Page last updated: 2024-10-16

quinacrine and Leukemia

quinacrine has been researched along with Leukemia in 12 studies

Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription."5.46Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. ( Chang, LS; Chen, YJ; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ, 2017)
"Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription."1.46Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. ( Chang, LS; Chen, YJ; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ, 2017)
"Macrothrombocytosis was observed in most of the cases of AML, was rare in AGL and was never found in ALL."1.26Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia. ( Boneu, B; Capdeville, J; Caranobe, C; Nouvel, C; Pris, J; Sie, P, 1978)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-199011 (91.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, CH1
Lee, YC1
Chen, YJ1
Wang, LJ1
Shi, YJ1
Chang, LS1
DOAN, CA1
RIGBY, PG1
HANSON, TA1
SMITH, RS1
Whang-Peng, J1
Nouvel, C1
Caranobe, C1
Sie, P1
Capdeville, J1
Pris, J1
Boneu, B1
Garson, OM1
Beck, WT2
Cirtain, MC1
Glover, CJ1
Felsted, RL1
Safa, AR1
Bellucci, S1
Levy-Toledano, S1
Maclouf, J1
Rendu, F1
Tobelem, G1
Caen, JP1
Zamora, JM1
Pearce, HL1
Lamborot-Manzur, M1
Tishler, PV1
Atkins, L1
Farrow, MG1
Van Dyke, K1
Anghileri, LJ1

Reviews

1 review available for quinacrine and Leukemia

ArticleYear
Chromosome-banding techniques and their implication in hematology.
    Progress in hematology, 1979, Volume: 11

    Topics: Acute Disease; Azure Stains; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Ban

1979

Other Studies

11 other studies available for quinacrine and Leukemia

ArticleYear
Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation.
    Toxicology and applied pharmacology, 2017, 11-01, Volume: 334

    Topics: Anticestodal Agents; Apoptosis; bcl-2-Associated X Protein; beta-Transducin Repeat-Containing Protei

2017
APLASTIC VERSUS HYPERPLASTIC BLOOD DYSCRASIAS.
    Postgraduate medicine, 1964, Volume: 35

    Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Benzene; Bone Marrow Diseases; Chlorpromazine; Coba

1964
PASSAGE OF LEUKEMIC CELLS ACROSS THE PLACENTA.
    The New England journal of medicine, 1964, Jul-16, Volume: 271

    Topics: Alkaline Phosphatase; Erythromycin; Female; Fluorescence; Humans; Leukemia; Leukemia, Myeloid; Leuko

1964
Banding in leukemia: techniques and implications.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:1

    Topics: Aneuploidy; Azure Stains; Bone Marrow; Bone Marrow Cells; Cell Division; Chromosome Aberrations; Chr

1977
Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia.
    Scandinavian journal of haematology, 1978, Volume: 21, Issue:5

    Topics: Blood Cell Count; Blood Platelets; Cytoplasmic Granules; Humans; Leukemia; Leukemia, Lymphoid; Leuke

1978
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
    Biochemical and biophysical research communications, 1988, Jun-30, Volume: 153, Issue:3

    Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Su

1988
Thrombocytopenia with thrombocytopathy possibly related to abnormalities of intracellular Ca++ fluxes and followed by the development of leukaemia.
    Scandinavian journal of haematology, 1986, Volume: 36, Issue:2

    Topics: Adenosine Diphosphate; Blood Platelet Disorders; Blood Platelets; Calcimycin; Calcium; Edetic Acid;

1986
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
    Molecular pharmacology, 1988, Volume: 33, Issue:4

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physic

1988
Quantitative studies of Y chromosomal fluorescence in human interphase nuclei.
    Clinical genetics, 1972, Volume: 3, Issue:2

    Topics: Adult; Aneuploidy; Carcinoma, Bronchogenic; Chromosome Aberrations; Female; Fluorescence; Humans; In

1972
A micro-system for screening anti-leukemic drugs utilizing human whole blood.
    Chemotherapy, 1971, Volume: 16, Issue:2

    Topics: Adult; Aged; Cytarabine; DNA; Evaluation Studies as Topic; Female; Humans; Infant; Leukemia; Leukocy

1971
Uptake of radioiodine labeled atabrine by enlarged spleen in leukemic mice.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1965, Volume: 6, Issue:8

    Topics: Animals; Chromatography, Ion Exchange; Injections, Intraperitoneal; Iodine Radioisotopes; Leukemia;

1965