Page last updated: 2024-10-16

quinacrine and Melanoma

quinacrine has been researched along with Melanoma in 6 studies

Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Malignant melanoma is one of the most aggressive and lethal skin cancer."5.91Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation. ( Ding, C; Ge, X; Jiang, J; Li, S; Li, Y; Qiao, Y; Wang, D; Wang, M; Wang, Y; Zheng, X, 2023)
" A study of spectra recorded from cultured Ehrlich ascites (EL2), and Harding Passey melanoma cells (HPM-67 and HPM-73 line) grown under comparable conditions, shows that free NAD(P)H predominates in HPM-67 and EL2, while this coenzyme is bound in HPM-73."3.66The effect of atebrine and an acridine analog (BCMA) on the coenzyme fluorescence spectra of cultured melanoma and Ehrlich ascites (EL2) cells. ( Kohen, C; Kohen, E; Leising, HB; Marty, A; Salmon, JM; Schachtschabel, DO; Thorell, B; Viallet, P, 1978)
"Malignant melanoma is one of the most aggressive and lethal skin cancer."1.91Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation. ( Ding, C; Ge, X; Jiang, J; Li, S; Li, Y; Qiao, Y; Wang, D; Wang, M; Wang, Y; Zheng, X, 2023)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Li, S1
Wang, D1
Zheng, X1
Li, Y1
Ding, C1
Wang, M1
Ge, X1
Jiang, J1
Qiao, Y1
Wang, Y1
López-Jornet, P1
Pons-Fuster, A1
Biller, H1
Schachtschabel, DO3
Leising, HB2
Pfab, R2
Hess, F1
Viallet, P1
Kohen, E1
Marty, A1
Salmon, JM1
Kohen, C1
Thorell, B1
Kern, HF1
Shaw, MW1

Other Studies

6 other studies available for quinacrine and Melanoma

ArticleYear
Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 163

    Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D1; Glucose; Humans; Melanoma; Niclosamide; Proto-Oncog

2023
Pigmented oral mucosa due to quinacrine.
    The New York state dental journal, 2011, Volume: 77, Issue:6

    Topics: Antimalarials; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Cutaneous; Melanoma; Mi

2011
[Influence of x-rays and quinacrine (atebrine) or chloroquine (resochine)--alone or in combination--on growth and melanin formation of Harding-Passey melanoma cells in monolayer culture].
    Strahlentherapie, 1982, Volume: 158, Issue:7

    Topics: Cell Survival; Cells, Cultured; Chloroquine; Dose-Response Relationship, Radiation; Melanins; Melano

1982
The effect of atebrine and an acridine analog (BCMA) on the coenzyme fluorescence spectra of cultured melanoma and Ehrlich ascites (EL2) cells.
    Histochemistry, 1978, Sep-15, Volume: 57, Issue:3

    Topics: Acridines; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; DNA, Neoplasm; Melanoma; NAD

1978
[Ultrastructural studies of the effect of x-rays and quinacrine (Atebrin) or chloroquine (Resochin)--alone or in combination--on Harding-Passey melanoma cells in monolayer culture].
    Strahlentherapie, 1985, Volume: 161, Issue:11

    Topics: Animals; Chloroquine; Combined Modality Therapy; In Vitro Techniques; Melanoma; Mice; Microscopy, El

1985
Uses of banding techniques for the identification of human diseases of cytogenetic origin.
    Environmental health perspectives, 1973, Volume: 6

    Topics: Burkitt Lymphoma; Chromosome Aberrations; Chromosome Disorders; Genetic Techniques; Humans; Leukemia

1973