quinacrine has been researched along with Malaria in 149 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The seleno-organic compound ebselen showed anti-malarial activity in vitro against the murine Plasmodium berghei and the human P." | 7.67 | Antimalarial properties of ebselen. ( Hüther, AM; Parnham, MJ; Sauer, A; Zhang, Y, 1989) |
| "Oral mepacrine dihydrochloride, 200 mg (158 mg of the base) six-hourly for five doses followed by 100 mg (79 mg of the base) eight-hourly for six days (half dosage for those less than or equal to 50 kg) was given to 21 patients with high-grade chloroquine-resistant falciparum malaria in eastern Thailand." | 7.67 | Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria. ( Chanthavanich, P; Edwards, G; Looareesuwan, S; Phillips, RE; Rodick, CL; Supanaranond, W; Warrell, DA, 1988) |
| "The seleno-organic compound ebselen showed anti-malarial activity in vitro against the murine Plasmodium berghei and the human P." | 3.67 | Antimalarial properties of ebselen. ( Hüther, AM; Parnham, MJ; Sauer, A; Zhang, Y, 1989) |
| " The antimalarial drugs quinacrine, primaquine, and quinine are shown to decrease the rate of oxygen consumption of the parasitized erythrocyte suspensions." | 3.67 | Effects of antimalarial drugs on oxygen consumption by erythrocytes infected with Plasmodium berghei: an ESR study. ( Butler, KW; Deslauriers, R; Smith, IC, 1986) |
| "Oral mepacrine dihydrochloride, 200 mg (158 mg of the base) six-hourly for five doses followed by 100 mg (79 mg of the base) eight-hourly for six days (half dosage for those less than or equal to 50 kg) was given to 21 patients with high-grade chloroquine-resistant falciparum malaria in eastern Thailand." | 3.67 | Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria. ( Chanthavanich, P; Edwards, G; Looareesuwan, S; Phillips, RE; Rodick, CL; Supanaranond, W; Warrell, DA, 1988) |
| " Eleven volunteers received chloroquine in usually curative doses on a three-day schedule during acute clinical malaria attacks." | 3.64 | STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND. ( ALVING, AS; BREWER, GJ; MILLAR, JW; POWELL, RD, 1964) |
| " The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity." | 1.37 | Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011) |
| "Malaria is one of the worst sicknesses to affect humankind." | 1.36 | A brief history of malaria chemotherapy. ( Butler, AR; Ferguson, E; Khan, S, 2010) |
| "Malaria was the major cause of casualties among allied forces in the South West Pacific campaigns during 1942 and 1943, despite the suppressive use of quinine and later atebrin." | 1.29 | The possibility of an "X" factor. The first documented drug resistance of human malaria. ( Sweeney, AW, 1996) |
| "Salinomycin was found to have a greater effect than lasalocid on asexual stages of this line." | 1.27 | The action of salinomycin-Na and lasalocid-Na on chloroquine- and mepacrine-resistant line of Plasmodium berghei K 173-strain in Wistar rats. ( Ganster, HJ; Mehlhorn, H; Raether, W; Seidenath, H, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 135 (90.60) | 18.7374 |
| 1990's | 4 (2.68) | 18.2507 |
| 2000's | 6 (4.03) | 29.6817 |
| 2010's | 4 (2.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muth, CW | 1 |
| Minigh, HL | 1 |
| Chookruvong, S | 1 |
| Hall, LA | 1 |
| Chao, HT | 1 |
| Plouffe, D | 1 |
| Brinker, A | 1 |
| McNamara, C | 1 |
| Henson, K | 1 |
| Kato, N | 2 |
| Kuhen, K | 1 |
| Nagle, A | 2 |
| Adrián, F | 1 |
| Matzen, JT | 1 |
| Anderson, P | 1 |
| Nam, TG | 2 |
| Gray, NS | 1 |
| Chatterjee, A | 2 |
| Janes, J | 1 |
| Yan, SF | 1 |
| Trager, R | 1 |
| Caldwell, JS | 1 |
| Schultz, PG | 2 |
| Zhou, Y | 2 |
| Winzeler, EA | 2 |
| Meister, S | 1 |
| Plouffe, DM | 1 |
| Kuhen, KL | 1 |
| Bonamy, GM | 1 |
| Wu, T | 1 |
| Barnes, SW | 1 |
| Bopp, SE | 1 |
| Borboa, R | 1 |
| Bright, AT | 1 |
| Che, J | 1 |
| Cohen, S | 1 |
| Dharia, NV | 1 |
| Gagaring, K | 1 |
| Gettayacamin, M | 1 |
| Gordon, P | 1 |
| Groessl, T | 1 |
| Lee, MC | 1 |
| McNamara, CW | 1 |
| Fidock, DA | 1 |
| Richmond, W | 1 |
| Roland, J | 1 |
| Rottmann, M | 1 |
| Zhou, B | 1 |
| Froissard, P | 1 |
| Glynne, RJ | 1 |
| Mazier, D | 1 |
| Sattabongkot, J | 1 |
| Tuntland, T | 1 |
| Walker, JR | 1 |
| Diagana, TT | 1 |
| Dodean, RA | 1 |
| Kancharla, P | 1 |
| Li, Y | 1 |
| Melendez, V | 1 |
| Read, L | 1 |
| Bane, CE | 1 |
| Vesely, B | 1 |
| Kreishman-Deitrick, M | 1 |
| Black, C | 1 |
| Li, Q | 1 |
| Sciotti, RJ | 1 |
| Olmeda, R | 1 |
| Luong, TL | 1 |
| Gaona, H | 1 |
| Potter, B | 1 |
| Sousa, J | 1 |
| Marcsisin, S | 1 |
