quinacrine has been researched along with Benign Neoplasms in 59 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighteen patients with advanced metastatic malignancy who had 21 pleural effusions requiring sclerosis for control were randomly allocated to intrapleural therapy with tetracycline or quinacrine." | 9.04 | Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial. ( Bayly, TC; Kisner, DL; Macdonald, JS; Schein, PS; Sybert, A; Tsou, E, 1978) |
| "Eighteen patients with advanced metastatic malignancy who had 21 pleural effusions requiring sclerosis for control were randomly allocated to intrapleural therapy with tetracycline or quinacrine." | 5.04 | Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial. ( Bayly, TC; Kisner, DL; Macdonald, JS; Schein, PS; Sybert, A; Tsou, E, 1978) |
| " Intratumor injection of quinacrine induces intense recruitment of activated immune cells that leads to necrosis and elimination of experimental malignant neoplasms; this effect seems to be mediated by immune molecules." | 3.72 | Interstitial quinacrine activates a distinctive immune response effective for tumor immunotherapy. ( Diaz, C; Guevara, P; Pineda, B; Sotelo, J, 2004) |
| "The mechanisms of anticancer effects of quinacrine are not well understood." | 2.72 | Repurposing quinacrine for treatment-refractory cancer. ( Kalogera, E; Oien, DB; Pathoulas, CL; Ray, U; Shridhar, V; Thirusangu, P, 2021) |
| "Quinacrine (QC) is a tricyclic compound and a derivative of 9-aminoacridine." | 2.72 | Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle. ( Das, B; Kundu, CN, 2021) |
| "Three drugs have been advocated for the treatment of giardiasis; furazolidone (Furoxone), metronidazole (Flagyl), and quinacrine (Atabrine)." | 2.36 | Treatment of giardiasis: literature review and recommendations. ( Lerman, SJ; Walker, RA, 1982) |
| "Quinacrine has potential as a chemosensitizer when combined with chemotherapy, but its anti-cancer mechanisms remain unclear." | 1.36 | Quinacrine enhances cisplatin-induced cytotoxicity in four cancer cell lines. ( Bi, Q; Dong, L; Fu, J; Ge, X; Li, S; Li, X; Wang, Y; Wu, D; Zhang, X, 2010) |
| "Several cancer treatment approaches, such as proteasome inhibitor Bortezomib and hsp90 inhibitor geldanamycin, involve activation of proteotoxic stress." | 1.35 | Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. ( Almasan, A; Banerjee, AK; Fairchild, RL; Gasparian, AV; Gorbachev, AV; Gudkov, AV; Gurova, KV; Komarov, AP; Neznanov, N; Neznanova, L, 2009) |
| "Cohort study." | 1.31 | Cancer risk among women sterilized with transcervical quinacrine in Chile: an update through 1996. ( Dabancens, A; Guzman-Serani, R; Sokal, DC; Zipper, J, 2000) |
| "To determine whether a cluster of eight cancers among 572 women who had received transcervical quinacrine hydrochloride was a random occurrence or evidence of an increased risk of cancer." | 1.29 | Cancer risk among women sterilized with transcervical quinacrine hydrochloride pellets, 1977 to 1991. ( Aldrich, TE; Guzman-Serani, R; Sokal, DC; Zipper, J, 1995) |
| "Concerned over a possible link to cancer, researchers from Family Health International (FHI) have begun investigating the long-term safety of the chemical used for non-surgical sterilization, a study being carried out among Chilean women." | 1.28 | Researchers assess data on long-term safety of non-surgical sterilization method. ( , 1991) |
