quinacrine has been researched along with Carcinoma, Hepatocellular in 6 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment by quinacrine alone at concentrations of 10-20 mM for 1-2 d cannot kill hepatocellular carcinoma cells, such as HepG2, Hep3B, Huh7, which are also resistant to TRAIL." | 5.37 | Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. ( Abdulghani, J; Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Hong, B; Katz, SI; Navaraj, A; Smith, CD; Wang, W, 2011) |
| "Treatment by quinacrine alone at concentrations of 10-20 mM for 1-2 d cannot kill hepatocellular carcinoma cells, such as HepG2, Hep3B, Huh7, which are also resistant to TRAIL." | 1.37 | Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. ( Abdulghani, J; Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Hong, B; Katz, SI; Navaraj, A; Smith, CD; Wang, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, W | 1 |
| Gallant, JN | 1 |
| Katz, SI | 1 |
| Dolloff, NG | 1 |
| Smith, CD | 1 |
| Abdulghani, J | 1 |
| Allen, JE | 1 |
| Dicker, DT | 1 |
| Hong, B | 1 |
| Navaraj, A | 1 |
| El-Deiry, WS | 1 |
| ACKERMAN, NB | 2 |
| SHEMESH, A | 1 |
| HALDORSEN, DK | 1 |
| WALLACE, DL | 1 |
| MADSEN, AJ | 1 |
| MCFEE, AS | 1 |
| Yoshioka, K | 1 |
| Clejan, S | 1 |
| Fisher, JW | 1 |
| Wolman, SR | 1 |
| Phillips, TF | 1 |
| Becker, FF | 1 |
| Miller, DA | 1 |
| Dev, VG | 1 |
| Borek, C | 1 |
| Miller, OJ | 1 |
6 other studies available for quinacrine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Camptothecin; Carcinoma, Hepatocellular; Cell Dea | 2011 |
LOCALIZATION OF AMINOACRIDINE FLUORESCENCE IN LUNG TUMORS OF RATS.
Topics: Acridines; Aminacrine; Aminoacridines; Animals; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatoc | 1964 |
AMINOACRIDINE UPTAKE BY EXPERIMENTAL TUMORS.
Topics: Acridines; Aminacrine; Animals; Autoradiography; Carcinoma 256, Walker; Carcinoma, Hepatocellular; F | 1965 |
Activation of protein kinase C in human hepatocellular carcinoma (HEP3B) cells increases erythropoietin production.
Topics: Alkaloids; Benzophenanthridines; Calcimycin; Carcinoma, Hepatocellular; Diglycerides; Enzyme Activat | 1998 |
Fluorescent banding patterns of rat chromosomes in normal cells and primary hepatocellular carcinomas.
Topics: Acetamides; Animals; Carcinoma, Hepatocellular; Cells, Cultured; Chromosome Aberrations; Female; Fib | 1972 |
The quinacrine fluorescent and Giemsa banding karyotype of the rat, Rattus norvegicus, and banded chromosome analysis of transformed and malignant rat liver cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chr | 1972 |