quinacrine has been researched along with Pleural Effusion in 26 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Pleural Effusion: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighteen patients with advanced metastatic malignancy who had 21 pleural effusions requiring sclerosis for control were randomly allocated to intrapleural therapy with tetracycline or quinacrine." | 9.04 | Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial. ( Bayly, TC; Kisner, DL; Macdonald, JS; Schein, PS; Sybert, A; Tsou, E, 1978) |
| "A total of 121 pleurodeses using instillations of quinacrine (mepacrine) in patients with recurrent pleural effusion were performed." | 7.66 | Treatment of recurrent pleural effusion by pleurodesis with quinacrine. Comparison between instillation by repeated thoracenteses and by tube drainage. ( Korsgaard, R; Simonsson, BG; Stiksa, G, 1979) |
| "Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine." | 7.65 | Quinacrine in the management of malignant pleural effusion. ( Hooton, NS; Macarthur, AM; Taylor, SA, 1977) |
| "A 73-year-old man with bilateral recurrent pleural effusions had relief of symptoms with intrapleural instillation of quinacrine hydrochloride and talcum powder." | 7.65 | Granulomatous pneumonitis. A result of intrapleural instillation of quinacrine and talcum powder. ( Factor, SM, 1975) |
| "Eighteen patients with advanced metastatic malignancy who had 21 pleural effusions requiring sclerosis for control were randomly allocated to intrapleural therapy with tetracycline or quinacrine." | 5.04 | Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial. ( Bayly, TC; Kisner, DL; Macdonald, JS; Schein, PS; Sybert, A; Tsou, E, 1978) |
| "A total of 121 pleurodeses using instillations of quinacrine (mepacrine) in patients with recurrent pleural effusion were performed." | 3.66 | Treatment of recurrent pleural effusion by pleurodesis with quinacrine. Comparison between instillation by repeated thoracenteses and by tube drainage. ( Korsgaard, R; Simonsson, BG; Stiksa, G, 1979) |
| "Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine." | 3.65 | Quinacrine in the management of malignant pleural effusion. ( Hooton, NS; Macarthur, AM; Taylor, SA, 1977) |
| "A 73-year-old man with bilateral recurrent pleural effusions had relief of symptoms with intrapleural instillation of quinacrine hydrochloride and talcum powder." | 3.65 | Granulomatous pneumonitis. A result of intrapleural instillation of quinacrine and talcum powder. ( Factor, SM, 1975) |
| "A pleural effusion is a frequent complication of malignant disease." | 1.26 | Management of malignant pleural effusion. ( Bennett, JM; Greenwald, DW; Phillips, C, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ULTMANN, JE | 1 |
| GELLHORN, A | 1 |
| OSNOS, M | 1 |
| HIRSCHBERG, E | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| WAGNER, DE | 1 |
| SILVA, AR | 1 |
| MENG, HY | 1 |
| CHIEN, TS | 1 |
| CHANG, KC | 1 |
| Dollinger, MR | 1 |
| Krakoff, IH | 1 |
| Karnofsky, DA | 1 |
| Borda, I | 1 |
| Krant, M | 1 |
| Sahn, SA | 1 |
| Good, JT | 1 |
| Ovrum, E | 1 |
| Pillgram-Larsen, J | 1 |
| McLoud, TC | 1 |
| Isler, R | 1 |
| Head, J | 1 |
| Johnson, LP | 1 |
| Rivkin, SE | 1 |
| Weber, EL | 1 |
| Greenwald, DW | 1 |
| Phillips, C | 1 |
| Bennett, JM | 1 |
| Bayly, TC | 1 |
| Kisner, DL | 1 |
| Sybert, A | 1 |
| Macdonald, JS | 1 |
| Tsou, E | 1 |
| Schein, PS | 1 |
| Austin, EH | 1 |
| Flye, MW | 1 |
| Mejer, J | 1 |
| Mortensen, KM | 1 |
| Hansen, HH | 1 |
| Stiksa, G | 1 |
| Korsgaard, R | 1 |
| Simonsson, BG | 2 |
| Taylor, SA | 1 |
| Hooton, NS | 1 |
| Macarthur, AM | 1 |
| Boe, J | 2 |
| Florvaag, E | 1 |
| Factor, SM | 1 |
| Kreuser, ED | 1 |
| Hausheer, FH | 1 |
| Yarbro, JW | 1 |
| Agrenius, V | 1 |
| Chmielewska, J | 1 |
| Widström, O | 1 |
| Blombäck, M | 1 |
| Borja, ER | 1 |
| Pugh, RP | 1 |
| Arvastson, B | 1 |
| Stiksa, J | 1 |
| Hiller, E | 1 |
| Rosenow, EC | 1 |
| Olsen, AM | 1 |
| Farber, LR | 1 |
| Hickman, JA | 1 |
| Jones, MC | 1 |
3 reviews available for quinacrine and Pleural Effusion
| Article | Year |
|---|---|
The treatment of recurrent malignant pleural effusion.
Topics: Drainage; Humans; Intubation; Neoplasm Metastasis; Neoplasms; Nitrogen Mustard Compounds; Pleura; Pl | 1979 |
[Malignant pleural effusions. Pathophysiology, diagnosis and therapy].
Topics: Absorption; Amylases; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Capillary Permea | 1985 |
Diagnosis and treatment of malignant pleural effusion.
