quinacrine has been researched along with Leukemia, Myeloid in 23 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 16 treated patients with acute myelogenous leukemia and a normal karyotype, 11 (69 per cent) had a complete remission and a median survival of 13 months." | 1.26 | Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977). ( Golomb, HM; Mintz, U; Rowley, JD; Testa, JR; Vardiman, JW, 1978) |
| "These chromosome abnormalities were compared to previous cytogenic analyses on the transplantable Shay chloroleukemia, in which new fluorescent banding techniques were not utilized." | 1.26 | Chromosome studies of the transplantable Shay chloroleukemia in rats. ( Alt, B, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (91.30) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| RIGBY, PG | 1 |
| HANSON, TA | 1 |
| SMITH, RS | 1 |
| Verma, RS | 1 |
| Dosik, H | 1 |
| Whang-Peng, J | 1 |
| Golomb, HM | 1 |
| Vardiman, JW | 1 |
| Rowley, JD | 2 |
| Testa, JR | 1 |
| Mintz, U | 1 |
| Alt, B | 1 |
| Garson, OM | 2 |
| Misawa, S | 1 |
| Takino, T | 1 |
| Sugishima, K | 1 |
| Abe, T | 1 |
| Boesch, D | 1 |
| Muller, K | 1 |
| Pourtier-Manzanedo, A | 1 |
| Loor, F | 1 |
| Spriggs, DR | 1 |
| Sherman, ML | 1 |
| Imamura, K | 1 |
| Mohri, M | 1 |
| Rodriguez, C | 1 |
| Robbins, G | 1 |
| Kufe, DW | 1 |
| O'Riordan, ML | 1 |
| Robinson, JA | 1 |
| Buckton, KE | 1 |
| Evans, HJ | 1 |
| Milligan, WJ | 1 |
| Baserga, A | 1 |
| Castoldi, GL | 1 |
| Shaw, MW | 1 |
| Gahrton, G | 4 |
| Lindsten, J | 4 |
| Zech, L | 4 |
| Mitelman, F | 1 |
| Hossfeld, DK | 1 |
| Hellriegel, KP | 1 |
| Borberg, H | 1 |
| Reitz, H | 1 |
| Gross, R | 1 |
| Berger, R | 1 |
| Caspersson, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised Multicentre Phase IV Study to Compare Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec® in Combination With Interferon Alpha at Low Doses in the Treatment of Newly-Diagnosed Chronic-Phase Chronic Myeloid Leukaemia[NCT00390897] | Phase 4 | 360 participants | Interventional | 2003-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for quinacrine and Leukemia, Myeloid
| Article | Year |
|---|---|
Chromosome-banding techniques and their implication in hematology.
Topics: Acute Disease; Azure Stains; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Ban | 1979 |
The Philadelphia chromosome.
Topics: Alkaline Phosphatase; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y; | 1973 |
21 other studies available for quinacrine and Leukemia, Myeloid
| Article | Year |
|---|---|
PASSAGE OF LEUKEMIC CELLS ACROSS THE PLACENTA.
Topics: Alkaline Phosphatase; Erythromycin; Female; Fluorescence; Humans; Leukemia; Leukemia, Myeloid; Leuko | 1964 |
Heteromorphisms of the Philadelphia (Ph1) chromosome in patients with chronic melogenous leukaemia (CML). I. Classification and clinical significance.
Topics: Acridine Orange; Aged; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y | 1980 |
Banding in leukemia: techniques and implications.
Topics: Aneuploidy; Azure Stains; Bone Marrow; Bone Marrow Cells; Cell Division; Chromosome Aberrations; Chr | 1977 |
Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977).
Topics: Adolescent; Adult; Aged; Chromosome Aberrations; Female; Humans; Leukemia, Monocytic, Acute; Leukemi | 1978 |
Chromosome studies of the transplantable Shay chloroleukemia in rats.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Fluorescent Dyes; Leukemia, Experimental; Leuk | 1977 |
Quinacrine-banding analysis of the Philadelphia chromosome from five patients with chronic myelogeneous leukemia.
Topics: Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Humans; Leukemia, Myeloid; Quinacrine | 1975 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; | 1991 |
Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor.
Topics: Acetophenones; Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Choline; Enzyme Activation; | 1990 |
Still more light on human chromosomes.
Topics: Amniotic Fluid; Autoradiography; Cervix Mucus; Chromosomes, Human, 21-22 and Y; Cytogenetics; DNA; D | 1971 |
Distinguishing between the chromosomes involved in Down's syndrome (trisomy 21) and cronic myeloid leukaemia (Ph1) by fluorescence.
Topics: Chromosomes; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Fluorescent Dyes; Humans; Karyo | 1971 |
The 45, XO, Ph 1 subgroup of chronic granulocytic leukaemia.
Topics: Bone Marrow Cells; Chromosome Aberrations; Chromosome Mapping; Fluorescence; Genotype; Humans; Karyo | 1972 |
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
Topics: Adolescent; Adult; Aged; Bone Marrow Cells; Chromosome Aberrations; Chromosome Disorders; Chromosome | 1973 |
Uses of banding techniques for the identification of human diseases of cytogenetic origin.
Topics: Burkitt Lymphoma; Chromosome Aberrations; Chromosome Disorders; Genetic Techniques; Humans; Leukemia | 1973 |
Clonal origin of the Philadelphia chromosome from either the paternal or the maternal chromosome number 22.
Topics: Bone Marrow Cells; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; | 1974 |
Heterogeneity of Ph1 in chronic myeloid leukaemia.
Topics: Bone Marrow Cells; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y; Ch | 1974 |
Identification of chromosome anomalies in the blastic phase of chronic myelocytic leukemia (CML) by Giemsa- and quinacrine-banding techniques.
Topics: Blood Cells; Bone Marrow Cells; Chromosome Aberrations; Chromosomes, Human, 19-20; Chromosomes, Huma | 1974 |
Evaluation of the efficiency of leukocyte transfers by Y-chromatin studies.
Topics: ABO Blood-Group System; Adult; Agranulocytosis; Female; Histocompatibility Testing; Humans; Leukemia | 1974 |
Origin of the Philadelphia chromosome. Tracing of chromosome 22 to parents of patients with chronic myelocytic leukemia.
Topics: Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Female; Fluorescence; Humans; Leukemia, Mye | 1973 |
Origin of the Philadelphia chromosome. Tracing of chromosome 22 to parents of patients with chronic myelocytic leukemia.
Topics: Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Female; Fluorescence; Humans; Leukemia, Mye | 1973 |
[Letter: Philadelphia chromosome].
Topics: Bone Marrow Cells; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 6-12 | 1973 |
Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysis.
Topics: Chromosomes, Human, 21-22 and Y; Fluorescence; Humans; Leukemia, Myeloid; Methods; Quinacrine | 1970 |