| Caridha, D | 1 |
| Xie, L | 1 |
| Vuong, C | 1 |
| Zeng, Q | 1 |
| Zhang, J | 1 |
| Zhang, P | 1 |
| Lin, H | 1 |
| Butler, K | 1 |
| Roncal, N | 1 |
| Gaynor-Ohnstad, L | 1 |
| Leed, SE | 1 |
| Nolan, C | 1 |
| Huezo, SJ | 1 |
| Rasmussen, SA | 1 |
| Stephens, MT | 1 |
| Tan, JC | 1 |
| Cooper, RA | 1 |
| Smilkstein, MJ | 1 |
| Pou, S | 1 |
| Winter, RW | 1 |
| Riscoe, MK | 1 |
| Kelly, JX | 1 |
| Gomes, A | 1 |
| Pérez, B | 1 |
| Albuquerque, I | 1 |
| Machado, M | 1 |
| Prudêncio, M | 1 |
| Nogueira, F | 1 |
| Teixeira, C | 1 |
| Gomes, P | 1 |
| RAY, AP | 3 |
| NAIR, CP | 2 |
| FOY, H | 1 |
| KONDI, A | 1 |
| MAIER, J | 1 |
| TAGGART, JV | 1 |
| EARLE, DP | 1 |
| ATCHLEY, JA | 1 |
| YOUNT, EH | 1 |
| TRAGER, W | 2 |
| YOUNG, MD | 1 |
| EYLES, DE | 2 |
| ADHIKARI, AK | 1 |
| TOPP, R | 1 |
| REID, J | 1 |
| BASUMULLICK, KL | 1 |
| GUPTA, JC | 1 |
| GERRING, JM | 1 |
| BAKER, BM | 1 |
| PLATT, D | 1 |
| MACHELLA, TE | 1 |
| KIMMELMAN, LJ | 1 |
| LEWIS, RA | 2 |
| WYNNE-GRIFFITH, G | 1 |
| MARSHALL, EK | 1 |
| DEARBORN, EH | 1 |
| LONDON, IM | 1 |
| LAVIETES, PH | 1 |
| CHOWDHURY, MZ | 1 |
| MANUAL, E | 1 |
| DAS, SN | 1 |
| BANG, FB | 5 |
| HAIRSTON, NG | 5 |
| SMITH, PK | 1 |
| GALLUP, BN | 1 |
| CAIN, LJ | 1 |
| SENEVET, G | 1 |
| BABKIN, BP | 1 |
| KARP, D | 1 |
| CHAUDHURI, RN | 1 |
| FAIRLEY, NH | 1 |
| ABBOTT, PH | 1 |
| BROWN, M | 2 |
| RENNIE, JL | 2 |
| MAEGRAITH, BG | 1 |
| TOTTEY, MM | 1 |
| Butler, AR | 1 |
| Khan, S | 1 |
| Ferguson, E | 1 |
| SCHAFFER, AJ | 1 |
| GOLDNER, JL | 1 |
| BERGER, M | 1 |
| GOMEZ MARCANO, A | 1 |
| GINSBERG, JE | 1 |
| SHALLENBERGER, PL | 1 |
| KIERLAND, RR | 1 |
| SHEARD, C | 1 |
| GORDON, HH | 1 |
| CHRISTIANSON, HB | 1 |
| LIPPINCOTT, SW | 1 |
| CUSTER, RP | 1 |
| GLAZOV, VA | 1 |
| DUNCAN, GG | 1 |
| TOOMEY, AG | 1 |
| MERGENER, JC | 1 |
| MOHANTY, JK | 1 |
| ADAMS, AR | 1 |
| SANDERSON, G | 1 |
| MOST, H | 2 |
| HAYMAN, JM | 1 |
| YUDKIN, J | 1 |
| WELCH, WJ | 1 |
| KNOWLTON, P | 1 |
| PFEIFFER, CC | 1 |
| PASTOR BOTIJA, F | 1 |
| OZERETSKOVSKAIA, NN | 1 |
| ZAITSEVA, KA | 1 |
| BASU, PC | 1 |
| MANWELL, RD | 1 |
| ALPERT, S | 1 |
| POWERS, D | 1 |
| FISCHER, O | 1 |
| TYAGI, N | 1 |
| BORODA, C | 1 |
| FRETLAND, A | 1 |
| FERNANDEZ NAFRIA, A | 1 |
| COX, HW | 1 |
| GROUNDS, JG | 1 |
| CONTACOS, PG | 3 |
| LUNN, JS | 2 |
| COATNEY, GR | 2 |
| POWELL, RD | 1 |
| BREWER, GJ | 1 |
| ALVING, AS | 1 |
| MILLAR, JW | 1 |
| SANDOSHAM, AA | 1 |
| MONTGOMERY, R | 1 |
| GUIJA MORALES, E | 1 |
| SOKAL, JE | 1 |
| SIMON, H | 1 |
| BRUCE-CHWATT, LJ | 3 |
| ZSCHUCKE, J | 1 |
| EPSHTEIN, EG | 1 |
| BOLOTINA, AA | 1 |
| RASKIN, AI | 1 |
| KUDRIASHEVA, TG | 1 |
| HANDFIELD-JONES, RP | 1 |
| Houston, DJ | 1 |
| Tuck, JJ | 1 |
| COOPER, WC | 2 |
| RUHE, DS | 1 |
| MACKERRAS, MJ | 2 |
| ERCOLE, QN | 2 |
| COATNEY, HR | 1 |
| IKONEN, E | 1 |
| WINCKEL, CW | 1 |
| Sheehy, TW | 1 |
| Reba, RC | 1 |
| Doberstyn, EB | 1 |
| Haworth, J | 1 |
| Lewin, PK | 1 |
| Sweeney, AW | 2 |
| Fenner, F | 1 |
| Weina, PJ | 1 |
| Wallace, DJ | 1 |
| Hays, CW | 1 |
| Eckart, WU | 1 |
| Vondra, H | 1 |
| Chauhan, PM | 1 |
| Srivastava, SK | 1 |
| Mahajan, RC | 1 |
| Chitkara, NL | 1 |
| Ganguly, NK | 1 |
| Sharma, SK | 1 |
| Fossati, C | 1 |
| Condon-Rall, ME | 1 |
| Hüther, AM | 1 |
| Zhang, Y | 1 |
| Sauer, A | 1 |
| Parnham, MJ | 1 |
| Butler, KW | 1 |
| Deslauriers, R | 1 |
| Smith, IC | 1 |
| Looareesuwan, S | 1 |
| Phillips, RE | 1 |
| Edwards, G | 1 |
| Rodick, CL | 1 |
| Chanthavanich, P | 1 |
| Supanaranond, W | 1 |
| Warrell, DA | 1 |
| Newman, MS | 1 |
| Raether, W | 1 |
| Seidenath, H | 1 |
| Mehlhorn, H | 1 |
| Ganster, HJ | 1 |
| Harinasuta, T | 1 |
| Suntharasamai, P | 1 |
| Viravan, C | 1 |
| Levy, MR | 1 |
| Chou, SC | 1 |
| Peters, W | 7 |
| Shute, PG | 1 |
| Maryon, M | 1 |
| Olatunde, IA | 1 |
| Gregory, KG | 3 |
| Glew, RH | 1 |
| Briesch, PE | 1 |
| Krotoski, WA | 1 |
| Neva, FA | 1 |
| Botha, D | 1 |
| Terzian, LA | 1 |
| Stahler, N | 1 |
| Dawkins, AT | 1 |
| Modell, W | 1 |
| Hunsicker, LG | 1 |
| Schmidt, LH | 1 |
| Hall, SA | 1 |
| Ford, E | 1 |
| Pinder, RM | 1 |
| Myint, UH | 1 |
| Win, UK | 1 |
| Barnes, MG | 1 |
| Polet, H | 2 |
| Barr, CF | 1 |
| Van Dyke, K | 2 |
| Szustkiewicz, C | 3 |
| Fink, E | 1 |
| Kretschmar, W | 1 |
| Criswell, BS | 1 |
| Butler, WT | 1 |
| Rossen, RD | 1 |
| Knight, V | 1 |
| Chin, W | 1 |
| Klein, P | 1 |
| Van DYDE, K | 1 |
| Lantz, C | 2 |
| Bengtsson, E | 1 |
| Chien, PL | 1 |
| Cheng, CC | 1 |
| Rockwell, DA | 1 |
| von Ardenne, M | 1 |
| Reitnauer, PG | 1 |
| Schneider, MD | 1 |
| Mason, RJ | 1 |
| Warren, J | 1 |
| Bucy, ML | 1 |
