quinacrine has been researched along with Inflammation in 16 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases." | 6.49 | Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013) |
| "Quinacrine (QC) is an anti-inflammatory drug that has been used for the treatment of malaria and rheumatoid diseases." | 5.34 | Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation. ( Fairchild, RL; Gasparian, AV; Gorbachev, AV; Gudkov, AV; Gurova, KV, 2007) |
| " For this, extended subacute ovalbumin mice model of asthma was developed; these mice showed an increased expression of profibrotic mediators, subepithelial fibrosis, and goblet cell metaplasia along with airway inflammation, increased Th(2) cytokines, allergen-specific IgE, IgG(1), increased cytosolic PLA(2) (cPLA(2)), and airway hyperresponsiveness." | 3.75 | Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. ( Agrawal, A; Aich, J; Ghosh, B; Mabalirajan, U, 2009) |
| "Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases." | 2.49 | Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013) |
| "Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs." | 1.48 | Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner. ( Das, S; Kundu, CN; Nayak, A; Nayak, D; Satapathy, SR; Siddharth, S, 2018) |
| "Quinacrine (QC) is an anti-inflammatory drug that has been used for the treatment of malaria and rheumatoid diseases." | 1.34 | Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation. ( Fairchild, RL; Gasparian, AV; Gorbachev, AV; Gudkov, AV; Gurova, KV, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 2 |
| Xiao, R | 1 |
| Zeng, R | 1 |
| He, E | 1 |
| Zhang, A | 1 |
| Satapathy, SR | 1 |
| Nayak, A | 1 |
| Siddharth, S | 1 |
| Das, S | 1 |
| Nayak, D | 1 |
| Kundu, CN | 1 |
| Xu, B | 1 |
| Chen, G | 1 |
| Zhang, Y | 1 |
| Wang, Q | 1 |
| Zhao, L | 1 |
| Zhou, H | 1 |
| Growe, RG | 1 |
| Luster, MI | 1 |
| Fail, PA | 1 |
| Lippes, J | 1 |
| Brown, J | 1 |
| Achille, N | 1 |
| Neafsey, EJ | 1 |
| Collins, MA | 1 |
| Yoo, S | 1 |
| Han, S | 1 |
| Park, YS | 1 |
| Lee, JH | 1 |
| Oh, U | 1 |
| Hwang, SW | 1 |
| Mabalirajan, U | 2 |
| Aich, J | 1 |
| Agrawal, A | 1 |
| Ghosh, B | 2 |
| Wu, Y | 1 |
| Su, ZT | 1 |
| Zhou, HM | 1 |
| Wang, F | 1 |
| Liu, SH | 1 |
| Ding, XF | 1 |
| Zhao, YQ | 1 |
| Fan, M | 1 |
| Ukale, V | 2 |
| Agrenius, V | 2 |
| Widström, O | 2 |
| Hassan, A | 1 |
| Hillerdal, G | 1 |
| Gorbachev, AV | 1 |
| Gasparian, AV | 1 |
| Gurova, KV | 1 |
| Gudkov, AV | 1 |
| Fairchild, RL | 1 |
| Ram, A | 1 |
| Singh, SK | 1 |
| Singh, VP | 1 |
| Lanham, JG | 1 |
| Hughes, GR | 1 |
| Källenius, G | 1 |
| Svenson, SB | 1 |
| Palmetshofer, A | 1 |
| Robson, SC | 1 |
| Nehls, V | 1 |
| Yew, NS | 1 |
| Zhao, H | 1 |
| Wu, IH | 1 |
| Song, A | 1 |
| Tousignant, JD | 1 |
| Przybylska, M | 1 |
| Cheng, SH | 1 |
| Yoshioka, A | 1 |
| Miyachi, Y | 1 |
| Imamura, S | 1 |
3 reviews available for quinacrine and Inflammation
| Article | Year |
|---|---|
Small molecules targeting cGAS-STING pathway for autoimmune disease.
Topics: Autoimmune Diseases; Humans; Inflammation; Membrane Proteins; Nucleotidyltransferases; Signal Transd | 2022 |
Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms.
Topics: Animals; Cell Adhesion; Chlamydia Infections; Chlamydia trachomatis; Contraception; Drug Implants; E | 2013 |
Antimalarial therapy in SLE.
Topics: Antimalarials; Binding Sites; Chloroquine; Corneal Diseases; Dose-Response Relationship, Drug; Femal | 1982 |
13 other studies available for quinacrine and Inflammation
| Article | Year |
|---|---|
Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cytokines; Gene Ex | 2018 |
Cryopreserved platelets augment the inflammatory response: role of phosphatidylserine- and P-selectin-mediated platelet phagocytosis in macrophages.
Topics: Blood Platelets; Cell Line; Cryopreservation; Humans; Inflammation; Macrophages; P-Selectin; Phagocy | 2019 |
Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA).
Topics: Animals; Docosahexaenoic Acids; Entorhinal Cortex; Enzyme Inhibitors; Ethanol; Hippocampus; In Vitro | 2009 |
Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat.
Topics: Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regu | 2009 |
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
Topics: Animals; Arginase; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Epithelial Cells; Fibr | 2009 |
[Effect of quinacrine on inflammatory reaction of blood system induced by microwave irradiation].
Topics: Animals; Inflammation; Interleukin-1; Interleukin-1beta; Interleukin-6; Leukocyte Count; Male; Mice; | 2011 |
Inflammatory parameters after pleurodesis in recurrent malignant pleural effusions and their predictive value.
Topics: Aged; Blood Sedimentation; C-Reactive Protein; Female; Glucose; Humans; Hydrogen-Ion Concentration; | 2004 |
Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.
Topics: Animals; Anti-Inflammatory Agents; CD8-Positive T-Lymphocytes; Chemokine CCL21; Chemokines, CC; Chem | 2007 |
Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bro | 2008 |
Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels.
Topics: Adult; Aged; Drainage; Female; Humans; Inflammation; Interleukin-1; Leukocyte Count; Male; Middle Ag | 1993 |
Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Drug Synergism; E-Selectin; Endothelium, Vascular; Gene Ex | 1999 |
Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs.
Topics: Administration, Intranasal; Animals; Antimalarials; Bronchoalveolar Lavage Fluid; Chloroquine; CpG I | 2000 |
The mechanism of the inhibitory effects of antimalarials on UV-induced skin inflammation in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chloroquine; Ear, External; Edema; Female; Inflammatio | 1988 |