| "A pleural effusion is a frequent complication of malignant disease." | 1.26 | Management of malignant pleural effusion. ( Bennett, JM; Greenwald, DW; Phillips, C, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (62.71) | 18.7374 |
| 1990's | 4 (6.78) | 18.2507 |
| 2000's | 8 (13.56) | 29.6817 |
| 2010's | 6 (10.17) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Pan, X | 1 |
| Mao, TY | 1 |
| Mai, YW | 1 |
| Liang, CC | 1 |
| Huang, WH | 1 |
| Rao, Y | 1 |
| Huang, ZS | 1 |
| Huang, SL | 1 |
| Oien, DB | 1 |
| Pathoulas, CL | 1 |
| Ray, U | 1 |
| Thirusangu, P | 1 |
| Kalogera, E | 1 |
| Shridhar, V | 1 |
| Forveille, S | 1 |
| Humeau, J | 1 |
| Sauvat, A | 1 |
| Bezu, L | 1 |
| Kroemer, G | 1 |
| Kepp, O | 1 |
| Das, B | 1 |
| Kundu, CN | 1 |
| Al-Mugotir, M | 1 |
| Lovelace, JJ | 1 |
| George, J | 1 |
| Bessho, M | 1 |
| Pal, D | 1 |
| Struble, L | 1 |
| Kolar, C | 1 |
| Rana, S | 1 |
| Natarajan, A | 1 |
| Bessho, T | 1 |
| Borgstahl, GEO | 1 |
| Pellerano, M | 1 |
| Tcherniuk, S | 1 |
| Perals, C | 1 |
| Ngoc Van, TN | 1 |
| Garcin, E | 1 |
| Mahuteau-Betzer, F | 1 |
| Teulade-Fichou, MP | 1 |
| Morris, MC | 1 |
| Yan, H | 1 |
| Bian, A | 1 |
| Gao, X | 1 |
| Li, H | 1 |
| Chen, Z | 1 |
| Liu, X | 1 |
| Gomes, A | 1 |
| Fernandes, I | 1 |
| Teixeira, C | 1 |
| Mateus, N | 1 |
| Sottomayor, MJ | 1 |
| Gomes, P | 1 |
| Lipka, D | 1 |
| Boratyński, J | 1 |
| Neznanov, N | 1 |
| Gorbachev, AV | 1 |
| Neznanova, L | 1 |
| Komarov, AP | 1 |
| Gurova, KV | 1 |
| Gasparian, AV | 1 |
| Banerjee, AK | 1 |
| Almasan, A | 1 |
| Fairchild, RL | 1 |
| Gudkov, AV | 1 |
| Chau, CH | 1 |
| Figg, WD | 1 |
| Wang, Y | 1 |
| Bi, Q | 1 |
| Dong, L | 1 |
| Li, X | 1 |
| Ge, X | 1 |
| Zhang, X | 1 |
| Fu, J | 1 |
| Wu, D | 1 |
| Li, S | 1 |
| Hede, K | 1 |
| CRAMER, H | 2 |
| BRILMAYER, C | 7 |
| SCHUTZE, R | 3 |
| SAWICKY, HH | 1 |
| KANOF, NB | 1 |
| SILVERBERG, MG | 1 |
| BRAITMAN, M | 1 |
| KALISH, B | 1 |
| ADERHOLD, K | 1 |
| KOHLER, A | 2 |
| MACK, A | 4 |
| KUGEL, E | 1 |
| VASSEY, JW | 1 |
| EDMONDS, J | 1 |
| IRVIN, JL | 1 |
| GREEN, JA | 1 |
| IRVIN, EM | 1 |
| REUSS, A | 1 |
| LINDNER, D | 1 |
| MASCITELLI-CORIANDOLI, E | 1 |
| BOLDRINI, R | 1 |
| CITTERIO, C | 1 |
| GELLHORN, A | 2 |
| ZAIDENWEBER, J | 1 |
| ULTMANN, J | 1 |
| HIRSCHBERG, E | 2 |
| WIENER, E | 1 |
| ACEL, H | 1 |
| ULTMANN, JE | 1 |
| OSNOS, M | 1 |
| ACKERMAN, NB | 2 |
| SHEMESH, A | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| WAGNER, DE | 1 |
| SILVA, AR | 1 |
| HALDORSEN, DK | 1 |
| WALLACE, DL | 1 |
| MADSEN, AJ | 1 |
| MCFEE, AS | 1 |
| YOUNG, JM | 1 |
| WILD, F | 1 |
| SIMON-REUSS, I | 1 |
| STORDEUR, K | 1 |
| BINGOLD, K | 1 |
| KLAR, E | 1 |
| CRAMER, VH | 1 |
| PABST, HW | 1 |
| Ukale, V | 1 |
| Agrenius, V | 1 |
| Hillerdal, G | 1 |
| Mohlkert, D | 1 |
| Widström, O | 1 |
| Sotelo, J | 1 |
| Guevara, P | 1 |
| Pineda, B | 1 |
| Diaz, C | 1 |
| Wang, W | 1 |
| Ho, WC | 1 |
| Dicker, DT | 1 |
| MacKinnon, C | 1 |
| Winkler, JD | 1 |
| Marmorstein, R | 1 |
| El-Deiry, WS | 1 |
| Dollinger, MR | 1 |
| Krakoff, IH | 1 |
| Karnofsky, DA | 1 |
| Lerman, SJ | 1 |
| Walker, RA | 1 |
| Sokal, DC | 2 |
| Zipper, J | 3 |
| Guzman-Serani, R | 2 |
| Aldrich, TE | 1 |
