quinacrine has been researched along with Muscle Relaxation in 16 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Eicosatetraynoic acid (50 microM), nordihydroguairetic acid (50 microM) and QUIN (10 microM) do not exert significant inhibitory effects at the level of smooth muscle relaxation mechanisms as isoproterenol-induced relaxation was resistant to inhibition by these agents." | 3.66 | Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism. ( Peach, MJ; Singer, HA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tarumi, T | 1 |
| Shirahase, H | 1 |
| Kanda, M | 1 |
| Nakamura, S | 1 |
| Kurahashi, K | 1 |
| Furchgott, RF | 1 |
| Rapoport, RM | 1 |
| Murad, F | 1 |
| Ignarro, LJ | 1 |
| Burke, TM | 1 |
| Wood, KS | 1 |
| Wolin, MS | 1 |
| Kadowitz, PJ | 1 |
| Singer, HA | 1 |
| Peach, MJ | 1 |
| Satake, N | 1 |
| Shibata, S | 1 |
| Hjoberg, J | 1 |
| Folkerts, G | 1 |
| van Gessel, SB | 1 |
| Högman, M | 1 |
| Hedenstierna, G | 1 |
| Nijkamp, FP | 1 |
| Abdalla, S | 1 |
| al-Khalil, S | 1 |
| Afifi, F | 1 |
| Klaas, M | 1 |
| Wadsworth, R | 1 |
| Diamond, J | 1 |
| Fernandes, LB | 1 |
| Knight, DA | 1 |
| Rigby, PJ | 1 |
| Spina, D | 2 |
| Paterson, JW | 2 |
| Goldie, RG | 2 |
| Bowman, A | 1 |
| Gillespie, JS | 1 |
| Soares-da-Silva, P | 1 |
| Lüscher, TF | 1 |
| Vanhoutte, PM | 2 |
| Bornfeldt, KE | 1 |
| Axelsson, KL | 1 |
| Rubanyi, GM | 1 |
1 review available for quinacrine and Muscle Relaxation
| Article | Year |
|---|---|
The role of endothelium in the responses of vascular smooth muscle to drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Acetylcholine; Adenosine Diphosphate; Adenosine Trip | 1984 |
15 other studies available for quinacrine and Muscle Relaxation
| Article | Year |
|---|---|
Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries.
Topics: Animals; Aspirin; Calcimycin; Calcium; Endothelium, Vascular; Enzyme Inhibitors; Indomethacin; Ionom | 2003 |
Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arachidonic Acids; Calcimycin; Cyclic GMP; Histamine; Male; | 1983 |
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.
Topics: Acetylcholine; Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endotheliu | 1984 |
Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Bacterial Agents; Aorta, Thoracic; Arachidonic Acid; | 1983 |
The potentiating effect of genistein on the relaxation induced by isoproterenol in rat aortic rings.
Topics: Adrenergic beta-Agonists; Animals; Aorta; Benzoflavones; Bucladesine; Colforsin; Dose-Response Relat | 1999 |
Hyperosmolarity-induced relaxation and prostaglandin release in guinea pig trachea in vitro.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Te | 2000 |
Observations on the pharmacology of thalicminine, an oxyaporphine alkaloid from Thalictrum isopyroides.
Topics: Animals; Aorta, Thoracic; Aporphines; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Epinephri | 1991 |
Contraction followed by relaxation in response to hypoxia in the sheep isolated middle cerebral artery.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cerebral Arteries; Endotheliu | 1989 |
Effects of LY83583, nordihydroguaiaretic acid, and quinacrine on cyclic GMP elevation and inhibition of tension by muscarinic agonists in rabbit aorta and left atrium.
Topics: Acetylcholine; Aminoquinolines; Animals; Aorta, Thoracic; Catechols; Cyclic GMP; Epoprostenol; Femal | 1987 |
Beta-adrenoceptor desensitization in guinea-pig isolated trachea.
Topics: Animals; Autoradiography; Carbachol; Female; Fenoterol; Guinea Pigs; Hydrocortisone; In Vitro Techni | 1988 |
A comparison of the action of the endothelium-derived relaxant factor and the inhibitory factor from the bovine retractor penis on rabbit aortic smooth muscle.
Topics: Animals; Carbachol; Catechols; Cattle; Endothelium; Flurbiprofen; Guanylate Cyclase; In Vitro Techni | 1986 |
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Cytochrome P-450 Enzyme System | 1986 |
Beta agonist-induced desensitization in pig bronchus.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Airway Resistance; Animals; Bronchi; Colforsi | 1986 |
Studies on the effect of different inhibitors of arachidonic acid metabolism on glyceryltrinitrate-induced relaxation and cGMP elevation in bovine vascular tissue.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Vessels; Cattle; Cyclic GMP; In Vitro Techniques; Masopro | 1987 |
Nature of endothelium-derived relaxing factor: are there two relaxing mediators?
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Assay; Biological Products; | 1987 |