| Owens, RE | 1 |
| Ott, KJ | 1 |
| Elslager, EF | 1 |
| Tendick, FH | 1 |
| Werbel, LM | 1 |
| Macomber, PB | 1 |
| O'Brien, RL | 1 |
| Hahn, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Novel Therapeutics For Prion Diseases: A Randomized, Double-blinded, Placebo-controlled Study of the Efficacy of Quinacrine in the Treatment of Sporadic Creutzfeldt-Jakob Disease[NCT00183092] | Phase 2 | 69 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Verbal fluency tests are a kind of psychological test in which participants have to say as many words as possible from a category in 60 seconds. This category (words beginning with letter D) is phonemic. Higher scores indicate better cognition." (NCT00183092)
Timeframe: Baseline, 2 months
| Intervention | number of words generated (Mean) |
|---|---|
| Placebo | -2.4 |
| Quinacrine | -2.2 |
ADAS-cog measures cognitive performance by combining ratings of 11 components (word recall, word recognition, constructional praxis, orientation, naming objects and fingers, commands, ideational praxis, remembering instruction, spoken language, word finding, comprehension) representing six areas of cognition: memory; language; orientation to time, place and person; construction of simple designs and planning; and performing simple behaviors in pursuit of a basic, predefined goal. Seven components are scored as the 'number incorrect'. For example, in the commands component, the number of five commands performed incorrectly (range: 0-5). Four components are scored from 0 (no limitations) to 5 (max limitations) as the examiner's perception of remembering instructions, spoken language ability, word finding and comprehension. Component scores are summed into a total ADAS-cog score ranging from 0-75, with low scores indicating better cognitive performance. (NCT00183092)
Timeframe: Baseline, 2 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 13.0 |
| Quinacrine | 12.6 |
An ordinal scale used to measure performance in activities of daily living. Scores range from 0 (worst, fully dependent) to 100 (best, independent); higher score associated with a greater likelihood of being able to live at home with a degree of independence following discharge from hospital. 10 individual items are scored and summed to derive the overall Barthel index score. Each item may be scored 0, 5, 10 or 15; not all items use the full range of 4 possible values. The amount of time and physical assistance required to perform each item are considered in scoring each item. For subjects unable to return for month-2 visit, Barthel Index was performed via telephone. (NCT00183092)
Timeframe: baseline, 2 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -23.2 |
| Quinacrine | -13.2 |
Clinical Dementia Rating Scale Sum of Boxes (CDRS-SB). The CDR is obtained through semistructured interviews of patients and informants, and cognitive functioning is rated in 6 domains of functioning: memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Each domain is rated on a 5-point scale of functioning: 0, no impairment; 0.5, questionable impairment; 1, mild impairment; 2, moderate impairment; and 3, severe impairment (personal care is scored on a 4-point scale without a 0.5 rating available). The global CDR score is computed via an algorithm. The CDR-SB score is obtained by summing each of the domain box scores, with scores ranging from 0 to 18. A higher value and/or positive change is worse. For subjects unable to return for month-2 visit, CDRS-SB was performed via telephone. (NCT00183092)
Timeframe: Baseline, 2 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 3.2 |
| Quinacrine | 0.3 |
The mini-mental state examination (MMSE) is a brief 30-point questionnaire that is used to screen for cognitive impairment. In about 10 minutes it samples functions including arithmetic, memory and orientation. A score greater than or equal to 25 points (out of 30) indicates a normal cognition. Lower scores can indicate severe (≤9 points), moderate (10-18 points) or mild (19-24 points) cognitive impairment. Low to very low scores correlate closely with the presence of dementia, although other mental disorders can also lead to abnormal findings on MMSE testing. (NCT00183092)
Timeframe: Baseline to Month-2
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -6.9 |
| Quinacrine | -3.9 |
