Page last updated: 2024-10-16

quinacrine and Cirrhosis

quinacrine has been researched along with Cirrhosis in 6 studies

Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.

Research Excerpts

ExcerptRelevanceReference
"Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases."6.49Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013)
" For this, extended subacute ovalbumin mice model of asthma was developed; these mice showed an increased expression of profibrotic mediators, subepithelial fibrosis, and goblet cell metaplasia along with airway inflammation, increased Th(2) cytokines, allergen-specific IgE, IgG(1), increased cytosolic PLA(2) (cPLA(2)), and airway hyperresponsiveness."3.75Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. ( Agrawal, A; Aich, J; Ghosh, B; Mabalirajan, U, 2009)
"Quinacrine has been widely used in treatment of parasitic diseases such as malaria and giardiasis, and in the treatment of autoimmune diseases."2.49Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms. ( Fail, PA; Growe, RG; Lippes, J; Luster, MI, 2013)
"Renal toxicity is a serious side effect that hinders the use of cisplatin, a commonly used and effective chemotherapeutic agent."1.62Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. ( Abo El-Magd, NF; Ebrahim, HA; Eisa, NH; El-Sherbiny, M, 2021)
"Using the stasis model of venous thrombosis and resolution in mice, we found that genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated with increased fibrosis and altered expression of matrix metalloproteinase-2."1.46Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. ( Antalis, TM; Hoofnagle, MH; Mukhopadhyay, S; Nguyen, KP; Sarkar, R, 2017)
"Quinacrine is an inhibitor of phospholipase A(2), an enzyme thought to be involved in activity-related injury of skeletal muscles."1.32Attenuation of stretch-induced histopathologic changes of skeletal muscles by quinacrine. ( Stauber, WT; Willems, ME, 2003)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Abo El-Magd, NF1
Ebrahim, HA1
El-Sherbiny, M1
Eisa, NH1
Mukhopadhyay, S1
Antalis, TM1
Nguyen, KP1
Hoofnagle, MH1
Sarkar, R1
Waas, RLV1
Meggitt, SJ1
Growe, RG1
Luster, MI1
Fail, PA1
Lippes, J1
Mabalirajan, U1
Aich, J1
Agrawal, A1
Ghosh, B1
Willems, ME1
Stauber, WT1

Reviews

1 review available for quinacrine and Cirrhosis

ArticleYear
Quinacrine-induced occlusive fibrosis in the human fallopian tube is due to a unique inflammatory response and modification of repair mechanisms.
    Journal of reproductive immunology, 2013, Volume: 97, Issue:2

    Topics: Animals; Cell Adhesion; Chlamydia Infections; Chlamydia trachomatis; Contraception; Drug Implants; E

2013

Other Studies

5 other studies available for quinacrine and Cirrhosis

ArticleYear
Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway.
    International journal of molecular sciences, 2021, Oct-01, Volume: 22, Issue:19

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Disease Models, Animal; Fibrosis; Immunohistoc

2021
Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.
    Blood, 2017, 06-15, Volume: 129, Issue:24

    Topics: Animals; Disease Models, Animal; Fibrosis; Gene Expression Regulation, Enzymologic; Macrophages; Mat

2017
Mepacrine-induced interstitial lung disease in discoid lupus erythematosus?
    The British journal of dermatology, 2018, Volume: 179, Issue:4

    Topics: Adult; Diagnosis, Differential; Female; Fibrosis; Glucocorticoids; Humans; Lung; Lung Diseases, Inte

2018
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:3

    Topics: Animals; Arginase; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Epithelial Cells; Fibr

2009
Attenuation of stretch-induced histopathologic changes of skeletal muscles by quinacrine.
    Muscle & nerve, 2003, Volume: 27, Issue:1

    Topics: Albumins; Animals; Desmin; Enzyme Inhibitors; Female; Fibrosis; Muscle Contraction; Muscle Fibers, S

2003