Topics: Biopsy; Bleomycin; Carcinoembryonic Antigen; Chromosome Aberrations; Cytodiagnosis; Drainage; Endosc | 1985 |
2 trials available for quinacrine and Pleural Effusion
| Article | Year |
|---|---|
Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial.
Topics: Clinical Trials as Topic; Female; Humans; Intubation; Neoplasms; Pleura; Pleural Effusion; Quinacrin | 1978 |
Mepacrine hydrochloride in the treatment of malignant pleural effusion. A controlled randomized trial.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Neoplasms; Pleura; Pleural | 1977 |
21 other studies available for quinacrine and Pleural Effusion
| Article | Year |
|---|---|
The effect of quinacrine on neoplastic effusions and certain of their enzymes.
Topics: Ascites; Humans; Neoplasms; Pleural Effusion; Quinacrine | 1963 |
THE CONTROL OF RECURRENT MALIGNANT EFFUSIONS USING QUINACRINE HYDROCHLORIDE.
Topics: Ascites; Biomedical Research; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; | 1964 |
PLEUROPULMONARY AMEBIASIS. CLINICAL ANALYSIS OF 64 CASES.
Topics: Amebiasis; Chloroquine; Diagnosis, Differential; Drainage; Drug Therapy; Emetine; Empyema; Humans; L | 1965 |
Quinacrine (Atabrine) in the treatment of neoplastic effusions.
Topics: Adult; Aged; Exudates and Transudates; Female; Humans; Male; Middle Aged; Neoplasms; Peritoneal Dise | 1967 |
Convulsions following intrapleural administration of quinacrine hydrochloride.
Topics: Adult; Breast Neoplasms; Epilepsy; Female; Genital Neoplasms, Female; Humans; Middle Aged; Neoplasm | 1967 |
The effect of common sclerosing agents on the rabbit pleural space.
Topics: Animals; Bleomycin; Mechlorethamine; Pleural Effusion; Quinacrine; Rabbits; Sclerosing Solutions; So | 1981 |
[Treatment of malignant pleural effusion with mepacrine chloride].
Topics: Aged; Female; Humans; Male; Middle Aged; Pleural Effusion; Quinacrine | 1983 |
The radiologic appearance of chemical pleurodesis.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Infusions, Parenteral; Male; Mec | 1980 |
Palliation in malignant pleural effusion.
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Drainage; Female; Hodgkin Disease; Humans; Lung Neopl | 1975 |
Management of malignant pleural effusion.
Topics: Bleomycin; Fluorouracil; Gold Radioisotopes; Humans; Mechlorethamine; Methods; Neoplasms; Phosphorus | 1978 |
Treatment of recurrent pleural effusion by pleurodesis with quinacrine. Comparison between instillation by repeated thoracenteses and by tube drainage.
Topics: Drainage; Humans; Pleural Effusion; Pleural Neoplasms; Postoperative Complications; Quality of Life; | 1979 |
Quinacrine in the management of malignant pleural effusion.
Topics: Breast Neoplasms; Bronchial Neoplasms; Female; Humans; Pleural Effusion; Pleural Neoplasms; Quinacri | 1977 |
[Chemical pleurodesis induced by mepacrine chloride. An alternative in the treatment of malignant pleural effusions].
Topics: Aged; Female; Humans; Male; Middle Aged; Pleural Diseases; Pleural Effusion; Pneumothorax; Quinacrin | 1976 |
Granulomatous pneumonitis. A result of intrapleural instillation of quinacrine and talcum powder.
Topics: Aged; Fluorescence; Foreign-Body Reaction; Granuloma; Humans; Injections; Light; Lung Diseases; Male | 1975 |
Pleural fibrinolytic activity is decreased in inflammation as demonstrated in quinacrine pleurodesis treatment of malignant pleural effusion.
Topics: Adult; Aged; Exudates and Transudates; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysis; | 1989 |
An agent for the palliative treatment of neoplastic effusions. Quinacrine (atabrine) hydrochloride.
Topics: Ascites; Humans; Neoplasms; Palliative Care; Pleural Effusion; Quinacrine | 1966 |
Single-dose quinacrine (atabrine) and thoracostomy in the control of pleural effusions in patients with neoplastic diseases.
Topics: Drainage; Fever; Hallucinations; Humans; Hypotension; Intubation; Nausea; Neoplasm Metastasis; Neopl | 1973 |
Mepacrine in malignant pleural effusion.
Topics: Aged; Female; Fever; Humans; Male; Middle Aged; Pain; Pleural Effusion; Pleural Neoplasms; Quinacrin | 1973 |
Pulmonary manifestations of the yellow nail syndrome.
Topics: Adolescent; Adult; Aged; Bronchiectasis; Cough; Disease Susceptibility; Female; Humans; Lymphedema; | 1972 |
Correctable complications of neoplastic disease. 3. Neoplastic effusions.
Topics: Alkylating Agents; Ascitic Fluid; Breast Neoplasms; Drainage; Exudates and Transudates; Female; Huma | 1971 |
Treatment of neoplastic pleural effusions with local instillations of quinacrine (mepacrine) hydrochloride.
Topics: Adult; Aged; Breast Neoplasms; Bronchial Neoplasms; Female; Hodgkin Disease; Humans; Male; Middle Ag | 1970 |