| Sandberg, MK | 2 |
| Wallén, P | 1 |
| Wikström, MA | 1 |
| Kristensson, K | 1 |
| Löw, P | 1 |
| Gayrard, V | 1 |
| Picard-Hagen, N | 1 |
| Viguié, C | 1 |
| Laroute, V | 1 |
| Andréoletti, O | 1 |
| Toutain, PL | 1 |
Trials
1 trial available for quinacrine and Rida
| Article | Year |
|---|---|
A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie.
Topics: Algorithms; Animals; Cell Line, Tumor; Culture Media; Extracellular Space; Female; Injections, Intra | 2005 |
Other Studies
3 other studies available for quinacrine and Rida
| Article | Year |
|---|---|
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
Topics: Aminacrine; Cell Line; Cell Survival; Humans; Molecular Structure; Neuroblastoma; Scrapie; Structure | 2006 |
Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Line; | 2004 |
Altered interaction and expression of proteins involved in neurosecretion in scrapie-infected GT1-1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Surface; Cell Line; Cyclic AMP; Membrane Proteins; M | 2005 |