quinacrine has been researched along with Glioma in 14 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine." | 7.80 | Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation. ( Gillespie, GY; Lobo, MR; Pike, MM; Wang, X; Woltjer, RL, 2014) |
| "Combined cediranib/quinacrine treatment synergistically increased antivascular/antitumor efficacy in intracranial 4C8 mouse glioma, suggesting a promising and facile treatment strategy for malignant glioma." | 7.79 | Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma. ( Gillespie, GY; Green, SC; Lobo, MR; Pike, MM; Schabel, MC; Woltjer, RL, 2013) |
| " We investigated whether quinacrine could improve carmustine therapy in C6 cell cultures and in C6 malignant gliomas implanted subcutaneously into Wistar rats." | 7.71 | Quinacrine enhances carmustine therapy of experimental rat glioma. ( Herrera, LA; Ostrosky, P; Reyes, S; Sotelo, J, 2001) |
| "In a controlled study, a single dose of 150 mg of quinacrine was injected interstitially into a C6 glioma implanted in the subcutaneous tissue of Wistar rats." | 7.70 | Interstitial quinacrine for elimination of abnormal tissue; therapy of experimental glioma. ( Arrieta, O; Guevara, P; Reyes, S; Sotelo, J, 2000) |
| "We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine." | 3.80 | Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation. ( Gillespie, GY; Lobo, MR; Pike, MM; Wang, X; Woltjer, RL, 2014) |
| "Combined cediranib/quinacrine treatment synergistically increased antivascular/antitumor efficacy in intracranial 4C8 mouse glioma, suggesting a promising and facile treatment strategy for malignant glioma." | 3.79 | Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma. ( Gillespie, GY; Green, SC; Lobo, MR; Pike, MM; Schabel, MC; Woltjer, RL, 2013) |
| " We investigated whether quinacrine could improve carmustine therapy in C6 cell cultures and in C6 malignant gliomas implanted subcutaneously into Wistar rats." | 3.71 | Quinacrine enhances carmustine therapy of experimental rat glioma. ( Herrera, LA; Ostrosky, P; Reyes, S; Sotelo, J, 2001) |
| "In a controlled study, a single dose of 150 mg of quinacrine was injected interstitially into a C6 glioma implanted in the subcutaneous tissue of Wistar rats." | 3.70 | Interstitial quinacrine for elimination of abnormal tissue; therapy of experimental glioma. ( Arrieta, O; Guevara, P; Reyes, S; Sotelo, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lobo, MR | 2 |
| Green, SC | 1 |
| Schabel, MC | 1 |
| Gillespie, GY | 2 |
| Woltjer, RL | 2 |
| Pike, MM | 2 |
| Li, XT | 1 |
| Ju, RJ | 1 |
| Li, XY | 1 |
| Zeng, F | 1 |
| Shi, JF | 1 |
| Liu, L | 1 |
| Zhang, CX | 1 |
| Sun, MG | 1 |
| Lou, JN | 1 |
| Lu, WL | 1 |
| Wang, X | 1 |
| Geng, Y | 1 |
| Kohli, L | 1 |
| Klocke, BJ | 1 |
| Roth, KA | 1 |
| Fishman, PH | 1 |
| Mallorga, P | 1 |
| Tallman, JF | 1 |
| Shitara, N | 1 |
| McKeever, PE | 1 |
| Cummins, C | 1 |
| Smith, BH | 1 |
| Kornblith, PL | 1 |
| Hirata, F | 1 |
| Lee, RK | 1 |
| Wurtman, RJ | 1 |
| Cox, AJ | 1 |
| Nitsch, RM | 1 |
| Ray, R | 1 |
| Legere, RH | 1 |
| Majerus, BJ | 1 |
| Petrali, JP | 1 |
| Kato, K | 1 |
| Ito, H | 1 |
| Hasegawa, K | 1 |
| Inaguma, Y | 1 |
| Suzuki, A | 1 |
| Kozawa, O | 1 |
| Asano, T | 1 |
| Sotelo, J | 2 |
| Guevara, P | 1 |
| Reyes, S | 2 |
| Arrieta, O | 1 |
| Herrera, LA | 1 |
| Ostrosky, P | 1 |
| Gàti, I | 1 |
| Bergström, M | 1 |
| Westerberg, G | 1 |
| Csòka, K | 1 |
| Muhr, C | 1 |
| Carlsson, J | 1 |
| Shirazi, Y | 1 |
| McMorris, FA | 1 |
| Shin, ML | 1 |
| DeGeorge, JJ | 1 |
| Ousley, AH | 1 |
| McCarthy, KD | 1 |
| Morell, P | 1 |
| Lapetina, EG | 1 |
14 other studies available for quinacrine and Glioma
| Article | Year |
|---|---|
Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Capil | 2013 |
Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neopl | 2014 |
Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neo | 2014 |
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.
Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chloroquine; | 2010 |
Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cells, Cultured; Cholera Toxin; Dihydroalprenolol; Gliom | 1981 |
beta-Adrenergic receptor desensitization stimulates glucose uptake in C6 rat glioma cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cyclic AMP; Deoxy Sugars; Deoxyglucose; Epinephrin | 1982 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents | 1995 |
Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Glioma; Glutathione; Hybrid Cells; | 1995 |
Enhancement of stress-induced synthesis of stress proteins by mastoparan in C6 rat glioma cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Crystallins; Depression, Chemical; Glioma; Heat-Shoc | 1995 |
Interstitial quinacrine for elimination of abnormal tissue; therapy of experimental glioma.
Topics: Animals; Antineoplastic Agents; Cicatrix; Cytokines; Extracellular Space; Female; Glioma; Humans; In | 2000 |
Quinacrine enhances carmustine therapy of experimental rat glioma.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergis | 2001 |
Effects of prostaglandin and leukotriene inhibitors on the growth of human glioma spheroids.
Topics: Arachidonic Acids; Dexamethasone; Glioma; Humans; Indomethacin; Ketoprofen; Leukotriene Antagonists; | 1990 |
Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic | 1989 |
Glucocorticoids inhibit the liberation of arachidonate but not the rapid production of phospholipase C-dependent metabolites in acetylcholine-stimulated C62B glioma cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cells, Cultured; Dexamethaso | 1987 |