quinacrine has been researched along with Experimental Leukemia in 16 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because the antigenic changes occurring after in vivo treatment of murine lymphoma cells with 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide (DTIC) were suggested to result from DTIC-induced somatic mutation(s), quinacrine dihydrochloride, an antimutagenic compound, was tested for possible antagonistic activity related to this phenomenon." | 3.66 | Drug-mediated antigenic changes in murine leukemia cells: antagonistic effects of quinacrine, an antimutagenic compound. ( Bonmassar, E; Fioretti, MC; Giampietri, A; Goldin, A, 1980) |
| "Methyl methanesulfonate (MMS) was used as a positive control in these studies." | 1.26 | Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma cells. ( Back, KC; Rogers, AM, 1982) |
| "These chromosome abnormalities were compared to previous cytogenic analyses on the transplantable Shay chloroleukemia, in which new fluorescent banding techniques were not utilized." | 1.26 | Chromosome studies of the transplantable Shay chloroleukemia in rats. ( Alt, B, 1977) |
| "2 had total and partial No." | 1.26 | Reproducible chromosome changes of polycyclic hydrocarbon-induced rat leukemia: incidence and chromosome banding pattern. ( Fukuhara, S; Maeda, S; Sugiyama, T; Ueda, N; Uenaka, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gourdie, TA | 1 |
| Valu, KK | 1 |
| Gravatt, GL | 1 |
| Boritzki, TJ | 1 |
| Baguley, BC | 2 |
| Wakelin, LP | 1 |
| Wilson, WR | 1 |
| Woodgate, PD | 1 |
| Denny, WA | 1 |
| Liang, GW | 1 |
| Lu, WL | 1 |
| Wu, JW | 1 |
| Zhao, JH | 1 |
| Hong, HY | 1 |
| Long, C | 1 |
| Li, T | 1 |
| Zhang, YT | 1 |
| Zhang, H | 1 |
| Wang, JC | 1 |
| Zhang, X | 1 |
| Zhang, Q | 1 |
| McGivney, A | 1 |
| Morita, Y | 1 |
| Crews, FT | 1 |
| Hirata, F | 1 |
| Axelrod, J | 1 |
| Siraganian, RP | 1 |
| Fioretti, MC | 2 |
| Bianchi, R | 1 |
| Romani, L | 1 |
| Bonmassar, E | 2 |
| Giampietri, A | 1 |
| Goldin, A | 1 |
| Rogers, AM | 1 |
| Back, KC | 1 |
| Alt, B | 1 |
| Sugiyama, T | 1 |
| Uenaka, H | 1 |
| Ueda, N | 1 |
| Fukuhara, S | 1 |
| Maeda, S | 1 |
| Boesch, D | 1 |
| Muller, K | 1 |
| Pourtier-Manzanedo, A | 1 |
| Loor, F | 1 |
| Jadus, MR | 1 |
| Schmunk, G | 1 |
| Djeu, JY | 1 |
| Parkman, R | 1 |
| Schneider, E | 1 |
| Darkin, SJ | 1 |
| Lawson, PA | 1 |
| Ching, LM | 1 |
| Ralph, RK | 1 |
| Hirafuji, M | 1 |
| Nave, JF | 1 |
| Inaba, M | 2 |
| Maruyama, E | 1 |
| Kolber, MA | 1 |
| Henkart, PA | 1 |
| Anghileri, LJ | 1 |
16 other studies available for quinacrine and Experimental Leukemia
| Article | Year |
|---|---|
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
Topics: Alkylating Agents; Alkylation; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line; Chemical | 1990 |
Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Dose-Response Relation | 2008 |
Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophilic leukemia cells.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Calcium; | 1981 |
Drug-induced immunogenic changes of murine leukemia cells: dissociation of onset of resistance and emergence of novel immunogenicity.
Topics: Animals; Cell Line; Clone Cells; Dacarbazine; Drug Resistance; Immunity, Cellular; Leukemia L5178; L | 1983 |
Drug-mediated antigenic changes in murine leukemia cells: antagonistic effects of quinacrine, an antimutagenic compound.
Topics: Animals; Antigens, Neoplasm; Dacarbazine; Immunity; Leukemia, Experimental; Lymphoma; Male; Mice; Mi | 1980 |
Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma cells.
Topics: Acridine Orange; Acridines; Animals; Cell Survival; Ethidium; Intercalating Agents; Leukemia L5178; | 1982 |
Chromosome studies of the transplantable Shay chloroleukemia in rats.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Fluorescent Dyes; Leukemia, Experimental; Leuk | 1977 |
Reproducible chromosome changes of polycyclic hydrocarbon-induced rat leukemia: incidence and chromosome banding pattern.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Anemia; Animals; Benz(a)Anthracenes; Chromosome Aberrations; Femal | 1978 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; | 1991 |
Morphology and lytic mechanisms of interleukin 3-dependent natural cytotoxic cells: tumor necrosis factor as a possible mediator.
Topics: Animals; Basophils; Bone Marrow Cells; Cell Line; Cytoplasmic Granules; Cytotoxicity, Immunologic; G | 1986 |
Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II.
Topics: Acridines; Aminacrine; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Survival; DNA | 1988 |
Platelet-activating factor (PAF-acether) formation in rat basophilic leukemia cells stimulated by ionophore A23187.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Leukemia, Experimental; Platele | 1987 |
Reversal of resistance to vincristine in P388 leukemia by various polycyclic clinical drugs, with a special emphasis on quinacrine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance; Drug Synergis | 1988 |
Quantitation of secretion by rat basophilic leukemia cells by measurements of quinacrine uptake.
Topics: Animals; Basophils; Biological Transport; Cell Line; Cytoplasmic Granules; Hydrogen-Ion Concentratio | 1988 |
[Studies on the mechanism of multidrug resistance].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; | 1987 |
Uptake of radioiodine labeled atabrine by enlarged spleen in leukemic mice.
Topics: Animals; Chromatography, Ion Exchange; Injections, Intraperitoneal; Iodine Radioisotopes; Leukemia; | 1965 |