quinacrine has been researched along with Astrocytoma, Grade IV in 6 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation." | 7.88 | Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis. ( Ascione, B; Buccarelli, M; D'Alessandris, QG; De Pascalis, I; Larocca, LM; Malorni, W; Marconi, M; Martini, M; Matarrese, P; Pacioni, S; Pallini, R; Ricci-Vitiani, L, 2018) |
| " Quinacrine (QC), a recently discovered TRAIL sensitizer drug, is loaded into the hydrogel carriers and the influence of this system on the apoptosis of a malignant type of brain cancer, glioblastoma multiforme (GBM), has been investigated in detail." | 7.85 | Quinacrine Mediated Sensitization of Glioblastoma (GBM) Cells to TRAIL through MMP-Sensitive PEG Hydrogel Carriers. ( Cingöz, A; Erkoc, P; Kizilel, S; Onder, TB, 2017) |
| " For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation." | 3.88 | Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis. ( Ascione, B; Buccarelli, M; D'Alessandris, QG; De Pascalis, I; Larocca, LM; Malorni, W; Marconi, M; Martini, M; Matarrese, P; Pacioni, S; Pallini, R; Ricci-Vitiani, L, 2018) |
| " Quinacrine (QC), a recently discovered TRAIL sensitizer drug, is loaded into the hydrogel carriers and the influence of this system on the apoptosis of a malignant type of brain cancer, glioblastoma multiforme (GBM), has been investigated in detail." | 3.85 | Quinacrine Mediated Sensitization of Glioblastoma (GBM) Cells to TRAIL through MMP-Sensitive PEG Hydrogel Carriers. ( Cingöz, A; Erkoc, P; Kizilel, S; Onder, TB, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandes, GFDS | 1 |
| Fernandes, BC | 1 |
| Valente, V | 1 |
| Dos Santos, JL | 1 |
| Fu, X | 1 |
| Xiong, B | 1 |
| Zhao, M | 1 |
| Wan, W | 1 |
| Zhang, S | 1 |
| Wu, X | 1 |
| Xu, J | 1 |
| Maletzki, C | 1 |
| Rosche, Y | 1 |
| Riess, C | 1 |
| Scholz, A | 1 |
| William, D | 1 |
| Classen, CF | 1 |
| Kreikemeyer, B | 1 |
| Linnebacher, M | 1 |
| Fiedler, T | 1 |
| Buccarelli, M | 1 |
| Marconi, M | 1 |
| Pacioni, S | 1 |
| De Pascalis, I | 1 |
| D'Alessandris, QG | 1 |
| Martini, M | 1 |
| Ascione, B | 1 |
| Malorni, W | 1 |
| Larocca, LM | 1 |
| Pallini, R | 1 |
| Ricci-Vitiani, L | 1 |
| Matarrese, P | 2 |
| Matteoni, S | 1 |
| Abbruzzese, C | 1 |
| De Luca, G | 1 |
| Mileo, AM | 1 |
| Miccadei, S | 1 |
| Schenone, S | 1 |
| Musumeci, F | 1 |
| Haas, TL | 1 |
| Sette, G | 1 |
| Carapella, CM | 1 |
| Amato, R | 1 |
| Perrotti, N | 1 |
| Signore, M | 1 |
| Paggi, MG | 1 |
| Erkoc, P | 1 |
| Cingöz, A | 1 |
| Onder, TB | 1 |
| Kizilel, S | 1 |
1 review available for quinacrine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Recent advances in the discovery of small molecules targeting glioblastoma.
Topics: Animals; Central Nervous System Neoplasms; Drug Discovery; Glioblastoma; Humans; Neoplastic Stem Cel | 2019 |
5 other studies available for quinacrine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Quinacrine is active in preclinical models of glioblastoma through suppressing angiogenesis, inducing oxidative stress and activating AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glioblastom | 2022 |
Deciphering molecular mechanisms of arginine deiminase-based therapy - Comparative response analysis in paired human primary and recurrent glioblastomas.
Topics: Autophagy; Bacterial Proteins; Cell Line, Tumor; Cell Survival; Cellular Senescence; Curcumin; Gamma | 2017 |
Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Kaplan-Meier | 2018 |
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Glioblast | 2019 |
Quinacrine Mediated Sensitization of Glioblastoma (GBM) Cells to TRAIL through MMP-Sensitive PEG Hydrogel Carriers.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Gene Expression Regulati | 2017 |