quinacrine has been researched along with Leukemia in 12 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription." | 5.46 | Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. ( Chang, LS; Chen, YJ; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ, 2017) |
| "Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription." | 1.46 | Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. ( Chang, LS; Chen, YJ; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ, 2017) |
| "Macrothrombocytosis was observed in most of the cases of AML, was rare in AGL and was never found in ALL." | 1.26 | Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia. ( Boneu, B; Capdeville, J; Caranobe, C; Nouvel, C; Pris, J; Sie, P, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, CH | 1 |
| Lee, YC | 1 |
| Chen, YJ | 1 |
| Wang, LJ | 1 |
| Shi, YJ | 1 |
| Chang, LS | 1 |
| DOAN, CA | 1 |
| RIGBY, PG | 1 |
| HANSON, TA | 1 |
| SMITH, RS | 1 |
| Whang-Peng, J | 1 |
| Nouvel, C | 1 |
| Caranobe, C | 1 |
| Sie, P | 1 |
| Capdeville, J | 1 |
| Pris, J | 1 |
| Boneu, B | 1 |
| Garson, OM | 1 |
| Beck, WT | 2 |
| Cirtain, MC | 1 |
| Glover, CJ | 1 |
| Felsted, RL | 1 |
| Safa, AR | 1 |
| Bellucci, S | 1 |
| Levy-Toledano, S | 1 |
| Maclouf, J | 1 |
| Rendu, F | 1 |
| Tobelem, G | 1 |
| Caen, JP | 1 |
| Zamora, JM | 1 |
| Pearce, HL | 1 |
| Lamborot-Manzur, M | 1 |
| Tishler, PV | 1 |
| Atkins, L | 1 |
| Farrow, MG | 1 |
| Van Dyke, K | 1 |
| Anghileri, LJ | 1 |
1 review available for quinacrine and Leukemia
| Article | Year |
|---|---|
Chromosome-banding techniques and their implication in hematology.
Topics: Acute Disease; Azure Stains; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Ban | 1979 |
11 other studies available for quinacrine and Leukemia
| Article | Year |
|---|---|
Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation.
Topics: Anticestodal Agents; Apoptosis; bcl-2-Associated X Protein; beta-Transducin Repeat-Containing Protei | 2017 |
APLASTIC VERSUS HYPERPLASTIC BLOOD DYSCRASIAS.
Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Benzene; Bone Marrow Diseases; Chlorpromazine; Coba | 1964 |
PASSAGE OF LEUKEMIC CELLS ACROSS THE PLACENTA.
Topics: Alkaline Phosphatase; Erythromycin; Female; Fluorescence; Humans; Leukemia; Leukemia, Myeloid; Leuko | 1964 |
Banding in leukemia: techniques and implications.
Topics: Aneuploidy; Azure Stains; Bone Marrow; Bone Marrow Cells; Cell Division; Chromosome Aberrations; Chr | 1977 |
Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia.
Topics: Blood Cell Count; Blood Platelets; Cytoplasmic Granules; Humans; Leukemia; Leukemia, Lymphoid; Leuke | 1978 |
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Su | 1988 |
Thrombocytopenia with thrombocytopathy possibly related to abnormalities of intracellular Ca++ fluxes and followed by the development of leukaemia.
Topics: Adenosine Diphosphate; Blood Platelet Disorders; Blood Platelets; Calcimycin; Calcium; Edetic Acid; | 1986 |
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physic | 1988 |
Quantitative studies of Y chromosomal fluorescence in human interphase nuclei.
Topics: Adult; Aneuploidy; Carcinoma, Bronchogenic; Chromosome Aberrations; Female; Fluorescence; Humans; In | 1972 |
A micro-system for screening anti-leukemic drugs utilizing human whole blood.
Topics: Adult; Aged; Cytarabine; DNA; Evaluation Studies as Topic; Female; Humans; Infant; Leukemia; Leukocy | 1971 |
Uptake of radioiodine labeled atabrine by enlarged spleen in leukemic mice.
Topics: Animals; Chromatography, Ion Exchange; Injections, Intraperitoneal; Iodine Radioisotopes; Leukemia; | 1965 |