quinacrine has been researched along with Down Syndrome in 23 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 61 families of children with trisomy 21, polymorphism of chromosome 21 elucidating the origin of the extra chromosome was found in 42." | 1.26 | Origin of the extra chromosome in trisomy 21. ( Ayme, S; Giraud, F; Mattei, JF; Mattei, MG, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Howell, WM | 1 |
| Howard-Peebles, PN | 1 |
| Block, BM | 1 |
| Stoddard, GR | 1 |
| Habedank, M | 1 |
| Faust, J | 1 |
| Mattei, JF | 1 |
| Mattei, MG | 1 |
| Ayme, S | 1 |
| Giraud, F | 1 |
| O'Riordan, ML | 1 |
| Robinson, JA | 1 |
| Buckton, KE | 1 |
| Evans, HJ | 1 |
| Gerald, PS | 1 |
| Mikkelsen, M | 2 |
| Uchida, IA | 1 |
| Lin, CC | 1 |
| Borgaonkar, DS | 1 |
| Bias, WB | 1 |
| Chase, GA | 1 |
| Sadasivan, G | 1 |
| Herr, HM | 1 |
| Golomb, HM | 1 |
| Bahr, GF | 1 |
| Kunkel, LM | 1 |
| Baserga, A | 1 |
| Castoldi, GL | 1 |
| Porter, IH | 1 |
| Breg, WR | 3 |
| Caspersson, T | 1 |
| Hultén, M | 1 |
| Lindsten, J | 1 |
| Zech, L | 1 |
| Miller, OJ | 2 |
| Miller, DA | 2 |
| Allderdice, PW | 2 |
| Alfi, OS | 2 |
| Donnell, GN | 2 |
| Derencsenyi, A | 2 |
| van der Hagen, CB | 1 |
| Berg, K | 1 |
| Schwinger, E | 1 |
| Roers, H | 1 |
| Rittner, C | 1 |
| Warren, RJ | 1 |
| Rimoin, DL | 1 |
| Summitt, RL | 1 |
| Ying, KL | 1 |
| Benirschike, K | 1 |
| Bogart, MH | 1 |
| McClure, HM | 1 |
| Nelson-Rees, WA | 1 |
1 review available for quinacrine and Down Syndrome
| Article | Year |
|---|---|
The Philadelphia chromosome.
Topics: Alkaline Phosphatase; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y; | 1973 |
22 other studies available for quinacrine and Down Syndrome
| Article | Year |
|---|---|
Silver stain reveals nucleolus organizer regions on a satellited Yq chromosome.
Topics: Azure Stains; Cell Nucleolus; Cytological Techniques; DNA; DNA, Satellite; Down Syndrome; Humans; Ma | 1978 |
Trisomy 9p and unusual translocation mongolism in siblings due to different 3:1 segregations of maternal translocation rcp(9;21)(p11;q11).
Topics: Adolescent; Adult; Azure Stains; Child, Preschool; Chromosomes; Chromosomes, Human, 21-22 and Y; Chr | 1978 |
Origin of the extra chromosome in trisomy 21.
Topics: Chromosome Banding; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Humans; Male; Meiosis; Q | 1979 |
Still more light on human chromosomes.
Topics: Amniotic Fluid; Autoradiography; Cervix Mucus; Chromosomes, Human, 21-22 and Y; Cytogenetics; DNA; D | 1971 |
Distinguishing between the chromosomes involved in Down's syndrome (trisomy 21) and cronic myeloid leukaemia (Ph1) by fluorescence.
Topics: Chromosomes; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Fluorescent Dyes; Humans; Karyo | 1971 |
Fluorescent staining of human chromosomes.
Topics: Chromosome Aberrations; Chromosomes; Down Syndrome; Fluorescence; Humans; Karyotyping; Male; Quinacr | 1971 |
Identification of G group anomalies in Down's syndrome by quinacrine dihydrochloride fluorescence staining.
Topics: Adult; Chromosome Aberrations; Chromosomes, Human, 13-15; Chromosomes, Human, 21-22 and Y; Down Synd | 1971 |
Identification of partial 12 trisomy by quinacrine fluorescence.
Topics: Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Cytogenetics; Dermatoglyphics; Down Syndrome | 1973 |
Identification of a C6-G21 translocation chromosome by the Q-M and Giemsa banding techniques in a patient with Down's syndrome, with possible assignment of Gm locus.
Topics: Adult; Autoradiography; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, | 1973 |
Human cytogenetics: trends and techniques.
Topics: Autoradiography; Chromosome Aberrations; Chromosome Disorders; Chromosome Mapping; Chromosomes; Cyto | 1973 |
Updating advances in cytogenetics. Applications of the new chromosome banding methods.
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosome Inversion; Chromosomes; Chromosomes, Human, | 1974 |
Distinction between extra G-like chromosomes by quinacrine mustard fluorescence analysis.
Topics: Adult; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Down Syndrome; Fem | 1970 |
[Fluorescence microscopic and cytologic examination in Down's syndrome].
Topics: Chromosomes, Human, 21-22 and Y; Down Syndrome; Humans; Microscopy, Fluorescence; Quinacrine | 1971 |
Distinctive fluorescence of quinacrine-labelled human G group chromosomes.
Topics: Chromosomes, Human, 21-22 and Y; Down Syndrome; Fluorescence; Humans; Karyotyping; Male; Quinacrine; | 1971 |
Quinacrine fluorescence patterns of human D group chromosomes.
Topics: Autoradiography; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 13-15; Down Syndr | 1971 |
Identification of the G chromosomes in Down's syndrome by quinacrine fluorescence microscopy.
Topics: Chromosome Aberrations; Chromosomes, Human, 13-15; Down Syndrome; Female; Humans; Karyotyping; Leuko | 1971 |
Quinacrine fluoromicroscopy in the identification of human mitotic chromosomes.
Topics: Chromosomes; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes, Human, 16-18; Chromoso | 1971 |
Studies of human chromosomes by DNA-binding fluorochromes. II. Fluorescence characteristics of the supernumerary G chromosome in Down's syndrome.
Topics: Child; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Fluorescence; Fluorescent Dyes; Human | 1971 |
[Studies on patients with Down's syndrome. 3. Fluorescence microscopy studies].
Topics: Adolescent; Adult; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Humans; Karyotyping; Male | 1971 |
Identification by fluorescent microscopy of the abnormal chromosomes associated with the G-deletion syndromes.
Topics: Blepharoptosis; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chromosomes, | 1973 |
Sporadic (GqGq) translocations in Down's syndrome.
Topics: Child; Chromosome Aberrations; Down Syndrome; Humans; Infant, Newborn; Karyotyping; Male; Quinacrine | 1973 |
Fluorescence of the trisomic chimpanzee chromosomes.
Topics: Animals; Chromosomes; Down Syndrome; Female; Fluorescence; Humans; Karyotyping; Pan troglodytes; Qui | 1974 |