"The scale runs from 0-6, running from perfect health without symptoms to death. 0 - No symptoms.~- No significant disability. Able to carry out all usual activities, despite some symptoms.~- Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.~- Moderate disability. Requires some help, but able to walk unassisted.~- Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.~- Severe disability. Requires constant nursing care and attention, bedridden, incontinent.~- Dead. For subjects unable to return for the 2-month visit, Rankin score was assessed via telephone." (NCT00183092)
Timeframe: Baseline, 2 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 0.8 |
| Quinacrine | 0.3 |
Verbal fluency tests are a kind of psychological test in which participants have to say as many words as possible from a category in 60 seconds. This category (naming animals) is semantic. Higher scores indicate better cognition. (NCT00183092)
Timeframe: Baseline, 2 months
| Intervention | number of words generated (Mean) |
|---|---|
| Placebo | -3.2 |
| Quinacrine | -2.2 |
Participants alive after 2 months on study treatment (NCT00183092)
Timeframe: Randomization to Month-2
| Intervention | participants (Number) |
|---|---|
| Placebo | 19 |
| Quinacrine | 13 |
11 reviews available for quinacrine and Malaria
| Article | Year |
|---|---|
Resistance of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia; Chloroquine; DNA; Drug Resistance; Drug Synergism; Hemin; Mala | 1984 |
Present trends and future strategy in chemotherapy of malaria.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; DNA Topoisomerases; Humans; Malaria; Plasmodium falci | 2001 |
[Treatment of intestinal parasitosis].
Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas | 1975 |
Recent advances in antimalarial chemotherapy and drug resistance.
Topics: Agglutination; Amodiaquine; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Cross Reacti | 1974 |
Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2.
Topics: Amebiasis; Amebicides; Anthelmintics; Antimalarials; Antimony; Benzenesulfonates; Chloroquine; Clono | 1972 |
The present status of chloroquine in the drug treatment of malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Primaquine; Proguanil; Pyrimet | 1972 |
Summary of recent abstracts. 3. Malaria. 2.
Topics: Animals; Antimalarials; Birds; Chloroquine; Dapsone; Humans; India; Malaria; Malaria, Avian; Mammals | 1972 |
The pharmacology of the antimalarials. A rational approach to the therapy of resistant falciparum malaria.
Topics: Amodiaquine; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Dapsone; Drug Resistance, Mi | 1969 |
Chemotherapy of the drug-resistant malarias.
Topics: Chloroquine; Cinchona; Drug Resistance, Microbial; Malaria; Mutation; Phytotherapy; Plants, Medicina | 1969 |
Malaria treatment and prevention. A review.
Topics: Adolescent; Adult; Africa, Eastern; Antimalarials; Biguanides; Child; Child, Preschool; Chloroquine; | 1969 |
Recent advances in the chemotherapy of malaria.
Topics: Acridines; Animals; Anti-Bacterial Agents; Antimalarials; Antineoplastic Agents; Cinchona; Culture M | 1971 |
138 other studies available for quinacrine and Malaria
| Article | Year |
|---|---|
Syntheses of 9-acridine- and 2-phenanthridinemethanols as potential antimalarials.
Topics: Acridines; Animals; Antimalarials; Drug Evaluation, Preclinical; Malaria; Mice; Phenanthridines; Pla | 1981 |
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug | 2008 |
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista | 2011 |
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Mal | 2019 |
N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.
Topics: Antimalarials; Cell Line; Chloroquine; Drug Design; Drug Resistance; Humans; Malaria; Plasmodium ber | 2014 |
Suppressive action of mepacrine, aphacrine, chloroquin, camoquin and proguanil against P. knowlesi in S. rhesus monkeys.
Topics: Amodiaquine; Animals; Chloroquine; Humans; Macaca mulatta; Malaria; Proguanil; Quinacrine | 1950 |
The correlation between blackwater fever, malaria, quinine and atebrin.
Topics: Blackwater Fever; Humans; Malaria; Quinacrine; Quinine | 1950 |
Quinacrine levels in plasma of persons with infectious jaundice during and after suppressive malaria therapy.
Topics: Humans; Jaundice; Leptospirosis; Malaria; Plasma; Quinacrine | 1948 |
Studies on the chemotherapy of the human malarias; the antimalarial activity of quinacrine.
Topics: Antimalarials; Humans; Malaria; Quinacrine | 1948 |
Reactions observed during treatment with pentaquine, administered with quinacrine (atabrine) metachloridine (SN-11,437) and with sulfadiazine.
Topics: Aminoquinolines; Malaria; Quinacrine; Sulfadiazine; Sulfonamides | 1948 |
The rate of asymptomatic malarial infection in white and Negro service troops taking suppressive atabrine.