| Dabancens, A | 2 |
| Guerrero, A | 1 |
| Trujillo, V | 1 |
| Kessel, E | 1 |
| Greenwald, DW | 1 |
| Phillips, C | 1 |
| Bennett, JM | 1 |
| Bayly, TC | 1 |
| Kisner, DL | 1 |
| Sybert, A | 1 |
| Macdonald, JS | 1 |
| Tsou, E | 1 |
| Schein, PS | 1 |
| Austin, EH | 1 |
| Flye, MW | 1 |
| Mejer, J | 1 |
| Mortensen, KM | 1 |
| Hansen, HH | 1 |
| Bocian, M | 1 |
| Mohandas, T | 1 |
| Hausheer, FH | 1 |
| Yarbro, JW | 1 |
| Shaw, MW | 1 |
| Sellyei, M | 1 |
| Vass, L | 1 |
| Borja, ER | 1 |
| Pugh, RP | 1 |
| Farber, LR | 1 |
| Nieper, HA | 1 |
8 reviews available for quinacrine and Benign Neoplasms
| Article | Year |
|---|---|
Repurposing quinacrine for treatment-refractory cancer.
Topics: Animals; Antimalarials; Antineoplastic Agents; Drug Discovery; Drug Repositioning; Drug Resistance, | 2021 |
Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle.
Topics: Antimalarials; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; DNA, Neoplasm; Dru | 2021 |
[Metalloproteinases. Structure and function].
Topics: 4-Aminobenzoic Acid; Animals; Apoptosis; Arthritis; Autoimmune Diseases; Cell Movement; Chloroquine; | 2008 |
Treatment of giardiasis: literature review and recommendations.
Topics: Animals; Child; Diarrhea; Drug Evaluation; Female; Fever; Furazolidone; Giardiasis; Humans; Metronid | 1982 |
Quinacrine revised.
Topics: Animals; Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Quinacrine; Sclerosing Solut | 1995 |
Quinacrine sterilization: an assessment of risks for ectopic pregnancy, birth defects and cancer.
Topics: Abnormalities, Drug-Induced; Animals; Drug Implants; Female; Humans; Mutagens; Neoplasms; Pregnancy; | 1998 |
The treatment of recurrent malignant pleural effusion.
Topics: Drainage; Humans; Intubation; Neoplasm Metastasis; Neoplasms; Nitrogen Mustard Compounds; Pleura; Pl | 1979 |
Diagnosis and treatment of malignant pleural effusion.
Topics: Biopsy; Bleomycin; Carcinoembryonic Antigen; Chromosome Aberrations; Cytodiagnosis; Drainage; Endosc | 1985 |
3 trials available for quinacrine and Benign Neoplasms
| Article | Year |
|---|---|
Pleurodesis in recurrent pleural effusions: a randomized comparison of a classical and a currently popular drug.
Topics: Antineoplastic Agents; Female; Humans; Male; Neoplasm Recurrence, Local; Neoplasms; Pleural Effusion | 2004 |
Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial.
Topics: Clinical Trials as Topic; Female; Humans; Intubation; Neoplasms; Pleura; Pleural Effusion; Quinacrin | 1978 |
Mepacrine hydrochloride in the treatment of malignant pleural effusion. A controlled randomized trial.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Neoplasms; Pleura; Pleural | 1977 |
48 other studies available for quinacrine and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy.
Topics: Adenosine Triphosphatases; Antigens, Neoplasm; Antineoplastic Agents; Cell Line, Tumor; DNA Topoisom | 2022 |
Quinacrine-mediated detection of intracellular ATP.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Cell Line, Tumor; High-Throughput Screening Assays; H | 2019 |
Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction.
Topics: Apoptosis; BRCA1 Protein; Cell Death; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Doxor | 2021 |
Targeting Conformational Activation of CDK2 Kinase.
