quinacrine has been researched along with Cystic Fibrosis in 13 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrapleural instillation of quinacrine HC1 (Atabrine) was used to treat spontaneous pneumothorax in 2 young men, aged 26 and 36 years, respectively, with advanced pulmonary disease due to cystic fibrosis." | 3.68 | [Pneumothorax in cystic fibrosis: intrapleural instillation of Atabrine]. ( Blau, H; Rosenman, Y; Szeinberg, A; Yahav, J; Yancu, Y; Zack, J, 1991) |
| "The primary treatment of pneumothorax should be partial pleurectomy." | 1.28 | Pneumothorax in cystic fibrosis: a 26-year experience. ( Spector, ML; Stern, RC, 1989) |
| "The various treatments of spontaneous pneumothorax in cystic fibrosis are examined over a 15-yr period." | 1.26 | Open thoracotomy and pleural abrasion in the treatment of spontaneous pneumothorax in cystic fibrosis. ( Leonard, AS; Rich, RH; Warwick, WJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burdzińska-Golowin, J | 1 |
| Lewandowska, J | 1 |
| Misiukowa, G | 1 |
| McLaughlin, FJ | 1 |
| Matthews, WJ | 1 |
| Strieder, DJ | 1 |
| Khaw, KT | 1 |
| Schuster, S | 1 |
| Shwachman, H | 1 |
| Levistre, R | 1 |
| Lemnaouar, M | 1 |
| Rybkine, T | 1 |
| Béréziat, G | 1 |
| Masliah, J | 1 |
| Lomaestro, BM | 1 |
| Lesar, TS | 1 |
| Kaslovsky, RA | 1 |
| Rich, RH | 1 |
| Warwick, WJ | 1 |
| Leonard, AS | 1 |
| Jones, RE | 1 |
| Giammona, ST | 1 |
| Yancu, Y | 1 |
| Szeinberg, A | 1 |
| Rosenman, Y | 1 |
| Blau, H | 1 |
| Zack, J | 1 |
| Yahav, J | 1 |
| Aebersold, A | 1 |
| Schaad, UB | 1 |
| Spector, ML | 1 |
| Stern, RC | 1 |
| Melon, V | 1 |
| Germaud, P | 1 |
| David, A | 1 |
| McCarthy, VP | 1 |
| Nash, TE | 1 |
| Hubbard, VS | 1 |
| Cattaneo, SM | 1 |
| Sirak, HD | 1 |
| Klassen, KP | 1 |
| Kattwinkel, J | 1 |
| Taussig, LM | 1 |
| McIntosh, CL | 1 |
| di Sant'Agnese, PA | 1 |
| Wood, RE | 1 |
1 review available for quinacrine and Cystic Fibrosis
| Article | Year |
|---|---|
[Pneumothorax in cystic fibrosis].
Topics: Adolescent; Chest Tubes; Child; Cystic Fibrosis; Female; Humans; Male; Pneumothorax; Prognosis; Quin | 1991 |
12 other studies available for quinacrine and Cystic Fibrosis
| Article | Year |
|---|---|
[Clinical forms of lambliasis in small children].
Topics: Celiac Disease; Child, Preschool; Cystic Fibrosis; Diagnosis, Differential; Giardiasis; Humans; Infa | 1967 |
Pneumothorax in cystic fibrosis: management and outcome.
Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Intubation; Male; Pleur | 1982 |
Increase of bradykinin-stimulated arachidonic acid release in a delta F508 cystic fibrosis epithelial cell line.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cholera Toxin; Culture Media; Cyclic AMP; Cystic Fibrosis; | 1993 |
Pleurodesis with solution prepared from quinacrine hydrochloride tablets.
Topics: Adult; Cystic Fibrosis; Humans; Male; Pleura; Pneumothorax; Quinacrine; Solutions; Tablets | 1993 |
Open thoracotomy and pleural abrasion in the treatment of spontaneous pneumothorax in cystic fibrosis.
Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Intubation; Male; Metho | 1978 |
Intrapleural injection of quinacrine for pneumothorax in a child with cystic fibrosis.
Topics: Carbenicillin; Child; Cystic Fibrosis; Gentamicins; Humans; Injections; Male; Mediastinal Emphysema; | 1976 |
[Pneumothorax in cystic fibrosis: intrapleural instillation of Atabrine].
Topics: Adult; Cystic Fibrosis; Humans; Male; Pleura; Pneumothorax; Quinacrine; Sclerotherapy | 1991 |
Pneumothorax in cystic fibrosis: a 26-year experience.
Topics: Adolescent; Adult; Child; Cystic Fibrosis; Female; Humans; Male; Pleura; Pneumothorax; Quinacrine; S | 1989 |
[Pneumothorax and cystic fibrosis. Intrapleural instillation of Quinacrine in 2 cases of recurrent pneumothorax].
Topics: Adolescent; Cystic Fibrosis; Humans; Instillation, Drug; Male; Pneumothorax; Quinacrine; Recurrence | 1987 |
Severe giardiasis in a patient with cystic fibrosis.
Topics: Adult; Body Weight; Cystic Fibrosis; Giardiasis; Humans; Intestinal Diseases, Parasitic; Male; Quina | 1985 |
Recurrent spontaneous pneumothorax in the high-risk patient. Management with intrapleural quinacrine.
Topics: Adolescent; Autopsy; Child; Cystic Fibrosis; Follow-Up Studies; Humans; Injections; Male; Marfan Syn | 1973 |
Intrapleural instillation of quinacrine for recurrent pneumothorax. Use in a patient with cystic fibrosis.
Topics: Adult; Autopsy; Cystic Fibrosis; Follow-Up Studies; Humans; Male; Methods; Pleura; Pleural Diseases; | 1973 |