Topics: Asymptomatic Infections; Biometry; Black People; Humans; Malaria; Quinacrine | 1947 |
The efficacy of chloroquine, quinacrine, quinine and totaquine in the treatment of Plasmodium malariae infections (quartan malaria).
Topics: Chloroquine; Humans; Malaria; Plasmodium malariae; Quinacrine; Quinine | 1948 |
Suppressive mepacrine treatment to the staff of B. A. Railway in 1945.
Topics: Humans; Malaria; Quinacrine | 1947 |
An observation on the effects of atebrin on malaria parasites (Plasmodium vivax).
Topics: Humans; Malaria; Quinacrine | 1946 |
Mepacrine and falciparum malaria.
Topics: Humans; Malaria; Malaria, Falciparum; Quinacrine | 1947 |
Parenteral quinacrine in malarial fevers.
Topics: Fever; Humans; Malaria; Quinacrine | 1947 |
Cerebral malaria treated with penicillin and mepacrine.
Topics: Humans; Malaria; Malaria, Cerebral; Penicillins; Quinacrine | 1947 |
Vivax relapse rates following continued atabrine suppressive medication; observations on malaria in an infantry regiment.
Topics: Chronic Disease; Humans; Malaria; Malaria, Vivax; Quinacrine; Recurrence | 1947 |
The intravenous administration of atabrine in falciparum malaria.
Topics: Humans; Infusions, Intravenous; Malaria; Malaria, Falciparum; Quinacrine | 1947 |
Suppression of malaria by mepacrine.
Topics: Humans; Malaria; Quinacrine | 1947 |
The relation of the plasma concentration of quinacrine to its antimalarial activity.
Topics: Antimalarials; Blood; Malaria; Quinacrine | 1946 |
The effects of quinacrine (atabrine) suppression on the course of Pacific vivax malaria.
Topics: Malaria; Malaria, Vivax; Quinacrine | 1946 |
Mepacrine and the relapse-rate of malaria.
Topics: Chronic Disease; Malaria; Quinacrine; Recurrence | 1946 |
Mepacrine in the treatment of malaria, resulting in temporary insanity and producing other toxic symptoms (with case notes).
Topics: Humans; Malaria; Mental Disorders; Psychotic Disorders; Quinacrine | 1946 |
Insanity following metoquine medication.
Topics: Humans; Malaria; Mental Disorders; Psychotic Disorders; Quinacrine | 1946 |
Treatment of acute attacks of vivax and falciparum malaria; a comparison of atabrine and quinine.
Topics: Animals; Behavior, Animal; Humans; Malaria; Malaria, Falciparum; Quinacrine; Quinine; Social Behavio | 1947 |
Blood plasma atabrine levels obtained with suppressive and therapeutic doses of atabrine dihydrochloride.
Topics: Blood; Malaria; Plasma; Quinacrine | 1946 |
Studies on atabrine suppression of malaria; an evaluation of atabrine suppression in the field.
Topics: Coloring Agents; Malaria; Quinacrine | 1946 |
Comparative action of prophylactic quinacrine on Plasmodium falciparum and Plasmodium vivax.
Topics: Humans; Malaria; Quinacrine | 1946 |
Effect of quinine and atabrine on gastric secretion; a preliminary communication.
Topics: Communication; Digestion; Gastric Juice; Gastric Mucosa; Malaria; Quinacrine; Quinine | 1947 |
Mepacrine in malaria.
Topics: Malaria; Quinacrine | 1946 |
Studies on atabrine (quinacrine) suppression of malaria; the epidemiological significance of atabrine suppression.
Topics: Malaria; Quinacrine | 1947 |
Atebrin susceptibility of the Aitaipe-Wewak strains of P. falciparum and P. vivax; a field and experimental investigation by L. H. Q. Medical Research Unit, Cairns.
Topics: Biomedical Research; Filariasis; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Quinacrine | 1946 |
A case of blackwater fever during mepacrine therapy.
Topics: Blackwater Fever; Humans; Malaria; Quinacrine | 1946 |
Mepacrine metabolism in recurring benign tertian malaria.
Topics: Malaria; Malaria, Vivax; Quinacrine; Recurrence | 1946 |
The absorption and excretion of paludrine in the human subject.
Topics: Guanidines; Malaria; Proguanil; Quinacrine | 1946 |
A brief history of malaria chemotherapy.
Topics: Antimalarials; Artemisinins; History, 17th Century; History, 18th Century; History, 19th Century; Hi | 2010 |
Atabrine studies in the field; the relation of serum atabrine level to breakthrough of previously contracted vivax malaria.
Topics: Blood; Coloring Agents; Malaria; Malaria, Vivax; Quinacrine | 1946 |
An experience with atabrine aboard a troop transport.
Topics: Biological Transport; Malaria; Quinacrine | 1946 |
Quinacrine: its general pharmacology and its therapeutic application in malaria.
Topics: Malaria; Quinacrine | 1945 |
Wood's light fluorescence phenomenon in quinacrine medication.
Topics: Fluorescence; Household Articles; Humans; Malaria; Quinacrine | 1946 |
Fluorescence of nails from quinacrine hydrochloride.
Topics: Fluorescence; Malaria; Nails; Quinacrine | 1946 |
A comparison of quinine and quinacrine in the treatment of the clinical attacks of vivax malaria.
Topics: Humans; Malaria; Malaria, Vivax; Quinacrine; Quinine | 1946 |
PLASMA quinacrine concentration as a function of dosage and environment.
Topics: Blood; Environment; Malaria; Quinacrine | 1946 |
Aplastic anemia in soldiers treated with atabrine (quinacrine).
Topics: Anemia, Aplastic; Malaria; Military Personnel; Quinacrine | 1946 |
Suppression of benign tertian malaria with mepacrine; an investigation of 247 cases of apparent failure.
