quinacrine has been researched along with Cardiovascular Stroke in 4 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study we sought to assess whether administration of the phospholipase inhibitor quinacrine would reduce the extent of myocardial necrosis after coronary artery occlusion." | 3.68 | Reduction in infarct size by the phospholipase inhibitor quinacrine in dogs with coronary artery occlusion. ( Ambrosio, G; Cappelli-Bigazzi, M; Chiariello, M; Golino, P; Nevola, E; Perrone-Filardi, P; Tritto, I, 1990) |
| "In quinacrine-treated animals phospholipids and CK also fell initially; however, 24 and 48 hr after occlusion they were higher than in controls (phospholipids: 0." | 1.27 | Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion. ( Ambrosio, G; Cappelli-Bigazzi, M; Chiariello, M; Condorelli, M; Marone, G; Nevola, E; Perrone-Filardi, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oinuma, H | 1 |
| Takamura, T | 1 |
| Hasegawa, T | 1 |
| Nomoto, K | 1 |
| Naitoh, T | 1 |
| Daiku, Y | 1 |
| Hamano, S | 1 |
| Kakisawa, H | 1 |
| Minami, N | 1 |
| Spata, T | 1 |
| Bobek, D | 1 |
| Whitson, BA | 1 |
| Parthasarathy, S | 1 |
| Mohler, PJ | 1 |
| Higgins, RS | 1 |
| Kilic, A | 1 |
| Chiariello, M | 2 |
| Ambrosio, G | 2 |
| Cappelli-Bigazzi, M | 2 |
| Perrone-Filardi, P | 2 |
| Tritto, I | 1 |
| Nevola, E | 2 |
| Golino, P | 1 |
| Marone, G | 1 |
| Condorelli, M | 1 |
4 other studies available for quinacrine and Cardiovascular Stroke
| Article | Year |
|---|---|
Synthesis and biological evaluation of substituted benzenesulfonamides as novel potent membrane-bound phospholipase A2 inhibitors.
Topics: Animals; Benzene Derivatives; Cell Membrane; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Heart | 1991 |
A nonthoracotomy myocardial infarction model in an ovine using autologous platelets.
Topics: Animals; Coloring Agents; Coronary Vessels; Disease Models, Animal; Male; Microscopy, Fluorescence; | 2013 |
Reduction in infarct size by the phospholipase inhibitor quinacrine in dogs with coronary artery occlusion.
Topics: Animals; Coronary Disease; Dogs; Hemodynamics; Myocardial Infarction; Myocardium; Necrosis; Phosphol | 1990 |
Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Creatine Kinase; Hemodynamics; Isoenzymes; Male; Mathematics; | 1987 |