quinacrine has been researched along with Brain Neoplasms in 7 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation." | 7.88 | Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis. ( Ascione, B; Buccarelli, M; D'Alessandris, QG; De Pascalis, I; Larocca, LM; Malorni, W; Marconi, M; Martini, M; Matarrese, P; Pacioni, S; Pallini, R; Ricci-Vitiani, L, 2018) |
| "We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine." | 7.80 | Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation. ( Gillespie, GY; Lobo, MR; Pike, MM; Wang, X; Woltjer, RL, 2014) |
| " We investigated whether quinacrine could improve carmustine therapy in C6 cell cultures and in C6 malignant gliomas implanted subcutaneously into Wistar rats." | 7.71 | Quinacrine enhances carmustine therapy of experimental rat glioma. ( Herrera, LA; Ostrosky, P; Reyes, S; Sotelo, J, 2001) |
| " For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation." | 3.88 | Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis. ( Ascione, B; Buccarelli, M; D'Alessandris, QG; De Pascalis, I; Larocca, LM; Malorni, W; Marconi, M; Martini, M; Matarrese, P; Pacioni, S; Pallini, R; Ricci-Vitiani, L, 2018) |
| "We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine." | 3.80 | Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation. ( Gillespie, GY; Lobo, MR; Pike, MM; Wang, X; Woltjer, RL, 2014) |
| " We investigated whether quinacrine could improve carmustine therapy in C6 cell cultures and in C6 malignant gliomas implanted subcutaneously into Wistar rats." | 3.71 | Quinacrine enhances carmustine therapy of experimental rat glioma. ( Herrera, LA; Ostrosky, P; Reyes, S; Sotelo, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buccarelli, M | 1 |
| Marconi, M | 1 |
| Pacioni, S | 1 |
| De Pascalis, I | 1 |
| D'Alessandris, QG | 1 |
| Martini, M | 1 |
| Ascione, B | 1 |
| Malorni, W | 1 |
| Larocca, LM | 1 |
| Pallini, R | 1 |
| Ricci-Vitiani, L | 1 |
| Matarrese, P | 1 |
| Li, XT | 1 |
| Ju, RJ | 1 |
| Li, XY | 1 |
| Zeng, F | 1 |
| Shi, JF | 1 |
| Liu, L | 1 |
| Zhang, CX | 1 |
| Sun, MG | 1 |
| Lou, JN | 1 |
| Lu, WL | 1 |
| Lobo, MR | 1 |
| Wang, X | 1 |
| Gillespie, GY | 1 |
| Woltjer, RL | 1 |
| Pike, MM | 1 |
| Geng, Y | 1 |
| Kohli, L | 1 |
| Klocke, BJ | 1 |
| Roth, KA | 1 |
| SCHUTZE, R | 1 |
| KLAR, E | 1 |
| Reyes, S | 2 |
| Herrera, LA | 1 |
| Ostrosky, P | 1 |
| Sotelo, J | 2 |
| Rembao, D | 1 |
7 other studies available for quinacrine and Brain Neoplasms
| Article | Year |
|---|---|
Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Kaplan-Meier | 2018 |
Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neopl | 2014 |
Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neo | 2014 |
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.
Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chloroquine; | 2010 |
[Vital fluorochromatization of brain tumors with atabrin as a diagnostic aid in brain tumor surgery].
Topics: Brain; Brain Neoplasms; Humans; Neoplasms; Quinacrine | 1951 |
Quinacrine enhances carmustine therapy of experimental rat glioma.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergis | 2001 |
The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells.
Topics: Animals; Antimalarials; Brain Neoplasms; Carcinogens; Chloroquine; Drug Synergism; Ependyma; Ependym | 2001 |