quinacrine has been researched along with Cancer of Colon in 6 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colorectal cancer is the third most common malignancy in the United States." | 5.36 | Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. ( Agyeman, A; DeVecchio, J; Houghton, JA; Jani, TS; Mazumdar, T, 2010) |
| "Colorectal cancer is the third most common malignancy in the United States." | 1.36 | Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. ( Agyeman, A; DeVecchio, J; Houghton, JA; Jani, TS; Mazumdar, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kohn, KW | 1 |
| Orr, A | 1 |
| O'Connor, PM | 1 |
| Guziec, LJ | 1 |
| Guziec, FS | 1 |
| Jani, TS | 1 |
| DeVecchio, J | 1 |
| Mazumdar, T | 1 |
| Agyeman, A | 1 |
| Houghton, JA | 1 |
| Mohapatra, P | 1 |
| Preet, R | 1 |
| Das, D | 1 |
| Satapathy, SR | 1 |
| Choudhuri, T | 1 |
| Wyatt, MD | 1 |
| Kundu, CN | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| WAGNER, DE | 1 |
| SILVA, AR | 1 |
| Shiiki, S | 1 |
| Fuchimoto, S | 1 |
| Orita, K | 1 |
| Atkin, NB | 1 |
6 other studies available for quinacrine and Cancer of Colon
| Article | Year |
|---|---|
Synthesis and DNA-sequence selectivity of a series of mono- and difunctional 9-aminoacridine nitrogen mustards.
Topics: Acridines; Alkylation; Base Sequence; Binding Sites; Colonic Neoplasms; DNA; Guanine; Humans; Interc | 1994 |
Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin.
Topics: Antineoplastic Agents; Carcinoma; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor | 2010 |
Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Proliferation; Colonic Neoplasm | 2012 |
THE CONTROL OF RECURRENT MALIGNANT EFFUSIONS USING QUINACRINE HYDROCHLORIDE.
Topics: Ascites; Biomedical Research; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; | 1964 |
A comparison of the antitumor effects of natural human tumor necrosis factors alpha and beta: the roles of arachidonic acid metabolism and intracellular cAMP.
Topics: Arachidonic Acid; Arachidonic Acids; Breast Neoplasms; Colforsin; Colonic Neoplasms; Cyclic AMP; Dex | 1990 |
Y bodies and similar fluorescent chromocentres in human tumours including teratomata.
Topics: Adenocarcinoma; Carcinoma; Colonic Neoplasms; Dysgerminoma; Female; Humans; Male; Microscopy, Fluore | 1973 |