quinacrine has been researched along with Pleural Effusion, Malignant in 13 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Pleural Effusion, Malignant: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pleural effusion secondary to breast cancer is a locoregional manifestation." | 1.29 | Pleural effusion in breast cancer: a review of the Nottingham experience. ( Banerjee, AK; Blamey, RW; Robertson, JF; Willetts, I, 1994) |
| "Chronic malignant pleural effusions are usually treated with an intrapleurally administered irritant that creates an inflammatory reaction." | 1.28 | Increased coagulation activity of the pleura after tube drainage and quinacrine instillation in malignant pleural effusion. ( Agrenius, V; Blombäck, M; Chmielewska, J; Widström, O, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Dipper, A | 1 |
| Jones, HE | 2 |
| Bhatnagar, R | 2 |
| Preston, NJ | 2 |
| Maskell, N | 2 |
| Clive, AO | 2 |
| Shaw, PH | 1 |
| Agarwal, R | 2 |
| Shaw, P | 1 |
| Ukale, V | 3 |
| Agrenius, V | 5 |
| Hillerdal, G | 2 |
| Mohlkert, D | 1 |
| Widström, O | 5 |
| Hassan, A | 1 |
| Koldsland, S | 1 |
| Svennevig, JL | 1 |
| Lehne, G | 1 |
| Johnson, E | 1 |
| Gustafsson, LE | 1 |
| Wallace, DJ | 1 |
| Banerjee, AK | 1 |
| Willetts, I | 1 |
| Robertson, JF | 1 |
| Blamey, RW | 1 |
| Källenius, G | 1 |
| Svenson, SB | 1 |
| Bjermer, L | 1 |
| Gruber, A | 1 |
| Sue-Chu, M | 1 |
| Sandström, T | 1 |
| Eksborg, S | 1 |
| Henriksson, R | 1 |
| Chmielewska, J | 1 |
| Blombäck, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Management Of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis[NCT03781908] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2019-01-01 | Not yet recruiting | ||
| A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions[NCT00758316] | Phase 3 | 120 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for quinacrine and Pleural Effusion, Malignant
| Article | Year |
|---|---|
Interventions for the management of malignant pleural effusions: a network meta-analysis.
Topics: Adult; Bleomycin; Doxycycline; Dyspnea; Fever; Humans; Iodine; Network Meta-Analysis; Pleural Effusi | 2020 |
WITHDRAWN: Pleurodesis for malignant pleural effusions.
Topics: Humans; Mitoxantrone; Pleural Effusion, Malignant; Pleurodesis; Propionibacterium acnes; Quinacrine; | 2013 |
Interventions for the management of malignant pleural effusions: a network meta-analysis.
Topics: Adult; Bleomycin; Doxycycline; Fever; Humans; Iodine; Pleural Effusion, Malignant; Pleurodesis; Quin | 2016 |
Pleurodesis for malignant pleural effusions.
Topics: Humans; Mitoxantrone; Pleural Effusion, Malignant; Pleurodesis; Propionibacterium acnes; Quinacrine; | 2004 |
3 trials available for quinacrine and Pleural Effusion, Malignant
| Article | Year |
|---|---|
Pleurodesis in recurrent pleural effusions: a randomized comparison of a classical and a currently popular drug.
Topics: Antineoplastic Agents; Female; Humans; Male; Neoplasm Recurrence, Local; Neoplasms; Pleural Effusion | 2004 |
Chemical pleurodesis in malignant pleural effusions: a randomised prospective study of mepacrine versus bleomycin.
Topics: Adult; Aged; Aged, 80 and over; Bleomycin; Drainage; Female; Humans; Male; Middle Aged; Pleural Effu | 1993 |
Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Fever; Humans; Male; Middle Aged; Mit | 1995 |
6 other studies available for quinacrine and Pleural Effusion, Malignant
| Article | Year |
|---|---|
Inflammatory parameters after pleurodesis in recurrent malignant pleural effusions and their predictive value.
Topics: Aged; Blood Sedimentation; C-Reactive Protein; Female; Glucose; Humans; Hydrogen-Ion Concentration; | 2004 |
Tumour necrosis factor-alpha and nitric oxide, determined as nitrite, in malignant pleural effusion.
Topics: Adult; Aged; Enzyme-Linked Immunosorbent Assay; Female; Humans; Luminescent Measurements; Male; Midd | 1994 |
Controversy over sclerotherapy for malignant pleural effusions.
Topics: Humans; Pleural Effusion, Malignant; Quinacrine; Sclerotherapy | 1994 |
Pleural effusion in breast cancer: a review of the Nottingham experience.
Topics: Adult; Aged; Breast Neoplasms; Chest Tubes; Female; Humans; Instillation, Drug; Middle Aged; Pleural | 1994 |
Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels.
Topics: Adult; Aged; Drainage; Female; Humans; Inflammation; Interleukin-1; Leukocyte Count; Male; Middle Ag | 1993 |
Increased coagulation activity of the pleura after tube drainage and quinacrine instillation in malignant pleural effusion.
Topics: beta-Thromboglobulin; Chest Tubes; Drainage; Female; Fibrinolysis; Fibrinopeptide A; Humans; Male; M | 1991 |