Topics: Adenosine Triphosphate; Allosteric Regulation; Biosensing Techniques; Cell Proliferation; Cyclin-Dep | 2017 |
Novel applications for an established antimalarial drug: tumoricidal activity of quinacrine.
Topics: Animals; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell C | 2018 |
A Quinacrine Analogue Selective Against Gastric Cancer Cells: Insight from Biochemical and Biophysical Studies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; MCF-7 Cells; Microscopy, Fluore | 2016 |
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; DNA-Bindi | 2009 |
New tricks from an old drug: a role for quinacrine in anti-cancer therapy?
Topics: Animals; Antineoplastic Agents; Drug Therapy, Combination; Enzyme Inhibitors; Heat-Shock Response; H | 2009 |
Quinacrine enhances cisplatin-induced cytotoxicity in four cancer cell lines.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tu | 2010 |
Antimalaria drug offers antitumor strategies.
Topics: Antimalarials; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trial | 2011 |
Researchers assess data on long-term safety of non-surgical sterilization method.
Topics: Americas; Chile; Cohort Studies; Contraception; Demography; Developing Countries; Disease; Evaluatio | 1991 |
[Diagnosis of tumors with atebrin].
Topics: Neoplasms; Quinacrine | 1952 |
[Ultraviolet radiation and atebrin, diagnostic means in tumor operations].
Topics: Neoplasms; Quinacrine; Ultraviolet Rays | 1952 |
Therapeutic assays of the Skin and Cancer Unit of the New York University Hospital. Assay VII-Quinacrine hydrochloride (atabrine hydrochloride) for chronic discoid lupus erythematosus.
Topics: Hospitals, University; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Neoplasms; New Y | 1952 |
[Determination of chromium fluoride excretion in urine after intravenous atabrine administrations as method of early and differential diagnosis of malignant tumors].
Topics: Chromium; Diagnosis, Differential; Fluorides; Neoplasms; Phosphates; Quinacrine | 1953 |
[Determination of trypaflavine in the urine in diagnosis of tumors in relation to the atebrin and eosin test].
Topics: Acridines; Body Fluids; Coloring Agents; Eosine Yellowish-(YS); Humans; Neoplasms; Quinacrine; Urine | 1954 |
[Chromophile property of lung tissue towards atebrin with special reference to malignant neoplasms].
Topics: Body Fluids; Lung Neoplasms; Neoplasms; Quinacrine; Urine | 1955 |
Studies on the administration of quinacrine to tumor-bearing mice.
Topics: Animals; Mice; Neoplasms; Neoplasms, Experimental; Quinacrine | 1955 |
[Can the photometric determination of urinary atebrin excretion be used in the early diagnosis of cancer].
Topics: Body Fluids; Early Detection of Cancer; Early Diagnosis; Neoplasms; Photometry; Quinacrine | 1958 |
Mepacrine effect on the liver riboflavin during chemical carcinogenesis.
Topics: Biochemical Phenomena; Encephalomyelitis; Liver; Neoplasms; Projective Techniques; Quinacrine; Ribof | 1958 |
The use of atabrine (quinacrine) in the control of recurrent neoplastic effusions. A preliminary report.
Topics: Exudates and Transudates; Humans; Neoplasms; Quinacrine; Recurrence | 1961 |
[A new contribution to the treatment of advanced inoperable carcinoma: preliminary report].
Topics: Carcinoma; Humans; Immunotherapy, Active; Neoplasms; Quinacrine | 1959 |
The effect of quinacrine on neoplastic effusions and certain of their enzymes.
Topics: Ascites; Humans; Neoplasms; Pleural Effusion; Quinacrine | 1963 |
LOCALIZATION OF AMINOACRIDINE FLUORESCENCE IN LUNG TUMORS OF RATS.
Topics: Acridines; Aminacrine; Aminoacridines; Animals; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatoc | 1964 |
THE CONTROL OF RECURRENT MALIGNANT EFFUSIONS USING QUINACRINE HYDROCHLORIDE.
Topics: Ascites; Biomedical Research; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; | 1964 |
AMINOACRIDINE UPTAKE BY EXPERIMENTAL TUMORS.
Topics: Acridines; Aminacrine; Animals; Autoradiography; Carcinoma 256, Walker; Carcinoma, Hepatocellular; F | 1965 |
STUDIES OF THE UPTAKE OF TRITIUM LABELLED MEPACRINE BY TUMOURS.