Topics: Malaria; Malaria, Vivax; Quinacrine | 1946 |
[Mental disorders induced by acrichine intoxication].
Topics: Humans; Malaria; Mental Disorders; Quinacrine | 1945 |
Studies on atabrine (quinacrine) suppression of malaria.
Topics: Malaria; Quinacrine | 1946 |
Quinacrine hydrochloride (atabrine) as a malaria suppressive agent.
Topics: Malaria; Quinacrine | 1945 |
Relation of plasma level of atabrine to morphology and motility of Plasmodium vivax.
Topics: Cell Movement; Malaria; Musculoskeletal Physiological Phenomena; Plasma; Plasmodium vivax; Quinacrin | 1945 |
Apparent lack of response to quinine and mepacrine in cases of subtertian malaria.
Topics: Malaria; Quinacrine; Quinine | 1945 |
Psychosis following administration of quinacrine hydrochloride for malaria; neuropsychiatric study of a case.
Topics: Malaria; Military Medicine; Neuropsychiatry; Psychiatry; Psychotic Disorders; Quinacrine | 1945 |
Atebrine brand of amyl-acridine derivative in human malaria.
Topics: Acridines; Malaria; Quinacrine | 1945 |
Studies on synthetic antimalarial drugs; a comparison of the therapeutic actions of 3349 and of mepacrine hydrochloride on acute attacks of benign tertian malaria.
Topics: Antimalarials; Malaria; Malaria, Vivax; Quinacrine | 1945 |
Relative efficiency of quinacrine (atabrine) and quinine in treatment of acute attacks of vivax malaria.
Topics: Malaria; Malaria, Vivax; Quinacrine; Quinine | 1946 |
Urinary mepacrine in relation to incidence and diagnosis of malaria.
Topics: Incidence; Malaria; Quinacrine; Urinary Tract; Urine | 1946 |
The incidence of convulsions in general paretics receiving quinacrine.
Topics: Incidence; Malaria; Neurosyphilis; Paralysis; Quinacrine; Seizures; Therapeutics | 1946 |
Modern antimalarial therapy.
Topics: Antimalarials; Malaria; Proguanil; Quinacrine; Quinolines; Uricosuric Agents | 1952 |
[Case of malaria due to Plasmodium falciparum resistant to quinacrine and to quinine and treated with nivaquine].
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Quinacrine; Quinine | 1952 |
[Results of therapy of quartan malaria with associated acrichine, bigumal, and plasmocid in polyclinics].
Topics: Aminoquinolines; Malaria; Proguanil; Quinacrine | 1953 |
Screening of antimalarials against P. gallinaceum in chicks.
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chickens; Chloroquine; Malaria; Proguanil; Qui | 1952 |
Experimental chemotherapy of Plasmodium hexamerium infections.
Topics: Malaria; Plasmodium; Quinacrine | 1953 |
[Atabrine fever].
Topics: Fever; Malaria; Quinacrine | 1955 |
Chemotherapy in malaria.
Topics: Humans; Malaria; Proguanil; Quinacrine; Quinine | 1955 |
Treatment on malaria with single doses of mepacrine, chloroquine and amodiaquin.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine | 1955 |
Studies on Nuri Strain of P. knowlesi. IX. Susceptibility to sulphonamide substituted dihydrotriazine, sulphadiazine and mepacrine.
Topics: Antimalarials; Malaria; Quinacrine; Sulfadiazine; Sulfanilamide; Sulfanilamides; Sulfonamides | 1955 |
[Problems concerning malaria; some cases of agranulocytosis following atabrine treatment].
Topics: Agranulocytosis; Humans; Malaria; Quinacrine | 1958 |
[Experimental malaria: Plasmodium berghei].
Topics: Chloroquine; Malaria; Plasmodium berghei; Quinacrine; Quinine | 1958 |
The roles of time and atabrine in inducing chronic Plasmodium berghei infections of white mice.
Topics: Animals; Malaria; Mice; Plasmodium berghei; Quinacrine | 1958 |
Single dose treatment of malaria with amodiaquin chloroquine and mepacrine in a semi-immune poplation.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine | 1960 |
DRUG-RESISTANT FALCIPARUM MALARIA FROM CAMBODIA AND MALAYA.
Topics: Animals; Cambodia; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Mala | 1963 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND.
Topics: Amodiaquine; Antimalarials; Asia, Southeastern; Biomedical Research; Chloroquine; Drug Resistance; D | 1964 |
DRUG-RESISTANCE IN FALCIPARUM MALARIA IN SOUTH-EAST ASIA.
Topics: Adolescent; Asia, Southeastern; Child; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Dru | 1964 |
[Atebrin psychosis].
Topics: Humans; Malaria; Mental Disorders; Psychoses, Substance-Induced; Psychotic Disorders; Quinacrine | 1955 |
Treatment of intolerance to quinacrine.
Topics: Humans; Malaria; Quinacrine | 1950 |
Epileptic fit after oral administration of atabrine (in Hebrew; English summary).
Topics: Administration, Oral; Epilepsy; Language; Malaria; Quinacrine; Seizures | 1950 |
Evaluation of synthetic anti-malarial drugs in children from a hyperendemic area in West Africa.
Topics: Africa, Western; Antimalarials; Child; Chloroquine; Humans; Malaria; Quinacrine | 1951 |
[On the virulence of malaria in Greece, and the efficacy of various forms of atabrine therapy].
Topics: Greece; Humans; Malaria; Quinacrine; Virulence | 1951 |
[Vernal anti-recurrent treatment of tertian malaria with acrichine].
