quinacrine has been researched along with Polycythemia Vera in 2 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In ET, thrombosis was associated with JAK2V617F mutation (p < 0." | 1.40 | JAK2V617F allele burden is associated with thrombotic mechanisms activation in polycythemia vera and essential thrombocythemia patients. ( Almeida Santos, S; Bento, C; Caetano, G; Coucelo, M; Duarte, M; Fidalgo, T; Fortuna, M; Menezes, C; Ribeiro, ML; Sevivas, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coucelo, M | 1 |
| Caetano, G | 1 |
| Sevivas, T | 1 |
| Almeida Santos, S | 1 |
| Fidalgo, T | 1 |
| Bento, C | 1 |
| Fortuna, M | 1 |
| Duarte, M | 1 |
| Menezes, C | 1 |
| Ribeiro, ML | 1 |
| Garson, OM | 1 |
1 review available for quinacrine and Polycythemia Vera
| Article | Year |
|---|---|
Chromosome-banding techniques and their implication in hematology.
Topics: Acute Disease; Azure Stains; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Ban | 1979 |
1 other study available for quinacrine and Polycythemia Vera
| Article | Year |
|---|---|
JAK2V617F allele burden is associated with thrombotic mechanisms activation in polycythemia vera and essential thrombocythemia patients.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Blood Platelets; Case-Control Studies; CD11b Antigen; Codon | 2014 |