quinacrine has been researched along with Intellectual Disability in 29 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bower, BD | 1 |
| Jeavons, PM | 1 |
| Thacker, SB | 1 |
| Simpson, S | 1 |
| Gordon, TJ | 1 |
| Wolfe, M | 1 |
| Kimball, AM | 1 |
| Bocian, M | 2 |
| Mohandas, T | 1 |
| Soudek, D | 2 |
| Sroka, H | 1 |
| Funderburk, SJ | 1 |
| Spence, MA | 1 |
| Sparkes, RS | 3 |
| Noël, B | 1 |
| Ayraud, N | 1 |
| Levy, M | 1 |
| Cau, D | 1 |
| Naritomi, K | 1 |
| Hirayama, K | 1 |
| Caspersson, T | 1 |
| Lindsten, J | 2 |
| Zech, L | 1 |
| Buckton, KE | 1 |
| Price, WH | 1 |
| Breg, WR | 4 |
| Miller, DA | 3 |
| Allderdice, PW | 2 |
| Miller, OJ | 3 |
| Schoepflin, GS | 1 |
| Centerwall, WR | 1 |
| Yanagisawa, S | 1 |
| Dutrillaux, B | 1 |
| Jonasson, J | 1 |
| Laurèn, K | 1 |
| Lejeune, J | 1 |
| Petersen, GB | 1 |
| Saldaña-Garcia, P | 1 |
| Jacobsen, P | 1 |
| Mikkelsen, M | 1 |
| Rosleff, F | 1 |
| del Solar, C | 1 |
| Uchida, IA | 1 |
| O'Shaughnessy, S | 1 |
| Laraya, P | 1 |
| McCreary, BD | 1 |
| Zackai, EH | 1 |
| Warren, RJ | 1 |
| Rimoin, DL | 1 |
| Summitt, RL | 1 |
| Alderdice, PW | 1 |
| Atkins, L | 1 |
| Miller, WL | 1 |
| Salam, M | 1 |
| Cohen, MM | 1 |
| Putnam, TI | 1 |
| Falk, RE | 1 |
| Carrel, RE | 1 |
| Valente, M | 1 |
| Crandall, BF | 3 |
| Rosenthal, IM | 1 |
| Krmpotic, E | 1 |
| Szego, K | 1 |
| Mayeda, K | 1 |
| Weiss, L | 1 |
| Lindahl, R | 1 |
| Dully, M | 1 |
| Francke, U | 1 |
| Campbell, MA | 1 |
| Gustavson, KH | 1 |
| Hitrec, V | 1 |
| Santesson, B | 1 |
| Weber, F | 1 |
| Muller, HM | 1 |
| Burwell, JK | 1 |
| Reiss, JA | 1 |
| Wyandt, HE | 1 |
| Magenis, RE | 1 |
| Lovrien, EW | 1 |
| Hecht, F | 1 |
| Meisner, LF | 1 |
| Inhorn, SL | 1 |
| Gendel, E | 1 |
| Zelson, C | 1 |
29 other studies available for quinacrine and Intellectual Disability
| Article | Year |
|---|---|
The "happy puppet" syndrome.
Topics: Child; Chlordiazepoxide; Electroencephalography; Epilepsy; Ethosuximide; Eye Diseases; Facial Expres | 1967 |
Parasitic disease control in a residential facility for the mentally retarded.
Topics: Adolescent; Adult; Aged; Child; District of Columbia; Entamoebiasis; Environment; Female; Follow-Up | 1979 |
Recent cytogenetic advances and implications for pediatric practice.
Topics: Abortion, Spontaneous; Azure Stains; Chromosome Aberrations; Chromosome Banding; Chromosome Disorder | 1978 |
Inversion of 'flourescent' segment in chromosome 3: a polymorphic trait.
Topics: Adolescent; Adult; Child; Chromosome Banding; Chromosome Inversion; Chromosomes, Human, 1-3; Female; | 1978 |
Mental retardation associated with "balanced" chromosome rearrangements.
Topics: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Chromosomes; Female; Humans; Infant; In | 1977 |
[Cat eye syndrome: chromosome study and genetic counseling].