Topics: Humans; Malaria; Quinacrine; Seasons | 1951 |
Chloroquine, proguanil, mepacrine and quinine in the treatment of malaria caused by Plasmodium falciparum.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Proguanil; Quinacrine; Quinine | 1949 |
Malaria on a military peacekeeping operation: a case study with no cases.
Topics: Antimalarials; Chemoprevention; Communicable Disease Control; Health Education; Humans; Malaria; Mil | 2005 |
Studies in human malaria; the protective and therapeutic action of quinacrine against St. Elizabeth strain vivax malaria.
Topics: Acridines; Coloring Agents; Malaria; Malaria, Vivax; Quinacrine; Sprains and Strains | 1949 |
Observations on the action of quinine, atebrin and plasmoquine on the gametocytes of Plasmodium falciparum.
Topics: Humans; Malaria; Plasmodium falciparum; Quinacrine; Quinine | 1949 |
Some observations on the action of quinine, atebrin, and plasmoquine on Plasmodium vivax.
Topics: Humans; Malaria; Plasmodium; Plasmodium vivax; Quinacrine; Quinine | 1949 |
Studies in human malaria; trials of quinacrine, colchicine (SN 12,080) and quinine against Chesson strain vivax malaria.
Topics: Acridines; Colchicine; Coloring Agents; Humans; Malaria; Malaria, Vivax; Quinacrine; Quinine; Sprain | 1949 |
On the occurrence of relapses in cases of malaria tertia treated with quinine and atebrin.
Topics: Malaria; Quinacrine; Quinine | 1949 |
The efficacy of quinacrine and quinine in the treatment of Plasmodium malariae infections.
Topics: Humans; Malaria; Plasmodium malariae; Quinacrine; Quinine | 1949 |
Treatment of chloroquine-resistant Plasmodium falciparum infections in Vietnam.
Topics: Chloroquine; Dapsone; Humans; Malaria; Military Medicine; Pyrimethamine; Quinacrine; Quinine; Sulfad | 1967 |
Drug prevention of malaria.
Topics: Antimalarials; Drug Resistance, Microbial; Female; Humans; Malaria; Pregnancy; Quinacrine | 1981 |
Quinacrine skin discoloration is associated with fluorescence of "Y" chromosome in male cells and malarial parasites in malaria.
Topics: Adult; Fluorescence; Humans; Malaria; Male; Quinacrine; Sex Chromosomes; Skin Pigmentation; Y Chromo | 1982 |
The possibility of an "X" factor. The first documented drug resistance of human malaria.
Topics: Antimalarials; Australia; Disease Outbreaks; Drug Resistance; History, 20th Century; Humans; Malaria | 1996 |
Malaria in New Guinea during the Second World War: the Land Headquarters Medical Research Unit.
Topics: Animals; Anopheles; Antimalarials; History, 20th Century; Humans; Malaria; Malaria, Falciparum; Mala | 1998 |
From atabrine in World War II to mefloquine in Somalia: the role of education in preventive medicine.
Topics: Antimalarials; Europe; History, 20th Century; Humans; Malaria; Mefloquine; Military Medicine; Preven | 1998 |
Is there a role for quinacrine (Atabrine) in the new millennium?
Topics: Antimalarials; Clinical Trials as Topic; Humans; Lupus Erythematosus, Systemic; Malaria; Quinacrine | 2000 |
The United States Army and malaria control in World War II.
Topics: Animals; Antimalarials; DDT; History, 20th Century; Humans; Insecticides; Malaria; Military Medicine | 2000 |
Malaria and World War II: German malaria experiments 1939-45.
Topics: Animals; Antimalarials; Concentration Camps; DDT; Germany; History, 20th Century; Hospitals, Psychia | 2000 |
Quinacrine fluorescence for rapid dection of malarial parasite a preliminary communication.
Topics: Fluorescence; Humans; Malaria; Plasmodium; Quinacrine; Staining and Labeling | 1975 |
Allied cooperation in malaria prevention and control: the World War II Southwest Pacific experience.
Topics: Australia; History, 20th Century; Malaria; Military Medicine; Pacific Islands; Quinacrine; United St | 1991 |
Antimalarial properties of ebselen.
Topics: Animals; Antimalarials; Antioxidants; Azoles; Cell Line; Humans; Isoindoles; Macrophages; Malaria; M | 1989 |
Effects of antimalarial drugs on oxygen consumption by erythrocytes infected with Plasmodium berghei: an ESR study.
Topics: Animals; Antimalarials; Depression, Chemical; Electron Spin Resonance Spectroscopy; Erythrocytes; Ma | 1986 |
Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Middle Aged | 1988 |
Concerning steric effects in antimalarial agents.
Topics: Acridines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Drug Tolerance; Female; Magnetic R | 1987 |
The action of salinomycin-Na and lasalocid-Na on chloroquine- and mepacrine-resistant line of Plasmodium berghei K 173-strain in Wistar rats.
Topics: Animals; Anti-Bacterial Agents; Cell Membrane; Chloroquine; Cytoplasm; Drug Resistance, Microbial; L | 1985 |
Postoperative malaria.
Topics: Humans; Malaria; Male; Plasmodium; Postoperative Complications; Quinacrine | 1972 |
Chloroquine-resistant falciparum malaria in Thailand.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malari | 1965 |
Activity and some properties of an acid proteinase from normal and Plasmodium berghei-infected red cells.
Topics: Acid Phosphatase; Animals; Cell-Free System; Chloroquine; Dithiothreitol; Edetic Acid; Erythrocytes; | 1973 |
Some observations on true latency and long-term relapses in P. vivax malaria.
Topics: Antimalarials; Culicidae; Humans; Insect Vectors; Malaria; Plasmodium vivax; Quinacrine; Quinine; Ti | 1968 |
The chemotherapy of rodent malaria. XVI. Primary resistance to mepacrine in the N67 strain of Plasmodium berghei-type parasite.
