quinacrine has been researched along with Cirrhosis in 6 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases." | 6.49 | Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013) |
| " For this, extended subacute ovalbumin mice model of asthma was developed; these mice showed an increased expression of profibrotic mediators, subepithelial fibrosis, and goblet cell metaplasia along with airway inflammation, increased Th(2) cytokines, allergen-specific IgE, IgG(1), increased cytosolic PLA(2) (cPLA(2)), and airway hyperresponsiveness." | 3.75 | Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. ( Agrawal, A; Aich, J; Ghosh, B; Mabalirajan, U, 2009) |
| "Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases." | 2.49 | Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013) |
| "Renal toxicity is a serious side effect that hinders the use of cisplatin, a commonly used and effective chemotherapeutic agent." | 1.62 | Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. ( Abo El-Magd, NF; Ebrahim, HA; Eisa, NH; El-Sherbiny, M, 2021) |
| "Using the stasis model of venous thrombosis and resolution in mice, we found that genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated with increased fibrosis and altered expression of matrix metalloproteinase-2." | 1.46 | Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. ( Antalis, TM; Hoofnagle, MH; Mukhopadhyay, S; Nguyen, KP; Sarkar, R, 2017) |
| "Quinacrine is an inhibitor of phospholipase A(2), an enzyme thought to be involved in activity-related injury of skeletal muscles." | 1.32 | Attenuation of stretch-induced histopathologic changes of skeletal muscles by quinacrine. ( Stauber, WT; Willems, ME, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Abo El-Magd, NF | 1 |
| Ebrahim, HA | 1 |
| El-Sherbiny, M | 1 |
| Eisa, NH | 1 |
| Mukhopadhyay, S | 1 |
| Antalis, TM | 1 |
| Nguyen, KP | 1 |
| Hoofnagle, MH | 1 |
| Sarkar, R | 1 |
| Waas, RLV | 1 |
| Meggitt, SJ | 1 |
| Growe, RG | 1 |
| Luster, MI | 1 |
| Fail, PA | 1 |
| Lippes, J | 1 |
| Mabalirajan, U | 1 |
| Aich, J | 1 |
| Agrawal, A | 1 |
| Ghosh, B | 1 |
| Willems, ME | 1 |
| Stauber, WT | 1 |
1 review available for quinacrine and Cirrhosis
| Article | Year |
|---|---|
Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms.
Topics: Animals; Cell Adhesion; Chlamydia Infections; Chlamydia trachomatis; Contraception; Drug Implants; E | 2013 |
5 other studies available for quinacrine and Cirrhosis
| Article | Year |
|---|---|
Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Disease Models, Animal; Fibrosis; Immunohistoc | 2021 |
Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.
Topics: Animals; Disease Models, Animal; Fibrosis; Gene Expression Regulation, Enzymologic; Macrophages; Mat | 2017 |
Mepacrine-induced interstitial lung disease in discoid lupus erythematosus?
Topics: Adult; Diagnosis, Differential; Female; Fibrosis; Glucocorticoids; Humans; Lung; Lung Diseases, Inte | 2018 |
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
Topics: Animals; Arginase; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Epithelial Cells; Fibr | 2009 |
Attenuation of stretch-induced histopathologic changes of skeletal muscles by quinacrine.
Topics: Albumins; Animals; Desmin; Enzyme Inhibitors; Female; Fibrosis; Muscle Contraction; Muscle Fibers, S | 2003 |