Topics: Adult; Aneuploidy; Bromodeoxyuridine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Col | 1976 |
Determination of the breakpoints and the parental origin of a ring 22 chromosome: an analysis by high-resolution banding technique, quinacrine and silver stainings.
Topics: Abnormalities, Multiple; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Chromosom | 1988 |
Four patients with trisomy 8 identified by the fluorescence and Giemsa banding techniques.
Topics: Abnormalities, Multiple; Adolescent; Blood Cells; Child; Child, Preschool; Chromosomes, Human, 6-12 | 1972 |
Identification of translocation chromosomes by quinacrine fluorescence.
Topics: Adult; Child; Child, Preschool; Chromosome Aberrations; Female; Fluorescence; Humans; Intellectual D | 1972 |
48,XYYY: a new syndrome?
Topics: Bone Diseases, Developmental; Bone Marrow Cells; Child; Dermatoglyphics; Diagnosis, Differential; He | 1972 |
Immunoglobulin abnormality in a girl with a large chromosome 18.
Topics: Adolescent; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 16-18; Dermatog | 1972 |
An unbalanced 4q-21q translocation identified by the R but not by the G and Q chromosome banding techniques.
Topics: Aneuploidy; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 4-5; Dermat | 1973 |
A ring chromosome, diagnosed by quinacrine fluorescence as No. 9, in a mentally retarded girl.
Topics: Adult; Amino Acids; Body Height; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 6 | 1973 |
Identification of chromosomal abnormalities by quinacrine-staining technique in patients with normal karyotypes by conventional analysis.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chromosome | 1974 |
Pericentric inversion of "fluorescent" segment in chromosome no. 3.
Topics: Adolescent; Adult; Child, Preschool; Chromosome Aberrations; Chromosome Inversion; Chromosomes, Huma | 1974 |
Ring chromosome 7 with variable phenotypic expression.
Topics: Abnormalities, Multiple; Blepharoptosis; Child; Chromosome Aberrations; Chromosomes, Human, 6-12 and | 1973 |
Identification by fluorescent microscopy of the abnormal chromosomes associated with the G-deletion syndromes.
Topics: Blepharoptosis; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chromosomes, | 1973 |
Quinacrine fluorescence patterns and terminal DNA labelling of human C group chromosomes.
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 6-12 and X; DNA; Female; Fluoresce | 1972 |
A ring-20 chromosome.
Topics: Child; Child Behavior Disorders; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 1 | 1972 |
An 18p21q translocation in a patient with presumptive "monosomy G".
Topics: Abnormalities, Multiple; Aneuploidy; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, 1 | 1972 |
Partial trisomy of chromosome 11: a case report.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 6-12 and | 1973 |
Trisomy of the short arm of chromosome 8: association with translocation between chromosomes 8 and 22 46,XY,22-,t(8p22q) plus.
Topics: Adult; Autoradiography; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chrom | 1973 |
Localization of the human lactate dehydrogenase B gene on the short arm of chromosome 12.
Topics: Abnormalities, Multiple; Child; Chromosome Aberrations; Chromosome Disorders; Chromosome Mapping; Ch | 1974 |
Inherited t(13q14q) in two retarded sisters.
Topics: Adolescent; Autoradiography; Blood Group Antigens; Body Height; Body Weight; Chromosome Aberrations; | 1972 |
Three non-mongoloid patients of similar phenotype with an extra G-like chromosome.
Topics: Abnormalities, Multiple; Autoradiography; Child; Child, Preschool; Chromosome Aberrations; Chromosom | 1972 |
Identification of 21r and 22r chromosomes by quinacrine fluorescence.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosome Disorders; Chromosome Mapping; Ch | 1972 |
Mosaicism with translocation: autoradiographic and fluorescent studies of an inherited reciprocal translocation t(2q+;14q-).
Topics: Abnormalities, Multiple; Adult; Aneuploidy; Autoradiography; Blood Group Antigens; Child; Chromosome | 1972 |
Normal male development with Y chromosome long arm deletion (Yq-).
Topics: Adult; Diagnosis, Differential; Fertility; Humans; Intellectual Disability; Karyotyping; Male; Micro | 1972 |
Familial translocation involving chromosomes 6, 14 and 20, identified by quinacrine fluorescence.
Topics: Cell Division; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, 13-15; Chromosomes, Hum | 1971 |