quinacrine has been researched along with Lipidoses in 7 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Drenckhahn, D | 1 |
| Jacobi, B | 1 |
| Lüllmann-Rauch, R | 3 |
| Frisch, W | 1 |
| Pods, R | 1 |
| von Witzendorff, B | 1 |
| Kardon, NB | 1 |
| Chernay, PR | 1 |
| Hsu, LY | 1 |
| Martin, JL | 1 |
| Hirschhorn, K | 1 |
| McKusick, VA | 1 |
| Chase, GA | 1 |
1 review available for quinacrine and Lipidoses
| Article | Year |
|---|---|
Human genetics.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Chromosome Mapping; Chromosomes; Crossing Ove | 1973 |
6 other studies available for quinacrine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Corneal lipidosis in rats treated with amphiphilic cationic drugs.
Topics: Animals; Cations; Chloroquine; Chlorphentermine; Corneal Diseases; Female; Iprindole; Lipidoses; Mal | 1983 |
Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites.
Topics: Animals; Blood-Brain Barrier; Brain Diseases; Chloroquine; Chlorphentermine; Female; Lipidoses; Male | 1980 |
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultu | 1996 |
Problems in prenatal diagnosis resulting from chromosomal mosaicism.
Topics: Abortion, Therapeutic; Adult; Amniocentesis; Amniotic Fluid; Female; Fetus; Gestational Age; Humans; | 1972 |