quinacrine has been researched along with Lung Neoplasms in 18 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine has been used for therapeutic drugs in some clinical settings." | 5.46 | Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand. ( Harada, M; Hiramatsu, R; Kataoka, T; Kondo, T; Matsuda, I; Morimoto, K; Muko, R; Okina, Y, 2017) |
| "Quinacrine has been used for therapeutic drugs in some clinical settings." | 1.46 | Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand. ( Harada, M; Hiramatsu, R; Kataoka, T; Kondo, T; Matsuda, I; Morimoto, K; Muko, R; Okina, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Vaidya, B | 2 |
| Kulkarni, NS | 2 |
| Shukla, SK | 1 |
| Parvathaneni, V | 1 |
| Chauhan, G | 1 |
| Damon, JK | 1 |
| Sarode, A | 1 |
| Garcia, JV | 1 |
| Kunda, N | 1 |
| Mitragotri, S | 1 |
| Gupta, V | 2 |
| Bhateja, P | 1 |
| Dowlati, A | 2 |
| Sharma, N | 2 |
| Harada, M | 1 |
| Morimoto, K | 1 |
| Kondo, T | 1 |
| Hiramatsu, R | 1 |
| Okina, Y | 1 |
| Muko, R | 1 |
| Matsuda, I | 1 |
| Kataoka, T | 1 |
| Dermawan, JK | 1 |
| Gurova, K | 1 |
| Pink, J | 1 |
| De, S | 1 |
| Narla, G | 1 |
| Stark, GR | 1 |
| Li, XT | 1 |
| Zhou, ZY | 1 |
| Jiang, Y | 1 |
| He, ML | 1 |
| Jia, LQ | 1 |
| Zhao, L | 1 |
| Cheng, L | 1 |
| Jia, TZ | 1 |
| de Leval, L | 1 |
| Defraigne, JO | 1 |
| Hermans, G | 1 |
| Dôme, F | 1 |
| Boniver, J | 1 |
| Herens, C | 1 |
| BRILMAYER, C | 1 |
| KUGEL, E | 1 |
| MACK, A | 1 |
| ACKERMAN, NB | 3 |
| SHEMESH, A | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| WAGNER, DE | 1 |
| SILVA, AR | 1 |
| WOLF, J | 1 |
| HALDORSEN, DK | 1 |
| WALLACE, DL | 1 |
| MADSEN, AJ | 1 |
| MCFEE, AS | 1 |
| Furukawa, F | 1 |
| Nishikawa, A | 1 |
| Imazawa, T | 1 |
| Kasahara, K | 1 |
| Takahashi, M | 1 |
| Johnson, LP | 1 |
| Rivkin, SE | 1 |
| Weber, EL | 1 |
| Morin, LJ | 1 |
| Loening, S | 1 |
| Lamborot-Manzur, M | 1 |
| Tishler, PV | 1 |
| Atkins, L | 1 |
| Smith, FE | 1 |
| Lane, M | 1 |
| Hudgins, PT | 1 |
| Fishbone, PA | 1 |
1 trial available for quinacrine and Lung Neoplasms
| Article | Year |
|---|---|
Phase I study of the combination of quinacrine and erlotinib in patients with locally advanced or metastatic non small cell lung cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carc | 2018 |
17 other studies available for quinacrine and Lung Neoplasms
| Article | Year |
|---|---|
Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics.
Topics: Administration, Inhalation; Aerosols; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle | 2020 |
Nano-synergistic combination of Erlotinib and Quinacrine for non-small cell lung cancer (NSCLC) therapeutics - Evaluation in biologically relevant in-vitro models.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Q | 2021 |
Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Proliferation; Cell | 2017 |
Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tu | 2014 |
PEGylated VRB plus quinacrine cationic liposomes for treating non-small cell lung cancer.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; | 2015 |
Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis.
Topics: Aneuploidy; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 8; Fatal Outcome; Huma | 2003 |
[Chromophile property of lung tissue towards atebrin with special reference to malignant neoplasms].
Topics: Body Fluids; Lung Neoplasms; Neoplasms; Quinacrine; Urine | 1955 |
LOCALIZATION OF AMINOACRIDINE FLUORESCENCE IN LUNG TUMORS OF RATS.
Topics: Acridines; Aminacrine; Aminoacridines; Animals; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatoc | 1964 |
THE CONTROL OF RECURRENT MALIGNANT EFFUSIONS USING QUINACRINE HYDROCHLORIDE.
Topics: Ascites; Biomedical Research; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; | 1964 |
NEW TOOLS FOR LUNG CANCER?
Topics: Acridines; Antineoplastic Agents; Humans; Iodine Isotopes; Lung Neoplasms; Quinacrine | 1964 |
AMINOACRIDINE UPTAKE BY EXPERIMENTAL TUMORS.
Topics: Acridines; Aminacrine; Animals; Autoradiography; Carcinoma 256, Walker; Carcinoma, Hepatocellular; F | 1965 |
Enhancing effects of quinacrine on development of hepatopancreatic lesions in N-nitrosobis(2-oxopropyl)amine-initiated hamsters.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinogens; Cricetinae; Drug Synergism; Female; Kidney | 1998 |
Palliation in malignant pleural effusion.
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Drainage; Female; Hodgkin Disease; Humans; Lung Neopl | 1975 |
Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature.
Topics: Cyclophosphamide; Dactinomycin; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pleu | 1975 |
Quantitative studies of Y chromosomal fluorescence in human interphase nuclei.
Topics: Adult; Aneuploidy; Carcinoma, Bronchogenic; Chromosome Aberrations; Female; Fluorescence; Humans; In | 1972 |
Conservative management of malignant pericardial effusion.
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Cardiomegaly; Female; Fluorouracil; Follow-Up Studies | 1974 |
The increased uptake of quinacrine by tumors in experimental animals: measurements of tissue levels by fluorometric technique.
Topics: Animals; Carcinoma 256, Walker; Fluorometry; Liver Neoplasms; Lung Neoplasms; Neoplasm Transplantati | 1968 |