Topics: Animals; Anopheles; Blood; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium berghei; Quin | 1973 |
Multidrug-resistant strain of Plasmodium falciparum from eastern Colombia.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Colombia; Drug Combinations; Drug Resistance, Microbi | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falcipa | 1974 |
The sporogonous of Plasmodium vivax in Anopheles mosquitoes as a system for evaluating the prophylactic and curative capabilities of potential antimalarial compounds.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Naphthoquinones; Oxytetracycline; Penicilli | 1968 |
Malaria and victory in Vietnam. The first battle against drug-resistant malignant malaria is described.
Topics: Anopheles; Antimalarials; Chloroquine; Folic Acid Antagonists; Folic Acid Deficiency; History, 16th | 1968 |
Neil Hamilton Fairley (1891-1966).
Topics: Australia; History, 20th Century; Humans; Malaria; Military Medicine; Quinacrine; Tropical Medicine; | 1969 |
The routine treatment of malaria.
Topics: Acute Disease; Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Chronic Disease | 1971 |
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria; | 1969 |
Uptake of chloroquine-3-H3 by plasmodium knowlesi in vitro.
Topics: Albumins; Animals; Chloroquine; Cyanates; Dinitrophenols; Erythrocytes; Fluorides; Glucose; Haplorhi | 1969 |
Apparent new modes of antimalarial action detected by inhibited incorporation of adenosine-8-3H into nucleic acids of Plasmodium berghei.
Topics: Antimalarials; Culture Techniques; Imipramine; Malaria; Microbial Sensitivity Tests; Nucleic Acids; | 1969 |
[Chemotherapeutic activity of standard antimalarials in a simplified test for Plasmodium vinckey infection in the NMPI mouse].
Topics: Animals; Antimalarials; Chloroquine; Long-Term Care; Malaria; Mice; Plasmodium; Primaquine; Pyrimeth | 1970 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaqui | 1972 |
Murine malaria: the role of humoral factors and macrophages in destruction of parasitized erythrocytes.
Topics: Animals; Chronic Disease; Endotoxins; Erythrocytes; Immunity; Immunity, Cellular; Iodine Isotopes; M | 1971 |
Resistance to cycloguanil pamoate (CI-501) by falciparum malaria in West Pakistan.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Malaria; Male; Pakistan; | 1965 |
[On the ideological history of the early period of chemotherapy].
Topics: Animals; Arsphenamine; Birds; Drug Therapy; History, 20th Century; Humans; Malaria; Malaria, Avian; | 1966 |
Quinacrine: mechanisms of antimalarial action.
Topics: Adenosine Triphosphate; Animals; Depression, Chemical; DNA; Erythrocytes; Malaria; Nucleosides; Plas | 1970 |
Quinacrine: mechanisms of antimalarial action.
Topics: Adenosine Triphosphate; Animals; Depression, Chemical; DNA; Erythrocytes; Malaria; Nucleosides; Plas | 1970 |
Rapid production of mepacrine resistance in rodent malaria.
Topics: Animals; Drug Resistance, Microbial; Malaria; Male; Mice; Quinacrine | 1970 |
The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Malaria; Male; Mice; Plasmodium; Primaquine; Proguanil | 1970 |
[Tropical diseases treated at Roslagstulls Hospital].
Topics: Adolescent; Adult; Aged; Amebiasis; Anti-Bacterial Agents; Antimony; Child; Chloroquine; Diethylcarb | 1967 |
Synthesis and antimalarial evaluation of some 1,7-nephthyridines and 2,9-diazaanthracenes.
Topics: Animals; Benzene Derivatives; Chloroquine; Malaria; Methods; Mice; Naphthyridines; Quinacrine | 1968 |
Psychiatric complications with chloroquine and quinacrine.
Topics: Anti-Inflammatory Agents; Chloroquine; Humans; Malaria; Malingering; Psychoses, Substance-Induced; Q | 1968 |
[Thermosensitization of mouse Ehrlich ascites tumor cells using atebrin].
Topics: Adaptation, Physiological; Animals; Carcinoma, Ehrlich Tumor; Hot Temperature; Humans; Malaria; Mice | 1968 |
Characteristics and cross-resistance patterns of chloroquine-resistant Plasmodium berghei infections in mice.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Female; Hemat | 1968 |
Reduction of tetrazolium salts by malarial parasites.
Topics: Animals; Colorimetry; Cricetinae; Culture Media; Histocytochemistry; In Vitro Techniques; Malaria; M | 1968 |
The Plasmodium chabaudi-mouse system in chemotherapy studies.
Topics: Animals; Antimalarials; Chloroquine; Injections, Intravenous; Malaria; Male; Mice; Plasmodium; Prima | 1969 |
Repository drugs. 8. Ester and amide congeners of amodiaquine, hydroxychloroquine, oxychloroquine, primaquine, quinacrine, and related substances as potential long-acting antimalarial agents.
Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Delayed-Action Preparations; Est | 1969 |
Partial inhibition by mepacrine of the development of sulphonamide resistance in Plasmodium berghei.
Topics: Animals; Drug Resistance, Microbial; Malaria; Mice; Plasmodium; Quinacrine; Sulfadiazine; Sulfaphena | 1969 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrime | 1965 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. 3. Multiple drug resistance.
Topics: Animals; Antimalarials; Dapsone; In Vitro Techniques; Malaria; Mice; Plasmodium; Quinacrine; Sulfadi | 1965 |
Chloroquine: physiological basis of drug resistance in Plasmodium berghei.
Topics: Animals; Carbon Isotopes; Chloroquine; Drug Resistance, Microbial; Erythrocytes; In Vitro Techniques | 1966 |