quinacrine has been researched along with Hirschsprung Disease in 1 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the Piebald mouse, animal model of congenital megacolon, the quinacrine positive plexus is thin in the distal narrowed segment and well developed in the large proximal zone." | 1.26 | [Colonic nerve network demonstrated by quinacrine]. ( Adnet, JJ; Arnaudies, J; Birembaut, P; Gaillard, D; Ploton, D; Visseaux-Coletto, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaillard, D | 1 |
| Birembaut, P | 1 |
| Ploton, D | 1 |
| Arnaudies, J | 1 |
| Visseaux-Coletto, B | 1 |
| Adnet, JJ | 1 |
1 other study available for quinacrine and Hirschsprung Disease
| Article | Year |
|---|---|
[Colonic nerve network demonstrated by quinacrine].
Topics: Adenosine Triphosphatases; Animals; Colon; Disease Models, Animal; Hirschsprung Disease; Humans; Mic | 1982 |