Topics: Autoradiography; Blood; Bone Marrow; Brain; Carcinoma 256, Walker; Humans; Intestines; Kidney; Liver | 1965 |
[Affinity of certain dyes for healthy and neoplastic tissue proved by quantitative tissue extractions].
Topics: Coloring Agents; Fluoresceins; Humans; Neoplasms; Quinacrine; Tissue Extracts | 1955 |
[Atebrin secretion in urine in diagnosis of malignant tumors].
Topics: Body Fluids; Neoplasms; Quinacrine | 1955 |
[Vital fluorochromatization of brain tumors with atabrin as a diagnostic aid in brain tumor surgery].
Topics: Brain; Brain Neoplasms; Humans; Neoplasms; Quinacrine | 1951 |
[Utilization of fluorescein sodium and atebrin in tumor diagnosis].
Topics: Fluorescein; Humans; Neoplasms; Quinacrine | 1951 |
[Vital fluor chrometization of tumors with atebrin as diagnostic aid in surgery of tumors].
Topics: Humans; Neoplasms; Quinacrine | 1951 |
[Diagnosis of tumors by selective concentration of radioactive phosphorus, fluorides and atabrine].
Topics: Fluorides; Neoplasms; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Quinacrine; Radioac | 1952 |
Interstitial quinacrine activates a distinctive immune response effective for tumor immunotherapy.
Topics: Animals; Antineoplastic Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemokine CC | 2004 |
Acridine derivatives activate p53 and induce tumor cell death through Bax.
Topics: Acridines; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Drug Design; Humans; In | 2005 |
Quinacrine (Atabrine) in the treatment of neoplastic effusions.
Topics: Adult; Aged; Exudates and Transudates; Female; Humans; Male; Middle Aged; Neoplasms; Peritoneal Dise | 1967 |
Cancer risk among women sterilized with transcervical quinacrine hydrochloride pellets, 1977 to 1991.
Topics: Adult; Cluster Analysis; Cohort Studies; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasms; | 1995 |
Cancer risk among women sterilized with transcervical quinacrine in Chile: an update through 1996.
Topics: Adult; Breast Neoplasms; Cervix Uteri; Cohort Studies; Female; Follow-Up Studies; Humans; Neoplasms; | 2000 |
Management of malignant pleural effusion.
Topics: Bleomycin; Fluorouracil; Gold Radioisotopes; Humans; Mechlorethamine; Methods; Neoplasms; Phosphorus | 1978 |
Recent cytogenetic advances and implications for pediatric practice.
Topics: Abortion, Spontaneous; Azure Stains; Chromosome Aberrations; Chromosome Banding; Chromosome Disorder | 1978 |
Uses of banding techniques for the identification of human diseases of cytogenetic origin.
Topics: Burkitt Lymphoma; Chromosome Aberrations; Chromosome Disorders; Genetic Techniques; Humans; Leukemia | 1973 |
An agent for the palliative treatment of neoplastic effusions. Quinacrine (atabrine) hydrochloride.
Topics: Ascites; Humans; Neoplasms; Palliative Care; Pleural Effusion; Quinacrine | 1966 |
Absence of fluorescent Y bodies in some malignant epithelial tumours in human males: preliminary results.
Topics: Adult; Aged; Cell Nucleus; Female; Fluorescence; Humans; Male; Methods; Microscopy, Fluorescence; Mi | 1972 |
Single-dose quinacrine (atabrine) and thoracostomy in the control of pleural effusions in patients with neoplastic diseases.
Topics: Drainage; Fever; Hallucinations; Humans; Hypotension; Intubation; Nausea; Neoplasm Metastasis; Neopl | 1973 |
Correctable complications of neoplastic disease. 3. Neoplastic effusions.
Topics: Alkylating Agents; Ascitic Fluid; Breast Neoplasms; Drainage; Exudates and Transudates; Female; Huma | 1971 |
[Cytostatic effect of resochin and atebrin (compare same journal 20 (N.F.) 28: 1591 (1969))].
Topics: Animals; Antineoplastic Agents; Chloroquine; Humans; Neoplasms; Neoplasms, Experimental; Quinacrine | 1970 |
Chromosome identification.
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Female; Humans; Male; Methods; Microscopy | 1971 |