quinacrine has been researched along with Nerve Degeneration in 6 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Goulding, SR | 1 |
| Lévesque, M | 1 |
| Sullivan, AM | 1 |
| Collins, LM | 1 |
| O'Keeffe, GW | 1 |
| Bajsarowicz, K | 1 |
| Ahn, M | 1 |
| Ackerman, L | 1 |
| Dearmond, BN | 1 |
| Carlson, G | 1 |
| DeArmond, SJ | 1 |
| Iijima, T | 2 |
| Miyachi, T | 1 |
| Asai, K | 1 |
| Tsuiki, H | 1 |
| Mizuno, H | 1 |
| Yamamoto, N | 1 |
| Yokoi, T | 1 |
| Aoyama, M | 1 |
| Togari, H | 1 |
| Wada, Y | 1 |
| Miura, Y | 1 |
| Kato, T | 1 |
| Lu, XR | 1 |
| Ong, WY | 1 |
| Halliwell, B | 1 |
| Hasegawa, K | 1 |
6 other studies available for quinacrine and Nerve Degeneration
| Article | Year |
|---|---|
Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration.
Topics: alpha-Synuclein; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line, Tumo | 2021 |
A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.
Topics: Alanine; Animals; Azepines; Brain; Cathepsin D; Dendrites; Disease Models, Animal; Embryo, Mammalian | 2012 |
Quinacrine-induced degeneration of non-adrenergic, non-cholinergic autonomic nerves in the rat anococcygeus muscle.
Topics: Animals; Autonomic Nervous System; Male; Microscopy, Electron; Muscles; Nerve Degeneration; Quinacri | 1983 |
Interleukin-1beta induces the expression of lipocortin 1 mRNA in cultured rat cortical astrocytes.
Topics: Animals; Annexin A1; Antibodies; Astrocytes; Brain Injuries; Cell Survival; Cells, Cultured; Cerebra | 2001 |
The phospholipase A2 inhibitor quinacrine prevents increased immunoreactivity to cytoplasmic phospholipase A2 (cPLA2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection.
Topics: Acetylcholine; Aldehydes; Animals; Choline O-Acetyltransferase; Cytoplasm; Enzyme Inhibitors; Fornix | 2001 |
Quinacrine-induced dilation of the rat cecum and degeneration of large granular vesicle-containing neurons in the myenteric plexus.
Topics: Animals; Cecum; Cytoplasmic Granules; Lysosomes; Male; Microscopy, Electron; Myenteric Plexus; Nerve | 1985 |